• Analytical Science and Technology
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• v.36 no.4
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• pp.180-190
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• 2023

The presence of process related impurities in any drug or the drug product was associated with its safety, stability and efficacy. The overall literature survey proved that there is no method published on the assessment of process related impurities in brigatinib. In this study, a simple, reliable and stable HPLC qualitative method was reported for quantification of process related impurities with easy and quick extraction procedure. The impurities along with standard brigatinib was resolved on Lichrospher^® C18 (250 mm × 4.6 mm; 5 ㎛ particle size) column in room temperature using methanol, acetonitrile, pH 4.5 phosphate buffer in 55:25:20 (v/v) at 1.0 mL/min as mobile phase and UV detection at 261 nm. The method produces well resolved peaks at retention time of 4.60 min, 12.28 min, 3.37 min, 7.34 min and 8.39 min respectively for brigatinib, impurity A, B, C and D. The method produces a very sensitive detection limit of 0.0065 ㎍/mL, 0.0068 ㎍/mL, 0.0053 ㎍/mL and 0.0058 ㎍/mL for impurity A, B, C and D respectively with calibration curve linear in the concentration range of 22.5-135 ㎍/mL for brigatinib and 0.0225-0.135 ㎍/mL for impurities. The method produces all the validation parameters under the acceptable level and doesn't produces any considerable changes in peak area response while minor changes in the developed method conditions. The method can effectively resolve the unknown stress degradation products along with known impurities with less % degradation. The method can efficiently resolve and quantify the impurities in formulation and hence can suitable for the routine quality analysis of brigatinib in raw material and formulation.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.9 no.5
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• pp.109-114
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• 2009

At the present time, buildings are designed higher and more complex than ever before. Therefore the potential disasters are happened such as fire, power outage, earthquake, flood, hurricanes. Their disasters require people inside buildings to be evacuated as soon as possible. This paper presents a new disaster evacuation guidance concept of inner buildings, whiche aims at integrated the constructing of a sensor network and a guidance light networks in order to provide a quick detection of disasters and accurate evacuation guidance based on indoor geo-information, and sends these instructions to people. In this paper, we present the integrated logical model based on sensor and guidance light networks for the fire disaster management in inner building using our concept. And we verify proposed logical model according to experiments with visualization and operations on map.

• Journal of Institute of Control, Robotics and Systems
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• v.19 no.8
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• pp.718-724
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• 2013

In today's automotive industry, there exist several systems that help drivers reduce the possibility of accidents, such as the ADAS (Advanced Driver Assistance System). The ADAS helps drivers make correct and quick decisions during dangerous situations. This study analyzed the performance of the IMM (Interacting Multiple Model) method based on multiple Kalman filters using the data acquired from a driving simulator. An IMM algorithm is developed to identify the current discrete state of neighboring vehicles using the sensor data and the vehicle dynamics. In particular, the driving modes of the neighboring vehicles are classified by the cruising and maneuvering modes, and the transition between the states is modeled using a Markovian switching coefficient. The performance of the IMM algorithm is analyzed through realistic simulations where a target vehicle executes sudden lane change or acceleration maneuver.

• Bulletin of the Korean Chemical Society
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• v.25 no.2
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• pp.172-176
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• 2004

A highly selective membrane electrode based on1,3,5-triphenylpyrylium perchlorate (TPPP) is presented. The proposed electrode shows very good selectivity for sulfate ions over a wide variety of common inorganic and organic anions. The sensor displays a nice Nernstian slope of -29.7 mV per decade. The working concentration ranges of the electrode is 1.0{\times}10^{-1}-6.3{\times}10^{-6} $M with a detection limit of $4.0{\times}10^{-6}$ M (480 ng per mL). The response time of the sensor in whole concentration ranges is very short (< 6 s). The response of the sensor is independent on the pH range of 2.5-9.5. The best performance was obtained with a membrane composition of 32% PVC, 59% benzyl acetate, 5% TPPP and 4% hexadecyltrimethylammonium bromide. It was successfully used as an indicator electrode for titration of sulfate ions with barium ions. The electrode was also applied for determination of salbutamol sulfate and paramomycine sulfate.

• Transactions of the Korean Society of Automotive Engineers
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• v.7 no.9
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• pp.36-47
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• 1999

Three-way catalyst converter, cleaning up the exhaust gas contamination of SI engine, has the best efficiency when A/F ratio is near the stoichiometry . The feedback control using oxygen sensors in the exhaust manifold has limits caused by the system delays. So the accurate measurement of air flow rate to an engine is essential to control the fuel injection rate especially on transient condition like the rapid throttle opening and closing. To measure the rapid change of flow rates. the air flow meter for the engine requires quick response, flow reversal detection, and linearity . Tjhe proposed integration type air flow meter (IFM), composed of an ultrasonic flow meter with an integration circuit, has significantly improved the measurement accuracy of air mass inducted through the throttle body. The proposed control method estimated the air mass at the cylinder port using the measured air mass at the throttle . For the fuel dynamic model, the two constant fuel model is introduced . The control parameters from air and fuel dynamics are tuned to minimize the excursion of the air fuel ratio. As a result A/F ratio excursion can be reduced within 5% when throttle rapidly opens and closes at the various engine conditions.

• Biomedical Science Letters
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• v.16 no.3
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• pp.193-196
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• 2010

Multiplex PCR-based short tandem repeat (STR) analysis is considered as a good tool for monitoring bone marrow engraftment after sex-mismatched allogeneic transplantation and provides a sensitive and accurate assessment of the contribution of both donor and/or recipient cells in post-transplantation specimens. Forensic STR analysis and quantitative real time PCR are used to determine the proportion of donor versus recipient each contained within the total DNA. The STR markers were co-amplified in a single reaction by using commercial $PowerPlex^{(R)}$ 16 system and $AmpFISTR^{(R)}$ $Identifiler^{(R)}$ / $Yfiler^{(R)}$ PCR amplification kits. Separation of the PCR products and fluorescence detection were performed by ABI $PRIS^{(R)}$ 3100 Genetic Analyzer with capillary electrophoresis. The $GeneMapper^{TM}$ ID software were used for size calling and analysis of STR profiles. Extracted DNA was quantified by the $Quantifiler^{TM}$ Human DNA / Y Human Male DNA Quantification Kit The intent of this study was to analyze the ratio of donor versus recipient cells in the post-transplant peripheral blood, spleen, lung and kidney specimens. Specimens were taken from the traffic accident male victim who had been engrafted from bone marrow female donor. Blood and spleen specimens displayed female donor DNA profile. Kidney specimen showed male recipient DNA profile. Interestingly, lung tissue showed mixed profiles. The findings of this study indicate that the forensic STR analysis using fluorescence labeling PCR combined with capillary electrophoresis is quick and reliable enough to assess the ratio of donor versus recipient cells and to monitor the mixed chimeric patterns.

• Fire Science and Engineering
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• v.18 no.4
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• pp.78-85
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• 2004

This research analyzes Clean Room accidents, and presents research Clean Room, major fire prevention standards of Clean Room (FM, IRI, and NFPA Code), various results from Fire Simulation of analysis. The results are : the smoke diffusion is very quick coupled with the Heating, Ventilating, and Air Conditioning (HVAC) systems under fire ; the possibility of getting the result and the possibility the role of the Sprinkler systems to reduce the diffusion of the smoke. We learn about the importance to stop operating Heating, Ventilating, and Air Conditioning (HVAC) systems and to operate the Sprinkler system for securing safety with fire detection. Therefore, This research will be contributing to secure safety of Clean Room.

• Analytical Science and Technology
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• v.30 no.2
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• pp.82-88
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• 2017

Adenophorae Radix (AR) is a frequently used medicinal herb; because of its popularity, products containing similar herbal products are often sold as substitutes, especially if their morphology is similar. However, any analytical method to identify AR based on quantitative analysis is not registered in Korea, Japan and China Pharmacopoeias. This study developed a simple HPLC method to discriminate between authentic AR and substitutes. Linoleic acid was used as a marker compound of AR. Our optimized HPLC-UV conditions included a mobile phase of 90 % acetonitrile under isocratic condition, and a flow rate of 1.0 mL/min at room temperature. Detection wavelength was set at 205 nm. Linoleic acid was detected at 13.5 minutes for a total analysis time of 20 minutes. The standard herb of AR contained 0.025 % of linoleic acid, while four authentic AR samples and eight substitutes contained 0.040~0.071 % and 0.004~0.014 %, respectively. Comparison of the linoleic acid concentrations of the sample types to reference AR showed that among 12 samples, only the four samples were authentic. Thus, our HPLC-UV method, along with our suggested content criterion for linoleic acid concentration, can be used for the quick and accurate determination whether the herbal products are authentic AR or substitute.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.60 no.5
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• pp.1049-1054
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• 2011

Color is discerned due to the reflectance of object and its hue is determined by the Ratio of RGB spectrum. The aim of this study is to evaluate the Color information using by the optical system in terms of convenience and simplicity. Firstly, the differential Ratio of RGB is evaluated by photodiode Sensor which achieves a high efficiency with quick tranducer output. To extract the information of RGB Ratio, light emitting diode is built in Color sensing system with photodiode. Our proposed method is very economical, simple, and convenient. Our results can be applied to confirm the accurate information of Color in the research environments and commercial purposes. Thus RGB information can be determined subjectively and thus, the inherent characteristic of Color will be revealed precisely and its related features can be resolved in a real time mode.

• Proceedings of the SCSK Conference
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• 2003.09a
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• pp.1-12
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• 2003

Instead of sensory evaluation, we designed an evaluation method of the setting function of hairstyling products, based on an original theory focusing on changes in bending stress observed when a load with continuous bending is applied to human hair. Specifically, we developed a device to measure bending stress to quickly and objectively evaluate the condition of human hair, particularly its dynamic properties such as the setting function, following the application of hairstyling products. This device generates a load with continuous bending while applying a pendulum motion to a hair tress, one end of which is anchored. The setting function and holding power of resins of various molecular weight and ionic properties were evaluated using this device. The results demonstrated a close correlation with those obtained by experts' sensory evaluation. The evaluation results of bending stress and holding rate confirmed that the combined use of two different resins could improve the function of setting preparations. Evaluation using this device was able to substitute for sensory evaluation, and offers quick objective evaluation and detection of changes in the holding power of hairstyling products over time. We conclude that evaluation using this device is a promising new method.