• 한국생활과학회지
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• 제17권4호
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• pp.797-805
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• 2008

The present study was investigated on type 2 diabetics' actual status of anti-diabetic functional food intake by patients who came to oriental medicine clinics in Daejeon. The male was 37.3% and female was 62.7% of the subjects. The onset of the disease was most common in the age of 50's. Also 40% of the subjects have been suffering for more than 5 years. 35.7% of men, 53.2% for women had family history. Also 61.5% of the patients chose to carry out both diabetic therapy and exercise at the same time. 69.3% of the subjects have had experiences in anti-diabetic functional foods. Anti-diabetic functional foods used to surveyed people were bean, ginseng, and ginseng steamed red of which efficacies were already well known. Besides these foods, other foods such as loach, crucian carp were also used as anti-diabetic foods, but their benefits as anti-diabetic functional foods are not yet fully investigated. Subjects first knew about the therapy because friends or relatives recommended to them and most of them have used for 6 months to 1 year. However, 78.9% of subjects answered 'not so effective' in a question about satisfaction of anti-diabetic functional food. Although many of the patients have tried taking functional foods, they only use them for short period of time and they don't show prominent effect. Therefore these results suggest that in order to use scientifically studied functional foods, education about anti-diabetic functional foods should taken.

• 한국경영과학회지
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• 제22권3호
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• pp.209-222
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• 1997

In this paper, we study a bargaining order problem where one buyer sequentially bargains with two sellers whose reservation prices are unknown to the buyer but correlated. Our main question is who the buyer should bargain first with to maximize his expected payoff. This type of problem is widely applicable to business and political situations where one party negotiates with multiple parties sequentially. One of the most important element in a sequential bargaining is "linkage effect" which exists when the aggreement of the previous bargaining affects the outcome of the following bargaining. To examine "linkage effect", we assume that the sellers'objects are similar so that the sellers' reservation prices are correlated. In addition, to consider incomplete information aspect regarding reservation prices, it is assumed that the sellers' reservation prices are unknown to the buyer. That is, we deal with one sided incomplete information case. In our model, there are two stages in each of which the buyer meets one seller. Since we are concerned with the bargaining order, we consider two different bargaining orders. Using game theory, we find a perfect Bayesian equilibrium and compute the buyer's expected payoff for each bargaining order. Finally we identify the advantageous bargaining order for the buyer by comparing the expected payoffs obtained under two different bargaining orders. Our results are as follows: the advantageous bargaining order depends on the prior probability of the seller type. However, in general, the buyer should bargain first with the seller whose object is less valuable to the buyer. The basic reason for our result is that the buyer wants to experiment in the first stage to find out the sellers' reservation prices and in doing so, to minimize the experimental cost and maximize potential gain in case of negotiation failure in the first stage. in the first stage.

• 대한물리치료과학회지
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• 제22권1호
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• pp.29-36
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• 2015

Purpose : The purpose of present study was to improve communication of pain expressing terms and pain intensity between patient and physical therapist, and initiated to objectify a measurement of subjective pain. Methods : Data were delivered to 249 people by a self-completion questionnaire, and analyzed 160 copies except for 87 mark error of the collected 247 questionnaires. The questionnaire included a question on 55 terms used to describe pain, the type of the pain, and pain intensity using VAS (visual analogue scale). Results : The results were as follows; 'Tight' was the most frequently being expressed term of muscular pain, subsequently to 'knot' and 'dull'. 'Tear' was the term representing the most strong pain of muscular pain, subsequently to 'rupture' and 'squeeze'. 'Stinging' was the most frequently being expressed term of neurologic pain, subsequently to 'get shocked' and 'wriggle'. 'Burn' was the term representing the most strong pain of neurologic pain, subsequently to 'sear' and 'get shocked'. 'Creak' was the most frequently being expressed term of joint pain, subsequently to 'peel' and 'out of joint'. 'Break' was the term representing the most strong pain of joint pain, subsequently to 'peel' and 'crack'. Conclusion : The objectification of pain terms will be used to help physical therapist to check the patient's pain.

• The Korean Journal of Physiology and Pharmacology
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• 제19권6호
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• pp.499-506
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• 2015

Angiotensin II (Ang II), a key mediator of hypertensive, causes structural changes in the arteries (vascular remodeling), which involve alterations in cell growth, vascular smooth muscle cell (VSMC) hypertrophy. Ang II promotes fibrotic factor like IGFBP5, which mediates the profibrotic effects of Ang II in the heart and kidneys, lung and so on. The purpose of this study was to identify the signaling pathway of IGFBP5 on cell proliferation and migration of Ang II-stimulated VSMC. We have been interested in Ang II-induced IGFBP5 and were curious to determine whether a Pitavastatin would ameliorate the effects. Herein, we investigated the question of whether Ang II induced the levels of IGFBP5 protein followed by proliferation and migration in VSMC. Pretreatment with the specific Angiotensin receptor type 1 (AT1) inhibitor (Losartan), Angiotensin receptor type 2 (AT2) inhibitor (PD123319), MAPK inhibitor (U0126), ERK1/2 inhibitor (PD98059), P38 inhibitor (SB600125) and PI3K inhibitor (LY294002) resulted in significantly inhibited IGFBP5 production, proliferation, and migration in Ang II-stimulated VSMC. In addition, IGFBP5 knockdown resulted in modulation of Ang II induced proliferation and migration via IGFBP5 induction. In addition, Pitavastatin modulated Ang II induced proliferation and migration in VSMC. Taken together, our results indicated that Ang II induces IGFBP5 through AT1, ERK1/2, P38, and PI3K signaling pathways, which were inhibited by Pitavastatin. These findings may suggest that Pitavastatin has an effect on vascular disease including hypertension.

• Asian Pacific Journal of Cancer Prevention
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• 제17권9호
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• pp.4223-4231
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• 2016

Background: Development of new apoptosis-inducing drugs is a promising trend in anticancer therapy. For this purpose several formamidinoderivatives of doxorubicin were synthesized. The aim of our study was to investigate effects of the five formamidinodoxorubicins in the ES-2 human ovarian clear cell carcinoma line, for comparison with data obtained previously for SKOV-3 human ovarian adenocarcinoma cells, to answer the question of whether and to what extent the histological cell type is a possible determinant of sensitivity to tested anthracyclines. Materials and Methods: In our experimental work the following methods were used: spectrophotometric assays with MTT; fluorimetric assays - double staining with Hoechst 33258 and propidium iodide (PI), measurement of caspase-3, -8, -9 activity, intracellular accumulation of DOX and analogues, estimation of drug uptake, mitochondrial transmembrane potential; flow cytometry - phosphatidylserine (PS) externalization with annexin V-FITC and PI fluorochromes. Results: Effects of the derivatives of doxorubicin were partially linked with the specific type of cancer cell although intracellular accumulation and cellular uptake of DOX and derivatives were similar in both. All of the investigated derivatives were considerably more cytotoxic than DOX. Formamidinodoxorubicins were able to induce caspase-dependent apoptotic cell death in both cell types. Conclusions: All new formamidine derivatives of DOX were able to induce caspase - dependent apoptosis in human ovarian cancer cell lines SKOV-3 and ES-2. Obtained results suggested that formamidine derivatives of DOX may be promising candidates for the prospective chemotherapeutic agents for the two different histological subtypes of ovarian cancer.

• 한국멀티미디어학회논문지
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• 제9권10호
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• pp.1344-1353
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• 2006

디지털과 디자인의 접목이라는 사회적 가치에 부합하는 제품의 측면에서, 최근 사용자층의 차장과 디자인 혁신을 꾀하면서 다양한 방식으로 디지털기술과의 융화를 시도하고 있는 브릭 완구에 대한 중요성이 나날이 높아지고 있다. 브릭에 대한 기존의 연구는 아날로그 측면의 놀이와 교육 도구로서의 역할에 치중함으로써 실제로 그 가치 이외의 무한한 가능성과 멀티미디어 측면에서의 확장성에 관한 연구가 부족한 것이 사실이다. 본 연구는 점차 사용성이 확대되고 있는 브릭 시스템 완구가 어떤 방식으로 진화되었는가에 대한 문제 제기에서 출발하여 브릭에 관한 기본적 이론 연구와 구체적 사례 분석을 통해 변화된 현황을 살펴보는 것으로 이루어져 있다. 이를 토대로 최종적으로는 확장된 형식의 대표적 브릭 시스템 사례를 적용한 디자인 프로세스를 수행함으로써 디지털 브릭 시스템의 가능성을 보다 체계적으로 보여 줄 수 있을 것으로 기대한다.

• 정보처리학회논문지D
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• 제10D권1호
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• pp.161-166
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• 2003

제품을 생산하고 공급하는데 소요되는 주문리드타임과 달리 주문이 처리되는데 소요되는데 지연되는 것을 정보리드타임이라고 하는데, 이는 공급체인에서 개별기업들이 수요예측의 변동폭을 높이게 되며 이것이 바로 비용 상승요인으로 작용하게 된다. 본 논문에서는 직렬형 가치사슬에서 정보리드타임이 공급체인 시스템에 주는 영향을 알아본다. 특별히, MIT 시뮬레이션 모형을 동해서 실험을 수행하며, 아래와 같은 두 가지의 이슈를 다룬다. 첫째는 비용-이익 관점에서 물류 리드타임보다 정보리드타임의 개선이 효과적인가\ulcorner 둘째는 정보리드타임이 고객에게 보다 인접한 기업(downstream)이 고객하고 떨어져 있는 기업(upstream)보다 비용을 크게 상승시키고 있는지에 대한 물음이다. 사례 분석에서는 공급체인상의 개변기업들이 갖는 정보리드타임의 중요성을 지적하고, 개별기업간의 정보리드타임의 차이 분석을 통해서 고객의 수요와 요구를 직접 받는 기업에서 정보리드타임의 중요성이 큼을 인증하고 있다.

• 대한지구과학교육학회지
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• 제6권1호
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• pp.69-77
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• 2013

The study aims to figure out pre-service elementary teachers' knowledge understanding on 'stratum and rock' as well as teaching-learning types on the same topic. A total of 65 seniors in an advanced science education course at B University of Education joined the research to fulfill the purpose above. With PCK classification framework, the study examined pre-service teachers' knowledge understanding on 'stratum and rock' while it analyzed how the teachers would teach the given topic to students. The results of the study are presented as follows. First, it was observed that the pre-service elementary teachers have a great understanding on 'stratum and rock' that would be taught via a science textbook for elementary fourth graders. However, regarding terms in 'shale and limestone', they appeared to have a relatively short understanding. Second, PCK elements of the pre-service teachers related to 'stratum and rock' were analyzed and according to the results, the teachers would be interested in teaching model selecting in the teaching-learning strategy field while they would be well aware of how important it is for them to perform an experiment in a teaching process. The teachers also appeared to understand that the teacher question can be mutual complementary during class. However, it turned out that the teachers would have a very much low understanding on learners' prior knowledge as they particularly believe that learning could be significantly affected by the learners' perception level as well as their learning interest and motive. Third, the pre-service elementary teachers were told to design teaching plans on 'stratum and rock' so that the study could find out what learning-teaching methods the teachers would adopt to teach the topic. It was learned that the teachers would proceed with the class basically by giving the learners a descriptive explanation on the topic and also by using pictures and drawings to enhance the learners' understanding during the class.

• 대한수학교육학회지:학교수학
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• 제9권1호
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• pp.45-64
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• 2007

본 연구는 초등학교 6학년 학생들의 그래프 이해 능력을 알아보기 위해, 자료 읽기, 자료 사이의 관계 찾기, 자료 해석하기, 상황 이해하기의 4가지 과제 유형을 설정하고 초등학교에서 학습하는 6가지의 그래프를 대상으로 검사 문항을 구성하였다. 이를 이용하여 서울 시내 초등학교 6학년 학생 187명을 대상으로 검사를 실시한 후, 과제유형별 반응과 그래프 종류별 반응을 분석하였다. 분석 결과 그래프를 보고 자료 읽기와 자료 사이의 관계 찾기 과제에서는 높은 이해도를 보였으나 자료 해석하기와 상황 이해하기에서는 상대적으로 낮은 이해도를 나타냈다. 또한 같은 수준의 과제 내에서도 그래프의 종류에 따라 상당히 다른 이해도를 보였다. 이를 통해 그래프 교수 학습 방향에 대한 시사점을 도출하였다.

• 정보학연구
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• 제2권1호
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• pp.35-52
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• 1999

구매자와 공급자가 새로운 전자화폐를 통한 결제시스템의 도입에 있어 공급자의 과제는 전자화폐의 유용성에 대한 평가기준인 상업성, 안정성, 제한조건 등의 문제를 중심으로 살펴볼 필요가 있다. 사용자인 구매자와 상인이 안전한 결제시스템을 선택할 경우에 그들의 needs를 분석하여 활용해야 하며, 특히, 상업적 조건은 새로운 지불방식에서 필수적으로 고려되어져야 한다. 즉, 사용하기 편리하고 비용이 적게 들어야 함을 물론 다용도로 쓰일 수 있어야 한다. 이러한 사용자의 필요성의 충족 없이(즉, 보안기술의 확보 등)는 궁극적으로 사용자들로부터 외면 받게 될 수 있다. 이에 따라 사용자들에게 선택의 폭을 넓게 해 줌으로써 궁극적으로 전자상거래의 활성화에 이바지 할 것이다.