• Journal of Microbiology and Biotechnology
• /
• v.13 no.5
• /
• pp.823-827
• /
• 2003

Streptomyces venezuelae ATCC 15439 is notable in its ability to produce two distinct groups of macrolactones. It has been reported that the generation of two macrolactone structures results from alternative expression of pikromycin (Pik) polyketide synthase (PKS). It was previously reported that the hybrid pikromycin-tylosin PKS can also produce two different macrolactones but its mechanistic basis remains unclear. In order to address this question, a series of site-directed mutagenesis of tentative alternative ribosome binding site and translation start codons in tylGV were performed. The results suggest that macrolactone ring size is not determined by the alternative expression of TylGV but through other mechanism(s) involving direct interaction between the PikAIII and TE domain or skipping of the final chain elongation step. This provides new insight into the mechanism of macrolactone ring size determination in hybrid PKS as well as an opportunity to develop novel termination activities for combinatorial biosynthesis.

• Journal of The Korean Association For Science Education
• /
• v.32 no.3
• /
• pp.486-501
• /
• 2012

The aims of this study are to investigate two main problems for the hypothetico-deduction method and to develop a scientific inquiry model to resolve these problems. The structure of this scientific inquiry model consists of accounts of the context of discovery and justification that the hypothetico-deduction holds as two main problems : 1) the heuristic flaw in the hypothetico-deduction method is that there is no limit to creating hypotheses to explain natural phenomena; 2) Logically, this brings into question affirming the consequent and modus tollens. The features of the model are as follows: first, the generation of hypotheses using an analogical abduction and the selection of hypotheses using consilience and simplicity; second, the expansion phase as resolution for the fallacy of affirming the consequent and the recycle phase as resolution for modus tollens involving auxiliary hypotheses. Finally, we examine the establishment process of Copernicus's Heliocentric Hypothesis and the main role of the history of science for the historical invalidity of this scientific inquiry model based on three examples of If/and/then type of explanation testing suggested by Lawson (International journal of science and Mathematics Education, 2005a, 3(1): 1-5) We claim that this hypotheticho-deduction process involving abduction approach produced favorable in scientific literacy rising for science teacher as well as students.

• Human Ecology Research
• /
• v.54 no.5
• /
• pp.475-485
• /
• 2016

This study explored mothers' and grandmothers' perception regarding child rearing practices as overprotective behaviors for first to third grade levels of elementary school. The study was conducted on 202 mothers and grandmothers of first to third grade elementary school students. Questionnaires were made with 40 questions on overprotection behaviors selected from the existing questions for preschooler, high grade elementary students, and youth. The questionnaires were distributed to target subjects to answer how they would perceive when each of question is applied to their lower grade elementary students. Based on the collected responses and the factor analysis, it was found out that the overprotective behaviors were classified into four factors such as "reduction in independence," "over-sensitiveness to safety," "interference in daily life," and "health anxiety." There were significant differences in the perception of the overprotective behavior by the subjects depending on the generations, features of children and mothers. This study focused on the lower grade elementary school students who have been removed from studies due to the lack of intervention measures. It has the implication in that the findings of the study can give the basic data for the development of the scale on overprotective behaviors in lower grade elementary school students.

• Fashion & Textile Research Journal
• /
• v.17 no.3
• /
• pp.421-428
• /
• 2015

This research is to understand customer satisfaction with virtual fitting based on a 3D body scanner and avatars as well as differences between avatars and the 'real me'. To this end, this research examined Korean college students to facilitate 3D body scanning, avatar generation and surveys. The author used 3D body scan data with direct measurements to identify differences between the 3D body scan data-based 'my avatar' and 'real me' in the virtual dress fitting system. The survey results on 'the level of customer awareness on 3D body scanner' found that the majority of both genders did not know about it and indicated a lower usability to incorporate IT technology into the fashion industry. The question in the 3D body scanning and avatar found an affirmative attitude. Satisfaction levels on the 3D avatars' similarity with 'own body' and garment fitting were positive and indicated a need for further technological improvements to express the avatars identical to customers' own body. More research is necessary for the accuracy of sizes for 3D body scanning that measure body sizes while wearing clothes. Avatars based on such datamay be less similar to 'own body' and cause customer dissatisfaction. Thus, further technology development is required to narrow gaps using data to make avatars that provide more accurate virtual fitting simulation services to customers.

• Journal of Industrial Technology
• /
• v.3
• /
• pp.69-74
• /
• 1983

For the determination of a reservoir capacity Rippl's mass-curve method has long been used with the past river flow data assuming the same flow records will be repeated in the future. This study aims to find out a better method for determining the reservoir capacity by employing the analytical theory based on the stochastic process. For the present study the synthetic generation methods of Thomas-Fiering type was used to synthetically generate 50 years of monthly river inflows to three single-purpose reservoirs and three multi-purpose reservoirs. The generated sequences of monthly flows were analyzed based on the range concept. With the optimum operation rule of the reservoirs as the one which maximizes the water-use downstream the waterrelease from the reservoir was determined and with due consideration to the mean inflows and the range of monthly flows the required reservoirs capacity was stochastically determined. It was possible to repersent the so-determined reservoir capacity in terms of the mean monthly inflows and the number of subseries in the determination of ranges. It is suggested that the result obtained in this study would be applied to approximately estimate, in the stage of preliminary design, the required capacity of a reservoir in question with the limited information such as the mean monthly inflow and the period of reservoir operation.

• Korean Journal of Digital Imaging in Medicine
• /
• v.11 no.2
• /
• pp.59-62
• /
• 2009

The purpose of this study is to know about solution of insecurity sense for solving the tediousness and inducing comfortableness in long time MRI examination. Studies were examined with total of 117 patients that the intention expression of self is possible for a month without dividing man and woman in november 2006. Examination methods were filled in questionnaire after testing using Siemens Impact 1.0T. The musical art were selected through intranet search and record sale inquiry using CD player and speaker. That kind of a music were selected with Korean classical music's 10 chapter, pop song 10's chapter, classic's 10 chapter and Korean popular song's 10 chapter. With analytical method, patients of under 40 year-old, or older and patients using ear-pad and head-phone were classified into groups. As analysis result with question item of questionnaire, most of the patients were showed a favor(36.72%) in playing a music, specially, examination of about 15.38% which uses the headphone prefer a music as older generation of over 40 year-old. In conclusion, with installing of the professional musical program in MRI test rooms, if listening to the music with selection by oneself before testing by season, age, time through development of appropriate musical program will be able to expect the more effect.

• International journal of advanced smart convergence
• /
• v.5 no.4
• /
• pp.48-53
• /
• 2016

In this paper, all elements used in integrated infrastructure for job competency assessments of NCS (National Competency Standards) will be merged into assessment system using multiple devices(ASMD). NCS is a systematic approach on required abilities (knowledge, technical expertise, attitude) to process the tasks in the fields by industry. Competiveness of ASMD design is that no limitation of time and space using personal devices like PC, laptop, smartphone, and tablet, while seeing screen, hearing, touching, speaking, and writing. Question type can be limitless to express the situation. To lead technologies and market for domestic and oversea assessment system, supporting on multiple devices with connectivity that will eliminate limitation of time and space is the key feature for design competitiveness. Design of integrated assessment system proposed in this paper can be applied to NCS, fundamental competency evaluation, online test, job aptitude test, and foreign language test which involve listening, reading, writing, and speaking. Compared with existing evaluation method, reduction of investment and operating cost will be greater. Along with development of ICT technologies, the next generation of integrated assessment system will be quickly changed to ASMD, which already involves connected service between internet and smart devices.

• Bulletin of the Korean Chemical Society
• /
• v.30 no.6
• /
• pp.1341-1348
• /
• 2009

Electrocatalytic oxidation of two anti-inflammatory drugs (Mefenamic acid and Indomethacin) was investigated on a cobalt hydroxide modified glassy carbon (CHM-GC) electrode in alkaline solution. The process of oxidation and its kinetics were established by using cyclic voltammetry and chronoamperometry techniques as well as steady state polarization measurements. Voltammetric studies indicated that in the presence of under study drugs, the anodic peak current of low-valence cobalt species increased, followed by a decrease in the corresponding cathodic current. This result indicates that the drugs were oxidized via cobalt hydroxide species immobilized on the electrode surface via an E$\acute{C}$ mechanism. A mechanism based on the electrochemical generation of Co (IV) active sites and their subsequent consumption by the drugs in question was also investigated. The constants rate of the catalytic oxidation of the drugs and the electron-transfer coefficients reported.

• Annual Conference on Human and Language Technology
• /
• 2006.10e
• /
• pp.15-21
• /
• 2006

본 논문에서는 올바른 한국어 생활과 한국어 실력 향상을 위하여, 한국어 어휘에 대한 풍부한 정보를 담고 있는 한국어사전, 사용자 어휘지능망(User-Word Intelligent Network : U-WIN)등의 언어자원을 이용한 자동문제생성기술을 소개하고, 이를 이용한 한국어 어휘학습시스템을 제시한다. 대부분의 학습시스템에서 사용하는 문제 은행식 출제 방식의 문제점을 해소할 수 있는 하나의 방법으로서, 기존의 한국어 어휘문제의 문항을 분석하여 8가지 문제 유형으로 재편성하고, 각 유형별 자동 문제 생성패턴에 따라 언어자원이 가지고 있는 한국어 어휘의 형태적 정보, 의미적 정보를 이용하여 한국어 어휘 문제를 자동 출제하는 한국어 어휘학습시스템을 구현하였다.

• Proceedings of the KIEE Conference
• /
• 2006.07c
• /
• pp.1735-1736
• /
• 2006

As developing the information society, Lighting Emitted diode(LED) which is light source for illumination of next generation is attracted public attention. LED have many problem as narrow light view angle, high price, drift phenomenon of color coordinate, high heating problem for lower power, lower weight and small size. So, many researches have continued in a illumination as LED module type. in this problem, heating problem is very important and difficult and that is caused in decreasing phenomenon of brightness and drift phenomenon of color coordinate. so the problem of heating is urgent question for illumination of LED. In this paper, structural design of PCB changed as two type for solving the heating problem. also the properties of heating is analysed and optical properties is measured with heating image camera and spectrometer according to change in this design.