• 한국재료학회지
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• 제20권6호
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• pp.319-325
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• 2010

3-D IC integration enables the smallest form factor and highest performance due to the shortest and most plentiful interconnects between chips. Direct metal bonding has several advantages over the solder-based bonding, including lower electrical resistivity, better electromigration resistance and more reduced interconnect RC delay, while high process temperature is one of the major bottlenecks of metal direct bonding because it can negatively influence device reliability and manufacturing yield. We performed quantitative analyses of the interfacial properties of Al-Al bonds with varying process parameters, bonding temperature, bonding time, and bonding environment. A 4-point bending method was used to measure the interfacial adhesion energy. The quantitative interfacial adhesion energy measured by a 4-point bending test shows 1.33, 2.25, and $6.44\;J/m^2$ for 400, 450, and $500^{\circ}C$, respectively, in a $N_2$ atmosphere. Increasing the bonding time from 1 to 4 hrs enhanced the interfacial fracture toughness while the effects of forming gas were negligible, which were correlated to the bonding interface analysis results. XPS depth analysis results on the delaminated interfaces showed that the relative area fraction of aluminum oxide to the pure aluminum phase near the bonding surfaces match well the variations of interfacial adhesion energies with bonding process conditions.

• Applied Biological Chemistry
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• 제47권1호
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• pp.33-40
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• 2004

Ubiquitin 폴딩 반응의 초기에 나타나는 transient 폴딩 intermediate 상태의 열역학적인 특성을 연구하였다. 온도와 화학변성제의 농도를 바꾸어주면서 측정한 폴딩 kinetics의 결과로부터 unfolded 상태와 intermediate 상태의 평형상수 및 자유에너지를 quantitative kinetic modeling을 통하여서 구하였으며 또한 온도에 따른 자유에너지의 변화로부터 unfolded 상태에서 intermediate 상태로 전환될 때의 열역학적 함수인 ${\Delta}H,\;{\Delta}S,\;{\Delta}C_p$를 구하였다. Ubiquitin이 unfolded 상태에서 intermediate 상태가 될 때의 ${\Delta}C_p$는 unfolded 상태에서 native 상태로 되는 과정의 ${\Delta}C_p$의 약 80% 정도 되었다. 이것은 intermediate가 native 상태에 가까운 매우 조밀한 구조를 이루고 있는 ensemble state임을 나타낸다. 상온에서의 ${\Delta}H$는 양의 값을 보였다. 이는 ubiquitin의 unfolded 상태에서 소수성 잔기 주위에 위치한 물 분자의 규칙적인 구조가 intermediate 상태가 될 때 와해되기 때문이라고 여겨진다. 이러한 양의 enthalpy는 자유로워진 물 분자에 의한 전체 계의 entropy의 증가에 의하여서 보상되어 unfolded 상태에서intermediate 상태로의 전환은 음의 자유에너지를 갖게 되며 폴딩 반응의 초기에 관찰되는 것으로 여겨진다.

• International Journal of Industrial Entomology and Biomaterials
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• 제13권1호
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• pp.15-22
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• 2006

An experiment was conducted to study the efficiency of cyanobacterial biofertilizer (CBB) with chemical (NPK) fertilizer on quantitative and qualitative characters of mulberry variety Kanva-2. Their influences on silkworm growth and cocoon characters were also studied. Ten different CBB and NPK fertilizer treatments were given to 5000 plants of established mulberry garden. Treatments were of four types viz., (i) T1 to T7: single and combination dose of CBB+50% NPK (ii) T8: combination dose of CBB + 25%NPK, (iii) T9: CBB only and (iv) T10: control-l00% NPK. Soil pH decreased and nutrients status increased in CBB (T1- T9) treated plots. Average of ten crops data on quantitative traits revealed that T7 (CBB [N. muscorum (1.0 g), A. variahilis (1.0) and S. millei (1.0 g)] + 50% NPK) was very effective in improving growth parameters. Leaf yield was also found high in treatment T7 (32.12 tons/ha/yr.) followed by T10 (31.17 tons/ha/yr.) and T8 (27.67 tons/ha/yr.). Leaf quality characters were found high in T7 and low in T9. Most of the quality traits in T7 are on par with control no. The results revealed that reduction in the dose of chemical fertilizers in T7 did not affect the leaf yield and leaf quality traits of mulberry. This clearly indicates that the efficiency of CBB (T7) provides nitrogen, increases essential nutrients available in soil, maintain soil pH and supply growth substances required for the improvement of leaf yield and leaf quality of mulberry. Bioassay study also revealed no significant difference in silkworm growth and cocoon characters between treatments T7 and T10. Economics calculated revealed that T7 is highly economical and beneficial over T10 by gaining an amount of Rs. 660/-/acre/crop. Thus, treatment T7 containing N. muscorum (1.0 g), A. variahilis (1.0 g) and S. millei (1.0 g) + 50% NPK fertilizers can be recommended to sericulturists mainly to reduce the use of NPK fertilizers, by saving 50% of its cost and to improve soil fertility conditions, which in turn improves leaf yield and quality of mulberry.

• 대한의용생체공학회:의공학회지
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• 제28권3호
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• pp.410-416
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• 2007

This paper presents quantitative analysis of a training system based on an unstable platform and a visual interactive system for improving sense of equilibrium. The training system consists of an unstable platform, a force plate, a safety harness, a monitoring device, and a personal-computer. To confirm the effects of the training system, fifteen young volunteers and five elderly volunteers went through a series of balance training using the system. During the training, we measured relevant parameters such as the time a subject maintain his or her center of pressure on a target, the time a subject moves his or her center of pressure to the target, and the mean absolute deviation of the trace before and after training with this system and training programs to evaluate the effects of the training. The results showed that the training system can successfully assess the gradual improvement of the postural control capability of the subject in the system and showed a possibility of improving balance of the subject. Moreover, the significant improvement in the postural capability of the elderly subject suggests that elderly subjects can benefit more from the training using the system for the improvement of sense of equilibrium.

• 농약과학회지
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• 제6권1호
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• pp.25-30
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• 2002

새로운 제초성 N-phenyl-3,4-dimethylphthalimide 유도체의 구조변화에 따른 물리-화학 파라미터와 다루어진 바 없는 TOPKAT 프로그램으로 계산된 랫트 및 마우스 등의 급만성 독성에 관한 판별점수(DS) 및 치사율과의 관계(QSTR)를 정량적으로 검토하였다. 그 결과, 발암성은 랫트보다 마우스가 그리고 수컷보다는 암컷이 높은 경향이었다. $R_2$-기만이 변화하는 조건에서 Hansch-Fujita 식을 유도한 결과, 발암성에서 랫트 암컷을 제외한 마우스(암, 수) 및 랫트 수컷은 공통적으로 LUMO 에너지가 영향을 미치는 주 요인이었으며 마우스 암컷과 수컷의 발암성에 관한 선택성 요소는 주로 $R_2$-치환기 길이의 적정값(약 $(L)_{opt.}=5.0{\AA}$)에 의존적이었다. 또한, Free-Wilson 식으로부터 $R_2$-기의 기여도는 랫트 수컷의 경우, 탄화수소로 구성된 치환체가 그리고 그 이외의 경우에는 불소 치환체들의 기여도가 우세한 경향이었다.

• 수산해양기술연구
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• 제53권1호
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• pp.77-88
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• 2017

The concern on the greenhouse gas emissions is increasing globally. Especially, the greenhouse gas emission from fisheries is an important issue due to Cancun Agreements Mexico in 1992 and the Kyoto protocol in 2005. Furthermore, the Korean government has a plan to reduce the GHG emissions as 5.2% compared to the BAU in fisheries until 2020. However, the investigation on the GHG emissions from Korean fisheries has not been executed much. Therefore, the quantitative analysis of GHG emissions from Korean fishery industry is needed as the first step to find a relevant way to reduce GHG emissions from fisheries. The purpose of this research is to investigate which degree of GHG emitted from the major coastal fisheries such as coastal gillnet fishery, coastal dual purpose fishery, coastal pots fishery and coastal small scale stow net fishery. Here, we calculated the GHG emission from the fisheries using the LCA (Life Cycle Assessment) method. The system boundary and input parameters for each process level are defined for LCA analysis. The fuel use coefficients of the fisheries are also calculated according to the fuel type. The GHG emissions from sea activities by the fisheries will be dealt with. Furthermore, the GHG emissions for the unit weight of fishes are also calculated with consideration to the different consuming areas. The results will be helpful to understand the circumstances of GHG emissions from Korean fisheries.

• 한국미생물·생명공학회지
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• 제46권3호
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• pp.277-287
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• 2018

Current reports suggest that obesity is a serious global health issue. Emerging evidence has predicted strong links between obesity and the human gut microbiota. However, only a few such studies have been conducted in Asia, and the gut microbiota of lean and obese adult Asians remains largely unexplored. Here, we investigated the potential relationship between gut microbiota, body massindex (BMI), and metabolic parameters in adults from Thailand, where obesity is increasing rapidly. Fecal and blood samples were collected from 42 volunteers who were allocated into lean, overweight, and obese groups. The fecal microbiota was examined by quantitative PCR analysis. Bacteroidetes, Firmicutes, and Staphylococcus spp. and methanogens were most abundant in lean volunteers. Overweight volunteers majorly harbored Christensenella minuta and Akkermansia muciniphila, ${\gamma}-Proteobacteria$, and bacteria belonging to the genus Ruminococcus. Methanogens and bacteria belonging to the phylum Bacteroidetes were negatively correlated with adiposity markers (BMI and waist circumference), but positive correlated with high-density lipoprotein, suggesting that they can be used as leanness markers. While some of our results agree with those of previous reports, results regarding the contributions of specific taxa to obesity were inconsistent. This is the first study to report the adult gut microbiota in Southeast Asian populations using molecular techniques and biochemical markers and provides a foundation for future studies in this field.

• Membrane and Water Treatment
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• 제8권3호
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• pp.279-292
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• 2017

This study was aimed at ultrafiltration (UF) as a pretreatment before reverse osmosis (RO) within the scheme of hybrid reverse osmosis-multistage flush (RO-MSF) desalination. Seawater at elevated temperature (after MSF heat-exchangers) was used as a feed in this process. The pretreatment system was represented as a set of functionally-linked technological segments such as: UF filtration, backwashing, chemical- enhanced backwashing, cleaning, waste disposal, etc. The process represents the sequences of operating cycles. The cycle, in turn, consists of the following unit operations: filtration, backwashing and chemical-enhanced backwashing (CEB). Quantitative assessment was based on the following indicators: normalized permeability, transmembrane pressure, specific energy and water consumption, specific waste generation. UF pre-treatment is accompanied by the following waste streams: $W1=1.19{\times}10$ power of $-2m^3$ (disposed NaOCl with 0.0044% wt.)/$m^3$ (filtrate); $W2=5.95{\times}10$ power of $-3m^3$ (disposed $H_2SO_4$ with 0.052% wt.)/$m^3$(filtrate); $W3=7.26{\times}10$ power of $-2m^3$ (disposed sea water)/$m^3$ (filtrate). Specific energy consumption is $1.11{\times}10$ power of $-1kWh/m^3$ (filtrate). The indicators evaluated over the cycles with conventional (non-chemical) backwashing were compared with the cycles accompanied by CEB. A positive impact of CEB on performance indicators was demonstrated namely: normalized UF resistance remains unchanged within the regime accompanied by CEB, whereas the lack of CEB results in 30% of its growth. Those quantitative indicators can be incorporated into the target function for solving different optimization problems. They can be used in the software for optimisation of operating regimes or in the synthesis of optimal flow- diagram. The cycle characteristics, process parameters and water quality data are attached.

• 한국대기환경학회지
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• 제24권2호
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• pp.153-161
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• 2008

The guidelines for indoor air quality of public transportations such as subway, train and bus was presented by Korean Ministry of Environment last end of year 2006 based on the great consequence of indoor air quality in daily life. Two main parameters, carbon dioxide($CO_2$) and particulate matters smaller than $10\;{\mu}m(PM_{10})$, were selected as index pollutants for the management of indoor air quality. The former pollutant, $CO_2$, is regarded as index of ventilation status and the major source of $CO_2$ in the train or subway is the exhalation of passengers. It is publically perceived that the high $CO_2$ concentration in a crowded subway will be reduced and ventilated with outdoor air by door-opening taken every 2 or 3 minutes when the train stops each station. However, there has not been any scientific proof and quantitative information on the effect of door-opening on the $CO_2$ reduction by ventilation with outdoor air. In this study, $CO_2$ concentration and number of passengers were measured at each station on the 3 lines of Korail metropolitan subway. In order to evaluate the effect of $CO_2$ reduction by door opening, the theoretical approach using the $CO_2$ balance equation was performed. By comparing the predicted data with monitoring one, the optimum $CO_2$ dilution factor was determined. For the first time, it was quantified that about 35% of $CO_2$ concentration in the subway indoor was removed by the door-opening at each station.

• Journal of Oral Medicine and Pain
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• 제25권4호
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• pp.345-353
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• 2000

This study was to investigate normal salivary flow rates and normal indices of Quantitative analysis of salivary scintigraphy. 96 adult volunteers were studied by Questionnaire evaluating salivary conditions and clinical examinations. 35(male 23, female 12, age range 23-31years) that absented subjective and objective symptoms related saliva were classified as normal group. The normal group underwent measurement unstimulated and stimulated salivary flow rates and salivary scintigraphy. The obtained results were as follows: 1. There were not significant in sex differences of unstimulated and stimulated salivary flow rates. The unstimulated salivary flow rate was $0.66{\pm}0.41g/min$, stimulated salivary flow rates was $1.61{\pm}0.69g/min$. 2. As comparing of parameters of salivary scintigraphy, the Uptake ratio(UR), $T_{max}$, $T_{min}$, Maximum accumulation (MA), Maximum secretion(MS) of parotid and submandibular glands were not significant in sex and side-ralated differences. 3. The UR, $T_{max}$, MA, MS of parotid gland were significantly higher than those of submandibular gland; in the parotid gland, UR, $3.67{\pm}0.88$, $T_{max}$, $18.77{\pm}0.43min$, MA, $41.35{\pm}9.22%$, MS, $43.13{\pm}9.13%$; in the submandibular gland, UR, $3.04{\pm}0.10$, $T_{max}$, $18.48{\pm}0.52min$, MA, $36.47{\pm}14.18%$, MS, $36.88{\pm}12.20%$. 4. As classifying of time-activity curve, the most of parotid gland was N-type(97.1%), submandibular gland was observed in order of M-type(67.1%), N-type(21.4%), F-type(11.4%), however, was not observed S-type. 5. As the type of time-activity curve of submandibular gland was more flattened, the UR, $T_{max}$, MA, MS were significantly decresed.