• Korean Journal of Radiology
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• 제23권1호
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• pp.112-123
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• 2022

Objective: To investigate the relationship between ¹⁸F-FDG PET/CT semi-quantitative parameters and the International Association for the Study of Lung Cancer, American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) histopathologic classification, including histological subtypes, proliferation activity, and somatic mutations. Materials and Methods: This retrospective study included 419 patients (150 males, 269 females; median age, 59.0 years; age range, 23.0-84.0 years) who had undergone surgical removal of stage IA-IIIA lung adenocarcinoma and had preoperative PET/CT data of lung tumors. The maximum standardized uptake values (SUVmax), background-subtracted volume (BSV), and background-subtracted lesion activity (BSL) derived from PET/CT were measured. The IASLC/ATS/ERS subtypes, Ki67 score, and epidermal growth factor/anaplastic lymphoma kinase (EGFR/ALK) mutation status were evaluated. The PET/CT semi-quantitative parameters were compared between the tumor subtypes using the Mann-Whitney U test or the Kruskal-Wallis test. The optimum cutoff values of the PET/CT semi-quantitative parameters for distinguishing the IASLC/ATS/ERS subtypes were calculated using receiver operating characteristic curve analysis. The correlation between the PET/CT semi-quantitative parameters and pathological parameters was analyzed using Spearman's correlation. Statistical significance was set at p < 0.05. Results: SUVmax, BSV, and BSL values were significantly higher in invasive adenocarcinoma (IA) than in minimally IA (MIA), and the values were higher in MIA than in adenocarcinoma in situ (AIS) (all p < 0.05). Remarkably, an SUVmax of 0.90 and a BSL of 3.62 were shown to be the optimal cutoff values for differentiating MIA from AIS, manifesting as pure ground-glass nodules with 100% sensitivity and specificity. Metabolic-volumetric parameters (BSV and BSL) were better potential independent factors than metabolic parameters (SUVmax) in differentiating growth patterns. SUVmax and BSL, rather than BSV, were strongly or moderately correlated with Ki67 in most subtypes, except for the micropapillary and solid predominant groups. PET/CT parameters were not correlated with EGFR/ALK mutation status. Conclusion: As noninvasive surrogates, preoperative PET/CT semi-quantitative parameters could imply IASLC/ATS/ERS subtypes and Ki67 index and thus may contribute to improved management of precise surgery and postoperative adjuvant therapy.

• International Journal of Industrial Entomology and Biomaterials
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• 제20권2호
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• pp.69-74
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• 2010

Feeding is an important aspect of insect nutrition which in turn supports growth, development, reproduction and survival. The impact of quantitative feeding on nutritional parameters of fifth instar Antheraea mylitta larvae was studied by providing fresh leaves of Terminalia tomentosa for 1 to 4 times a day. All the parameters improved upon providing fresh diets more times over the single diet (1FD). The absolute body weight increased with increase in number of feeds/day significantly (P<0.001). While the maximum weight recorded was 29.61 g in 1FD, the respective weights for two feeds/day (2FD), three feeds/day (3FD) and four feeds/day (4FD) were 39.41 g, 40.63 g and 42.66 g respectively. Feeding period and instar duration were declined (P<0.001) and survival increased significantly (P<0.001) upon increase in the number of diets. Nutritional indices like ingestion, digestion, relative consumption rate (RCR), relative growth rate (RGR) and gain in body weight increased significantly with the increase in number of feeds/day, but approximate digestibility (AD) and efficiency of conversion of ingested food (ECI) declined, while efficiency of conversion of digested food (ECD) did not change.

• Korean Journal of Radiology
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• 제25권1호
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• pp.43-54
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• 2024

Objective: To evaluate the added value of diffusion-weighted imaging (DWI)-based quantitative parameters to distinguish uterine sarcomas from atypical leiomyomas on preoperative magnetic resonance imaging (MRI). Materials and Methods: A total of 138 patients (age, 43.7 ± 10.3 years) with uterine sarcoma (n = 44) and atypical leiomyoma (n = 94) were retrospectively collected from four institutions. The cohort was randomly divided into training (84/138, 60.0%) and validation (54/138, 40.0%) sets. Two independent readers evaluated six qualitative MRI features and two DWI-based quantitative parameters for each index tumor. Multivariable logistic regression was used to identify the relevant qualitative MRI features. Diagnostic classifiers based on qualitative MRI features alone and in combination with DWI-based quantitative parameters were developed using a logistic regression algorithm. The diagnostic performance of the classifiers was evaluated using a cross-table analysis and calculation of the area under the receiver operating characteristic curve (AUC). Results: Mean apparent diffusion coefficient value of uterine sarcoma was lower than that of atypical leiomyoma (mean ± standard deviation, 0.94 ± 0.30 10^-3 mm²/s vs. 1.23 ± 0.25 10^-3 mm²/s; P < 0.001), and the relative contrast ratio was higher in the uterine sarcoma (8.16 ± 2.94 vs. 4.19 ± 2.66; P < 0.001). Selected qualitative MRI features included ill-defined margin (adjusted odds ratio [aOR], 17.9; 95% confidence interval [CI], 1.41-503, P = 0.040), intratumoral hemorrhage (aOR, 27.3; 95% CI, 3.74-596, P = 0.006), and absence of T2 dark area (aOR, 83.5; 95% CI, 12.4-1916, P < 0.001). The classifier that combined qualitative MRI features and DWI-based quantitative parameters showed significantly better performance than without DWI-based parameters in the validation set (AUC, 0.92 vs. 0.78; P < 0.001). Conclusion: The addition of DWI-based quantitative parameters to qualitative MRI features improved the diagnostic performance of the logistic regression classifier in differentiating uterine sarcomas from atypical leiomyomas on preoperative MRI.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2004년도 춘계학술대회 논문집
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• pp.194-197
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• 2004

In the tube hydroforming process, a tube is placed into the die cavity and the ends of the tube are sealed by fixing the axial cylinder piston into the ends. Then the tube is pressurized with a hydraulic fluid and simultaneously the axial cylinders move to feed the material into the expansion zone. Therefore, the quantitative relationship between process parameters such as internal pressure and feeding amount and hydroformabillity, is hard to establish because of their high complexity and many unknown factors. In this study, the empirical and the quantitative relationship between process parameters and hydroformabillity are analyzed by fuzzy rules. Fuzzy expert system is an advanced expert system which uses fuzzy rule and approximate reasoning. Many process parameters are converted to the quantitative relationship by use of approximate reasoning of fuzzy expert system. The comparison between experimentally measured hydroformabillity from hydroforming experiments and the predicted values by fuzzy expert system shows a good agreement.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2000년도 춘계학술대회논문집A
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• pp.268-273
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• 2000

Velocity-dependent increase in tonic stretch reflexes is one of the prominent characteristics of spasticity. It is very important to evaluate spasticity objectively and quantitatively before and after treatment for physicians. An accurate quantitative biomechanical evaluation for the spasticity which is caused by the disorder of central nervous system is made in this study. A sudden leg dropper which is designed to generate objective testing environment at every trial gives very effective environment for the test. Kinematic data are archived by the 3-dimensional motion analysis system($Elite^{(R)}$, B.T.S., Italy). Kinematic data are angle and angular velocity of lower limb joints, and length and lengthening velocity of lower limb muscle. A program is also developed to analyze the kinematic data of lower limb, contraction and relaxation length of muscles, and dynamic EMG data at the same tim. To evaluate spasticity quantitatively, total 31 parameters extracted from goniogram, EMG and muscle model are analyzed. Statistical analysis are made for bilateral correlations for all parameters. The described instrumentation and parameters to make quantitative and objective evaluation of spasticity shows good results.

• 한국해양공학회지
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• 제11권1호
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• pp.36-43
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• 1997

Weld bead shape is an important measure for evaluation of weld quality. Many welding parameters have influence on the weld bead shape. The quantitative relationship between welding parameters and bead shape, however, is not determined yet because of their high complexity and many unknown factors. Fuzzy expert system is an advanced expert system which uses fuzzy rules and approximate reasoning. It is a vert useful tool for welding technology because is can process rationally the uncertain and inexact information such as the welding information. In this paper, the empirical and the qualitative relationship between welding parameters and bead shape are analyzed and represented by fuzzy rules. They are converted to the quantitative relationship by use of approximate reasoning of fuzzy expert system. Weld bead shape is estimated from the welding parameters using fuzzy expert system. The result of comparison between measured values of weld bead by welding experiments and the estimates values by fuzzy expert system shows a good consistancy.

• 한국전문물리치료학회지
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• 제12권2호
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• pp.20-27
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• 2005

Osteoporosis is characterized by low bone mass and the microarchitectural deterioration of bone tissue with a consequent increase in bone fragility and susceptibility to fracture. It has been suggested that speed of sound (SOS) and broadband ultrasound attenuation (BUA) of quantitative ultrasound sonography (QUS) may provide information about not only bone density but also the microarchitecture and elastic properties of bone. Physical inactivity reduced mechanical usage and it made process to the bone changes. This study aimed to association between the physical activity and the QUS parameters in 1305 (593 men, 712 women) aged 20 years over in a rural population. Two QUS parameters, BUA (p=.23) and SOS(p=.73) were measured at the right calcaneus of postmenopausal women, no significant associations were observed between sports index and SOS and BUA. These results suggest that work, non-sports leisure physical activity (p<.01) have a significant influence on QUS parameters in a rural population. Physical activity are meaningful predictor of QUS parameters of the calcaneus in a rural population.

• Geomechanics and Engineering
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• 제11권4호
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• pp.515-530
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• 2016

In this paper, five different quantitative parameters were proposed for the characterization of the primary roughness which is the component of surface morphology that prevails during large strike-slip faults of more than 50 m. These parameters are mostly the anisotropic properties of rock surface morphology at various scales: (i) coefficient ($k_a$) and degree (${\delta}_a$) of apparent structural anisotropy of surface; (ii) coefficient ($k_r$) and degree (${\delta}_r$) of real structural anisotropy of surface; (iii) surface anisotropy function P(${\varphi}$); and (iv) degree of surface waviness ($W_s$). The coefficient and degree of apparent structural anisotropy allow qualifying the anisotropy/isotropy of a discontinuity according to a classification into four classes: anisotropic, moderately anisotropic/isotropic and isotropic. The coefficient and degree of real structural anisotropy of surface captures directly the actual surface anisotropy using geostatistical method. The anisotropy function predicts directional geometric properties of a surface of discontinuity from measurements in two orthogonal directions. These predicted data may subsequently be used to highlight the anisotropy/isotropy of the surface (radar plot). The degree of surface waviness allows qualifying the undulation of anisotropic surfaces. The proposed quantitative parameters allows their application at both lab and field scales.

• 한국터널지하공간학회 논문집
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• 제14권1호
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• pp.23-35
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• 2012

RMR은 평가방법의 수월성으로 인해 터널과 사면 등 토목공사 현장에서 암반평가 방법으로 널리 활용되고 있는 만큼 좀 더 쉽고 신뢰성 있는 수정 RMR법을 찾기 위한 연구는 꾸준히 진행되어 왔다. 그만큼 RMR에 대한 다수의 연구들이 여러 가지 통계적 분석 및 평가기법에 의해 변수의 개수나 배점을 조정한 수정 RMR법 제시에 치중된 측면도 있다. 따라서 본 연구에서는 정규화한 RMR변수들의 평가 경향 분석을 통하여 기 연구들에서 중요 평가 변수들을 공통적으로 포함하면서도 다양한 변수조합의 수정 RMR법들이 제안될 수 있었던 당위성에 대하여 고찰하였다. 나아가 변수들의 분포경향으로부터 현장에서의 평가경향에 대해서도 역 추론 하였다. 약 2000개의 현장 측정 데이터들에 대해 정규화한 후 RMR과 각 변수들의 1:1 평가를 실시한 결과 일정한 패턴의 상관관계와 평가경향이 나타났다. 정량적 평가 변수인 일축압축강도와 RQD는 RMR 기준선 대비 항시 상향 분포 추세로 나타나 RMR 값들을 평가절상 하는 역할을 하는 반면, 정성적 평가 성향이 큰 절리 상태와 지하수는 기준선 대비 대부분 하향 분포 추세로 나타나 RMR 값들을 평가절하 하는 역할을 하는 것으로 판단된다. 이를 통해 정량적인 변수들과 정성적인 변수들을 적절히 조합하면 어려운 통계분석 없이도 수정 RMR법을 제시할 수 있음을 알 수 있다. 또한 정성적인 변수에 대한 현장 엔지니어의 보수적인 암반평가 경향도 추론할 수 있다.

• Applied Microscopy
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• 제41권1호
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• pp.75-79
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• 2011

For quantitative analysis of nano-crystal structure, we reported the accuracy improvement method of lattice parameters measured from electron diffraction. For calculation of Au lattice parameters used as a standard crystal structure, it was considered two different acquisition methods (detector and enegy-filter) and three different calculation methods (conventional, least-square and regression fit). As a result, the measurement reliability could be enhanced by using CCD camera which gives higher performance, while energy-filtering did not affect the improvement the camera constant accuracy. Also, the accuracy of lattice parameters could be improved up to $10^{-4}$ order by regression fitting with correction formula. Finally, it is expected that the combination of regression fitting and intensity extraction from energy-filtered precession electron diffraction gives a solution of quantitative structure analysis for unknown nano-crystals.