• Journal of the Ergonomics Society of Korea
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• v.29 no.6
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• pp.875-887
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• 2010

The quantitative effectiveness of powered support surfaces such as APAM in preventing and treating pressure ulcers has not been sufficiently evaluated because of uncertainty of alternating pressure load input and lack of interpretation of dynamic perfusion characteristics of soft tissue. The aim was to verify the dynamic loading effects to sacral tissue perfusion characteristics from alternating set pressure changes. We developed integrated experiment system to supply alternating load to supinely positioned sacrum and concurrently measured $TcPO_2$, $TcPCO_2$ and air cell pressure. Ten aged subjects (5 female, 5 male) were tested with alternating set pressure 20, 30, 40, 50 and 60mmHg. From the dynamic perfusion response eight characteristic parameters were proposed such as average, minimum, maximum and perfusion range regarding to $TcPO_2$ and $TcPCO_2$. A one-way ANOVA was carried out to determine whether the manipulation of alternating set pressure had any effect on $TcPO_2$ and $TcPCO_2$. From the dynamic tissue perfusion response we found mean $TcPO_2$ decreased exponentially as alternating pressure load increased and perfusion range varied mainly because of minimum level change of $TcPO_2$. And perfusion range of $TcPCO_2$ affected by increase of maximum value of $TcPCO_2$. From the results we can get more strict insights about actual physiological dynamic tissue perfusion mechanism under alternating pressure load.

• Interdisciplinary Bio Central
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• v.3 no.4
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• pp.15.1-15.11
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• 2011

Background: Histone deacetylase (HDAC) 8 is one of its family members catalyzes the removal of acetyl groups from N-terminal lysine residues of histone proteins thereby restricts transcription factors from being expressed. Inhibition of HDAC8 has become an emerging and effective anti-cancer therapy for various cancers. Application computational methodologies may result in identifying the key components that can be used in developing future potent HDAC8 inhibitors. Results: Facilitating the discovery of novel and potential chemical scaffolds as starting points in the future HDAC8 inhibitor design, quantitative structure-activity relationship models were generated with 30 training set compounds using genetic function approximation (GFA) and Bayesian algorithms. Six GFA models were selected based on the significant statistical parameters calculated during model development. A Bayesian model using fingerprints was developed with a receiver operating characteristic curve cross-validation value of 0.902. An external test set of 54 diverse compounds was used in validating the models. Conclusions: Finally two out of six models based on their predictive ability over the test set compounds were selected as final GFA models. The Bayesian model has displayed a high classifying ability with the same test set compounds and the positively and negatively contributing molecular fingerprints were also unveiled by the model. The effectively contributing physicochemical properties and molecular fingerprints from a set of known HDAC8 inhibitors were identified and can be used in designing future HDAC8 inhibitors.

• Journal of the Korean Society for Railway
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• v.8 no.6 s.31
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• pp.520-524
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• 2005

It is consequential to reduce the environmental impact of a product for sustainable development in 21st Century. In the field of transportation, especially, the technological market concerned about reduction and assessment of greenhouse gas emission is expected to be extended. The LCA gas been esteemed and utilized as a realistic alternative greenhouse gas emission is expected to be extended. The LCA has been esteemed and utilized as a realistic alternative to improve the environment by the assessment of environmental impacts. In this study, simplified life cycle assessment(S-LCA), was performed to analyze the environmental impacts quantitatively, which were produced through the life cycle of a electric motor unit(EMU). The object of the present work is rth investigate main parameters of environmental impacts and to establish the plans to improve the environment impact of EMU. As a result of quantitative assessment for environmental impact and manufacturing, the EMU carbody made of SUS showed acidification(AD) and marine water aquatic ecotoxicity(MAET) the most, while that made of Mild showed high impact of global warning(GW) and abiotic resources depletion(ARD). For the SUS EMU, the high AD and MAET impact is occurred by the discharged pollutants during acid-washing process. Also, high value of GW and ARD for Mild EMU is resulted from the consumption of iron ore, coal and crude oil during manufacturing. Therefore, the environment impact of carbody would be decreased by enhancing of energy efficiency and the lightening the weight of it.

• Journal of the Ergonomics Society of Korea
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• v.25 no.3
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• pp.49-60
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• 2006

Technological encroachment provides human operators with flood of information that must be analyzed to understand the environment and make judgments that lead to strategic actions. Further, the environment is not static and therefore uncertain, changing its aspect dynamically. Complexity accompanied with its dynamics imposes substantial difficulty to human operators' task. Criticality of having situational understanding becomes more important than ever. Situationalunderstanding requires the human operators possessing tacit knowledge in order for them to make the sense out of the situation while interacting with information from many heterogeneous sources, the notion of sensemaking. Sensemaking refers to the process of developing mental framework to assemble pieces of information representing different aspects of the environment that can be used to develop one's own actionable knowledge to implement their judgments in the uncertain environment. Therefore, judgment process and performance is a key component of sensemaking process. Among many judgment and decision making models, the lens model with its extension can be utilized to partially describe the judgmental aspect of sensemaking. One of the lens model parameters, unmodeled knowledge, can be a corresponding quantitative measure for the tacit knowledge that plays an important role in sensemaking. In this paper, a comprehensive literature for sensemaking is provided to formally define the notion of sensemaking in the military domain. Also, it is proposed that there is a crucial link between the sensemaking and human judgment process and performance from the lens model perspective. Potential implications for experimental framework are also proposed.

• The Journal of the Acoustical Society of Korea
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• v.35 no.2
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• pp.134-142
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• 2016

In this paper, a method synthesizing speech signal using the 40 kHz ultrasonic signals reflected from the articulatory muscles was introduced and performance was evaluated. When the ultrasound signals are radiated to articulating face, the Doppler effects caused by movements of lips, jaw, and chin observed. The signals that have different frequencies from that of the transmitted signals are found in the received signals. These ADS (Acoustic-Doppler Signals) were used for estimating of the speech parameters in this study. Prior to synthesizing speech signal, a quantitative correlation analysis between ADS and speech signals was carried out on each frequency bin. According to the results, the feasibility of the ADS-based speech synthesis was validated. ADS-to-speech transformation was achieved by the joint Gaussian mixture model-based conversion rules. The experimental results from the 5 subjects showed that filter bank energy and LPC (Linear Predictive Coefficient) cepstrum coefficients are the optimal features for ADS, and speech, respectively. In the subjective evaluation where synthesized speech signals were obtained using the excitation sources extracted from original speech signals, it was confirmed that the ADS-to-speech conversion method yielded 72.2 % average recognition rates.

• Polymer(Korea)
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• v.33 no.4
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• pp.273-283
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• 2009

Recent research issues on the scratch behaviors of polymeric materials has been investigated. In this study, the scratch characterization of polymeric materials with respect of experimental parameters, such as nature of the material, temperature, applied load, test speed, surface treatment, scratch number of times, polymer structure/functional groups, degree of cross-linking, and crystallinity, are reviewed. In addition, the testing standards and methodologies which could quantify the scratch behaviors are introduced and the current international standards are compared and summarized. The latest technical approaches for evaluating the scratch behaviors and improving the scratch resistance of polymers are also discussed.

• Plant Journal
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• v.12 no.3
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• pp.24-31
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• 2016

Wind-induced vibration is a phenomenon that a struture is oscillated due to wind force such as buffeting, vortex shedding wake and etc., which is one of important characteristics to be considered for design in case that stack has significant slenderness ratio or low natural frequency. International design standards of stack define several criteria for evaluating the suitability of stack design, which describe the required design considerations for each range of design parameters and provide the instruction to verify the stack design against wind-induced vibration simply. However, there is a limitation that they cannot provide quantitative information in case code requirement cannot be satisfied due to constraints of plant space or economical design. In order to overcome the limiation of code, integrated numerical analysis of computational fluid dynamics, harmonic analysis and finite element analysis were proposed to investigate wind-induced vibration for multiple stacks in actual plant. Simulated results of mutual wake interference effect between adjacent stacks were evaluated and compared to the criteria in international standards.

• Journal of Korea Water Resources Association
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• v.39 no.12 s.173
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• pp.1031-1042
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• 2006

In recent years, a growing concern exists in watershed and stream improvement projects. Under these circumstances, this paper estimates monetary value of the attributes of alternatives for rehabilitation of hydrologic cycle using choice experiments. Choice experiments shows vivid image and estimates a willingness to pay based on their preference for environmental goods. A preliminary survey shows that the attributes of the Anyangcheon watershed are flood-damage possibilities, Instreamflow, water quality, river characteristic and estimates the tax for the Anyangcheon watershed improvements. We surveyed 200 citizens were selected as samples of watershed beneficing in Seoul and Gyeonggi Province and used conditional logit model to analyze the implicit values of the attributive per household. The benefit of the attributes by province based on the implicit price obtained from estimated parameters were calculated. This study is expected to contribute to the decision-making process for policy-makers by providing useful methodological framework and quantitative information related to watershed improvement projects.

• Journal of Life Science
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• v.10 no.2
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• pp.177-181
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• 2000

This study was conducted to estimate the genetic parameters such as combining ability, heritabilities and correlation coefficients forsome agronomic characters by 6$\times$6 dialled crosses of barley. The results obtained were summarized as follows. Mean squares of general combining ability(GCA) and specific combining ability(SCA) were significant for all characters observed. Mean squares of general combining ability for all characters were expressed as higher values than those of specific combining ability. Jecheon #5 showed the high general combining ability effects for culm length, and Waegwanpimack #1 showed the highest general combining ability effects for tiller number. Cygne also showed the high general combining ability effects for spike length and 1,000 grains weight. Furthermore, Plumage was expressed with the highest general combining ability effects for spike length and 1,000 grains weight. Furthermore, Plumage was expressed with the highest general combining ability effects for number of grains per spike. In specific combining ability effects, Samdugjeonbug # 45$\times$Plumage showed the high value for culm length, and Suwon #6 $\times$Waegwanpimack #1$\times$ was expressed with the highest specific combining ability effects for tiller number. Jecheon #5$\times$Plumage also showed the high specific combining ability effects for spike length and number of grains per spike. Suwon #6$\times$Cygne showed the high specific combining ability effects for 1,000 grains weight. The heritabilities of spike length an number of grains per spike were over 90%. In correlation coefficients among characters, relationships between culm length and tiller number, culm length and spike length, culm length and 1,000 grains weight, and spike length and 1,000 grains weight showed highly positively correlation.

• Journal of the Korean GEO-environmental Society
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• v.13 no.8
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• pp.35-43
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• 2012

Construction of sheet pile retaining walls in urban and coastal regions has resulted in sheet pile walls in close proximity to laterally loaded pile foundations. However, there is currently little information available in the literature to assist engineers for quantifying the response of sheet pile walls. This study provides a quantitative method for estimating sheet pile wall response due to loads imposed from a nearby laterally loaded pile. Three dimensional finite element analyses using commercial software, ABAQUS, were performed to assess the response of a sheet pile wall and nearby laterally loaded pile. The soils were modeled using Drucker-Prager constitutive model with associated flow rule, and the sheet pile wall and pile foundation were assumed to behave linear elastic. Four parameters were investigated: sheet pile wall bending stiffness, distance from the pile face to the wall, excavation depth in front of the sheet pile wall, and elastic modulus of the soil. Results from the analyses have been used to develop preliminary design charts and simple equations for estimating the maximum horizontal displacement and maximum bending moment in the sheet pile wall.