• 융합보안논문지
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• 제11권6호
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• pp.67-72
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• 2011

유비쿼터스 서비스(U-service)를 제공하는 시스템은 서비스 생존성이 취약한 환경을 극복해야하는 네트워크 시스템이다. 네트워크 시스템의 생존성은 시스템 구성요소에 장애나 사고, 물리적 공격이 발생하더라도 시스템에 부여된 본연의 서비스를 중단 없이 제공할 수 있는 시스템 능력으로 정의하고 있다. 본 논문에서는 비잔틴 장애를 초래하는 의도적인 사이버테러가 네트워크 시스템에 가해졌을 때의 상황을 고려하여, 사용자 입장에서 서비스 생존성을 정량적으로 평가 할 수 있는 프레임워크를 제시한다. 본 논문에서는 무선 LAN 기반의 Jini 시스템을 생존성 정량화 모델의 예로 삼는다. 그리고 Jini 시스템이 제공하는 U-service의 생존성을 평가하기 위한 연속시간 마코프 모델을 제시하고 이를 토대로 사용자가 서비스에 접근할 수 없는 확률(blocking probability)로서 U-service 생존성을 평가하는 방안을 제시한다.

• 한국근적외분광분석학회:학술대회논문집
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• 한국근적외분광분석학회 2001년도 NIR-2001
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• pp.3111-3111
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• 2001

The implementation of NIR and chemometrics in the Pharmaceutical industries is still in strong progress, both regarding qualitative and quantitative applications and beneficial results are seen. Looking at the development so far, NIR will change the pharmaceutical industry even more in the future. This presentation will address the experiences and progress achieved regarding the application and implementation of quantitative methods for determination of content uniformity and assay of tablets with less than 10% w/w of active, using Near Infrared transmittance spectroscopy in combination with PLS. Also qualitative methods for identification of the same tablets by Near Infrared reflectance spectroscopy will be discussed. Four commercial tablet strengths are formulated and produced from two different compositions by direct compression. Three different strengths are dose proportional, i.e. fixed concentration by varying in size. The aim was to replace the conventional primary methods for analysing content uniformity, assay and identification by NIR. Studies were performed on comparing transmittance versus reflectance spectroscopy for both applications on the dose proportional tablets. The model for determination of content uniformity and assay was developed to cover both coated and uncoated tablets, whereas the qualitative model was developed to identify coated tablets only. The impact of the tablet formulation, tablet size and coating, resulted in individual models far each composition The best calibration was achieved using diffuse reflectance for the identification purposes and diffuse transmittance for the quantitative determination of the active content within the tablets. As NIR in combination with other techniques opens up the possibility of total quality management within the production, the transfer of the above-mentioned models from a laboratory based approach to an at-line approach at H.Lundbeck will be addressed too.

• 디지털콘텐츠학회 논문지
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• 제16권2호
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• pp.335-343
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• 2015

본 논문은 건물의 동선에 대한 정량적 평가기준을 마련하기 위한 하나의 접근방법을 제안하며, 이를 위해 건물정보모델링(BIM, Building Information Modeling)을 이용하여 동선관련 객체 및 속성의 정량적 데이터를 활용한다. 동선을 계획하고 분석하는 작업은 설계 초기부터 중요하며, 건축법규나 설계지침 등에 제시된 동선 관련 규정을 따르기 위한 목적 외에도 거주자의 편의성의 관점에서도 중요하다. 본 논문에서 제시하는 방법에 의거하면, BIM에서 추출할 수 있는 다양한 값들을 이용하여 '편리한 동선'과 같은 정성적인 내용의 정량적 비교 및 판단을 사용자의 가중치 설정에 따라 가능하도록 지원한다. 해당 가중치는 물리적 거리, 공간의 깊이 및 동선 방향 전환수, 매개공간의 창문면적 등을 포함하며, 사용자가 부여한 가중치에 따라 정량화된 비교 방안을 통해 동선관련 설계품질에 대한 평가에 활용 가능하다.

• Molecules and Cells
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• 제44권7호
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• pp.500-516
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• 2021

Cardiac hypertrophic signaling cascades resulting in heart failure diseases are mediated by protein phosphorylation. Recent developments in mass spectrometry-based phosphoproteomics have led to the identification of thousands of differentially phosphorylated proteins and their phosphorylation sites. However, functional studies of these differentially phosphorylated proteins have not been conducted in a large-scale or high-throughput manner due to a lack of methods capable of revealing the functional relevance of each phosphorylation site. In this study, an integrated approach combining quantitative phosphoproteomics and cell-based functional screening using phosphorylation competition peptides was developed. A pathological cardiac hypertrophy model, junctate-1 transgenic mice and control mice, were analyzed using label-free quantitative phosphoproteomics to identify differentially phosphorylated proteins and sites. A cell-based functional assay system measuring hypertrophic cell growth of neonatal rat ventricle cardiomyocytes (NRVMs) following phenylephrine treatment was applied, and changes in phosphorylation of individual differentially phosphorylated sites were induced by incorporation of phosphorylation competition peptides conjugated with cell-penetrating peptides. Cell-based functional screening against 18 selected phosphorylation sites identified three phosphorylation sites (Ser-98, Ser-179 of Ldb3, and Ser-1146 of palladin) displaying near-complete inhibition of cardiac hypertrophic growth of NRVMs. Changes in phosphorylation levels of Ser-98 and Ser-179 in Ldb3 were further confirmed in NRVMs and other pathological/physiological hypertrophy models, including transverse aortic constriction and swimming models, using site-specific phospho-antibodies. Our integrated approach can be used to identify functionally important phosphorylation sites among differentially phosphorylated sites, and unlike conventional approaches, it is easily applicable for large-scale and/or high-throughput analyses.

• 한국전자거래학회지
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• 제26권3호
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• pp.119-132
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• 2021

내용적 연관성에 기반한 연관지식의 파악은 핵심 지식에 대한 서비스와 보안의 기본적인 기능이다. 본 연구는 내용적 연관성을 기준으로 연관지식을 파악하는 기존의 방식, 즉 키워드 기반 방식과 워드임베딩 방식의 연관문서 네트워크 구성 성능을 비교하여 어떤 방식이 정량적/정성적 측면에서 우월한 성능을 나타내는가를 검토한다. 검토 결과 키워드 기반 방식은 핵심 문서 파악 능력과 시맨틱 정보 표현 능력 면에서 우월한 성능을, 워드임베딩 방식은 F1-Score와 Accuracy, 연관성 강도 표현 능력, 대량 문서 처리 능력 면에서 우월한 성능을 나타냈다. 본 연구의 결과는 기업과 사용자의 요구를 반영하여 보다 현실적인 연관지식 서비스 관리에 활용될 수 있다.

• Smart Structures and Systems
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• 제14권6호
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• pp.1197-1220
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• 2014

Accurate actuator tracking is critical to achieve reliable real-time hybrid simulation results for earthquake engineering research. The frequency-domain evaluation approach provides an innovative way for more quantitative post-simulation evaluation of actuator tracking errors compared with existing time domain based techniques. Utilizing the Fast Fourier Transform the approach analyzes the actuator error in terms of amplitude and phrase errors. Existing application of the approach requires using the complete length of the experimental data. To improve the computational efficiency, two techniques including data decimation and frequency decimation are analyzed to reduce the amount of data involved in the frequency-domain evaluation. The presented study aims to enhance the computational efficiency of the approach in order to utilize it for future on-line actuator tracking evaluation. Both computational simulation and laboratory experimental results are analyzed and recommendations on the two decimation factors are provided based on the findings from this study.

• 제어로봇시스템학회논문지
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• 제21권11호
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• pp.1081-1087
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• 2015

This article aims to provide a design method of warning thresholds for active safety systems based on the performance-based approach considering driver behaviors. Both positive and negative consequences of warnings are considered, and the main idea is to choose a warning threshold where the positive consequence is maximized, whereas the negative consequence is minimized. The process of the performance-based approach involves: Defining the operating scenarios; setting the trajectory models, including human characteristics; estimating the alert and nominal trajectories; estimating the performance metrics; generating a performance-metric plot; and determining the alert thresholds. This paper chose a lane-departure warning system as an example to show the usefulness of the performance-based approach. Both human and sensor characteristics were considered in the system design, and this paper provided a quantitative method to include human factors in designing active safety systems.

• 한국환경과학회지
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• 제3권3호
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• pp.285-296
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• 1994

The objective of this study was to examine and compare to transient response to quantitative and hydraulic shocks which produce equal changes in mass rate of organic feed in aerobic fixed-film process. The general experimental approach was to operate the system at several growth rates under steady-state(pre-shock) conditions, then to apply step changes during day 3 in dilution rate(hydraulic shock) , or feed concentration(Quantitative shock) at the same organic mass loading rate. Performance was assessed in both the transient state and the new steady-state (post- shock). Shock load of different type did not produced equivalent disruptions of effluent quality for equal increases in mass loading rate. Based on effluent concentrations, a hydraulic and a Quantitative shock at the same mass loading caused equal increase in total effluent COD, but the increase was primarily a result of suspended solids the hydraulic shock and COD in the quantitative shock. The time which effluent COD came to peak values were about 32~48 hours at the low organic loads and 52 ~ 72 hours at the high organic loads, respectively A quantitative shock produced a much greater increase in effluent COD than did a hydraulic shock at the same mass loading. Mean and peak values of effluent concentration weve increased in 2.8~4.2 times at low organic loading rate, 5.2~6.6 times at the high organic loading rate, respectively. Key words : Aerobic fixed-film reactor, Quantitative shock, hydraulic shock, mass loading rate.

• International Journal of Contents
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• 제5권2호
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• pp.43-52
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• 2009

The article first presents a broad overview of the design and management for survivable network. We review the concept of network survivability, various protection and restoration schemes. Also we introduce design architectures of Quantitative model and a Survivable Ad hoc and Mesh Network Architecture. In the other side of study like these(traditional engineering approach), there is the concept of the survivable network systems based on an immune approach. There is one sample of the dynamic multi-routing algorithms in this paper.

• 한국시스템다이내믹스연구
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• 제3권1호
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• pp.61-77
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• 2002

This paper reviews issues and methodological status of system dynamics and suggest some research agenda for its development in Korea. After reviewing some characteristics of system dynamics approach, including dynamic feedback perspective and endogenous point of view, the paper pointed out methodological characteristics of system dynamics. It seems to be the most notable characteristics of System Dynamics that it use both quantitative and qualitative approach in explaining and modelling reality. Besides, System Dynamicists rely more heavily on refutationism than instrumentalism and this allows System Dynamicists follow more strict way of scientific inquiry. For the development of System Dynamics in Korean academic circle, developing training program and curriculum, networking scattered System Dynamicist all over the country, would be the most important task.