• 제목/요약/키워드: Quantitative Approaches

검색결과 412건 처리시간 0.032초

Recent Advances in Sheep Genome Mapping

  • Crawford, A.M.
    • Asian-Australasian Journal of Animal Sciences
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    • 제12권7호
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    • pp.1129-1134
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    • 1999
  • The rapid development of the sheep genetic linkage map over the last five years has given us the ability to follow the inheritance of chromosomal regions. Initially this powerful resource was used to find markers linked to monogenic traits but there is now increasing interest in using the genetic linkage map to define the complex of genes that control multigenic production traits. Of particular interest are those production traits that are difficult to measure and select for using classical quantitative genetic approaches. These include resistance to disease where a disease challenge (necessary for selection) poses too much risk to valuable stud animals and meat and carcass qualities which can be measured only after the animal has been slaughtered. The goal for the new millennium will be to fully characterise the genetic basis of multigenic production traits. The genetic linkage map is a vital tool required to achieve this.

Molecular Docking, 3D QSAR and Designing of New Quinazolinone Analogues as DHFR Inhibitors

  • Yamini, L.;Kumari, K. Meena;Vijjulatha, M.
    • Bulletin of the Korean Chemical Society
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    • 제32권7호
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    • pp.2433-2442
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    • 2011
  • The three dimensional quantitative structure activity relationship (3D QSAR) models were developed using Comparative molecular field analysis (CoMFA), comparative molecular similarity indices analysis (CoMSIA) and docking studies. The fit of Quinazolinone antifolates inside the active site of modeled bovine dihydrofolate reductase (DHFR) was assessed. Both ligand based (LB) and receptor based (RB) QSAR models were generated, these models showed good internal and external statistical reliability that is evident from the $q^2_{loo}$, $r^2_{ncv}$ and $r^2_{pred}$. The identified key features enabled us to design new Quinazolinone analogues as DHFR inhibitors. This study is a building bridge between docking studies of homology modeled bovine DHFR protein as well as ligand and target based 3D QSAR techniques of CoMFA and CoMSIA approaches.

소프트웨어 프로세스 개선활동이 조직성과에 미치는 영향 (The Effect of Software Process Improvement on Organizational Performance)

  • 윤재욱;김인재
    • 한국경영과학회지
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    • 제31권1호
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    • pp.37-53
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    • 2006
  • SPI (Software Process Improvement) activities have been considered one of the crucial approaches to achieve high quality, productivity and timely delivery of software products and services. The basic premise of SPI model is that higher maturity levels lead to better performance. In this research, the relationships between SPI results and performance were empirically investigated with Korean software companies. CMM key process areas were categorized into two dimensions, 'Process Implementation' and 'Quantitative Management'. The relationship between process implementation and performance was significant, but the relationship between quantitative management and performance was insignificant. The control variable, size of OU(Organizational Unit), did not have significant impact on the relation ships between SPI activities and OU performance.

SCADA 시스템의 보안취약성을 고려한 정전비용 산정기법에 관한 연구 (A Study on Estimation Method of Outage Cost caused by Vulnerabilities of SCADA System)

  • 김발호;강동주
    • 조명전기설비학회논문지
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    • 제25권6호
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    • pp.90-99
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    • 2011
  • As power industry evolves into Smart Grid scheme, previously closed power systems are being integrated into public communication networks. It increases the controllability and efficiency of the system, but also accompanies many cyber threats having existed in the Internet to the SCADA system. Therefore it is required to apply security countermeasures to the Smart Grid, which brings about investment costs. There have been few approaches to assess risks from cyber attack especially in electric power industry. So this paper proposes a methodology to assess quantitative impacts of various types of cyber attacks to a power system, and also shows the feasibility of the method through a case study.

건설공사의 위험도분석을 위한 확률적 위험도 평가 (Probabilistic Risk Assessment Techniques for the Risk Analysis of Construction Projects)

  • 조효남;임종권;박영빈
    • 한국전산구조공학회:학술대회논문집
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    • 한국전산구조공학회 1997년도 봄 학술발표회 논문집
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    • pp.27-34
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    • 1997
  • In this paper, systematic and comprehensive approaches are suggested for the application of quantitative PRA techniques especially for those risk events that cannot be easily evaluated quantitatively In addition, dominant risk events are identified based on their occurrence frequency assessed by both actual survey of construction site conditions and the statistical data related with the probable accidents. Practical FTA(Fault Tree Analysis) and ETA(Event Tree Analysis) models are used for the assessment of the identified risks. When the risk events are lack of statistical data, appropriate Bayesian models incorporating engineering judgement and test results are also introduced in this paper. Moreover, a fuzzy probability technique is used for the quantitative risk assessment of those risk components which are difficult to evaluate quantitatively.

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Quantifying user interface usability

  • Park, Kyung S.;Lim, Chee H.
    • 대한인간공학회:학술대회논문집
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    • 대한인간공학회 1995년도 춘계학술대회논문집
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    • pp.16-22
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    • 1995
  • The importance of usability evaluation is increasing in developing a new system and product. The current approaches for usability evaluation are: the comparative evaluation to measure usability, and the iterative user interface design to find usability problems. This paper pressents three types of characteristics and a set of criteria for usability evaluation. The methodology for criteria-based quantitative analysis of user interface usability is investigated with a view to measuring usability. The fuzzy weighted-checklist method with linguistic variables is used for quantitatie analysis. This analysis provides a quantitative measure, which reflects the degree of excellence of user interface usability during the design and development phases.

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정자생성 주기법을 이용한 고환독성 평가 필요성과 정량적인 고환독성 평가방법에 대한 고찰 (The Recommended Approaches for the Evaluation of Testicular Toxicity with Awareness of the Spermatogenic Cycle and Quantitative Testicular Toxicity Evaluation Methods)

  • 손우찬;김종춘;유일재
    • Toxicological Research
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    • 제19권2호
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    • pp.83-90
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    • 2003
  • Since histopathological examination was known to be the most sensitive evaluation for testicular toxicity, regulatory authorities have been published the guidelines on practical testicular assay approach. Those guidelines specified details of evaluation including fixation, embedding, stain-ing, histological examination and also seminiferous tubular staging methods. However, there have been confusing understanding among toxicologists and even pathologists on staging theory and its application on industrial testicular toxicity. Guidelines did not intend to conduct quantitative assay with staging but recommended the use of knowledge of staging. To count each tubular stage with statistical analysis is known to be time consuming and labor burdening work but the significance of toxicity has little value. It also has been pointed out that the application of staging theory for longer-term toxicity considered to be lacking of rationale. It could be recommended that qualitative assay with aware-ness of germ cell loss is more efficient method rather than quantitative counting of each tubular stage. Therefore it would be required that comprehensive understanding of testicular toxicity evaluation and the use of testicular staging method.

마을 만들기 연구의 정량적 접근에 관한 소고 - 마을 만들기 사업규모와 성과의 관계를 중심으로 - (A Note on the Quantitative Approach to the Study of Community Design - Focused on the Relationship between Project Scale and Outcomes -)

  • 김동윤;김선직;강래천
    • 한국디지털건축인테리어학회논문집
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    • 제11권2호
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    • pp.41-50
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    • 2011
  • Skeptical responses to urban design based on the Physical Planning theory assuming the existence of social agreement and the absolute authorities of planners bring about alternatives such as Participatory Planning and Community Design derived from Harbermas' Communicative Rationality. But the normative contentions do not progress any more to the stage of presenting practical strategies. This is the cause why there should be systematic approaches to reveal the relationships among various concepts or variables. With regard to the Community Design this study intends to take a statistical approach to find relationship between project scale and its accomplishment. The hypothesis that the smaller scale of project begets the better outcomes was tested to be rejected as a result of the analysis of variance. But the result also shows that appropriate density in relatively large area makes residents' expected satisfaction high. Although this discovery has its own meaning the tryout is anticipated to laying the cornerstone of quantitative analyses in the following studies.

질적 디자인 가치의 수량화(I) (A Study on the Quantification of Qualitative Attributes in Industrial Design)

  • 우흥룡
    • 디자인학연구
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    • 제2권1호
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    • pp.117-130
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    • 1989
  • Evaluation is to be seen a~ a central component of design activity. It is an attempt to ensure that the proposal which arises is accepted and that the resulting artefact itself suited to its purposes in practice. Recent surveys of Evaluation show that most methods require quantitative and explicit attributes. Always a significant part of the attributes of design proposals is qualitative. Therefore we need some study that convert qualitative attributes into quantitative scale values, because in many cases con\ulcornerclusions can be drawn about the order of the overall value of the design proposals. Following to Thurstone's psychological scaling methods, attributive values are assigned by ruting scale methods, met, hod of rank-order and method of paired comparisons. The problem of psycho\ulcornerlogical scaling is then to determine whether the stimuli can be ordered on a psychological continuum with respect to the degree of the attributes each possesses. The law of comparative judgement assumes that for a given stimulus there is associated a most frequently aroused or modal discriminal process on a psychological continuum. This paper is based upon the premise that the modal discriminul process will also be the same as the mean or median of the distribution.The objective of this paper is to argue for an acceptance of qualitative approaches to the evalua\ulcornertion of Design as a complement to the existing quantitative techniques. The scale values of 10 attri\ulcornerbutes \ulcorner(1) originality, (2) aesthetics, (3) satisfaction, (4) effeciency, (5) function, (6) size, (7) texture, (8) simplicity, (9) symbol, and (10) facility) in case of TV sets are obtained and their interactions are examined.

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베이지안 망 연결 구조에 대한 데이터 군집별 기여도의 정량화 방법에 대한 연구 (Quantitative Annotation of Edges, in Bayesian Networks with Condition-Specific Data)

  • 정성원;이도헌;이광형
    • 한국지능시스템학회논문지
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    • 제17권3호
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    • pp.316-321
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    • 2007
  • 본 연구에서는 베이지안 망 구조 학습에서, 학습 데이터의 특정 부분집합이 학습된 망의 각 연결 구조(edge)의 형성에 기여하는 정도를 정량화하는 방법을 제안한다. 생물학 정보의 분석 등에 베이지안 망 학습을 이용하는 경우, 제안된 방법은 망의 각 연결 구조의 형성에 특정 군집 데이터가 기여하는 정도의 정량화가 가능하다. 제안된 방법의 유효성을 보이기 위해, 벤치마크 베이지안 망을 이용하여 제안된 방법이 망 연결 구조에 대한 데이터 군집별 기여도를 효과적으로 정량화 할 수 있음을 보인다.