• Journal of the Korean Society of Safety
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• v.35 no.1
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• pp.87-96
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• 2020

The purpose of this paper is to develop a fire HRA (Human Reliability Analysis) procedure for full power operation of domestic NPPs (Nuclear Power Plants). For the development of fire HRA procedure, the recent research results of NUREG-1921 in an effort to meet the requirements of the ASME/ANS PRA Standard were reviewed. The K-HRA method, a standard method for HRA of a domestic level 1 PSA (Probabilistic Safety Assessment) and fire related procedures in domestic NPPs were reviewed. Based on the review, a procedure for the fire HRA required for a domestic fire PSA based on the K-HRA method was developed. To this end, HRA issues such as new operator actions required in the event of a fire and complexity of fire situations were considered. Based on the four kinds of HFE (Human Failure Event) developed for a fire HRA in this research, a qualitative analysis such as feasibility evaluation was suggested. And also a quantitative analysis process which consists of screening analysis and detailed analysis was proposed. For the qualitative analysis, a screening analysis by NUREG-1921 was used. In this research, the screening criteria for the screening analysis was modified to reduce vague description and to reflect recent experimental results. For a detailed analysis, the K-HRA method and scoping analysis by NUREG-1921 were adopted. To apply K-HRA to fire HRA for quantification, efforts to modify PSFs (Performance Shaping Factors) of K-HRA to reflect fire situation and effects were made. For example, an absence of STA (Shift Technical Advisor) to command a fire brigade at a fire area is considered and the absence time should be reflected for a HEP (Human Error Probability) quantification. Based on the fire HRA procedure developed in this paper, a case study for HEP quantification such as a screening analysis and detailed analysis with the modified K-HRA was performed. It is expected that the HRA procedure suggested in this paper will be utilized for fire PSA for domestic NPPs as it is the first attempt to establish an HRA process considering fire effects.

• Mass Spectrometry Letters
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• v.2 no.3
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• pp.69-72
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• 2011

Defective synthesis of the steroid hormones by the adrenal cortex has profound effects on human development and homeostasis. Due to the time-consuming chromatography procedure combined with mass spectrometry, the matrix-assisted laser desorption ionization method coupled to the linear ion-trap tandem mass spectrometry (MALDI-LTQ-MS/MS) was developed for quantitative analysis of 10 adrenal steroids in human serum. Although MALDI-MS can be introduced for its applicability as a high-throughput screening method, it has a limitation on reproducibility within and between samples, which renders poor reproducibility for quantification. For quantitative MALDI-MS/MS analysis, the stable-isotope labeled internal standards were used and the conditions of crystallization were tested. The precision and accuracy were 3.1~35.5% and 83.8~138.5%, respectively, when a mixture of 10 mg/mL ${\alpha}$-cyano-4-hydroxycinnamic acid in 0.2% TFA of 70% acetonitrile was used as the MALDI matrix. The limit of quantification ranged from 5 to 340 ng/mL, and the linearity as a correlation coefficient was higher than 0.988 for all analytes in the calibration range. Clinical applications include quantitative analyses of patients with congenital adrenal hyperplasia. The devised MALDI-MS/MS technique could be successfully applied to diagnosis of clinical samples.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.41 no.5
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• pp.350-356
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• 2013

Photogrammetry has been widely used for measuring the important physical quantities in aerospace areas because it is a remote and non-contact measurement method. In this study, we analyzed photogrammetric error which can be occur in six degrees of freedom(6DOF) analysis among coordinates systems with single camera. Error analysis program were developed, and validated using geometric problem converted from imaging process. We analogized that the statistic from estimated camera pose which is need to 6DOF analysis is normally distributed, and quantified the photogrammetric error using estimated population standard deviation.

• Proceedings of the Korean Geotechical Society Conference
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• 2009.03a
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• pp.444-455
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• 2009

Great concerns on geotechnical risk & hazard assessment have been increased due to human and economic damage by natural disasters with recent global climate changes. In this paper, geotechnical problems in particular, landslides which is interested in European countries and North America, were mainly discussed. For these, 18 key topics on geotechnical risk and hazards which had been discussed at the LARAM 2008 workshop in Italy were analyzed after grouping by subjects. Main topic contents consisted of applications such as field measurement, early warning systems, uncertainty analysis of parameters using radar, optical data and statistical theory and so on. And the problems related to analysis of vulnerability and deformation due to earthquakes, investigation of gas zone using seismic reflection data in a landslide area, risk quantification and hazard assessment of landslide movements and multi-dimensional analysis for stability of complex slopes were attracted. Also, there were studies on risk matters of cultural heritage, the blockglide of clayey ground, simulations of debris flows based on GIS, quantification of the failure processes of rock slopes, a meshless method for 3D crack modelling, and finally risk assessment for cryological processes due to global warming.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2016.05a
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• pp.252-255
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• 2016

The objective of this paper is to find an easier and non-invasive a way of diagnosing heart diseases based on the heart sound, rigidly heart murmurs, recordings from subjects. Although most of the heart sounds can be easily heard, analysis of the findings by auscultation strongly depends on skills and experience of the physician. Therefore, the heart murmur is require quantitative analysis for automatic diagnosis equipment. For a good sound analysis, the noisy component ware filtered. This can be done using Wiener filter. Once the signal is filtered, it can be segmented into its basic components by signal energy using FFT. After segment the heart sound signal, the relative positions of the different heart sound components will be identified and will be used for quantification purposes. We are using murmur energy ratio. The experimental results are fairly good in relation to automatic diagnosis.

• Journal of the Korean Society of Safety
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• v.38 no.4
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• pp.15-22
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• 2023

LPG-related accidents, which account for half of all gas accidents in Korea, have not shown any sign of decrease over the past decade, partially owing to the lack of effective safety improvement measures. The purpose of this study was to identify the effectiveness of improvement measures by analyzing the traits of accidents in terms of human factors, and to seek more effective accident prevention strategies. In this study, 108 accident cases were collected and analyzed in the aspect of accident characteristics such as violation type, human factors, and so on. The results showed that the work procedures of suppliers and engineers related to LPG accidents seemed to be similar in outward appearance; however, specific accident causes and unsafe behaviors were different. Particularly, type and target of violations were different, which could be visually confirmed by the Principal Component Analysis (PCA) and the Quantification Techniques (QT). Furthermore, for engineers, insufficient supervision was a major influencing factor. In conclusion, because the accident characteristics of suppliers and engineers are different, differentiated accident prevention strategies should be implemented, which was discussed in this study.

• Nuclear Engineering and Technology
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• v.54 no.11
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• pp.4272-4279
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• 2022

In this study, a cross section stochastic sampling (S.S.) capability is implemented into both the McCARD continuous energy Monte Carlo code and MIG multiple-correlated data sampling code. The ENDF/B-VII.1 covariance data based 30 group cross section sets and the SCALE6 covariance data based 44 group cross section sets are sampled by the MIG code. Through various uncertainty quantification (UQ) benchmark calculations, the McCARD/MIG results are verified to be consistent with the McCARD stand-alone sensitivity/uncertainty (S/U) results and the XSUSA S.S. results. UQ analyses for Three Mile Island Unit 1, Peach Bottom Unit 2, and Kozloduy-6 fuel pin problems are conducted to provide the uncertainties of k_eff and microscopic and macroscopic cross sections by the McCARD/MIG code system. Moreover, the SNU S/U formulations for uncertainty propagation in a MC depletion analysis are validated through a comparison with the McCARD/MIG S.S. results for the UAM Exercise I-1b burnup benchmark. It is therefore concluded that the SNU formulation based on the S/U method has the capability to accurately estimate the uncertainty propagation in a MC depletion analysis.

• Steel and Composite Structures
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• v.44 no.5
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• pp.651-676
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• 2022

Most of the experimental, theoretical, and numerical studies on the stability of functionally graded composites are deterministic, while there are full of complex interactions of variables with an inherently probabilistic nature, this paper presents a non-intrusive framework to investigate the stochastic nonlinear buckling behaviors of porous functionally graded cylindrical shells exposed to inevitable source-uncertainties. Euler-Lagrange equations are theoretically derived based on the three variable refined shear deformation theory. Closed-form solutions for the shell buckling loads are achieved by solving the deterministic eigenvalue problems. The analytical results are verified with numerical results obtained from finite element analyses that are conducted in the commercial software ABAQUS. The non-intrusive framework is completed by integrating the Monte Carlo simulation with the verified closed-form solutions. The convergence studies are performed to determine the effective pseudorandom draws of the simulation. The accuracy and efficiency of the framework are verified with statistical results that are obtained from the first and second-order perturbation techniques. Eleven cases of individual and compound uncertainties are investigated. Sensitivity analyses are conducted to figure out the five cases that have profound perturbative effects on the shell buckling loads. Complete probability distributions of the first three critical buckling loads are completely presented for each profound uncertainty case. The effects of the shell thickness, volume fraction index, and stochasticity degree on the shell buckling load under compound uncertainties are studied. There is a high probability that the shell has non-unique buckling modes in stochastic environments, which should be known for reliable analysis and design of engineering structures.

• International conference on construction engineering and project management
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• 2020.12a
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• pp.303-312
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• 2020

Safety culture is a collection of the beliefs, perceptions and values that employees share in relation to risks within an organisation. On the other hand, a resilient safety culture (RSC) means a culture with readiness of the organisation to respond effectively under stress, bounce back from shocks and continuously learn from them. RSC helps organisations to protect their interest which can be attributed to behavioural, psychological and managerial capabilities of the organization. Quantification of the degree of resilience in an organisation's safety culture can provide insights about the strong and weak links of the organisation's overall health and safety situation by identifying potential causes of system or sub-system failure. One of the major challenges of quantification of RSC is that the attributes that determine RSC need to be measured through constructs and indicators which are complex and often interrelated. In this paper, we address this challenge by applying a fault tree analysis (FTA) technique which can help analyse complex and interrelated constructs and indicators. The fault tree model of RSC is used to evaluate resilience levels of two organisations with remote and urban locations in order to demonstrate the failure path of the weak links in the RSC model.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.1
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• pp.343-347
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• 2014

Background: Maspin expression is a potential prognostic factor for various malignancies but its relation with gallbladder cancer is unknown and needs to be investigated needs to be investigated. We therefore here focused on maspin mRNA expression in normal, gall stone disease and gallbladder cancer subjects, with particular attention to prognostic importance in individuals with malignancies. Materials and Methods: This study was carried out at the Department of Surgical Gastroenterology, King George's Medical University, Lucknow, India. Gallbladder samples from normal (n=25), gall stone disease (n=25) and cancer patients (n=38) were analysed for maspin mRNA expression by semi-quantitative reverse transcriptase PCR and quantitative real time PCR. Statistical analysis was carried out using the Students t test or ANOVA. Survival analysis was conducted according to the Kaplan-Meier method and correlations were assessed using the Pearson correlation method. p<0.05 was considered statistically significant. Results: Significant increase (p=0.028) in expression of maspin mRNA was observed in gallbladder cancer as compared to gall stone disease, whereas no expression was found in normal tissues. Significant correlation (Pearson's coefficient(r)=-0.798, p<0.0001) was observed between relative quantification of maspin mRNA and survival of cancer patients after surgery, with significantly shorter (p=0.002) survival in patients having relative quantification >1.5 as compared to those having relative quantification <1.5. Similarly, significant differences in patient survival for maspin mRNA expression was observed for stage II (p=0.025) and III (p=0.011) cancer. Conclusions: Higher expression of maspin mRNA in gallbladder cancer has prognostic significance for stage II and III cancer, which needs to be investigated further.