• Title/Summary/Keyword: Quality regulation

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Muscle differentiation induced up-regulation of calcium-related gene expression in quail myoblasts

  • Park, Jeong-Woong;Lee, Jeong Hyo;Kim, Seo Woo;Han, Ji Seon;Kang, Kyung Soo;Kim, Sung-Jo;Park, Tae Sub
    • Asian-Australasian Journal of Animal Sciences
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    • v.31 no.9
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    • pp.1507-1515
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    • 2018
  • Objective: In the poultry industry, the most important economic traits are meat quality and carcass yield. Thus, many studies were conducted to investigate the regulatory pathways during muscle differentiation. To gain insight of muscle differentiation mechanism during growth period, we identified and validated calcium-related genes which were highly expressed during muscle differentiation through mRNA sequencing analysis. Methods: We conducted next-generation-sequencing (NGS) analysis of mRNA from undifferentiated QM7 cells and differentiated QM7 cells (day 1 to day 3 of differentiation periods). Subsequently, we obtained calcium related genes related to muscle differentiation process and examined the expression patterns by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Results: Through RNA sequencing analysis, we found that the transcription levels of six genes (troponin C1, slow skeletal and cardiac type [TNNC1], myosin light chain 1 [MYL1], MYL3, phospholamban [PLN], caveolin 3 [CAV3], and calsequestrin 2 [CASQ2]) particularly related to calcium regulation were gradually increased according to days of myotube differentiation. Subsequently, we validated the expression patterns of calcium-related genes in quail myoblasts. These results indicated that TNNC1, MYL1, MYL3, PLN, CAV3, CASQ2 responded to differentiation and growth performance in quail muscle. Conclusion: These results indicated that calcium regulation might play a critical role in muscle differentiation. Thus, these findings suggest that further studies would be warranted to investigate the role of calcium ion in muscle differentiation and could provide a useful biomarker for muscle differentiation and growth.

Haussmann's Urban Green Space System in Paris' The Efficacities and the Logic of the Green Politics (오스만의 파리시 도심녹지시스템 : 그 효용성과 녹지정책의 논리)

  • 견진현
    • Journal of the Korean Institute of Landscape Architecture
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    • v.31 no.4
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    • pp.1-12
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    • 2003
  • The urban park provides a safe rest and leisure area, and offers the beauty of nature to counter the drearyness of urban space. It can provide benefits such as the reduction of environmental pollution, the regulation of the local climate, and it can also provide a safe area during times of disaster. However, there was no interest in urban park development and control in Korea during the economic boom of the mid 1960s. Furthermore, during the industrialization process, the population grew significantly in the cities and the cities' scales were noticeably extended; as a result of this, the living environment and the natural environment in the cities worsened. With rapid urbanization and industrialization, urban green area diminished, and it became necessary to organize the urban park system to improve quality of life. 45% of south korea's population lives in 6 cities, which is only 4% of Korea's land size. The Urban park system has to be considered in the urban planning process. Paris' urban green system can be a role-model for Korea's urban green development plan to function organically. Urban public park concepts have been used in Paris's urban planning since 1850. There were hardly any parks, gardens and squares for the public before the middle of the 19th century. For improving life-styles for the poor, Napoleon III strongly supported the development of green space systems in Paris by G.E. Haussmann. Napoleon III and Haussmann established and applied the urban green regulation within Paris urban planning. The purpose of this study is to investigate the green regulations Haussmann's Paris urban plan and urban green space system: and as a result of this, it can be an indicator for urban green space development in Korea.

A Study on IT Outsourcing Policy Based on Operational Risks of Financial Industries (금융보안 리스크 기반의 IT도급 정책 연구)

  • Choi, Chang-Lai;Yun, Jang-Ho;Lee, Kyung-Ho
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.24 no.4
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    • pp.681-694
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    • 2014
  • For the continuous financial incidents occurred in 2011, Korean government has announced the amendment on electronic finance supervision regulation including human resources, organization and budget. The major part of the regulation is mainly focused on human resources and budget. It states that company has to employ at least 5 percent of IT staff out of total staff, and at least 5 percent of security staff in IT staff employment number. Budget for security should be at least 7 percent of total IT budgets. This paper studies IT outsourcing policy based on operational risks of financial industries caused by amendment of regulation. This paper provides the policy decision procedure for resolving the 3rd party problems and suggests the effective operation policy to 3rd party for the program quality improvement and case studies at the IT task classification.

A Case Note on the Medical Negligence of Traditional Chinese Herbal Medicine in the UK

  • Lee, Hai Woong
    • Journal of Society of Preventive Korean Medicine
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    • v.18 no.3
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    • pp.105-115
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    • 2014
  • Objective : Traditional medicine (TM) has been playing its role in national healthcare system and it is taken as complementary and alternative medicine (CAM) from the viewpoint of modern Western medicine. In the UK, not a few practitioners of Traditional Chinese Medicine (TCM) are working as CAM practitioners using herbal medicine and acupuncture therapy. Cases of dispute in the TCM practice are not rare these days because patients who take TCM service are increasing by year. Method : In the UK, dispute cases of the Traditional Medicine of East Asia can be found these days, however, it is hard to find a reported court case. A medical dispute case of TCM will be analysed to see the legal management and the resolving principle in the alternative medicine practice with some cases of Korean Medicine (KM) being discussed. Results : The usual pattern of clinical negligence can be discussed from the points of a duty of care, breach of that duty by negligence, and the harm to the patient from that breach of duty. The judge followed this procedure In this case to discuss the claims. The department of health proposed to introduce regulation to provide the reasonable quality in TCM practice, and the governmental system would be essential to regulate both the TCM practice and practitioners. Conclusion : The dispute case of traditional Chinese herbal medicine (TCHM) practice is important for the clinical negligence in TCHM practice. Judging the negligence of a TCHM practitioner involves the conventional negligence principle in tort law, and the TCHM practitioners are required to keep up with the up-to-date information on the related medical specialty. The reasoning is almost the same as that shown in the court case of Korea. The TCHM practice in the UK needs to be under the regulation by the government. The standard of care we expect of a TCHM practitioner is a further matter to discuss from the healthcare and social viewpoints.

A Study on the Regulation for Type and Design Guideline of Mental Health Service (정신보건서비스 유형 및 시설기준 수립을 위한 관련 법제도 분석 연구)

  • Moon, Ha Ni;Yun, Woo Yong;Chai, Choul Gyun
    • Journal of The Korea Institute of Healthcare Architecture
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    • v.22 no.2
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    • pp.25-33
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    • 2016
  • Purpose : The information of mental health facilities in Korean law is so unclear that people hardly enable to understand what sort of proper mental health service is prepared for them. Futhermore, there is not enough regulation and standard to classify each type of facilities in the law. Therefore the purpose of this study is to provide data on the basis for classification and facility standards by analysing Korean law and policies. Methods : This study was conducted by a research on law and regulation of mental health facility. Results : The result of this study can be summarized into three points. The first one, current law and policy do not reflect a change in community mental health services paradigm. The second one, the classified facility should be designed to fit the community mental health services. The third one, overall, it requires more detailed guidelines to enhance the quality of mental health services. Besides, the treatment as well as the function of the prevention and rehabilitation are necessary criteria that can also be enhanced. Implications : This study looked at the classification and facility standard of mental health facility by the change in community mental health services paradigm. Forward according to these changes, there is a need for specific guidelines for mental health facility.

Role and Contaminant Selection Methods of Soil Quality Standards in Developed Countries (선진국 토양오염 기준의 역할과 기준항목 설정방법)

  • Jeong, Seung-Woo;An, Youn-Joo;Kim, Tae-Seung
    • Journal of Soil and Groundwater Environment
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    • v.14 no.1
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    • pp.18-28
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    • 2009
  • Many countries have recently established legal regulations and soil quality standards for soil protection, This study investigated the role of soil quality standards in soil protection policy and methods of selecting standard substances from various types of chemicals. In most countries, soil quality standards act as guidance for further detail surveyor risk assessment from comparing soil concentration with the soil quality standards. Soil quality standards of Switzerland, Demark and Japan were used as enforcement tools. Priority substances for the standards were first selected from frequently detected chemicals in contaminated sites. Those substances were extensively evaluated for toxic effects, exposure potential and availability in chemical analysis.

A Study on the Application of UPQC in AC Railway System (교류철도급전계통에 전력품질보상장치 적용에 관한 연구)

  • Choi, Joon-Ho
    • Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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    • v.18 no.6
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    • pp.220-229
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    • 2004
  • The AC railway system is quite differing from the general electric power system because it is single- phase and intermittently heavy loads. Thus, inevitably power quality problems are occurred in the AC railway system, i.e. voltage regulation voltage sags, voltage imbalance, and harmonic distortion. Recently, the power quality of the AC railway system becoming a hot issue because it is affect the control and safety of high-speed traction. In addition it is also affect the power quality of the electric power system. In this paper, single-phase Unified Power Quality Conditioner(UPQS) for the AC railway system is proposed to compensate the voltage sags and harmonic distortion. The configurations and control schemes of the proposed single-phase UPQC are presented. The effectiveness of the proposed single-phase UPQC application is verified by the PSCAD/EMTDC simulation works. It can be shown that the application of UPQC in the AC railway system is very useful to compensate the voltage sags and harmonic distortion from the results of related simulation works.

Dietary supplementation of Eucommia leaf extract to growing-finishing pigs alters muscle metabolism and improves meat quality

  • Zhenglei Shen;Chuxin Liu;Chuangye Deng;Qiuping Guo;Fengna Li;Qingwu W. Shen
    • Animal Bioscience
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    • v.37 no.4
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    • pp.697-708
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    • 2024
  • Objective: The objective of this study was to investigate the influence of dietary supplementation of Eucommia ulmoides leaf extract (ELE) on muscle metabolism and meat quality of pigs with and without pre-slaughter transportation. Methods: In a 43-day feeding experiment, a total of 160 pigs with an initial body weight 60.00±2.00 kg were randomly assigned into four groups in a completely randomized design with 10 replicates. Pigs in groups A and C were fed a basal diet and pigs in groups B and D were fed a basal diet supplemented with 0.5% ELE. Pigs were slaughtered with (group B and D) or without (group A and C) pre-slaughter transport. Muscle chemical composition, postmortem glycolysis, meat quality and muscle metabolome were analyzed. Results: Dietary ELE supplementation had no effect on the proximate composition of porcine muscle, but increased free phenylalanine, proline, citruline, norvaline, and the total free amino acids in muscle. In addition, dietary ELE increased decanoic acid and eicosapentaenoic acid, but decreased heptadecanoic acid, oleic acid, trans-oleic acid, and monounsaturated fatty acids in muscle. Meat quality measurement demonstrated that ELE improved meat water holding capacity and eliminated the negative effects of pre-slaughter transport on meat cooking yield and tenderness. Dietary ELE reduced muscle glycolytic potential, inhibited glycolysis and muscle pH decline in the postmortem conversion of muscle to meat and increased the activity of citrate synthase in muscle. Metabolomics analysis by liquid chromatographic tandem mass spectrometric showed that ELE enhanced muscle energy level, regulated AMP-activated protein kinase (AMPK) signaling, modulated glycogenolysis/glycolysis, and altered the metabolism of carbohydrate, fatty acids, ketone bodies, amino acids, purine, and pyrimidine. Conclusion: Dietary ELE improved meat quality and alleviated the negative effect of pre-slaughter transport on meat quality by enhancing muscle oxidative metabolism capacity and inhibiting glycolysis in postmortem muscle, which is probably involved its regulation of AMPK.

Quality Improvement in Patient Care Services : Obstacles and Approaches (진료의 질관리에 대한 시론 -장애와 접근-)

  • 한달선
    • Health Policy and Management
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    • v.2 no.2
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    • pp.112-130
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    • 1992
  • Patient care services are provided to individual patients in response to their health needs produced by illnesses or injuries. The services are often addressed to very serious conditions, and also they constitute the most expensive component of health care services. Therefore, the importance of quality is emphasized, but there are many indications that patient care quality is far from a satisfactory state in most of the countries. Based upon this observation, it is attempted to examine obstacles and approaches to quality improvement in patient care services. In doing so, following Taguchi's(1986) definition of product quality, quality of patient care services is conceived of as better when the less is the sociental loss attributalbe to variability of intended function and harmful side effects they emhibit after being delivered. Some distinguishing features of medical care sector pose difficulties in implementing effective quality improvement programs in patient care services. Nevertheless, newly proposed method of quality management, based on industrial quality management approach, seems to have a great deal of potential to effectively cope with such difficulties. This method, unlike the traditional approach to quality assurance, focuses on total organisational processes, not individuals, as the obproach to quality assurance, focuses on total organizational processes, not individuals, as the objects of quality improvement; variation, not comparison with standards, in quality measurement; and continuous improvement, not removing only bad quality care, as an ideal. Prerequisite to a successful use of any quality mangement method is motivating providers to improve quality. Conceivable approaches for such motivation are self-regulation, external controls and promotion of competition. Since these approaches are not mutually exclusive, they may be employed in an appropriate combination. In Korea, medical care providers are now functioning under the circumstances where they have little reason for making efforts to improve quality of their services. Once these circumstantial conditions are changed to exert pressures on providers to improve quality, the use of adequate quality management method becomes an issue. In this connection, much attention shoould be directed to the newly proposed method described above. In all these efforts for improving quality of patient care services, health insurance would be able to play a pivotal role. Poviders of medical care, buth indiciduals and organizations, are usually very responsive to the measures that affect their financing, and thus health insurance can be a strong instrument for motivationg providers to improve quality. Also, the insurance continuously acquires data on patient care, which could be processed to produce information required to effective quality control.

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Engine Management System remodeling from diesel to CNG system on used diesel truck(3.3L) (노후 경유자동차의 천연가스 자동차로의 개조기술 개발)

  • Lee, J.S.;Kim, B.G.;Chea, J.M.;Han, J.O.;Na, P.C.
    • Proceedings of the KSME Conference
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    • 2007.05b
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    • pp.3335-3340
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    • 2007
  • The government have been tightening EM regulation gradually but the effect is not good because of rapid increase of vehicles. And medium & heavy duty diesel vehicles, even though the number is small, exhaust very large pollutants(about over 50%). Especially it is more severe about old trucks and buses. Accordingly, CNG vehicle and the retrofit of diesel to CNG must be an alternative in order to protect the atmospheric environment and improve the air quality in the metropolitan area. The main object of this study is to secure the retrofit technology of diesel to CNG vehicle and the management system of CNG engine. we passed the government emission certification test. In addition to this, the mass production for retrofit is also studied. Results of emission and durability test for certification are as follows; there was no problem during 30,000km vehicle durability test and good emission levels satisfying the regulation.

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