• Natural Product Sciences
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• v.16 no.4
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• pp.233-238
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• 2010

In order to facilitate the quality control of Artemisia capillaris, a simple, accurate and reliable HPLC method was developed for the simultaneous determination of the six bioactive compounds: scopolin (1), chlorogenic acid (2), 2,4-dihydroxy-6-methoxyacetophenone 4-glycoside (3), hyperoside (4), isorhamnetin 3-Orobinobioside (5), and scoparone (6), which were selected as the chemical markers of A. capillaris. Separation was achieved on an Agilent Eclipse XDB-C18 column with a gradient solvent system of 0.1% trifluoroacetic acid aqueous-acetonitrile at a flow-rate of 1.0 mL/min and detected at 254 nm. All six calibration curves showed good linearity ($R^2$ > 0.998). A simple reversed phase HPLC method was developed for extracting pharmacologically active compounds scopolin, chlorogenic acid, 2,4-dihydroxy-6-methoxyacetophenone 4-glycoside, hyperoside, isorhamnetin 3-O-robinobioside, and scoparone from A. capillaris using a binary gradient of acetonitrile : 0.1% trifluoroacetic acid with UV detection at 254 nm. The scopolin (1), chlorogenic acid (2), 2,4-dihydroxy-6-methoxyacetophenone 4-glycoside (3), hyperoside (4), isorhamnetin 3-O-robinobioside (5), and scoparone (6) contents of the herb of A. capillaris collected from fifteen district markets in Korea were 0.00~0.90 mg/g, 0.06~7.29 mg/g, 0.06~0.91 mg/g, 0.07~5.05 mg/g, 0.42~13.11 mg/g, and 1.11~29.82 mg/g, respectively. The results demonstrated that this method is simple and reliable for the quality control of A. capillaris.

• Journal of Korean Society for Quality Management
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• v.46 no.3
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• pp.651-658
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• 2018

Purpose: The algorithm described in Lim(1998) is available to determine the sample size directly given specified significance level, power and signal-to-noise ratio. We research on the efficient determination of the sample size by visual methods. Methods: We propose three graphs for investigating the mutual relationship between the sample size r, power $1-{\beta}$ and the detectable signal-to-noise ratio ${\Delta}$. First graph shows the relationship between ${\Delta}$ and $1-{\beta}$ for the given r and it can be checked whether the power is sufficient enough. Second graph shows the relationship between r and ${\Delta}$ for the given power $1-{\beta}$. Third graph shows the relationship between r and $1-{\beta}$ for the given ${\Delta}$. It can be checked that which effects are sensitive to the efficient sample size by investigating those graphs. Results: In factorial design, randomized block design and the split plot design how to determine the sample size directly given specified significance level, power and signal-to-noise ratio is programmed by using R. A experiment to study the split plot design in Hicks(1982) is used as an example. We compare the sample sizes calculated by randomized block design with those by split plot design. By using graphs, we can check the possibility of reducing the sample size efficiently. Conclusion: The proposed visual methods can help an engineer to make a proper plan to reduce the sample size.

• The Journal of Industrial Distribution & Business
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• v.9 no.2
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• pp.39-45
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• 2018

Purpose - The purpose of this study is to examine the image similarity and attribute recognition of the top 10 rated spa destinations (Chungnam Deoksan, Chungnam Dogo, Busan Dongrae, Daejeon Yuseong, Chungnam Asan, Gyeongbuk Bomun, Chungbuk Suanbo, Gyeongnam Jangyu, Chungnam Onyang, & Gyeongbol Bugok) in Korea based on the visits to these spa places by the customers. Research design, data, and methodology - The survey of this study was conducted on the visitors to the top 10 spa destinations in Korea from April 8 ~ April 21, 2017, and a total of 300 questionnaires were distributed. Of them, effective questionnaires used in the final study were a total of 241. In this study, empirical analysis was made through frequency analysis, factor analysis, and multidimensional scaling ALSCAL(spinning symmetry for image similarity and rectangle for attributes recognition) by using the Statistics Package SPSS 24.0. Results - According to the analysis result of spa destination image similarity, the stress level was 0.16453 and the level of the stress was good. Moreover, the coefficient of determination (RSQ) was, which had a description of each aspect of the spa destination, 0.79908. According to the results of attribute recognition, the stress value of 0.11805 represents a degree of conformity, and the coefficient of determination(RSQ) appeared at 0.98665. Therefore, the results of this analysis are that the similarities between spa destinations and the attribute recognition of the spa destinations is a suitable model that is properly expressed in two dimensions. Conclusions - First, according to the analysis result of image similarity, Deoksan & Dogo spa revealed similar images, as well as the Dongrae and Yuseong spa, while on the contrary Asan, Bomun, Suanbo spa has different images from the rest. Second, according to the results of attribute recognition, Asan and Onyang spa has competitiveness in terms of accessibility to spa destination; Yuseong, Dongrae, Jangyu spa in terms of spa facilities, spa tourism conditions, and service & shopping conditions. while spa water quality and spa costs showed low attribute reflection for all 10 spas. Therefore, the spa visitors cannot recognize the differentiation of spa water quality and spa costs.

• YAKHAK HOEJI
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• v.52 no.1
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• pp.7-11
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• 2008

A high performance liquid chromatographic (HPLC) method for the determination of glycyrrhizic acid was developed for the quality control of traditional herbal medicinal preparation Bu-Zhong-Yi-Qi-Tang (BZYQT), which is well-known herbal medicine used as tonic. RP-HPLC analysis was carried out using Capcell pak $C_{18}$ MG column $(5\;{\mu},\;150{\times}4.6\;mm)$ and a mobile phase consisting of acetonitrile and water containing 0.03% phosphoric acid (pH 2.46) at a flow rate of 1.0 ml/min. The optimum wavelength for the detection of the glycyrrhizic acid was found at 250 nm using diode-array UV/VIS detector. The glycyrrhizic acid in BZYQT shows good linearity $(r^2>0.999)$ in the range of $15\;{\mu}g/ml$ to 500 ${\mu}g/ml$. The limit of detection (LOD) was less than 5 ng and R.S.D for intra-day and inter-day reproducibility was less than 7%. The mean recovery of the glycyrrhizic acid was $97.3{\sim}113.0%$. These results suggest that the developed HPLC method is simple and efficient, and could be contributed for the quality control of commercial BZYQT products.

• Journal of the Korean Data and Information Science Society
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• v.27 no.3
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• pp.629-638
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• 2016

Among data mining techniques, the association rule is one of the most used in the real fields because it clearly displays the relationship between two or more items in large databases by quantifying the relationship between the items. There are three primary quality measures for association rule; support, confidence, and lift. We evaluate association rules using these measures. The approach taken in the previous literatures as to estimation of association rule number has been one of a determination function method or a regression modeling approach. In this paper, we proposed a few of non-linear regression equations useful in estimating the number of rules and also evaluated the estimated association rules using the quality measures. Furthermore we assessed their usefulness as compared to conventional regression models using the values of regression coefficients, F statistics, adjusted coefficients of determination and variation inflation factor.

• Journal of Korean Society for Quality Management
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• v.45 no.4
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• pp.889-902
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• 2017

Purpose: The orthogonality and trace optimal properties are desirable for constructing designs of experiments. This article focuses on the determination of the sizes of experiments for the balanced trace optimal resolution-V fractional factorial designs for 2-level factorial designs, which have near-orthogonal properties. Methods: In this paper, first we introduce the trace optimal $2^t$ fractional factorial designs for $4{\leq}t{\leq}7$, by exploiting the partially balanced array for various cases of experimental sizes. Moreover some orthogonality criteria are also suggested with which the degree of the orthogonality of the designs can be evaluated. And we appraise the orthogonal properties of the introduced designs from various aspects. Results: We evaluate the orthogonal properties for the various experimental sizes of the balanced trace optimal resolution-V fractional factorial designs of the 2-level factorials in which each factor has two levels. And the near-orthogonal 2-level balanced trace optimal resolution-V fractional factorial designs are suggested, which have adequate sizes of experiments. Conclusion: We can construct the trace optimal $2^t$ fractional factorial designs for $4{\leq}t{\leq}7$ by exploiting the results suggested in this paper, which have near-orthogonal property and appropriate experimental sizes. The suggested designs can be employed usefully especially when we intend to analyze both the main effects and two factor interactions of the 2-level factorial experiments.

• Korean Journal of Pharmacognosy
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• v.43 no.2
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• pp.137-146
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• 2012

Dipsaci Radix (Dipsacaceae) has been used as a tonic, an analgesic, anti-inflammatory and anti-complement agents in traditional herbal medicine for the therapy of low back pain, knee pain, rheumatic arthritis, traumatic hematoma, and bone fractures. A high-performance liquid chromatography-electrospray ionization-mass spectrometric method (HPLC-ESI-MS) was developed for the simultaneous quantitation method of the five compounds from the herbal drug: asperosaponin VI and asperosaponin XII (terpene glycosides), sweroside, loganin and dipsacus A(iridoid glycosides). HPLC separation of the analytes was achieved on a C18 column ($150{\times}2.0$ mm i.d., 5 ${\mu}m$) using the aqueous methanol containing 5 mM ammonium acetate with gradient flow of the mobile phase. Detection of the analytes was performed by positive ion electrospray ionization, and selected ion monitoring was used for data acquisition using m/z corresponding molecular adduct ion, $[M+NH_4]^+$ and $[M+H]^+$. Calibration graphs showed good linearity ($r^2$=0.9997) over the wide range of the analytes; intra- and inter-day precisions (RSD, %) were within 9.1% and the accuracy between 94.0-111.0%. Recoveries of the analytes through the assay procedure were in the range of 93.7-110.8%. Analytical results of the herbal drugs of Dipsaci Radix (17 samples) show wide distribution of the five marker compounds and clear difference of the species from Phlomidis Radix (4 samples). The developed method would provide a practical guide for the quality control of the herbal drug.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.26 no.4
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• pp.379-386
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• 2008

To determine the precise geoid, the quality land gravity data as well as the accurate position information of the observation points are required. Here, the land gravity data should be processed in a consistent way from the raw data level producing the quality free-air anomaly being used in the geoid determination. In this study, we processed land gravity data of KIGAM(Korea Institute of Geoscience and Mineral Resources) and Pusan national university which has precise position information acquired from GPS and raw gravity data. The conversion from readings of gravimeter to the gravity value, corrections of instrumental height and tide were carried out from the raw gravity data for each surveying session. Then, a cross-over adjustment was applied to generate a free-air anomaly for whole data with precision of 0.48 mGal. It is expected that the data processed through this study shall be a foundation on the determination of the precise geoid model in Korea.

• Natural Product Sciences
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• v.22 no.3
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• pp.162-167
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• 2016

Peucedani Radix is the root of Angelica decursiva Franchet et Savatier (=Peucedanum decursivum Maximowicz) or Peucedanum praeruptorum Dunn in several Asian countries. The coumarins contained in Peucedani Radix were quantitatively analyzed using HPLC-DAD to develop a simultaneous determination for the quality control of A. decursiva and P. praeruptorum. For quantitative analysis, four major coumarins contained in these medicinal plants were assessed. Nodakenin (1), nodakenetin (2), praeruptorin A (3), and praeruptorin B (4) were separated with a Phenomenex Luna C18 column ($5{\mu}m$, $4.6{\times}250mm$) under the gradient conditions using distilled water with 0.1% phosphoric acid and acetonitrile with 0.1% phosphoric acid as the mobile phase, at a flow rate of 1.0 ml/min and a detection wavelength of 330 nm. This method was fully validated for linearity, accuracy, precision, recovery, and limit of detection and quantification. As a result, A. decursiva and P. praeruptorum were clearly classified by the quantification of four major coumarins in extracts. Also, the pattern recognition analysis based on HPLC indicates that all of the samples were largely clustered into two groups. Therefore, it is possible to distinguish between A. decursiva and P. praeruptorum and contribute to quality control.

• Korean Journal of Food Science and Technology
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• v.22 no.6
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• pp.675-680
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• 1990

A near-infrared reflectance spectroscopic(NIRS) method which has been recently developed for a non-destructive method for measuring ingredients in foods and agricultural products especially was evaluated for the determination of capsanthin, total sugar, capsaicin and moisture contents in Korean domestic red peppers. A multiple linear regression analysis with the data obtained by standard-laboratory methods(capsaicin by GC, capsanthin by Colorimetry, total sugar by HPLC and moisture by Vacuum drying method) and NIRS method was carried out to make a calibration. The accuracy of the NIRS method was found to be adequate when the standard-laboratory values for a set of sample that were not included in the calibration, were compared. It is concluded that the NIRS method is suitable for the determination of total sugar and capsanthin.