• 한국초등과학교육학회지:초등과학교육
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• 제19권1호
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• pp.71-83
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• 2000

This study examined the influences of science project activities based on multiple intelligences on problem solving behaviors of elementary school children. Specifically, the influences of the project activities on the problem solving skills and propensities of the children were investigated. Forty-four fifth graders were selected for the study. They performed the projects and made their products of it during five months on the units of "Weather" and "Our Body" Criteria for assessment of problem solving abilities were determined. The patterns reflected in products of the project activities were examined, then the observation of the subjects' problem solving behaviors and the interviews were performed based on the criteria. The results were analyzed through both of qualitative and quantitative approaches. In these analyses, the implementation of the science projects was found to contribute to the improvement in all sub-factors of problem solving, specially, skills associated with the propensities of problem identification and of the collection, analysis, and synthesis of data significantly increased

• 천문학회지
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• 제31권2호
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• pp.77-87
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• 1998

The accumulated knowledge of the influence of solar granulation on spectral lines, i.e. their asymmetry, provides a key to analyze stellar spectral line asymmetries. In this paper, a simple line synthesis using a simple 'model' of granulation was calculated. By adjusting the properties of the granule model, the observed imprints of convection on spectral lines can be reproduced. Since we depict convective flows using a continuous function rather than using a few components of flows (cf. Gray and Toner 1985, 1986; dravins 1990), we were able to identify which components of convection are important in line bisector shapes. The results of this study can be summarized as follows: Firstly, the intensity contrast (i.e. temperature fluctuation), and the area coverage of up- and down-flows are the two important factors which determine the line bisector shapes. Secondly, on the contrary to the assumption of other studies, the effect of horizontal flows is non-negligible. This exercise provides a qualitative understanding of the effect of convection on spectral lines. This knowledge serves as a guideline for understanding the characteristic difference in convection for stars on either side of the 'Granulation Boundary' (Gray 1982; Gray and Nagel 1989).

• 한국방사선학회논문지
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• 제18권6호
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• pp.715-724
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• 2024

구조 제약형 주기 일관성 적대적 생성 신경망(Structure-constraints Cycle Genarative Adversarial Neural Networks, scCycleGANs)을 기반으로 MR-CT 간 상호 변환 모델을 구축하고자 하였다. 하드웨어 장비로 MDCT(Somatom Definition Flash CT, SIEMENS, Germany) 및 3.0T MRI(Ingenia 3.0T CX MRI, PHILIPS, Netherlands)와 소프트웨어로 Python(3.12.6), PyTorch(2.4.0)를 사용하였다. 연구 모델로는 scCycleGAN을 채택하였다. 87명의 환자의 두부 CT 및 MR(T2WI) 영상을 각각 2,871장, 2,436장 획득하였으며 총 5,307장의 의료 영상에 대해 동일 높이에서 촬영된 CT 및 MR 영상을 일차적 평가를 통해 분류해 각각 364쌍, 27쌍, 8쌍의 영상을 학습, 검증, 테스트 데이터로 라벨링 하였다. 이후 기본적인 APS frameworks 기반의 GAN 모델에 Hybrid objective function을 적용하여 모델을 구축하였으며 생성한 모델에 대한 평가를 정량적 평가와 정성적 평가로 나누어 진행하였다. 정성적 평가는 20년 이상의 경력을 가진 10인의 방사선사를 대상으로 진행하였으며 정량적 평가는 PSNR, IOU, SSIM, MAE 지표로 설정하였다. 정성평가 결과 '보통'이상의 응답으로 정의된 '긍정 응답' 비율은 합성 CT 및 MR 그룹에 대해 각 63%, 96%로 산출되었으며, 정량 평가 지표인 PSNR, SSIM, MAE에 대해 두 그룹 모두 초기의 목표 수치를 달성하였다. 우리의 연구는 의료 영상 간의 변환 및 합성 분야에 대한 기초 연구 자료로 사용될 수 있을 것이며 나아가 후속 연구 및 보완 연구를 통해 모델 경량화 등의 문제를 해결하여 임상 환경에 적용한다면 환자의 피폭 선량 부담 및 의료비 부담을 경감할 수 있을 것으로 기대된다.

• Journal of Hospice and Palliative Care
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• 제19권2호
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• pp.127-135
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• 2016

목적: 본 연구의 목적은 암환자 가족의 고통체험의 구조를 밝혀 이론적 기초를 개발하고 암환자 및 그 가족을 위한 임상간호에 기여하고자 한다. 방법: 본 연구는 Parse의 인간되어감 연구방법을 적용한 질적 연구이다. 대상자들은 암환자를 돌보고 있는 가족으로 4명이었다. 자료는 2009년 2월부터 2010년 4월까지 연구자와 참여자의 '너와 나'의 관계형성을 통해 수집하였고, 추출-종합과 발견적 해석 단계를 거치는 과정으로 분석하였다. 결과: 분석결과 다음과 같은 구조를 확인하였다: 암환자 가족의 고통 체험은 암 진단으로 인한 충격과 가족관계에서의 역할부담으로 힘겨워하나 정성껏 돌보며 노력하는 과정이었다. 결론: 암환자 가족의 고통체험은 인간-건강-우주의 과정에 초점을 두고 충격과 슬픔, 아픔, 불안, 죄책감, 두려움, 고통의 경험 속에서 사랑, 극복, 책임, 희망을 향해 자신의 경험에 의미를 부여하며 긍정적으로 변형되어가는 인간되어감의 과정으로 확인되었다.

• 디자인학연구
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• 제3권1호
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• pp.17-33
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• 1990

Evaluation plays an essential role in design activity. Many theorist have agreed that designing involves problem solving or decision making. In evaluation, designers attempt to determine the value of a particular proposal arrived at by synthesis. And the results of designing, the product, is evaluated twice, objectively and subjectively.Alternatives in $$\mu$ti-objective decision problems generally possess numerous attributes by which they can be described and compared. The evaluation factors include all attributes that have levels specified by quantitative and qualitative objectives. However since qualitiative factors are difficult to quantify as $$\mu$eral estmates, these factors have tended to be ignored without regard for their importance to human content. Therefore we need some study that convert qualitative attributes into quantitative scale values. Following to Thurstone' s Psychological scaling methods (The method of successive intervals), attribute values of TV set are assigned by rating scale methods. The method of successive intervals, like the method of equal-appearing intervals, requires but a single judgement from each subject for each statement to be scaled. It is, therefore, a convinient method to use when the number of to be scaled is large. We make the assumtion that those cu$$\mu$ative proportion distributions are normal for each statement when they are projected on the unknown psychological continuum. In this study, we have determined the scale values of 42 statements of TV set by the method of successive intervals. Then we can apply a test of internal consistency similar to that used with the method of paired comparisons. We have as our absolute average deviation, -1.748/252= -0.0069. We have reason to believe that our scale values are consistent with the empirical data, because these discrepanicies are very small.

• 한국정보과학회논문지:소프트웨어및응용
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• 제27권5호
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• pp.463-472
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• 2000

본 논문에서는 연상 메모리 기능을 수행하는 셀룰라 신경망(Cellular Neural Network)의 설계를 위한 새로운 방법론을 제안한다. 먼저, 셀룰라 신경망 모델의 기본적 특성들을 소개한 후, 최적 성능을 가지고 이진 원형 패턴들을 저장할 수 있는 셀룰라 신경망 모델의 설계 방법을 제약 조건이 가해진 최적화 문제로 공식화한다. 다음으로 이 문제의 제약 조건을 선형 행렬 부등식(Linear Matrix Inequalities)을 포함하는 부등식의 형태로 변환시킬 수 있음을 관찰한다. 마지막으로 셀룰라 신경망 최적 설계 문제를 내부점 방법(interior point method)에 의해 효율적으로 풀릴 수 있는 일반화된 고유값 문제(Genaralized EigenValue Problem)로 변환한다. 본 논문에서 제시하는 셀룰라 신경망 설계 방법론은 공간 변형 형판 셀룰라 신경망과 공간 불변 형판 셀룰라 신경망 설계에 모두 적용될 수 있다. 설계 예제를 통해 제안된 방법의 유효성을 검증한다.

• 한국근적외분광분석학회:학술대회논문집
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• 한국근적외분광분석학회 2001년도 NIR-2001
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• pp.1158-1158
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• 2001

Fast and dynamic biochemical, enzymatic and morphological changes occur during the so-called generative development and during the vegetative processes in seeds. The most characteristic biochemical and compositional changes of this period are the formation and decline of storage components or their precursors, the change of their degree in polymerization and an extensive change in water content. The aim of the present study was to detect the maturation processes in seed nondestructively and to verify the applicability of near infrared spectroscopic methods in the measurement of physiological, chemical and biochemical changes in wheat seed. The amount and variation of different water “species” has been changed intensively during maturation. Characteristic changes of three water absorption bands (1920, 1420 and 1150 nm) during maturation were analysed. It was concluded that the free/bound transition of water molecules could be followed sensitively in different region of NIR spectra. Kinetic changes of carbohydrate reserves were characteristic during maturation. An intensive formation and decline of carbohydrate reserves were observed during early stage of maturation (0 -13 days, high energy demand). An accelerated formation of storage carbohydrates (starch) was detected in the second phase of maturation. Five characteristic absorption bands were analysed which were sensitive indicators the changes of carbohydrates occurred during maturation. Precursors of protein synthesis and the synthesis of reserve proteins and their kinetic changes during maturation were followed from NIR spectra qualitative and qualitatively. Dynamic formation of amino acids and the changes of N forms were detected by spectroscopic, chromatographic and by capillary electrophoresis methods. Calibration equations were developed and validated in order to measure the optimal maturation time protein and moisture content of developing wheat seeds. The spectroscopic methods are offering chance and measurement potential in order to detect fine details of physiological processes. The spectra have many hidden details, which can help to understand the biochemical background of processes.

• The Plant Pathology Journal
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• 제31권2호
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• pp.108-114
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• 2015

Curvularia lunata is an important maize foliar fungal pathogen that distributes widely in maize growing area in China, and several key pathogenic factors have been isolated. An yeast two-hybrid (Y2H) library is a very useful platform to further unravel novel pathogenic factors in C. lunata. To construct a high-quality full length-expression cDNA library from the C. lunata for application to pathogenesis-related protein-protein interaction screening, total RNA was extracted. The SMART (Switching Mechanism At 5' end of the RNA Transcript) technique was used for cDNA synthesis. Double-stranded cDNA was ligated into the pGADT7-Rec vector with Herring Testes Carrier DNA using homologous recombination method. The ligation mixture was transformed into competent yeast AH109 cells to construct the primary cDNA library. Eventually, a high qualitative library was successfully established according to an evaluation on quality. The transformation efficiency was about $6.39{\times}10^5$ transformants/$3{\mu}g$ pGADT7-Rec. The titer of the primary cDNA library was $2.5{\times}10^8cfu/mL$. The numbers for the cDNA library was $2.46{\times}10^5$. Randomly picked clones show that the recombination rate was 88.24%. Gel electrophoresis results indicated that the fragments ranged from 0.4 kb to 3.0 kb. Melanin synthesis protein Brn1 (1,3,8-hydroxynaphthalene reductase) was used as a "bait" to test the sufficiency of the Y2H library. As a result, a cDNA clone encoding VelB protein that was known to be involved in the regulation of diverse cellular processes, including control of secondary metabolism containing melanin and toxin production in many filamentous fungi was identified. Further study on the exact role of the VelB gene is underway.

• 분석과학
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• 제33권2호
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• pp.98-107
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• 2020

Methamphetamine (MA) is currently the most abused illicit drug in Korea. MA is produced by chemical synthesis, and the final target drug that is produced contains small amounts of the precursor chemicals, intermediates, and by-products. To identify and quantify these trace compounds in MA seizures, a practical and feasible approach for conducting chromatographic fingerprinting with a suite of traditional chemometric methods and recently introduced machine learning approaches was examined. This was achieved using gas chromatography (GC) coupled with a flame ionization detector (FID) and mass spectrometry (MS). Following appropriate examination of all the peaks in 71 samples, 166 impurities were selected as the characteristic components. Unsupervised (principal component analysis (PCA), hierarchical cluster analysis (HCA), and K-means clustering) and supervised (partial least squares-discriminant analysis (PLS-DA), orthogonal partial least squares-discriminant analysis (OPLS-DA), support vector machines (SVM), and deep neural network (DNN) with Keras) chemometric techniques were employed for classifying the 71 MA seizures. The results of the PCA, HCA, K-means clustering, PLS-DA, OPLS-DA, SVM, and DNN methods for quality evaluation were in good agreement. However, the tested MA seizures possessed distinct features, such as chirality, cutting agents, and boiling points. The study indicated that the established qualitative and semi-quantitative methods will be practical and useful analytical tools for characterizing trace compounds in illicit MA seizures. Moreover, they will provide a statistical basis for identifying the synthesis route, sources of supply, trafficking routes, and connections between seizures, which will support drug law enforcement agencies in their effort to eliminate organized MA crime.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book II
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• pp.32-43
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• 2003

UV irradiation on a skin brings about the qualitative and quantitative alterations of the extracellular matrix. Repeated-UV irradiation suppressed the synthesis of collagen and activated the expression of the matrix metalloprotease (MMP). In this paper, on the purpose of development of novel anti-aging agents from natural sources, effects of several natural products on in vitro MMP-1 activity and UVA induced MMP-1 synthesis in human dermal fibroblast (HDF) culture were studied. We measured MMP-1 activities by fluorescence assay using gelatin as substrates. As a result, the extract of Dicentra spectabilis, and flower buds of Tussilago farfara showed strong inhibitory effect. Among them, the extract of flower buds of Tussilago fartara and Dicentra spectabilis inhibited MMP-1 activity by 92% and 87% at 0.05% (w/v). And UVA induced MMP-1 expression were analyzed by enzyme-linked immunosorbent assay (ELISA) and gelatin-based zymography in HDF culture. The extract of flower buds of Tussilago farfara and Dicentra spectabilis suppressed the UVA induced expression of MMP-1 by similar level of Vitamin C 200$\mu$M at 0.1% (w/v). These results suggest that the extract of Dicentra spectabilis, and flower buds of Tussilago farfara effectively prevent skin from the UV-induced photoaging. So the extracts are thought to have potential as effective raw materials for anti-aging cosmetics.