• Journal of the Korean Society for Industrial and Applied Mathematics
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• 제9권1호
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• pp.79-90
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• 2005

In this paper we study the numerical solutions of the stochastic differential equations of the form $$du(x,\;t)=f(x,\;t,\;u)dt\;+\;g(x,\;t,\;u)dW(t)\;+\;\sum\limits_{|q|\leq2m}\;A_q(x,\;t)D^qu(x,\;t)dt$$ where $0\;{\leq}\;t\;{\leq}\;T,\;x\;{\in}\;R^{\nu}$, ($R^{nu}$ is the $\nu$-dimensional Euclidean space). Here $u\;{\in}\;R^n$, W(t) is an n-dimensional Brownian motion, $$f\;:\;R^{n+\nu+1}\;{\rightarrow}\;R^n,\;g\;:\;R^{n+\nu+1}\;{\rightarrow}\;R^{n{\times}n},$$, and $$A_q\;:\;R^{\nu}\;{\times}\;[0,\;T]\;{\rightarrow}\;R^{n{\times}n}$$ where ($A_q,\;|\;q\;|{\leq}\;2m$) is a family of square matrices whose elements are sufficiently smooth functions on $R^{\nu}\;{\times}\;[0,\;T]\;and\;D^q\;=\;D^{q_1}_1_{\ldots}_{\ldots}D^{q_{\nu}}_{\nu},\;D_i\;=\;{\frac{\partial}{\partial_{x_i}}}$.

• 한국균학회지
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• 제15권2호
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• pp.71-75
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• 1987

1985年 3月부터 1986년 9월까지 무학산(舞鶴山) 일대(一帶)에서 자생(自生)하는 한국산(韓國産) 고등균류( 高等菌類) 120여종(餘種)을 채집(採集)하여 동정(同定)한 결과(結果) 한국산(韓國産) 미기록종(未記錄種)으로 확인(確認)한 것은 다음과 같으며 이들에 대하여 보통명(普通名)을 신칭(新稱)하였다. Hygrocybe ovina(Fr.) Kuhn.(변색무명버섯) Inocybe albodisca (백색꼭지땀버섯) I. calospora Qu'el.(비늘땀버섯) I. kobayasii Hongo (원추땀버섯)

• 한국균학회지
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• 제21권4호
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• pp.273-278
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• 1993

한국에서 야생(野生)하는 6종 식용(食用)버석에 함유된 미량 금속원소의 함량순서는 다음과 같다. 뽕나무버섯은 K가 778.2 ppm으로 가장 많았고 그 다음이 Fe, Na, Zn, Mn, Cu 순이고 Ca은 검출되지 않았으며 뽕나무버섯부치는 K가 (972.9 ppm), Zn, Mn, Fe, Na, CU, Ca 순으로 K함량이 가장 많았다. 자주방망이버섯은 K(699.8 ppin), Zn, Fe, Na, Cu, Mn 순으로 K가 가장 많이 함유되어 있었고 Ca은 검출되지 않았으며 자주방망이버섯아재비는 K(945.2 ppm), Zn, Fe, Na, Cu, Mn, Ca 순으로 K이 가장많이 검출되었다. 벚꽃버섯은 K(878.6 ppm), Zn, Fe, Na, Cu, Ca, Mn 순으로 K가 최고치였고 붉은산무명버섯은 Zn(6637.3 ppm), Fe, K, Na, Ca 순으로 Zn이 특히 가장 많았고 Cu는 검출되지 않았다. 실험분석한 전(全)미량금속원소(Cd는 제외)가 가장 많이 함유된 버섯은 붉은산무명버섯이었고 그 다음이 자주방망이버섯아재비, 벚꽃버섯, 자주방망이버섯, 뽕나무버섯, 뽕나무버섯부치의 순이었다. 6종의 버섯중 가장 많이 함유된 미량금속원소는 Zn이었고 그 다음이 K, Fe, Na, Mn, Cu, Ca 순이었다. Cd는 채집장소인 서울산업대, 광릉, 동구릉, 설악산 순으로 설악산에서 채집한 벚꽃버섯, 붉은산무명버섯에 가장 적은 분석치(흔적량)을 얻었다.

• Biomolecules & Therapeutics
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• 제32권3호
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• pp.267-280
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• 2024

Apoptosis, programmed cell death pathway, is a vital physiological mechanism that ensures cellular homeostasis and overall cellular well-being. In the context of cancer, where evasion of apoptosis is a hallmark, the overexpression of anti-apoptotic proteins like Bcl2, Bcl-xL and Mcl-1 has been documented. Consequently, these proteins have emerged as promising targets for therapeutic interventions. The BCL-2 protein family is central to apoptosis and plays a significant importance in determining cellular fate serving as a critical determinant in this biological process. This review offers a comprehensive exploration of the BCL-2 protein family, emphasizing its dual nature. Specifically, certain members of this family promote cell survival (known as anti-apoptotic proteins), while others are involved in facilitating cell death (referred to as pro-apoptotic and BH3-only proteins). The potential of directly targeting these proteins is examined, particularly due to their involvement in conferring resistance to traditional cancer therapies. The effectiveness of such targeting strategies is also discussed, considering the tumor's propensity for anti-apoptotic pathways. Furthermore, the review highlights emerging research on combination therapies, where BCL-2 inhibitors are used synergistically with other treatments to enhance therapeutic outcomes. By understanding and manipulating the BCL-2 family and its associated pathways, we open doors to innovative and more effective cancer treatments, offering hope for resistant and aggressive cases.