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Lobaplatin Combined Floxuridine/Pirarubicin-based Transcatheter Hepatic Arterial Chemoembolization for Unresectable Primary Hepatocellular Carcinoma

  • Zhao, Chang;Wang, Xu-Jie;Wang, Song;Feng, Wei-Hua;Shi, Lei;Yu, Chun-Peng
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.5
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    • pp.2057-2060
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    • 2014
  • Purpose: To assess the effect and safety of lobaplatin combinated floxuridine /pirarubicin in transcatheter hepatic arterial chemoembolization(TACE) of unresectable primary liver cancer. Patients and Methods: TACE combined with the chemotherapy regimen was used to treat 34 unresectable primary liver cancer patients. DSA/MRI/CT/blood routine examinations were used to evaluate short term activity and toxicity after 4-5 weeks, the process being repeated if necessary. Results: Among the 34 cases, 1 (2.9%) showed a complete response, 21 (61.7%) a partial response, 8 (23.5%) stable disease, and 4 progressive disease, with a total effective rate of 67.6%. The content of alpha fetoprotein dropped by over 50% in 20 cases (58.8%). The rate of recovery was hepatalgia (88.2%), ascites (47.1%), appetite (55.9%), Performance Status(30.4%). The median follow-up time (MFT) was 281 days (63-558 days), and median progression-free survival was 118.5 days (95%, CI:88.8-148.2days). Adverse reactions (III-IV grade) were not common, with only 4 cases of vomiting and 2 cases of thrombocytopenia (III grade). Conclusions: Lobaplatin-based TACE is an effective and safe treatment for primary liver cancer.

Lack of Effects of Dietary Folate Intake on Risk of Breast Cancer: An Updated Meta-analysis of Prospective Studies

  • Liu, Meng;Cui, Lian-Hua;Ma, Ai-Guo;Li, Na;Piao, Jin-Mei
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.5
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    • pp.2323-2328
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    • 2014
  • Background: Epidemiological findings are controversial relating to the relationship between dietary folate intake and the risk of breast cancer. We therefore conducted a meta-analysis of prospective cohort studies to clarify this association. Materials and Methods: PUBMED, EMBASE, and MEDLINE databases were searched for all relevant literature published in English from January 1, 1966 to August 2013. Summary relative risk (RR) and 95% confidence intervals (CIs) were calculated using a fixed or random effects model. Results: Dietary folate intake was not significantly associated with the risk of breast cancer. The combined RR with 95%CI for the highest vs. lowest category dietary intake of folate [fifteen studies; 1,836,566 participants and 24,083 patients with breast cancer] was 0.98 (0.90-1.05). Among subgroup analysis by menstrual status, hormonal status and the consumption of alcohol, methionine and vitamin B12, no significant association was observed for the dietary intake of folate and the risk of breast cancer. Dose-response analysis showed that a 220 ${\mu}g/day$ increment in dietary folate intake was not associated with the risk of breast cancer. Conclusions: Our findings indicate that dietary folate intake has no significant effect on the risk of breast cancer.

Access-Authorizing and Privacy-Preserving Auditing with Group Dynamic for Shared Cloud Data

  • Shen, Wenting;Yu, Jia;Yang, Guangyang;Zhang, Yue;Fu, Zhangjie;Hao, Rong
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.10 no.7
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    • pp.3319-3338
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    • 2016
  • Cloud storage is becoming more and more popular because of its elasticity and pay-as-you-go storage service manner. In some cloud storage scenarios, the data that are stored in the cloud may be shared by a group of users. To verify the integrity of cloud data in this kind of applications, many auditing schemes for shared cloud data have been proposed. However, all of these schemes do not consider the access authorization problem for users, which makes the revoked users still able to access the shared cloud data belonging to the group. In order to deal with this problem, we propose a novel public auditing scheme for shared cloud data in this paper. Different from previous work, in our scheme, the user in a group cannot any longer access the shared cloud data belonging to this group once this user is revoked. In addition, we propose a new random masking technique to make our scheme preserve both data privacy and identity privacy. Furthermore, our scheme supports to enroll a new user in a group and revoke an old user from a group. We analyze the security of the proposed scheme and justify its performance by concrete implementations.

DISTRIBUTION CHARACTERISTICS AND AFFECTING FACTORS OF SPRING HETEROTROPHIC BACTERIA IN BOHAI SEA

  • Bai, Jie;Li, Kuiran;Li, Zhengyan;Gao, Huiwang;Wu, Zengmao
    • Proceedings of the Korean Environmental Health Society Conference
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    • 2001.11a
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    • pp.6-10
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    • 2001
  • Distribution characteristics, variation patterns and affecting factors of hetorotrophic bacteria were studied from April to May 1999 in Bohai Sea by standard Acridine Orange epifluorescence microscopy (AO method). The biomass in surface waters showed a small day-night variation, varying from 0.13-2.51$\mu\textrm{m}$$.$dm$\^$-3/ with an average of 0.84 $\mu\textrm{m}$$.$dm$\^$-3/. The biomass in bottom waters showed, however, a large variation, changing from 0.15-4.18 $\mu\textrm{m}$$.$dm$\^$-3/ with an average of 1.36 $\mu\textrm{m}$$.$dm$\^$-3/. The peak values were obtained at 5 and 11 am. The bottom water biomass showed a significant correlation with particulate organic carbon (r=0.639, p<0.05). Heterotrophic bacteria showed high biomass in nearshore waters and low values in offshore areas with a high biomass zone around Yellow Sea river mouth, which was consistent with the distribution of nutrients. The vertical distribution of heterotrophic bacteria showed biomass in bottom waters was higher than in surface water. The biomass of heterotrophic bacteria in Bohai Sea was similar with that in other marine waters.

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State-of-charge Estimation for Lithium-ion Batteries Using a Multi-state Closed-loop Observer

  • Zhao, Yulan;Yun, Haitao;Liu, Shude;Jiao, Huirong;Wang, Chengzhen
    • Journal of Power Electronics
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    • v.14 no.5
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    • pp.1038-1046
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    • 2014
  • Lithium-ion batteries are widely used in hybrid and pure electric vehicles. State-of-charge (SOC) estimation is a fundamental issue in vehicle power train control and battery management systems. This study proposes a novel model-based SOC estimation method that applies closed-loop state observer theory and a comprehensive battery model. The state-space model of lithium-ion battery is developed based on a three-order resistor-capacitor equivalent circuit model. The least square algorithm is used to identify model parameters. A multi-state closed-loop state observer is designed to predict the open-circuit voltage (OCV) of a battery based on the battery state-space model. Battery SOC can then be estimated based on the corresponding relationship between battery OCV and SOC. Finally, practical driving tests that use two types of typical driving cycle are performed to verify the proposed SOC estimation method. Test results prove that the proposed estimation method is reasonably accurate and exhibits accuracy in estimating SOC within 2% under different driving cycles.

Assessment and Correction of the Spectral Quality for the Savart Polarization Interference Imaging Spectrometer

  • Zhongyi Han;Peng Gao;Jingjing Ai;Gongju Liu;Hanlin Xiao
    • Current Optics and Photonics
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    • v.7 no.5
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    • pp.518-528
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    • 2023
  • As an effective means of remotely detecting the spectral information of the object, the spectral calibration for the Savart polarization interference imaging spectrometer (SPIIS) is a basis and prerequisite of information quantification, and its experimental calibration scheme is firstly proposed in this paper. In order to evaluate the accuracy of the spectral information acquisition, the linear interpolation, cubic spline interpolation, and piecewise cubic interpolation algorithms are adopted, and the precision of the quadratic polynomial fitting is the highest, whose fitting error is better than 5.8642 nm in the wavelength range of [500 nm, 820 nm]. Besides, the inversed value of the spectral resolution for the monochromatic light is greater than the theoretical value, and the deviation between them becomes larger with the wavelength increasing, which is mainly caused by the structural design of the SPIIS, together with the rationality of the spectral restoration algorithm and the selection of the maximum optical path difference (OPD). This work demonstrates that the SPIIS has achieved high performance assuring the feasibility of its practical use in various fields.

The effect of mechanical inhomogeneity in microzones of welded joints on CTOD fracture toughness of nuclear thick-walled steel

  • Long Tan;Songyang Li;Liangyin Zhao;Lulu Wang;Xiuxiu Zhao
    • Nuclear Engineering and Technology
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    • v.55 no.11
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    • pp.4112-4119
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    • 2023
  • This study employs the microshear test method to examine the local mechanical properties of narrow-gap welded joints, revealing the mechanical inhomogeneity by evaluating the microshear strength, stress-strain curves, and failure strain. On this basis, the influence of weld joints micromechanical inhomogeneity on the crack tip opening displacement (CTOD) fracture toughness is investigated. From the root weld layer to the cover weld layer, the fracture toughness at the center of the weld seam demonstrates an increasing trend, with the experimental and calculated CTOD values showing a good correspondence. The microproperties of the welded joints significantly impact the load-bearing capacity and fracture toughness. During the deformation process of the "low-matching" microregions, the plastic zone expansion is hindered by the surrounding microregion strength constraints, thus reducing the fracture toughness. In contrast, during the deformation of the "high-matching" microregions, the surrounding microregions absorb some of the loading energy, partially releasing the concentrated stress at the crack tip, which in turn increases the fracture toughness.

A NONLINEAR CONJUGATE GRADIENT METHOD AND ITS GLOBAL CONVERGENCE ANALYSIS

  • CHU, AJIE;SU, YIXIAO;DU, SHOUQIANG
    • Journal of applied mathematics & informatics
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    • v.34 no.1_2
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    • pp.157-165
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    • 2016
  • In this paper, we develop a new hybridization conjugate gradient method for solving the unconstrained optimization problem. Under mild assumptions, we get the sufficient descent property of the given method. The global convergence of the given method is also presented under the Wolfe-type line search and the general Wolfe line search. The numerical results show that the method is also efficient.