• 제목/요약/키워드: Pyrene group

검색결과 60건 처리시간 0.02초

Novel Electroluminescent Polymer Derived from Pyrene-Functionalized Polyaniline

  • Amarnath, Chellachamy Anbalagan;Kim, Hyoung-Kun;Yi, Dong-Kee;Lee, Sang-Hyup;Do, Young-Rag;Paik, Un-Gyu
    • Bulletin of the Korean Chemical Society
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    • 제32권5호
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    • pp.1495-1499
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    • 2011
  • A solution processable polymer was synthesized, by incorporating pyrene groups into the backbone of the polyaniline chain, and used as an emissive layer in an organic light emitting diode. The polyaniline base was reacted with acid chloride of pyrene butyric acid to form pyrene-functionalized polyaniline chains. The source of pyrene moiety was acid chloride of pyrene butyric acid. The formation of polymer from acid chloride of pyrene butyric acid and polyaniline was confirmed by the FTIR and $^1H$-NMR spectroscopy. Differential scanning calorimetry revealed high glass transition temperature of 210 $^{\circ}C$. Due to the presence of pyrene moieties in the backbone, the polyaniline synthesized in the present study is solution processable with light emitting property. The photoluminescence spectrum of the polymer revealed that emission lies in the blue region, with a peak at 475 nm. The light emitting device of this polymer exhibits the turn-on voltage of 15 V.

오미자 메탄올 추출액이 흰쥐에 있어서 Benzo(a)pyrene에 이해 유도된 간장해에 미치는 영향 (Effect of Omija(Schizandra chinensis Baillon) Methanal Extract on Benzo(a)pyrene induced Hepatotoxicity in Rats)

  • 이윤경
    • 동아시아식생활학회지
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    • 제5권1호
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    • pp.21-27
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    • 1995
  • The protective effect of omija methanol extract on benzo(a)pyrene induce liver injury was studied in rats in vitro and in vivo. In vitro experiment, primary cultured hepatocytes(5${\times}$105cells/$m\ell$) were cultured for 20∼24 hours after adding omija methanol extract(5.1$\mu\textrm{g}$/$m\ell$) and B(a)P(50$\mu\textrm{m}$) in culture medium. In vivo experiment, omija methanol extract(0.1g/kg/day, per os) was administered for 7days and B(a)P(0.1mg/kg body weight, intraperitoneally) was given to the rats after the last administration of extract. Omija methanol extract significantly recovered serum enzyme activities(AST, ALT and LDH) and lipid contents(total cholesterol, triglyceride and HDL-cholesterol) changed by benzo(a)pyrene (B(a)P) to normal levels in vivo. In vitro experiment, as a result of 3-(4, 5-dimethlythiazol-2-yl)-2, 5-diphenyl tetrazolium bromide(MTT) assay, omija methanol extract showed a little hepatotoxicity compared with group I (normal) but significantly recovered enzyme activities(AST, ALT and LDH) changed by B(a)P in comparison to group IIadministered B(a)P only. It was suggested that omija methanol extract has a protective effect on liver injury induced by B(a)P.

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벤조피렌의 급성독성 수준에 따른 관리적 방안 연구 (A Study on the Management of benzo[a]pyrene according to the Level of Acute Toxicity)

  • 김미나;이승길;이용식;조삼래;김덕현
    • 한국환경보건학회지
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    • 제44권2호
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    • pp.153-159
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    • 2018
  • Objectives: This study was carried out to determine $LD_{50}$ of benzo[a]pyrene to decide the possibility to designate them as toxic substance on the Act on the Registration and Evaluation, etc. of Chemical Substances, and to suggest that they should be managed in what level on the Chemical Control Act. Methods: Based on the result of a preliminary study, 300 mg/kg was set as the middle dose. A highest dose of 2,000 mg/kg and a lowest dose of 50 mg/kg were selected based on the OECD TG 423. Benzo[a]pyrene was orally administered once to female and male SD rats at dose levels of 50, 300, 2,000 mg/kg (body weight). All animals were monitored daily for clinical signs and mortality over 14 days. Also testicular spermatid count, motility and etc. were examined as well. Results: Under the condition of this experiment, $LD_{50}$ of benzo[a]pyrene was assumed to be >2,000 mg/kg. In the lesion according to autopsy, there were no specific symptoms in the control and experimental groups. At 2,000 mg/kg, a decrease in the sperm motility was observed. Benzo[a]pyrene should be designated to be toxic substance as the material assumed to be reproduction-toxicity on the Act on the Registration and Evaluation, etc. of Chemicals. Therefore we should abide by legal procedures determined by Chemicals Control Act in treating it. Conclusion: Considering the significant result that sperm motility in the experimental group was inferior to that in the reference group, we suggest that benzo[a]pyrene be designated as a toxic substance.

사료를 통한 Benzo(a)pyrene 노출에 따른 조피볼락, Sebastes schlegeli의 생화학 및 조직병리학적 변화 (Biochemical and Histopathological Changes of Rockfish, Sebastes schlegeli by Dietary Benzo(a)pyrene)

  • 박대국;김재원;지정훈;박수일;강주찬
    • 환경생물
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    • 제22권3호
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    • pp.387-393
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    • 2004
  • 사료를 통한 benzo(a)pyrene이 조피볼락, Sebastes schlegeli의 lipid peroxidation (LPO), superoxide dismutase(SOD)활성과 간 조직의 병변 현상에 미치는 영향을 연구하기위해 0 (대조구), 0.5, 1.0, 1.5, 2.0 mg $kg^{-1}$ 농도의 사료를 조제하여 30일간 급이하였다. LPO는 2.0mg kg$^{-1}$농도구에서 전 실험기간 동안 유의적으로 증가하였고, SOD 활성도 2.0 mg $kg^{-1}$ 농도구에서 30일째에 유의적으로 증가하였다. 간 조직 검경시 10일째에 1.0mg $kg^{-1}$ 이상의 농도구에서 세포비대가 나타났고, 같은 농도에서 periodic acid-Schiff (PAS) 염색시 양성으로 나타나는 granule이 30일째에 나타났고, 2.0mg $kg^{-1}$ 농도구에서는 20일째부터 관찰되었다. 그리고, 30일째 2.0mg $kg^{-1}$ 농도구의 일부 어체에서는 간 세포의 괴사가 관찰되었다.

농산물 및 경작지 토양 시료 중 Benzo(a)pyrene 신속잔류분석법 개선 연구 (A Study on Rapid Residual Analysis of Benzo(a)pyrene in Agricultural Products and Soils)

  • 김희곤;함헌주;홍경숙;신희창;허장현
    • 한국환경농학회지
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    • 제39권1호
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    • pp.44-49
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    • 2020
  • BACKGROUND: Benzo(a)pyrene is a highly toxic substance which has been listed as a Group I carcinogen by the International Agency for Research on Cancer. There have been numerous studies by researchers worldwide on benzo(a)pyrene. Soxhlet, ultrasound-assisted, and liquid-liquid extractions have been widely used for the analysis of benzo(a)pyrene. However these extraction methods have significant drawbacks, such as long extraction time and large amount of solvent usage. To overcome these disadvantages, we aimed to establish a rapid residual analysis of benzo(a)pyrene content in agricultural products and soil samples. METHODS AND RESULTS: A Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) method was used as the pretreatment procedure. For rapid residual analysis of benzo(a)pyrene, a modified QuEChERS method were used, and the best codition was demonstrated after various performing instrument analysis. The extraction efficiency of this method was also compared with Soxhlet extraction, the current benzo(a)pyrene extracting method. Although both methods showed high recovery rates, the rapid residual analysis method markedly reduced both the measurement time and solvent usage by approximately 97% and 96%, respectively. CONCLUSION: Based on these results, we suggest the rapid residual analysis method established through this study, faster and more efficient analysis of residual benzo(a)pyrene in major agricultural products such as rice, green and red chili peppers and also soil samples.

Benzo(a)pyrene 과 Cytochrome P-450의 대한 상호작용에 대한 이론적 연구 (Theoretical Study on The Interaction Between Benzo(a)pyrene and Cytochrome P-450)

  • 도성탁
    • 대한의생명과학회지
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    • 제1권1호
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    • pp.89-94
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    • 1995
  • B(a)P와 cytochrome P-450의 heme부분은 구조가 평면이므로 겹침 상호작용이 가능하다. 가능성이 큰 겹침 상호작용모형을 결정하기 위해 이들 분자에 대해 MO계산을 행하였다. 이 경우 궤도함수 상호작용이 가장 중요하므로, 프론티어궤도함수의 eigen vetor값이 크며 상호 결합성을 보여야 한다. 이를 바탕으로 다섯가지 가능성이 있는 모형을 선택한 수 MN2와 MO방법을 실행하였다. 이중 B(a)P의 4, 5, 6번 위치와 heme group의 Y탄소와 III pyrrole환이 포개어지는 형태가 가장 안전하였다.

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대추 메탄올 추출액이 Benzo(a)pyrene에 의해 유도된 간기능 장해에 미치는 영향 (Effect of Jujube Methanol Extract on Benzo(a)pyrene Induced Hepatotoxicity)

  • 조수열;이윤경
    • 한국식품영양과학회지
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    • 제24권1호
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    • pp.127-132
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    • 1995
  • The protective effect of jujube methanol extract on benzo(a)pyrene(B(a)P)-induced liver injury was studied in rats in vitro and in vivo. Jujube methanol extract significantly recovered the enzyme activities(GOT, GPT, LDH and ALP) and lipid contents(total cholesterol, triglyceride and HDL-cholesterol) changed by B(a)P to normal levels in vivo. in viro experiment jujube methanol extract didn't stimulate hepatocyte proliferation but significantly recovered the enzyme activities(GOT, GPT and LDH) in comparison to group Ⅱ administered B(a)P only. It was suggested that jujube methanol extract have a protective effect on liver injury by B(a)P.

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유통 한약재 중 벤조피렌 함량 모니터링 및 안전성 평가 (Monitoring and Risk Assessment of Benzo(a)pyrene Content in Medicinal Herbs)

  • 이새람;김애경;김성단;이현경;이희진;류회진;이정미;유인실;정권
    • 생약학회지
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    • 제48권3호
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    • pp.237-242
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    • 2017
  • In this study, to investigate of safety for Benzo(a)pyrene in medicinal herb, 8 kinds of selected commercial herbal medicines (Rehmanniae Radix, Rehmanniae Radix Preparata, Amomi Tsao-Ko Fructus, Cimicifugae Rhizoma, Cyperi Rhizoma, Magnoliae Cortex, Scutellariae Radix, Scrophulariae Radix) were analysed using the high performance liquid chromatography with fluorescence detector and assessed the health risk. The levels of benzo(a)pyrene were from non-detection to $28.1{\mu}g/kg$, and the average was $3.6{\mu}g/kg$. Based on a nationwide survey of the consumption of medicinal herb by the Korean population, we estimated the potential risk from the ingestion of benzo(a)pyrene. The estimated daily intake of benzo(a)pyrene was 1.6 ng/kg b.w./day for group only know the daily average intake of medicinal herb. The MOE (margin of exposure) of benzo(a)pyrene for estimate of health risk was $1.93{\times}10^5$. Therefore, health risk from benzo(a)pyrene through intake of herbal medicine was considered negligible.

벤조피렌의 급성독성시험 연구 (An Experimental Study on Acute Toxicity of Benzo[a]pyrene)

  • 김미나;이승길;조삼래;김덕현
    • 한국산업보건학회지
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    • 제28권1호
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    • pp.43-50
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    • 2018
  • Objectives: This study was performed to observe the toxicological changes caused by a single exposure to benzo[a]pyrene. Methods: Based on the results of a preliminary study, 300 mg/kg was set as the middle dose. A highest dose of 2,000 mg/kg and a lowest dose of 50 mg/kg were selected based on GHS guidelines. Benzo[a]pyrene was orally administered once to female and male SD rats at dose levels of 50, 300, and 2,000 mg/kg(body weight). All animals were monitored daily for clinical signs and mortality over 14 days. Hematological and biochemical values were examined as well. Results: There were neither dead animals nor significant changes in body weights during the experimental period. In addition, no differences were found between the control and treated groups in clinical sign, hematology, serum biochemical, and histopathological analysis. Conclusion: Compared with the control group, we could not detect any toxic alteration in all treated groups. These studies indicate that the acute toxicity of benzo[a]pyrene is relatively low.

Inhibitory effect of Phenethyl Isothiocyanate Against Benzo[a] Pyrene-Induced Rise in CYP1A1 mRNA and Apoprotein Levels as its Chemopreventive Properties

  • Razis, Ahmad Faizal Abdull;Konsue, Nattaya;Ioannides, Costas
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권7호
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    • pp.2679-2683
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    • 2015
  • Background: Phenethyl isothiocyanate (PEITC), the most comprehensively studied aromatic isothiocyanate, has been shown to act as an anti-cancer agent mainly through modulation of biotransformation enzymes responsible for metabolizing carcinogens in the human body. Humans are often exposed to carcinogenic factors, some of which through the diet, such as polycyclic aromatic hydrocarbon benzo[a]pyrene via the consumption of over-cooked meats. Inhibition of the enzymes responsible for the bioactivation of this carcinogen, for example CYP1A1, the major enzyme required for polycyclic aromatic hydrocarbons (PAHs) bioactivation, is recognized as a chemoprevention strategy. Objective: To evaluate the inhibitory effects of PEITC against benzo[a]pyrene-induced rise in rat liver CYP1A1 mRNA and apoprotein levels. Materials and Methods: Precision cut rat liver slices were treated with benzo[a]pyrene at 1 and $5{\mu}M$ in the presence of PEITC ($1-25{\mu}M$) for 24 hours, followed by determination of CYP1A1 mRNA and apoprotein levels using quantitative polymerase chain reaction and immunoblotting. Results: Findings revealed that PEITC inhibited benzo[a]pyrene-induced rise in rat liver CYP1A1 mRNA in a dose-dependent manner as well as the apoprotein levels of CYP1A. Conclusions: It was demonstrated that PEITC can directly inhibit the bioactivation of benzo[a]pyrene, indicating chemopreventive potential.