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Effects of Ethanol on GABA-Activated Chloride Current in Sprague-Dawley rat Hippocampal Neurons

  • Sohn, Yeong-Jae;Chung, In-Kyo;Kim, Inn-Se;Cho, Goon-Jae;Chung, Yong-Za;Il Yun
    • Journal of Life Science
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    • v.9 no.2
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    • pp.15-18
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    • 1999

  • Tempting to further understand the molecular mechanism of pharmacological action of ethanol, we investigated the acute effects of ethanol on the GABA-activated current (IGABA) of the cultured Sprague-Dawley rat hippocampal neurons in primary culture using the whole-cell patch-clamp technique. Patch-clamp recordings revealed that ethanol potentiated the Cl- current in a concentration-dependent manner(1-300mM) in the majority of the cell studied. This study demonstrates that ethanol can potentiate IGABA in mammalian central neurons.

Bistable Property in a Splay Cell with a Chiral Additive

  • Lee, Seo-Hern;Kim, Tae-Jin;Lee, Jong-Lac;Jung, Mi-Jun;Park, Kyoung-Ho;Lee, Gi-Dong;Yoon, Tae-Hoon;Kim, Jae-Chang
    • Journal of Information Display
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    • v.4 no.3
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    • pp.22-25
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    • 2003

  • In this paper, we propose the bistability the bistability in a chiral-splay nematic liquid crystal cell, which is obtained by adding a chiral additive to a splay cell and introduce a novel switching method for the bistable chiral-splay nematic cell in order to transit the LC director between the non-twisted state with splay and the 180$^{\circ}$ twist state.

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