Journal of Life Science

Korean Society of Life Science (한국생명과학회)
권호 표지

Effects of Ethanol on GABA-Activated Chloride Current in Sprague-Dawley rat Hippocampal Neurons

  • Sohn, Yeong-Jae (College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University, Pusan 602-739) ;
  • Chung, In-Kyo (College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University, Pusan 602-739) ;
  • Kim, Inn-Se (College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University, Pusan 602-739) ;
  • Cho, Goon-Jae (College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University, Pusan 602-739) ;
  • Chung, Yong-Za (College of Pharmacy, Kyungsung University, Pusan 608-736) ;
  • Il Yun (Corresponding author, College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University, Pusan 602-739)
  • Published : 1999.10.01

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Abstract

Tempting to further understand the molecular mechanism of pharmacological action of ethanol, we investigated the acute effects of ethanol on the GABA-activated current (IGABA) of the cultured Sprague-Dawley rat hippocampal neurons in primary culture using the whole-cell patch-clamp technique. Patch-clamp recordings revealed that ethanol potentiated the Cl- current in a concentration-dependent manner(1-300mM) in the majority of the cell studied. This study demonstrates that ethanol can potentiate IGABA in mammalian central neurons.

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