• 대한물리의학회지
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• 제8권4호
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• pp.627-635
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• 2013

PURPOSE: The purpose of this study is to identify how the body composition changes after jump-roping exercise. METHODS: The subjects are 40 college students, 20 females and 20 males. The subjects were selected among college students who had not taken any drug for more than 4 weeks before the experiment started. The experiment was performed for 4 weeks, from May 23rd to June 13rd, 2012. To collect the data, the vital signs such as pulse, blood pressure, weight), and the body composition were measured before and after the experiment. The data on the body composition were analyzed by the electrical resistance analyzer. RESULT: Muscle mass was increased and body fat was decreased for both females and males after the exercise. In particular the increase of the muscle mass and the decrease of the body fat for the females were statistically significant. The result that the body fat of the females was decreased significantly more than that of males is interpreted that the body fat of females are comparatively higher than that of males. Additionally the muscle mass of the left arm and leg of the subjects were significantly increased(p<.05). Correlation analysis between general characteristics such as body composition, abdominal obesity and specific muscle areas for both men and women showed generally positive between before and after the jump-roping exercise (p<.05, p<.01). However the correlation between sleeping time and each variable showed negative. CONCLUSION: A according to the result of this study, jump-roping exercise had a very positive effect on the body composition. The study suggests that college students keep jump roping for a long period to change their body composition favorably.

• Childhood Kidney Diseases
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• 제9권2호
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• pp.231-236
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• 2005

소아기 류마티스 관절염에서의 극소면역성 반월상 사구체신염은 매우 드문 신질환으로 국내에서는 보고된 바가 없다. 이 신질환의 발병에 소아기 류마티스 관절염이 어떻게 작용하였는지를 명확히 밝혀져 있지 않지만, 여러 가지 면역학적 기전이 작용할 것으로 생각한다. 저자들은 3년 전에 소아기 류마티스 관절염을 진단받고 치료중인 15세 남아가 혈뇨와 신기능 저하로 내원하여 시행한 신생검소견과 혈청학적 검사를 통해 p-ANCA 양성을 보인 극소면역싱 반월상 사구체신염을 진단받고 면역억제제 치료후 신기능 회복을 보인 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• Childhood Kidney Diseases
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• 제6권1호
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• pp.114-119
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• 2002

다카야스 동맥염은 주로 대동맥과 대동맥의 주분지를 침범하는 만성 혈관염으로 자가면역질환의 일종으로 생각되며 우리나라에서는 결핵과 관련된 예 들이 주로 보고되어 있다 저자들은 특발성으로 대동맥과 그의 주분지들을 모두 침범하여 심한 허혈성 증상과 상지의 무맥현상을 보였던 중증의 다카야스 동맥염 1례를 진단하고 스테로이드와 세포독성약제의 병합요법으로 치료하여 증상의 관해를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• Childhood Kidney Diseases
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• 제10권2호
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• pp.162-173
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• 2006

Purpose : To report the decreasing indicence of HBV(Hepatitis B virus)-associated membranous nephropathy in children after HBV vaccination and to elucidate the clinical course and treatment strategies of IMN(Idiopathic membranous nephropathy). Methods : We retrospectively reviewed the clinico-pathological findings of HBV-MN and IMN patients who underwent a renal biopsy from 1986 to 2005. We compared the HBV-MN and the IMN groups and the remission and the non-remission groups of patients with IMN. Results : Among 24 cases of MN patients, HBV-MN comprised 6 cases(25%) and IMN 18 cases(75%). Clinical masnifestations were nephrotic syndrome(3 cases, 50%), nephritic syndrome(1 case, 16.7%), asymptomatic(2 cases, 33.4%) in the HBV-MN group, asymptomatic(10 cases, 55.5%), nephrotic syndrome(5 cases, 27.8%), and gross hematuria(3 cases, 16.7%) in the IMN groups. From 1996 to 2000, there were 2 cases(28%) of HBV-MN and 5 cases(72%) of IMN. After 2001 all 10 cases were IMN. In the HBV-MN group, 4 cases(66.7%) received interferon and 1 cases received methylprednisolone pulse therapy. In the IMN group, 16 cases(88.9%) received methylprednisolone, 8 cases(44.4%) were in complete remission, 2 cases(11.1%) were in partial remission, 2 cases(11.1%) were in chronic renal failure, and 5 cases(27.8%) were lost to follow-up with sustained proteinuria, 1 case(5.6%) continued to have frequent relapse of nephrotic syndrome without renal insufficiency. In the comparison between remission and non-remission groups, nephrotic range proteinuria and hypertension were more significantly common in the non-remission group(P<0.05). Conclusion : With HBV vaccination, HBV-MN has decreased markedly. IMN is a rare glomerular disease in children. Because the prognosis for patients with nephrotic range proteinuria is poor this group needs more aggressive treatment.

• 전기전자학회논문지
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• 제11권4호
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• pp.257-264
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• 2007

MM22 마이크로트론은 1986년도 11월부터 2006년 2월까지 암 환자를 위한 방사선 치료 장비로 사용되었다. 장비의 노후로 치료 장비에서 연구 및 교육용으로 전환하기 위해 방사선의학연구센터로 이전 설치하였다. 본 논문에서는 이전 설치 한 후 빔 인출을 수행하기 위해 마이크로트론의 동작원리, 시스템을 구성하는 각 장치의 특성을 분석하여 보았고 주요 부분의 파라메타인 펄스구조의 특징을 살펴보았다. 실제, 각 주요 시스템의 펄스를 측정하였고 빔 인출부, 빔 라인 및 최종단인 타겟에서 빔 인출 기법을 통하여 빔 인출 및 빔 측정을 수행하였다. 이전 설치 후 10 MV X-선의 경우 최종 단 치료기에서 30 mA 타겟 전류를 인출하였고, 필름을 SSD 100 cm, $10{\times}10cm^2$ 조사면에 놓고 100 MU 방사선을 조사하였다. 조사면의 방사선분포의 평탄도 측정 결과 3%이내로 안정적인 빔을 인출하여 이전설치가 성공적으로 수행되었음을 확인할 수 있었다.

• Journal of Microbiology and Biotechnology
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• 제9권3호
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• pp.346-351
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• 1999

Tumor cells may alter the expression of proteins involved in antigen processing and presentation, allowing them to avoid recognition and elimination by cytotoxic T cells. In order to investigate whether the major histocompatibility complex (MHC) class I-mediated antigen processing machinery is preserved in human lung cancer cell lines, we examined the expression of multiple components of the MHC class I antigen processing pathway, including transporter associated with antigen processing (TAP), $\beta_2$-microglobulin, MHC class I molecules, and chaperones which have not been previously examined in this context. Row cytometry analysis showed that the cell surface expression of MHC class I molecules was downregulated in all of the cell lines. While some cell lines showed no detectable expression of MHC class I molecules, pulse-chase experiments showed that MHC class I molecules were synthesized in the other cell lines but not transported from the endoplasmic reticulum to the cell surface. Low or nondetectable levels of TAP1 and/or TAP2 expression were demonstrated by Western blot analysis in all of the cell lines, representing a variety of lung tissue types. In some cases, this was accompanied by loss of tapasin expression. Our findings suggest that downregulation of antigen processing may be one of the strategies used by tumors to escape immune surveillance. This study provides further information for designing the potential therapeutic applications such as immunotherapy and gene therapy against cancers.

• Archives of Plastic Surgery
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• 제44권1호
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• pp.34-41
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• 2017

Background The current indications of cardiac implantable electronic devices (CIEDs) have expanded to include young patients with serious cardiac risk factors, but CIED placement has the disadvantage of involving unsightly scarring and bulging of the chest wall. A collaborative team of cardiologists and plastic surgeons developed a technique for the subpectoral placement of CIEDs in young female patients via a transaxillary approach. Methods From July 2012 to December 2015, subpectoral CIED placement via an axillary incision was performed in 10 young female patients, with a mean age of 25.9 years and mean body mass index of $20.1kg/m^2$. In the supine position, with the patient's shoulder abducted, an approximately 5-cm linear incision was made along one of the deepest axillary creases. The submuscular plane was identified at the lateral border of the pectoralis major, and the dissection continued over the clavipectoral fascia until the subpectoral pocket could securely receive a pulse generator. Slight upward dissection also exposed an entrance to the subclavian vein, allowing the cardiology team to gain access to the vein. One patient with dilated cardiomyopathy underwent augmentation mammoplasty and CIED insertion simultaneously. Results One case of late-onset device infection occurred. All patients were highly satisfied with the results and reported that they would recommend the procedure to others. Conclusions With superior aesthetic outcomes compared to conventional methods, the subpectoral placement of CIEDs via a transaxillary approach is an effective, single-incision method to hide operative scarring and minimize bulging of the device, and is particularly beneficial for young female or lean patients.

• 대한수의학회지
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• 제44권2호
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• pp.311-315
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• 2004

The detection of lymph node metastasis is an important step in tumor staging and is significant for therapy planning. It has been challenged to yield an appropriate image with diagnostic methods such as Magnetic Resonance (MR) and Computed Tomography (CT). Though CT has been used widely and accessed easily to show internal organs, it can hardly provide difference between lymph node and adjacent vessel or fat tissue. It has been well established that MR can reveal the subtle discrepancy within soft tissue. This study investigated the suitability of MR lymph node imaging without contrast enhancement by comparison of T1-weighted image (T1WI) and T2- weighted image (T2WI) in ten normal rabbits. According to the pulse sequence optimized from preliminary study, T1-weighted spin-echo (repetition time/echo time=400/12 ms) and T-2 weighted fast spin-echo (repetition time/echo time=3500/84 ms) images covering the hind limbs and pelvic region were acquired at 1.5 T. Two radiologists scrupulously evaluated the MR images in consensus. And signal intensity of lymph nodes was compared with that of adjacent fat. Statistical analysis showed that T1-weighted coronal image visualized the lymph nodes (iliac, superficial inguinal and popliteal lymph nodes) quickly and consistently rather than T2-weighted one. Conclusively, T1WI for evaluation of lymph nodes is moderately better than T2WI and appears to have potential for quick and sufficient mapping of the lymph nodes. In addition, this normal MR image of lymph nodes could be applied to further study for the evaluation of lymphatic system in abscess and tumor bearing animal model.

• 한국화재소방학회논문지
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• 제26권3호
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• pp.14-20
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• 2012

이 연구는 뇌졸중 환자에게 시행되는 환자평가와 응급처치의 실태를 파악하는 연구이다. 구급대에 의해 이송된 뇌졸중환자 123명을 대상으로 하였으며, 수집된 자료는 SPSS 18.0 프로그램을 이용하여 분석하였다. 분석 결과 뇌졸중으로 진단 받은 123명의 환자 중 환자평가는 혈압 73.2 %, 맥박 73.2 %, 호흡 64.2 %, 산소포화도 79.7 %, 공동반응 88.6 %, 심전도 감시 14.6 %, 혈당측정 19.5 %의 시행률을 보였고, 시행된 응급처치로는 기도유지기 삽입 2.4 %, 손으로 조작하는 기도확보 17.1 %, 기관내삽관 2.7 %, 산소공급 35.4 %, 흡인, 정맥로 확보 및 수액투여가 시행된 환자는 아무도 없었다. 전반적으로 의식상태 평가는 적절하였으나 119구급대원에 의해 시행되는 환자평가 및 응급처치는 전반적으로 적절하지 못하였다.

• Journal of Acupuncture Research
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• 제23권5호
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• pp.79-92
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• 2006

Acupuncture has acupoints to treat, prevent, and reduce disease and to recover health by meridian guidance and reflexion. In the oriental medicine, meridian and acupoints are the foundations of treatment. Therefore, in the clinical treatment, we have to decide the therapeutic methods, meridian, acupoints, acupoint place, and acupoint match according to the disease. This study was designed to investigate the combined effects of ST36, ST37, and ST39 using electroacupuncture in rats. The present study was conducted to see the effects produced by combined electro-acupuncture(EA) at ST36, ST37, and ST39 on small intestine transportation in rats. EA(2 Hz, 5mA, pulse duration 1 ms) was applied for 30 minutes at acupoints of ST36, ST37, and ST39. The results are as follows. Compared to other acupoint place matches, ST36(left)+ ST37(right), ST36(left)+ST39(right), and ST37(left)+ST39 (right) were more effective than ST36(right)+ST37(left), ST36 (right)+ST39(left), and ST37(right)+ST39(left) for small intestine transporation(+ means acupoint place match). In terms of acupoint placement, ST36(left), ST37(right), and ST39(right) were more effective than the other sides for small intestine transporation. The data suggests that we have to consider acupoint place and acupoint match for acupucture therapy.