• 한국콘텐츠학회논문지
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• 제11권6호
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• pp.289-301
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• 2011

본 연구는 음악요법이 자기공명영상(MRI) 검사로 인한 불안정도와 검사시 불편감에 미치는 음악요법의 효과를 파악하고자 시도된 비동등성 대조군 사전-사후 실험설계의 유사실험이다. "음악요법을 받은 군은 음악요법을 받지 않는 군보다 검사 중 불안 점수가 낮을 것이다"는 음악요법 실시 후 실험군의 불안점수가 대조군의 불안점수와 비교하여 유의한 차이가 있어 채택되었다. "음악요법을 받은 군은 음악요법을 받지 않는 군보다 검사 후 활력징후가 낮을 것이다"는 수축기 혈압, 이완기혈압에 대한 가설은 기각되었지만, 맥박에서는 유의 한 차이가 나타나 부분적으로 채택 되었다. "음악요법을 받은군은 음악요법을 받지 않는 군보다 주간적 불편감이 낮을 것이다"는 두 집단간의 유의한 차이를 보였다. 한편 주관적인 불편감의 하부요인 중 긴장감 에서만 유의한 차이가 있었으며, 동통, 어지러움, 공포감에서는 유의한 차이가 없었다. 이상의 연구결과로 볼 때 음악요법은 자기공명영상(MRI) 검사중 환자의 상태불안을 감소시킬 수 있는 유용한 대체검사법이 될 수 있을 것이라고 생각된다.

• 한국동물번식학회:학술대회논문집
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• 한국동물번식학회 2001년도 춘계학술발표대회
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• pp.61-61
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• 2001

The main goal of this study was to produce transgenic piglets by the method of injection of sperm-mediated exogenous DNA. Spermatozoa (1$\times$106 sperm of final concentration) obtained from caudal epididymis were mixed with pBC1-hEPO (20 ng/${mu}ell$) or pcDNA3 LAC Z (20 ng/${mu}ell$), and followed by electroporation (500 V, 25 ㎌). Matured oocytes having the first polar body and dense cytoplasm were selected and centrifuged at 12,000g for 6 min. After sperm injection, the oocytes were activated electrically (1.7 ㎸/cm, 30 $\mu$ sec, single pulse) in 0.3 M mannitol solution. Eggs injected sperm were cultured in NCSU 23 medium (0.4% BSA) at 39$^{\circ}C$, 5% $CO_2$ in air for 192 h. This study were comprised 3 experiments. Experiment 1 compared the developmental efficiencies between the sperm-injected oocytes (Group 1) and further activated electrically (Group 2). Experiment 2 compared the expression of pcDNA3 LAC Z in the embryos produced by Group 1 and Group 2. Finally, experiment 3 carried out transfer of embryos (1-8 cell stage) transfected with pBC1 -hEPO into surrogate recipients synchronized by injection of combination of PG600 with hCG. The rates of cleavage and development into blastocyst stage in Group 2 were significantly higher than those of Group 1 (71.3% and 28.1% vs. 43.3% and 10.3%, respectively, p<0.05). Thirty (24.2%) out of 124 embryos analyzed in Group 2 were positive by X-gal. Similarly, in Group 1, 16.3% (8/49) were positive. After transfer of 789 embryos to 7 recipient gilts, three out of them examined by ultrasound became pregnant. One recipient is in day 50 pregnancy. On day 54 of gestation, two were carried out uterotomy in order to confirm the pregnancy One had 7 and another had 2 fetuses. We conclude that injection of sperm-mediated gene transfer will be used as a valuable tool for the production of transgenic piglets.

• 한국수산과학회지
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• 제20권1호
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• pp.16-23
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• 1987

실내사육중이던 미꾸라지 친어에 생식선자극 호르몬을 복강주사하여 20시간 후인 1986년 7월 10일에 얻은 난을 인공수정시켜 난발생과정과 부화자어의 성장에 따른 형태변화에 대해 관찰한 결과를 요약하면 다음과 같다. 성숙란은 난경이 $1.04\~1.18mm$(평균 1.12mm, n=25)로 난막은 아주 얇으며, 담황색을 띤 분리침성 점착난이다. 사육수온 $25^{\circ}C$에서 수정후 약 24시간만에 첫 부화가 일어났다. 부화직후의 자어는 전장이 $2.60\~2.80mm$ 두부는 난황 앞쪽 아래에 위치하며, 근절수는 $35\~36$개 이다. 부화후 4일째의 자어는 금장이 $5.10\~5.40mm$로 난황이 완전히 흡수되고 소화관이 발달한다. 부화후 16일째의 자어는 전장이 $9.4\~10.1mm$로 각 지느러미의 기조가 분화하며, 몸전체에 걸쳐 흑색소포가 골고루 분포한다. 부화후 24일째의 자어는 전장이 $15.40\~16.40mm$로 각 기조가 정수에 달하여 치어기에 이른다.

• The Korean Journal of Physiology
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• 제24권1호
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• pp.51-65
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• 1990

The purpose of the present study was to examine the hemodynamic responses, especially in arterial and skin blood flows, in conjunction with the changes of plasma catecholamine levels as an indirect marker of adrenergic tone during the early stage of head-down tilt (HDT), and to evaluate the early physiological regulatory mechanism in simulated weightlessness. Ten mongrel dogs, weighing8\;{\sim}\;14\;kg, were intravenously anesthetized with nembutal, and postural changes were performed by using the tilting table. The postural changes were performed in the following order: supine, prone, HDT $(-6^{\circ}C)$ and lastly recovery prone position. The duration of each position was 30 minutes. The measurements were made before, during and after each postural change. The arterial blood flow $({\.{Q}})$ at the left common carotid and right brachial arteries was measured by the electromagnetic flowmeter. Blood pressure (BP) was directly measured by pressure transducer in the left brachial artery. To evaluate the peripheral blood flow, skin blood flow $({\.{Q}})$ was calculated by the percent changes of photoelectric pulse amplitude on the forepaw, and skin temperature was recorded. The peripheral vascular resistance (PR) was calculated by dividing respective mean BP values by ${\.{Q}}$ of both sides of common carotid and brachial arteries. Heart rate (HR), respiratory rate (f) and PH, $Po_{2},\;Pco_{2}$ and hematocrit of arterial and venous blood were also measured. The concentration of plasma epinephrine and norepinephrine was measured by radioenzymatic method. The results are summarized as follows: Tilting to head-down position from prone position, HR was initially increased (p<0.05) and BP was not significantly changed. While ${\.{Q}}$ of the common carotid artery was decreased (p<0.05) and PR through the head was increased, ${\.{Q}}$ of the brachial artery was increased (p<0.05) and PR through forelimbs was decreased. ${\.{Q}}$ of the forepaw was initially increased (p<0.05) and then slightly decreased, on the whole revealing an increasing trend. Plasma norepinephrine was slightly decreased and the epinephrine was slightly increased. f was increased and arterial pH was increased (p<0.05). In conclusion, the central blood pooling during HDT shows an increased HR via Bainbridge reflex and an increased ${\.{Q}}$ of the forepaw and brachial ${\.{Q}}$, due to decreased PR which may be originated from the depressor reflex of cardiopulmonary baroreceptors. It is suggested that the blood flow to the brain was adequately regulated throughout HDT $(-6^{\circ}C)$ in spite of central blood pooling. And it is apparent that the changes of plasma norepinephrine level are inversely proportional to those of ${\.{Q}}$ of the forepaw, and the changes of epinephrine level are paralleled with those of the brachial ${\.{Q}}$.

• 한국항해항만학회지
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• 제36권6호
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• pp.475-480
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• 2012

eLoran (enhanced Long Range Navigation)의 구축을 위해서는 로란시스템 설비업그레이드, 시스템 정보데이터 채널추가, dLoran (differential Loran) 사이트, ASF(Additional Secondary Factor) 데이터베이스 등이 필요하다. 특히 eLoran 송신국들의 정확한 UTC (세계협 정시, Coordinated Universal Time) 동기는 eLoran 시스템의 항법성능 향상을 위해 필수적이다. 따라서 송신국들의 정확한 UTC 동기를 위해서는 송신국의 절대 지연시간 측정 및 모니터링이 필요하며, 측정된 송신국 지연시간의 변화량을 보정정보로 이용자에게 제공하여야 한다. 본 연구에서는 포항 LORAN-C 송신국(9930M)을 대상으로 수신지점에서의 TOA(Time of Arrival) 산출을 위한 송신신호의 기준시점을 측정하는 방법을 제시하였고 지연측정 시스템 및 송출신호 위상 모니터링 시스템을 개발하여 포항 송신국의 기준시점을 평가하였다. 측정결과 포항 송신국의 기준점 오프셋은 $-2.23{\mu}s$로 측정되었으며 송신 로란펄스의 위상을 관측한 결과 1 개월간에 약 $0.3{\mu}s$ 정도 흐르는 것이 관측되어 로란의 PNT(Positioning, Navigation and Timing) 활용을 위해 위상 모니터링과 보상이 필수적임을 알 수 있었다.

• 한국산학기술학회논문지
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• 제17권11호
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• pp.746-754
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• 2016

ICT기반의 융합산업인 스마트 헬스케어 시스템은 건강관리부터 원격진료 범위에 걸쳐 다양한 산업분야의 핵심 연구주제이다. 스마트 헬스케어 환경은 웨어러블 디바이스를 통하여 사용자의 심박 수, 체온, 건강상태 등과 같은 생체정보를 주치의가 있는 병원 네트워크로 전달하는 기술을 의미하며 환자의 다양한 데이터를 수집하고 복합적인 정보를 추론할 수 있는 기술은 스마트 헬스케어 기술의 핵심기술이라 할 수 있다. 그러나 환자에 대한 개인의 의료정보를 다루는 만큼 정보관리에 대한 보안위협이 있으며, 무선 네트워크 환경에서 발생하는 공격기법에 대해서 취약점이 발생할 수 있다. 그러므로 본 논문에서는 스마트 헬스케어 기반의 디바이스 접근제어를 위한 키를 생성 후 생성한 키를 활용하여 안전한 통신 프로토콜을 설계하여 스마트 헬스케어 시스템의 보안성을 강화하였다. 성능평가에서는 스마트 헬스케어 환경에서 발생하는 공격기법에 대해서 안전성 분석을 하고, 기존의 키 암호화 방식과의 보안성 및 효율성을 분석하여 기존의 암호화 방식 대비 대략 15% 향상된 수치를 확인할 수 있었다.

• 한국수자원학회논문집
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• 제49권4호
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• pp.335-346
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• 2016

본 연구에서는 포아송 클러스터 강우생성모형의 하나인 MBLRP 모형의 매개변수지도를 우리나라에 대하여 제작하고 이에 기반을 둔 가상강우생성 웹 어플리케이션을 개발 및 검증하였다. 이를 위하여 우리나라의 62개 ASOS 지상 강우 관측소에서 관측된 강우자료를 기반으로 서로 다른 수문모의의 목적(홍수량 모의, 장기 유출량 모의, 일반 모의)에 따른 MBLRP 모형의 매개변수지도를 산정한 후, 이를 Ordinary Kriging 기법을 통해 공간 보간하여 우리나라에 대한 매개변수지도를 제작하였으며, 이에 기반을 두고 가상강우 시계열을 생성하는 웹 어플리케이션을 개발하였다. 검증을 위하여 웹어플리케이션을 사용하여 가상강우를 생성한 후 평균, 분산, 자기상관계수, 무강우 확률, 극한강우량 및 다양한 유역에 대한 극한홍수량과 유출량을 계산하고 이를 관측 강우에 근거하여 산출된 값과 비교하였다. 비교 결과 가상 강우의 각종 통계값은 관측강우에 근거한 값과 매우 유사하게 나타났으나, 극한강우와 극한홍수는 관측치에 근거한 값과 비교하여 16%-40% 정도 과소산정되는 경향을 보였다. 이러한 결과는 교정계수로 활용할 수 있도록 등고선도의 형태로 제공되었다. 본 연구에서 개발한 웹 어플리케이션은 모형의 매개변수 산정부터 가상 강우 시계열 생성까지 일련의 과정을 포함하고 있어 강우자료를 필요로 하는 다양한 수문 분석에 활발히 활용될 것으로 기대된다.

• Carbon letters
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• 제28권
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• pp.31-37
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• 2018

This paper examines a simple one-step and catalyst-free method for synthesizing carbon nanoparticles from aliphatic alcohols and n-hexane with linear molecule formations by using a stable solution plasma process with a bipolar pulse and an external resistor. When the external resistor is adopted, it is observed that the current spikes are dramatically decreased, which induced production of a more stable discharge. Six aliphatic linear alcohols (methanol-hexanol) containing carbon with oxygen sources are studied as possible precursors for the massive production of carbon nanoparticles. Additional study is also carried out with the use of n-hexane containing many carbons without an oxygen source in order to enhance the formation of carbon nanoparticles and to eliminate unwanted oxygen effects. The obtained carbon nanoparticles are characterized with field emission-scanning electron microscopy, energy dispersive X-ray spectroscopy, and Raman spectroscopy. The results show that with increasing carbon ratios in alcohol content, the synthesis rate of carbon nanoparticles is increased, whereas the size of the carbon nanoparticles is decreased. Moreover, the degree of graphitization of the carbon nanoparticles synthesized from 1-hexanol and n-hexane with a high carbon (C)/oxygen (O) ratio and low or no oxygen is observed to be greater than that of the carbon nanoparticles synthesized from the corresponding materials with a low C/O ratio.

• 대한간호학회지
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• 제24권3호
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• pp.377-388
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• 1994

The purpose of this study was to determine the effects of music therapy on changes in the vital signs of patients about to undergo an operation. The patients listened to the music at a time when they were feeling preoperative anxiety up until the preanesthesia was given in the operating room. The subjects for this study were selected from sixty patients to undergo operations, who were hospitalized at Dong Eui hospital in Pusan city. They were assigned to two groups, thirty to the experimental group and thirty to the control group. The subjects were from 20 years old to 69 years old, and had no other problem except the one requiring the operation, and no premedication. The data were collected during the period from July 1 to September 30, 1993. The method used in this study was to measure state-anxiety on the ward in the morning of the operation, and vital signs immediately before leaving for the operating room. Vital signs were measured immediately before the anesthesia was given and after the experimental group had listened to the music during the ten minutes needed to prepare the operation setting. The control group just waited during ten mimutes. Vital signs were check again before the anesthesia was given. The data were analyzed by descriptive statistics, mean±SD, p-value, and t-test using the SPSS progrom. The results of this study are : 1. Systolic blood pressure taken in the operating room was elevated, over the level measured on the ward, by 5.00 ± 15.26㎜Hg in experimental group and 18.67±14.56㎜Hg in control group. (t=-3.5496, p=.0008) 2. Diastolic blood pressure was elevated by 6.67±12.95㎜Hg in experimental group and 18.67±12. 79㎜Hg in control group. (t=-3.6100, p=.0006) 3. Pulse was elevated by 2.931±9.44 / min in experimental group and 8.03±8.37 /min in control group. (t=-2.2144, p=.0307) 4. Respiration was elevated by 0.60±1.35 /min in experimental group and 1.57±1.48 /min in control group. (t=-2.6409, p=.0106) 5. Body temperature was down by 0.13±1.91'c in experimental group and elevated by 1.13±1.11'c in control group. (t=-3.1471, p=.0026) Thus, in this study there was a statistically significant difference in the change in the vital signs between the experimental group treated with music therapy and the control group which received no treatment. Because music therapy is valuable to decrease the anxiety of patients facing operations, the result of this study support its effect in relieving anxiety as a valuable nursing intervention. From this study, the following recommendations can be made : First, it is necessary to further study music therapy to develope a better system and determine optimal time. Second, it is necessary that more detailed re-search on measurement of changes in vital signs be done to determine changes over time intervals.

• 한국의사학회지
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• 제29권2호
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• pp.35-47
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• 2016

"JeSeBoGam (濟世寶鑑)" was a medical document authored by Moon Gi-hong during the Japanese colonial rule in 1933, and the author acted as a Korean medicine doctor, an acupuncturist, a medicine practitioner and an apothecary. Since its first publication in 1933, it has been published three times in 1966 and 1975, from the Japanese colonial period to the liberation period. "JeSeBoGam" is largely divided into Preface part, "List of drugs according to symptoms [隨症用藥目錄]", "JeSeBoGam-Gap (濟世寶鑑甲)", and the Appendix includes "Key points for diagnosing the disease [察病要訣]" "Key points of acupuncture and pulse [脈訣]" "Key points of acupuncture and moxibustion treatment [針灸訣]" in the back of the book. In 1933, there are attached exam books and license application forms related to Korean medicine doctor and pharmacist, so strict regulations on them during the Japanese occupation period can be confirmed. "JeSeBoGam-Gap" contains 208 prescriptions from 143 prescriptions taken from "BangYakHapPyeon" and 65 prescriptions from other books. It divided into Gap (甲) Eul (乙) Byung (丙) Jung (丁). These prescriptions were placed in "List of drugs according to symptoms [隨症用藥目錄]" according to a symptom 1,286 times. Considerable parts of organization and prescription drug composition of "JeSeBoGam" are closely related with "BangYakHapPyeon", but there were adjustments in all medicinal ingredients and capacity for the rest of them except 23 prescription drugs. Compared to "BangYakHapPyeon", there was a tendency to substitute the basic prescription in "JeSeBoGam" for prescriptions used for the same disease. Though only 65 prescriptions were taken from books other than "BangYakHapPyeon", 575 times were reflected in "List of drugs according to symptoms [隨症用藥目錄]", and the rate of utilization is high compared with the number of prescriptions of "BangYakHapPyeon". It is thought that the circumstances of the Japanese occupation period, limits in medicinal ingredients composition due to regional characteristics, and changes in a patient's condition and the treatment method might have an influence on the author's drug use tendency. "JeSeBoGam" is similar to "BangYakHapPyeon" in composition, but it is a new practical medical book in which the author's clinical records are concentrated.