• Journal of computational fluids engineering
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• v.16 no.2
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• pp.81-87
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• 2011

The importance of shear thinning non-Newtonian blood rheology on the hemodynamic characteristics of idealized cerebral saccular aneurysms were investigated by carrying out CFD simulations assuming two different non-Newtonian rheology models (Carreau and Ballyk models). To explore effects of vessel curvature, a straight and a curved vessel geometry were considered. The wall shear stress(WSS), relative residence time(RRT) and velocity distribution were compared at the different phases of cardiac cycle. As expected, blood entered the aneurysm at the distal neck and created large vortex in both aneurysms, but with higher momentum on the curved vessel. Hemodynamic characteristics such as WSS, and RRT exhibited only minor effects by choice of different rheological models although Ballyk model produced relatively higher effects. We conclude that the assumption of Newtonian fluid is reasonable for studies aimed at quantifying the hemodynamic characteristics, in particular, WSS-based parameters, considering the current accuracy level of medical image of cerebral aneurysm.

• Journal of the Institute of Convergence Signal Processing
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• v.14 no.1
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• pp.1-5
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• 2013

The two major problems related to the blood flow in replaced prosthetic heart valve are thrombus formation and hemolysis. Reliability of prosthetic valve is very important because its failure means the death of patient. There are many factors affecting the valvular failures and their representatives are mechanical failure and thrombosis, so early noninvasive detection is essentially required. The purpose of this study is to detect the various thromboses formation by using acoustic signal acquisition and its spectral analysis on the frequency domain. We made the thrombosis models using Polydimethylsiloxane (PDMS) and they are thrombosis model on the disc, around the sewing ring and fibrous tissue growth across the orifice of valve. Using microphone and amplifier, we measured the acoustic signal from the prosthetic valve, which is attached to the pulsatile mock circulation system. A/D converter sampled the acoustic signal and the spectral analysis is the main algorithm for obtaining spectrum. Then the spectrum of normal and 5 different kinds of abnormal valve were obtained. Each spectrum waveform shows a primary and secondary peak. The secondary peak changes according to the thrombus model. To quantitatively distinguish the frequency peak of the normal valve from that of the thrombosed valves, analysis using a neural network was employed. Acoustic measurement has been used as a noninvasive diagnostic tool and is thought to be a good method for detecting possible mechanical failure or thrombus.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.11
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• pp.109-112
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• 1997

The Hydrodynamic performance of the trileaflet polymer prosthetic valves depends on the design of the leaflet and the physical properties of the leaflet membrane. In order to study the effect of leaflet membrane elasticity on the hemodynamic performance of trileaflet prosthetic valve, leaflet membranes are manufactured using two different polymers - Biospan and Tecoflex SG-93A. The hemodynamic performance parameters are measured under steady and physiological pulsatile flow, and compared with monoleaflet polymer valve(floating valve) and bileaflet mechanical valve(St. Jude Medical valve). Well designed trileaflet valve shows the lowest mean pressure drop among the tested valves. The trileaflet valves with Biospan membrane show lower pressure drop and back low comparing to those with Tecoflex membrane. More elastic membrane may provide wide opening area during systole and close membrane ree edge contact during diastole. Durability of trileaflet valves are also tested in vitro. Trileaflet valves with non-uniform membrane thickness ail within 17 days because of stress concentration. Trileaflet polymer valves with uniform membrane thickness perform well over 55 days without failure.

• Journal of Biomedical Engineering Research
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• v.22 no.1
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• pp.59-68
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• 2001

유체-고체 상호작용을 고려하여 다양한 복부대동맥류 모델에 대해서 맥동유동 및 구조를 동시에 해석하였다. 동맥류의 확장부 크기와 혈관벽 두께에 따라서 총 여덟 개의 축대칭 동맥류 모델을 선정하였다. 유한체적법 및 압력기반의 유한차분법을 이용하여 유동을 해석하였으며, 유한요소법을 이용하여 구조해석을 수행하였다. 동맥류의 확장부위가 클수록 최대응력은 최대확장부위와 변곡점에 해당하는 동맥류의 입구 및 출구 부분에 집중되었으며, Von Mises 응력은 최대확장부위 뿐만 아니라 동맥류의 근위부와 원위부($\pm$1D)에서도 현저하게 증가하였다. 또한 더욱 확장된 모델일수록 혈관벽은 직경방향의 변위보다 축방향의 변위가 지배적이었으며, 동맥류 원위부보다 근위부에서 큰 축방향 변위를 나타냈다. 동맥류 입구부의 미약한 와류는 한 주기동안 그 크기와 강도를 더해가며 동맥류 원외부로 이동하였고, 동맥류의 내부 유동은 압력차이가 감소하는 기간동안 더 큰 영향을 받았다. 확장정도가 심할수록 동맥류 내부에 더 크고 강한 와류가 관찰되었다. 압력차이가 최소가 된 직후 동맥류의 근위부와 원위부동맥 벽 근처에서의 역방향 유동이 관찰되었다. 대체로 혈관벽 두께가 감소한 모델과 더욱 확장된 모델일수록 벽전달률은 감소하였다. 혈관벽의 탄성에 의하여 압력차이와 벽전달률 사이에 위상차가 존재함이 확인되었다. 유체-고체의 상호작용을 고려한 연구는 다른 심혈관계를 이해하는데도 매우 유익할 것으로 생각된다.

• Structural Engineering and Mechanics
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• v.86 no.6
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• pp.751-764
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• 2023

In practical engineering such as aerial refueling pipes, the boundary of the fluid-conveying pipe is difficult to be completely immovable. Pipes under movable and immovable boundaries are controlled by different dominant nonlinear factors, where the boundary mobility will affect the nonlinear dynamic characteristics, which should be focused on for adopting different strategies for vibration suppression and control. The nonlinear dynamic instability characteristics of functionally graded fluid-conveying pipes lying on a viscoelastic foundation under movable and immovable boundary conditions are systematically studied for the first time. Nonlinear factors involving nonlinear inertia and nonlinear curvature for pipes with a movable boundary as well as tensile hardening and nonlinear curvature for pipes with an immovable boundary are comprehensively considered during the derivation of the governing equations of the principal parametric resonance. The stability boundary and amplitude-frequency bifurcation diagrams are obtained by employing the two-step perturbation- incremental harmonic balance method (TSP-IHBM). Results show that the movability of the boundary of the pipe has a great influence on the vibration amplitude, bifurcation topology, and the physical meanings of the stability boundary due to different dominant nonlinear factors. This research has guidance significance for nonlinear dynamic design of fluid-conveying pipe with avoiding in the instability regions.

• Journal of Biomedical Engineering Research
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• v.25 no.4
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• pp.295-300
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• 2004

Coil embolization technique has been used recently to treat cerebral aneurysms. When a giant or a multilobular aneurysm are treated by roils, filling an aneurysm sac completely with coils is difficult and partial blocking of an aneurysm sac is inevitable. Blood flow characteristics, which nay affect the embolization process of an aneurysm sac, are changed by the locations of coils for the Partially blocked aneurysms. Blood flow fields are also influenced by the geometry of a parent vessel. In order to suggest the coil locations effective for aneurysm embolization, the blood flow fields of lateral aneurysm models were analyzed for the different coil locations and parent vessel geometries. Three dimensional pulsatile flow fields are analyzed by numerical methods considering non-Newtonian viscosity characteristics of blood. Flow rate into the aneurysm sac (inflow rate) and wall shear stress, which are suspected as flow dynamic factors influencing aneurysm embolization, are also calculated. Inflow rates were smaller and the low wall shear stress zones were larger in the neck blocked models compared to the dome blocked models. Smaller inflow and larger low wall shear stress zones in the distal neck blocked model imply that the distal neck should be the effective coil locations for aneurysm embolization.

• Journal of radiological science and technology
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• v.30 no.3
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• pp.205-212
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• 2007

To evaluate the feasibility and efficacy of a pulsatile aortic aneurysm phantoms for in-vitro study. The phantoms consisted of a pulsating motor part(heart part) and an aortic aneurysm part, which mimicked true physiologic conditions. The heart part was created from a high-pressured water pump and a pulsatile flow solenoid valve for the simulation of aortic flow. The aortic aneurysm part was manufactured from paper clay, which was placed inside a acrylic plastic square box, where liquid silicone was poured. After the silicone was formed, the clay was removed, and a silicone tube was used to connect the heart and aneurysm part. We measured the change in pressure as related to the opening time(pulse rate, Kruskal-Wallis method) and pressure before and after the stent-graft implantation(n = 5, Wilcoxon's signed ranks test). The changes in blood pressures according to pulse rate were all statistically significant(p<0.05). The systolic/diastolic pressures at the proximal aorta, the aortic aneurysm, and the distal aorta of the model were $157.80{\pm}1.92/130.20{\pm}1.92$, $159.40{\pm}1.14/134.00{\pm}2.92$, and $147.20{\pm}1.480/129.60{\pm}2.70\;mmHg$, respectively, when the pulse rate was 0.5 beat/second. The pressures changed to $161.40{\pm}1.34/90.20{\pm}1.64$, $175.00{\pm}1.58/93.00{\pm}1.58$, and $176.80{\pm}1.48/90.80{\pm}1.92\;mmHg$, respectively, when the pulse rate was 1.0 beat/second, and $159.40{\pm}1.82/127.20{\pm}1.48$, $166.60{\pm}1.67/138.00{\pm}1.87$, and $161.00{\pm}1.22/135.40{\pm}1.67\;mmHg$, respectively, when it was 1.5 beat/second. When pulse rate was set at 1.0 beat/second, the pressures were $143.60{\pm}1.67/90.20{\pm}1.64$, $147.20{\pm}1.92/84.60{\pm}1.82$, and $137.40{\pm}1.52/88.80{\pm}1.64\;mmHg$ after stent-graft implantation. The changes of pressure before and after stent-graft implantation were statistically significant(p<0.05) except the diastolic pressures at the proximal(p =1.00) and distal aorta(p=0.157). The aortic aneurysm phantoms seems to be useful for the evaluation of the efficacy of stent-graft before animal or clinical studies because of its easy reproducibility and ability to display a wide range of pressures.

• Archives of Plastic Surgery
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• v.35 no.2
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• pp.159-164
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• 2008

Purpose: Microvascular free tissue transfer has become a reliable technique for the reconstruction of complex wounds. Occasionally, unexpected intraoperative thrombosis and/or spasm of recipient artery might be annoying problems even for the technically competent microvascular surgeons. If such problems are not treated properly, they will inevitably cause to flap failure. Methods: From January 2006 to February 2007, soft tissue reconstructions by free tissue transfers were performed on 21 patients having complex defects in the lower extremity. Although segmental revision and various pharmacologic agents were repeatedly applied, arterial occlusions were not managed in 6 cases. For removal of thrombi and release of spasm, Fogarty No. 2 or No. 3 catheters were inserted into the lumen to the proximal recipient artery. Its balloon was then inflated after passing through a resistant area. Next, the catheter was gently withdrawn backward. Results: After the Fogarty catheter was inserted two or three times, the pulsatile arterial flow was restored. When the catheter was inserted into the lumen, a feeling of resistance existed in a 5-10cm more proximal portion that could not be easily accessed from the vascular end. After the reestablishment of blood flow, successful anastomoses were achieved and immediate rethrombosis or spasm did not occur. No long-term sequelae associated with balloon trauma to the arterial wall were observed. Conclusion: The use of the Fogarty catheter can be an effective method in treating pedicle thrombosis and spasm. This is a very simple and rapid technique that offers microvascular surgeons another option to increase the success rate of microvascular anastomosis in free tissue transfers.

• Journal of the Korean Society of Visualization
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• v.21 no.1
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• pp.80-93
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• 2023

We performed numerical simulations of blood flow in an arterial cerebral artery aneurysm to investigate the hemodynamic behavior after coil embolization. A patient-specific model was created based on CTA data. We also conducted the coil embolization simulation to obtain the coil placement within the aneurysm. Blood was assumed to be an incompressible Newtonian fluid, and both the vessel and coil were considered rigid walls. The pulsatile boundary condition was applied at the inlet, and the outflow boundary conditions were used at the outlets. Our findings demonstrated that the coil embolization significantly reduces the blood volume flowrate entering the aneurysm by effectively blocking the inflow jet, leading to a decrease in both TAWSS and WSS, especially at the systolic peak in the impingement zone. While several high OSI regions disappeared over the aneurysm surface, we observed high OSI regions with a relatively small area where the coil did not completely occlude the aneurysm. Overall, these results quantitatively analyzed the effectiveness of coil embolization by focusing on hemodynamic indicators, potentially preventing aneurysm rupture. The present work could contribute to the development of patient-specific coil embolization.

• Investigative Magnetic Resonance Imaging
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• v.6 no.1
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• pp.41-46
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• 2002

The Fourier transform arteriography (FTA) exploits the periodic variation of arterial flow velociety of arterial flow velocity in stnchronized with cardiac cycles. This technique is intrinsically unique compared to other modern techniques. This technique separates the arteries from the veins using the pulsatile arterial flow without using the presaturation RF pulses. Therefore, it has less RF deposition and is free from the dark band artifacts that can arise from retrograde flow and curved arteries. Furthermore, it is free from the artifacts induced by eddy currents. However, there are some drawbacks such as a single projection view and the saturation of arteries at the end of an imaging slab. These drawbacks are circumvented by applying recently developed techniques. The fast gradient switching capability of modern MRI systems enabled us to incorporate dual projection views into the conventional FTA sequence without increasing the repetition time. In addition, signals from the distal arteries were enhanced by use of a ramped RF pulse and therefore the distal arteries were less saturated. By use of the FTA sequence with dual projection views and the ramped RF pulse, we acquired the sagittal and coronal projection views of femoral arteriograms simultaneously with more enhanced signals of distal arteries than the conventional FTA.