• Title/Summary/Keyword: Public University

Search Result 23,484, Processing Time 0.049 seconds

Acute Intramuscular Toxicity Study of Typhoid Vaccine in Rats and Beagle Dogs

  • Lee, Won-Woo;Che, Jeong-Hwan;Li, Guang-Xum;Kang, Byeong-Cheol;Ihm, Jong-Hee;Jun
    • Toxicological Research
    • /
    • v.15 no.1
    • /
    • pp.69-73
    • /
    • 1999

  • Acute toxicity of typhoid vaccine was investigated using Sprague-Dawley (SD) rats and beagle dogs. SD rats and beagle dogs were administered intramuscularly with dosages of 0,. 0.2, 0.1, 0.05 and 0.025 mg/kg, respectively. In animals administered with typhoid vaccine, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical signs and autopsy findings. Therefore, LD50 of typhoid vaccine was considered to be higher than 0.2 mg/kg in SD rats and beagle dogs.

  • PDF

Association of asthma with $\beta$2-adrenergic receptor gene, Epoxide Hydrolase gene and CD14 gene polymorphism in Korean population

  • Kwon, Seul-ah;Lee, Young-Jun;Lee, Ra mi;Jung, Hyun-Sook;Song, Joo-Young;Chung, Hai-Won
    • Proceedings of the Korean Society of Toxicology Conference
    • /
    • 2002.11b
    • /
    • pp.177-177
    • /
    • 2002

  • In order to investigate the association of genetic factor with asthma and contribution of the genetic interactions to the incidence of asthma in Korean population, the genetic polymorphisms of Epoxide Hydrolase(EH), CD14 and ${\beta}$2-adrenergic receptor genese(${\beta}$2AR) among 33 asthma patients and 66 controls were examined.(omitted)

  • PDF