Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Acute Intramuscular Toxicity Study of Typhoid Vaccine in Rats and Beagle Dogs

  • Lee, Won-Woo (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Che, Jeong-Hwan (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Li, Guang-Xum (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Kang, Byeong-Cheol (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Ihm, Jong-Hee (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Jun (Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University)
  • Published : 1999.03.01
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Abstract

Acute toxicity of typhoid vaccine was investigated using Sprague-Dawley (SD) rats and beagle dogs. SD rats and beagle dogs were administered intramuscularly with dosages of 0,. 0.2, 0.1, 0.05 and 0.025 mg/kg, respectively. In animals administered with typhoid vaccine, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical signs and autopsy findings. Therefore, LD50 of typhoid vaccine was considered to be higher than 0.2 mg/kg in SD rats and beagle dogs.

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References

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