Next generation sequencing (NGS), a high-throughput DNA sequencing technology, is widely used for molecular biological studies. In NGS, RNA-sequencing (RNA-Seq), which is a short-read massively parallel sequencing, is a major quantitative transcriptome tool for different transcriptome studies. To utilize the RNA-Seq data, various quantification and analysis methods have been developed to solve specific research goals, including identification of differentially expressed genes and detection of novel transcripts. Because of the accumulation of RNA-Seq data in the public databases, there is a demand for integrative analysis. However, the available RNA-Seq data are stored in different formats such as read count, transcripts per million, and fragments per kilobase million. This hinders the integrative analysis of the RNA-Seq data. To solve this problem, we have developed a web-based application using Shiny, COEX-seq (Convert a Variety of Measurements of Gene Expression in RNA-Seq) that easily converts data in a variety of measurement formats of gene expression used in most bioinformatic tools for RNA-Seq. It provides a workflow that includes loading data set, selecting measurement formats of gene expression, and identifying gene names. COEX-seq is freely available for academic purposes and can be run on Windows, Mac OS, and Linux operating systems. Source code, sample data sets, and supplementary documentation are available as well.
Park, Choon Seon;Park, Nam Hee;Sim, Sung Bo;Yun, Sang Cheol;Ahn, Hye Mi;Kim, Myunghwa;Choi, Ji Suk;Kim, Myo Jeong;Kim, Hyunsu;Chee, Hyun Keun;Oh, Sanggi;Kang, Shinkwang;Lee, Sok-Goo;Shin, Jun Ho;Kim, Keonyeop;Lee, Kun Sei
Journal of Chest Surgery
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v.49
no.sup1
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pp.28-36
/
2016
Background: This study aimed to develop the models for regional cardiac surgery centers, which take regional characteristics into consideration, as a policy measure that could alleviate the concentration of cardiac surgery in the metropolitan area and enhance the accessibility for patients who reside in the regions. Methods: To develop the models and set standards for the necessary personnel and facilities for the initial management plan, we held workshops, debates, and conference meetings with various experts. Results: After partitioning the plan into two parts (the operational autonomy and the functional comprehensiveness), three models were developed: the 'independent regional cardiac surgery center' model, the 'satellite cardiac surgery center within hospitals' model, and the 'extended cardiac surgery department within hospitals' model. Proposals on personnel and facility management for each of the models were also presented. A regional cardiac surgery center model that could be applied to each treatment area was proposed, which was developed based on the anticipated demand for cardiac surgery. The independent model or the satellite model was proposed for Chungcheong, Jeolla, North Gyeongsang, and South Gyeongsang area, where more than 500 cardiac surgeries are performed annually. The extended model was proposed as most effective for the Gangwon and Jeju area, where more than 200 cardiac surgeries are performed annually. Conclusion: The operation of regional cardiac surgery centers with high caliber professionals and quality resources such as optimal equipment and facility size, should enhance regional healthcare accessibility and the quality of cardiac surgery in South Korea.
The purpose of this survey was to measure the health service activity of the Public health nurses and analyze the related factors influencing to their activities. The subjects of this study were 249 PHN in Health Centers, Pusan and Kyung Nam area and survey was conducted from 5th, January to 28th, February, 1987. The results of this study were as follow; 1. Total performance average of health service activities was 2.52. Among the 1 t health categories, health service planning (3.05) was the most and others health care (2.07) was the least active. 2. In performed degree of activities in department of Health Center. The hightest performed activities were T.B care in T.B clinic (3.79), family planning in family planning clinic (3.94), screening for disease in medical office (3.42), prenatal care in M.C.H. room (3.46) work planning in injection room (3.76), postpartum care in MCH center (3.63). 3. There were significient difference in age, education, religion, section of service, duty between the general characteristics and health service activities.(p<.05).
The Journal of the Convergence on Culture Technology
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v.8
no.5
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pp.297-306
/
2022
This study In relationship between knowledge, health beliefs, and preventive health behavior of corona 19 was made for the purpose of the investigation of nursing college students in health care practice.,The survey target was 231 persons, and the data collected from October 27, 2021 to November 4, 2021 was analyzed using the SPSS23.0 program.,In order to examine factors affecting preventive health behavior of nursing college students for corona 19, hierarchical regression analysis was carried out.,The degree of regression model fitness (F=9.71, p<.005) was related to major satisfaction (β=.18, p=.009), corona 19 knowledge (β=.20, p=.001), corona 19 health belief (β=.36, p=.000) and the descriptive power was 30.6%.,Therefore, it is necessary to develop a strategy of the health education program to promote preventive health behavior for corona 19 of nursing college students.
This study has targeted to comparatively analyze smoking cessation success rates and success factors among new enrollees and re-enrollees in Smoking Cessation Clinics for its efficient operation. A total of 319,908 smokers who were enrolled in the Smoking Cessation Clinics in one of 253 public health centers across the nation for more than 6 months from July 16, 2009 to July 15, 2010 were examined. According to the comparative analysis, the following results have been obtained. According to the results, it has been confirmed that it is necessary to determine why smoking cessation success rates are low and take additional efforts to increase the rates for the effective operation of smoking cessation clinics. In addition, smoking cessation success rates were higher when only BT(Behavior Therapy) was given than when both BT and NRT(Nicotine Replacement Therapy) were provided to new enrollees while they were lower when only BT was provided than when both BT and NRT were given to re-enrollees. Therefore, it is necessary to provide differentiated service types depending on the type of enrollment. Hence, it is also required for the government to take various approaches in terms of a direction for a smoking cessation policy.
Objectives: The aim of the study was to identify the effects of a community-level individual health counseling program for community. Methods: Data included baseline demographics, blood pressure, blood sugar, waist circumference, total cholesterol and health behavior index(body mass index, dietary practice guidelines score, physical activity, high-risk drinking) collected at public health centers in Chungnam province from January to September, 2011. Data obtained from the individual health counseling program in Chungnam province were analyzed using Wilcoxon Signed Rank Test and McNemar Test. Results: After the individual health counseling intervention, the results of health measurement index; systolic blood pressure, diastolic blood pressure, total cholesterol, waist circumference decreased in the health risk group, while total cholesterol and waist circumference decreased in the disease management group. Health behavior change in both groups. Body mass index, moderate physical activity, dietary practice guidelines scores were improved. Conclusions: These results indicate that the individual health counseling program for community was effective in improving health behaviors and status. The results demonstrate that step-by-step counseling program development and intervention studies are needed.
Bae, Sung-Heui;Choi, Eun-Ok;Lee, In sook;Lee, In Young;Chun, Chae min
Journal of Korean Biological Nursing Science
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v.18
no.3
/
pp.144-152
/
2016
Purpose: This study compares beneficiaries of Korean Medicaid with those under the National Health Insurance program, seeking to understand how each group utilizes their healthcare. Methods: Data were obtained from a Health Promotion Survey in 2005. Health status was measured by the respondents' perception of health. Health service utilization included the availability of healthcare services, the type of healthcare institution, and intent to revisit. Predisposing and enabling factors, as well as health care needs were used for this study. Results: Compared to National Health Insurance beneficiaries, Medicaid beneficiaries reported lower levels of health status and fewer enabling factors. They had more chronic diseases and disabilities. Education level, existence of chronic diseases, exercise patterns, and disabilities were associated with health status. Conclusion: We found that Medicaid beneficiaries had fewer resources and higher levels of health needs. As Medicaid is reformed, policy makers and administrators should understand healthcare utilization behaviors of Medicaid beneficiaries and the factors hindering access to care.
The purpose of this study was to develop a home health care model in the public health system and to test the effectiveness of the model. Seven com-munity health practitioners in Yon- Cheon county. Kyunggi province, carried out home health care service for this research. The subjects of the home health care were a total of 111 community residents with chronic health problems and risk-prone infants and children; 29 persons with hypertension, 18 persons with diabetes, 12 persons with neurologic problems, 12 elderly, and 40 infants and children. During the period of study, from December, 1993 to March, 1995, a demonstrative home health care model was developed in the Yon-Cheon County community health centers with the cooperation of the Yon-Cheon Medical Center and Yon-Cheon Public Health Center for the first six months. A home care practice manual and recording system for home visits were also co-developed by the researchers and community health practitioners. Four workshops and monthly conferences were held for this purpose. Actual home care practice took place for two months, and on-going evaluation and replanning accompanied this process. The result of the evaluation of home care service were as follows. 1) For persons with hypertension, diabetes, neurologic problems, there was significant improvement in knowledge of disease and care, but no significant difference was seen in health behavior or symptoms after home care service. 2) No significant difference was seen in level of self esteem or depression after reminiscence therapy among 12 elderly subjects. 3) There were significant differences in satis-faction toward child rearing and parental sup-port, but no significant difference In education needs for parental role after home care service among parents of infants and children. 4) There was significant improvement in the quality of life among the subjects after the home care service. 5) Subjects responded that they were highly satisfied with the home care service given by the community health practitioners. Although, the actual implementation period was very short, and not all of the evaluation outcomes showed significant improvement, the home health care model of community health practitioners was, in general, positively evaluated. Through this re-search, the possibility of community health practitioners working as active home care personnel in the public health care system is supported. Further research with an expanded area and subjects for a longer period is recommended. Cost effectiveness research is also needed.
Purpose: This study examined the characteristics of in-home injuries of children in low-income families and sought to identify the factors affecting parental in-home injury prevention practices. Methods: A cross-sectional descriptive survey design was applied, using questionnaires on in-home injury characteristics in children, parental in-home injury prevention practices, parental perceptions and knowledge on childhood injuries, and the Parental Stress Index. We queried 169 parents of children less than 5years of age who were enrolled in Nutrition Plus Projects at community health centers. Results: Overall, 92.7% of children had experienced in-home injuries, with sliding crashes and bumping injuries as the most frequent type of injury. The recovery rate with a scar after injury was 26.3%. Parental practices for in-home injury prevention were higher according parental age, educational status, and previous learning experiences regarding in-home safety and injury prevention. The two most significant factors affecting parental in-home injury prevention practices were age and parental perception of childhood injuries as being controllable and preventable. Conclusions: Considering the high risk of in-home childhood injuries in low-income families, safety education and the promotion of injury prevention practices for parents are recommended. The strategy to enhance the parental perception on preventing childhood injuries needs to be addressed.
Purpose: The purpose of this study is to investigate the drinking, stress, and sleep on depression of Korean obese women. Methods: The data of this study were derived from the Sixth Korea National Health and Nutrition Examination Survey (KNHANES VI-3), conducted from January to December 2015 by Korea Centers for Disease Control and Prevention. The study subjects were 935 adult women between 20 and 70 years old (Body Mass Index${\geq}25$). The data were analyzed by the complex sampling design method applying the weights to the IBM SPSS 23.0 program. Results: The study result showed that the frequency of binge drinking, stress perception, sleeping time and depression of Korean obese women showed significant differences according to age group. In the 20-30's, the stress and sleeping time, the 40-50's were drinking at once, the frequency of drinking and stress, and the drinking and stress at 60-70's were significantly associated with an increased risk of depression in obese women. Conclusion: The intervention program for the management of depression in Korean obese women should include the strategies for managing stress and drinking, taking into account differences according to age.
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