• Korean Journal of Schizophrenia Research
• /
• v.23 no.2
• /
• pp.51-57
• /
• 2020

Treatment-resistant schizophrenia (TRS) has been defined as the persistence of positive symptoms despite two or more trials of antipsychotic medication of adequate dose and duration. TRS is a serious clinical problem and occurs in approximately 30% of patients with schizophrenia. It is important that patients who do not adequately respond to antipsychotics be reevaluated to exclude or address causes other than non-responsiveness to medication, that is, the possibility of pseudo-resistance. In particular, non-adherence to oral antipsychotic treatment should be monitored to rule out pseudo-resistant cases of TRS. Moreover, patients with TRS who take their medication as required may have subtherapeutic antipsychotic plasma levels, secondary to pharmacokinetic factors. In this paper, we review the concept and exclusion of pseudo-resistance, especially owing to non-adherence or pharmacokinetic factors, and present methods to enhance drug adherence.

• Archives of Pharmacal Research
• /
• v.21 no.3
• /
• pp.344-347
• /
• 1998

To overcome multidrug resistance (MDR) in cancer chemotherapy, we prepared various plant extracts and searched for a component which is effective for inhibition of MDR. MDR inhibition activity was determined by measuring cytotoxicity to MDR cells using multidrug resistant human fibrocarcinoma KB V20C, which is resistant to 20 nM vincristine and expresses high level of mdr1 gene. Of various plant extracts, the MeOH extract of the root of Aconitum pseudo-laeve var. erectum was found to have potent inhibitory activity on MDR. The bioassayguided fractionation of the MeOH extract of the plant led to the isolation of an alkaloid, lycaconitine, as an active principle. And the $IC_{50}$ of lycaconitne for KB V20C cells was $74\mu{g}$/ml.

• Structural Engineering and Mechanics
• /
• v.58 no.2
• /
• pp.327-345
• /
• 2016

Many experimental and analytical studies have been conducted with beam-column subassemblages composed of a two-span beam to investigate the progressive collapse resistance of RC frames. Most study results reveal a strength-decreased transition phase in the nonlinear static load-deflection curve, which may induce dynamic snap-through response and increase the chord rotation demand for effective catenary action (ECA). In this study, the nonlinear static response is idealized as a piecewise linear curve and analytical pseudo-static response is derived for each linearized region to investigate the rotation demands for the ECA of the two-span RC beams. With analytical parameters determined from several published test results, numerical analysis results indicate that the rotation demand of 0.20 rad recommended in the design guidelines does not always guarantee the ECA. A higher rotation demand may be induced for the two-span beams designed with smaller span-to-depth ratios and it is better to use their peak arch resistance (PAR) as the collapse strength. A tensile reinforcement ratio not greater than 1.0% and a span-to-depth ratio not less than 7.0 are suggested for the two-span RC beams bridging the removed column if the ECA is expected for the collapse resistance. Also, complementary pseudo-static analysis is advised to verify the ECA under realistic dynamic column loss even though the static PAR is recovered in the nonlinear static response. A practical empirical formula is provided to estimate an approximate rotation demand for the ECA.

• Proceedings of the KWS Conference
• /
• 2003.11a
• /
• pp.45-48
• /
• 2003

Over the past few decades, there has been increasing research and commercial activity in invasive and non-invasive biomedical technology. One important challenge to developing these devices involves the increasing density of electrical interconnects. Resistance spot welding is limited in the density of interconnect based on either the size of welding head or the positional precision with which a weld can be made. Development of an automated laser microwelding system would permit the continued advancement of these important biomedical technologies. The objective of this work is to demonstrate the application of pseudo-pulse Nd:YAG laser technology as an alternative to resistance spot welding in performing electrical interconnection within biomedical products. To date, some experiments have been conducted by using a pseudo-pulse 1064 nm Nd:YAG laser, a successful weld of a 25 ${\mu}{\textrm}{m}$ diameter Pt/Ir wire to a 316 stainless steel shim can be made. Another application involves welding clips, which may be used for external interconnection, to electrodeposited nickel domes that make particular interconnections to specific insulated wires within a cable. These results show a great deal of promise for developing such a process.

• Proceedings of the Korean Institute of Building Construction Conference
• /
• 2008.11a
• /
• pp.199-203
• /
• 2008

With recent trend in domestic and global market requiring architectures' conversion into skyscrapers seasoned with the features of landmarks, structural problems in relation with explosive spatting during fire emergencies are arising as controversial issues. Accordingly, many productive researches have been made in relation to the reinforcement techniques for improving fire resistance and the number of applications in the field is gradually increasing. In this study, a ductile outline form using ECC (Engineered Cementations Composites) was made with improvements on the structure and fire resistance to examine its applicability. Also, currently in Japan, the number of studies and applications is increasing focusing on reduction of construction time and improvement of workability with application of Half-PCa method. However, using such method of construction, large structural members decrease the utilization of space and architecture-wise, there is a disadvantage of the weight increase. Therefore, in such context, it would be worth reducing the weight of the structural members by reducing the size using ECC. In addition, its excellent pseudo strain-hardening due to fiber may have great effects on seismic designs. In the mean time, this study planned 3 equal conditions for mix water, PVA fiber and additives excluding binder and refractory to evaluate the mechanical properties of resistance against pressure and internal force. Finally, an evaluation was executed on the fire resistance of the newly made ductile outline form. As a result, from ECC-I to ECC-III, all showed excellent mechanical properties due to pseudo strain-hardening and in the fire resistance test conducted with ISO 834 heating curve, most of them tended to be in the range of the reference temperature (538℃-180min), so there was no occurrence of any explosive spatting.

• Membrane Journal
• /
• v.13 no.2
• /
• pp.88-100
• /
• 2003

A change of filtrate flux in Taylor vortex flow filtration was investigated experimentally by rotating speed of inner cellulose ester membrane cylinder (average pore size: 1.2 ${\mu}m$), slurry concentration, and particle size. The filtrate flux was a direct proportion relation with TMP, but an inverse relation with resistances. A change of cake resistance with time was examined by rotating speed, slurry concentration, and particle size. Initial resistance increased dramatically as raising slurry concentration, and the pseudo-steady state was maintained at high resistance value. However, times to reach the pseudo-steady state did not depend on slurry concentration. The resistance was larger as smaller particle size, because possibility of pore blocking inside membrane could be higher and shear effect should be lower as smaller particle size. A model equation suggested in this study was composed of particle deposition and removal terms, and could confirm well experimental data using average values of experimental coefficients.

• Korean Journal of Metals and Materials
• /
• v.48 no.3
• /
• pp.225-234
• /
• 2010

Salt bath nitriding, which has been developed recently by domestic company, is an emerging ecofriendly surface treatment. The salt bath nitriding is accompanied by the electrolysis process in the pretreatment step, and this whole processis called Pseudo-Electrolysised Salt bath Nitriding (PESN). The PESN creates only $NH_3$ and non-toxic salts without harmful $CN^{-}$ or toxic gas such as that found in previous salt bath nitriding. In general, ion nitriding and gas nitriding create high hardness and a strong brittle white layer on the surface. However, the PESN shows a thin white and gray layer. The PESN was applied to the defense material, 3%Cr-Mo-V steel, to study the surface characteristics at $480^{\circ}C$, $530^{\circ}C$, and $580^{\circ}C$ for 4 hrs, 20 hrs, 40 hrs, and 60 hrs of nitriding time condition. As a result, the best nitriding layer was found at $530^{\circ}C$ for 40 hrs. If we improve corrosion resistance and nitriding layer depth, the PESN will be able to be applied to the defense industry parts.

• Proceedings of the Earthquake Engineering Society of Korea Conference
• /
• 2002.03a
• /
• pp.250-257
• /
• 2002

Pseudo dynamic test is an on-line computer control method to achieve the realism of shaking table test with the economy and versatility of the conventional quasi-static approach Pseudo dynamic tests of six full-size RC bridge piers have been carried out to investigate their seismic performance. For the purpose of precise evaluation, the experimental investigation was conducted to study the seismic performance of the real size specimen, which is constructed for highway bridge piers in Korean peninsula. Since it is believed that Korea belongs to the moderate seismicity region, five test specimens were designed in accordance with limited ductility design concept. Another one test specimen was nonseismically designed according to a conventional code. Important test parameters were transverse reinforcement and lap splicing. Lap splicing was frequently used in the plastic hinge region of many bridge columns. Furthermore, the seismic design code is not present about lap splice in Korean Roadway Bridge Design Code. The results show that specimens designed according to the limited ductility design concept exhibit higher seismic resistance. Specimens with longitudinal steel lap splice in the plastic hinge region appeared to significantly fail at low ductility level.

• JSTS:Journal of Semiconductor Technology and Science
• /
• v.10 no.4
• /
• pp.309-315
• /
• 2010

A fully-differential low-voltage low-power electrocardiogram (ECG) amplifier by using the nonfeedback PMOS pseudo-resistors is proposed. It consists of two operational-transconductance amplifiers (OTA) in series (a preamplifier and a variable-gain amplifier). To make it insensitive to the gate leakage current of the OTA input transistor, the feedback pseudo-resistor of the conventional ECG amplifier is moved to input branch between the OP amp summing node and the DC reference voltage. Also, an OTA circuit with a Gm boosting block without reducing the output resistance (Ro) is proposed to maximize the OTA DC gain. The measurements shows the frequency bandwidth from 7 Hz to 480 Hz, the midband gain programmable from 48.7 dB to 59.5 dB, the total harmonic distortion (THD) less than 1.21% with a full voltage swing, and the power consumption of 233 nW in a 0.13 ${\mu}m$ CMOS process at the supply voltage of 0.7 V.

• Proceedings of the Korea Concrete Institute Conference
• /
• 2002.05a
• /
• pp.885-890
• /
• 2002

Pseudo dynamic test is an on-line computer control method to achieve the realism of shaking table test with the economy and versatility of the conventional quasi-static approach. Pseudo dynamic tests of four full-size RC bridge piers have been carried out to investigate their seismic performance. For the purpose of precise evaluation, the experimental investigation was conducted to study the seismic performance of the real size specimen, which is constructed for highway bridge piers in Korean peninsula. Since it is believed that Korea belongs to the moderate seismicity region, three test specimens were designed in accordance with limited ductility design concept. Another one test specimen was nonseismically designed according to a conventional code. Important test parameters were transverse reinforcement and lap splicing. Lap splicing was frequently used in the plastic hinge region of many bridge columns. Furthermore, the seismic design code is not present about lap splice in Korean Roadway Bridge Design Code. The results show that specimens designed according to the limited ductility design concept exhibit higher seismic resistance. Specimens with longitudinal steel lap splice in the plastic hinge region appeared to significantly fail at low ductility level.