• 혜화의학회지
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• 제14권2호
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• pp.133-136
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• 2005

Objective : There are no Clinical reports on Nephrotic syndromes Which the patients improved by only oriental medical treatment. Method : We had administered Sin Youm-Bang for three months, and that time the patient didn't take the western medicine anymore by her own(steroid). And we observe edema, fatigue, headache, dizziness, lumbago and 24'h proteinuria, when we use only Sin Youm Bang. Result : We use Sin Youm-Bang during 3 month, edema, fatigue, headache, dizziness, lumbago was disappeared. And also 24'hr proteinuria was decreased(520mg/day to 28mg/day). Conclusion : Accordingly, We think, Sin Youm-Bang is used to Nephrotic syndromes and from now on we need more study at protecting proteinuria mechanism and immunological mechanism of Sin Youm Bang.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제19권2호
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• pp.139-142
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• 2016

The coexistence of Wilson disease with Alport syndrome has not previously been reported. The diagnosis of Wilson disease and its ongoing monitoring is challenging when associated with an underlying renal disease such as Alport syndrome. Proteinuria can lead to low ceruloplasmin since it is among serum proteins inappropriately filtered by the damaged glomerulus, and can also lead to increased urinary loss of heavy metals such as zinc and copper. Elevated transaminases may be attributed to dyslipidemia or drug induced hepatotoxicity. The accurate diagnosis of Wilson disease is essential for targeted therapy and improved prognosis. We describe a patient with a diagnosis of Alport syndrome who has had chronic elevation of transaminases eventually diagnosed with Wilson disease based on liver histology and genetics.

• 대한수의학회지
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• 제46권1호
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• pp.77-81
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• 2006

A 1-year and 6-month-old, intact male, Shih-tzu dog was referred to the Konkuk University Veterinary Teaching Hospital, due to ascite, melena, severe anemia, and polyuria/polydipsia. Complete blood count showed moderate leukocytosis, lymphocytosis, monocytosis, and microcytic hypochromic nonregenerative anemia. On serum biochemistry profiles, hypoalbuminemia and hypoproteinemia were observed, and proteinuria was detected on urinalysis. Pleural effusion and mild ascites were noted in radiological findings, and bilateral nephromegaly was noted on ultrasonography. Babesia gibsoni was detected by PCR. Babesiosis and glomerular disease was treated at a time with prednisolone and buparvaquone. This therapeutic regime was very efficacious and clinical sings were rapidly improved. Proteinuria and severe anemia were disappeared following therapy.

• Childhood Kidney Diseases
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• 제27권2호
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• pp.133-138
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• 2023

Nutcracker syndrome (NCS) is a disease caused by compression of the left renal vein between the superior mesenteric artery and the abdominal aorta. Immunoglobulin A (IgA) nephropathy (IgAN) is characterized by the predominance of IgA deposits in the glomerular mesangial area. Hematuria and proteinuria can be present in both diseases, and some patients can be concurrently diagnosed with NCS and IgAN; however, a causal relationship between the two diseases has not yet been clarified. Here, we report two pediatric cases of NCS combined with IgAN. The first patient presenting with microscopic hematuria and proteinuria was diagnosed with NCS at the initial visit, and the second patient was later diagnosed with NCS when proteinuria worsened. Both patients were diagnosed with IgAN based on kidney biopsy findings and treated with angiotensin-converting enzyme inhibitors and immunosuppressants. A high index of suspicion and timely imaging or biopsy are essential for the proper management of NCS combined with glomerulopathy.

• Childhood Kidney Diseases
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• 제22권2호
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• pp.91-96
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• 2018

Nephrotic syndrome in the first year of life, characterized by renal dysfunction and proteinuria, is associated with a heterogeneous group of disorders. These disorders are often related to genetic mutations, but the syndrome can also be caused by a variety of other diseases. We report an infant with nephrotic syndrome associated with a neuroblastoma. A 6-month-old girl was admitted with a 10% weight loss over 10 days and nephrotic-range proteinuria. She was ill-looking, and her blood pressure was higher than normal for her age. Her cystatin-C glomerular filtration rate was decreased, and levels of plasma renin, aldosterone, and catecholamines were elevated. Renal ultrasonography and abdominal computed tomography showed a retroperitoneal prevertebral mass encasing both renal arteries and the left renal vein. The mass was partially resected laparoscopically, and the pathologic diagnosis was neuroblastoma. Findings on a simultaneous renal biopsy were unremarkable. The patient was treated with chemotherapy and several anti-hypertensive drugs, including an alpha blocker. Two months later, the mass had decreased in size and the proteinuria and hypertension were gradually improving. In an infant with abnormal renin-angiotensin system activation, severe hypertension, and nephrotic-range proteinuria, neuroblastoma can be considered in the differential diagnosis.

• Childhood Kidney Diseases
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• 제14권1호
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• pp.94-99
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• 2010

Obesity-related glomerulopathy (ORG)는 단백뇨를 보이는 비만아에서 신장 조직학적 소견상 사구체 비대, 국소 분절성 사구체 경화 소견이 관찰되고 기저막 비후, 국소 간질조직 증식, 중등도의 발 돌기 소실 등을 보이는 질환으로 정의된다. 특발성 국소분절 사구체경화증과 비교하여 신증후군이 적으며 콜레스테롤 상승이 적고, 병의 진행이 느리다는 점에서 차이가 있다고 알려져 있으며, 체중감소를 통해 신장 기능이 회복될 수 있다고 알려져 있다. 본 증례의 9세된 비만아는 임상증상과 신장 조직검사에서 ORG로 진단되어 치료하였으나, 지속적인 체중 증가와 단백뇨로 말기 신부전으로 진행하여 소아 ORG 환아에서는 드문 경과를 취하여 이를 보고하는 바이다.

• Journal of Nutrition and Health
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• 제23권6호
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• pp.451-458
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• 1990

고혈압 증세를 나타내는 정상체중과 비만의 SHR/Mcc-cp 숫쥐들에게 0.001% estrone 식이를 생후 6주부터 18주까지 투여하고, 매주 일회 24시간 금식 시키는 동안 뇨를 채취하여 뇨단백량을 측정하였다. Estrone 식이를 시작하기 직전에는 정상체중의 쥐와 비만의 주 모두에게서, estrone 식이군과 대조군 사이에 뇨단백량이 있어서, 유의한 차이가 없었다. 그러나, 정상체중의 쥐에게서, estrone 투여후 1주부터 estrone 식이군의 뇨단백량이 내조군에 비해 유의적으로 낮았다(p<0.05). 비만인 쥐도 estrone 식이후 1주부터 estrone 식이 군의 뇨단백량이 대조군에 비해 현저하게 낮아지기 시작해서 제 5주부터는 유의한 차이가 보였다. 그러므로, 0.001% estrone 식이가 성장기의 정상체중과 비만의 SHR/Mcc-cp 숫쥐들의 단백뇨 상태를 호전시킴을 발견했다. 또한, SHr/Mcc-cp 쥐들이 13주령 이전에는 정상체중의 쥐들이 비만인 쥐들보다, 더 높은 뇨단백량을 보였으나, 그이후부터 18주 사이의 주령에는 정상체중의 쥐와 비만의 쥐들 사이에는 유의적 차이가 없었다. 그러므로, SHR/Mcc-cp 쥐에게 있어서, 비만증 자체가 단백뇨 증세를 악화시키는 요인이 아님을 알 수 있었다.

• 대한한방부인과학회지
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• 제34권4호
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• pp.1-11
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• 2021

Objectives: Nephrotic syndrome is a kidney disorder, which is characterized by proteinuria, edema (swelling), and hyperlipidemia. Maydis Stigma (Corn silk) has been widely used in Asia as a traditional medicine and is known to have a diuretic effect and is used for the treatment of edema and indigestion. Methods: The aim of this study is to investigate the improvement effect of Maydis Stigma in treating nephrotic syndrome induced by puromycin aminonucleoside. Sprague-Dawley rats were intravenously injected with 75 mg/kg/day puromycin aminonucleoside, then treated with either Losartan or 200 mg/kg/day Maydis Stigma for seven days. Results: Maydis Stigma significantly decreased ascites and proteinuria level. Plasma levels of blood urea nitrogen (BUN) and plasma creatinine reduced significantly by Maydis Stigma. In addition, treatment with Maydis Stigma attenuated histological damage. Treatment with Maydis Stigma also restored podocin expression and reduced inflammation markers such as intracellular adhesion molecules (ICAM-1), monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor alpha (TNF-α) and high-mobility group box-1 (HMGB1). Conclusions: Maydis Stigma ameliorates kidney injury in nephrotic syndrome rat models. Maydis Stigma exerts a renoprotective effect owing to its anti-inflammatory effects and reductions of ascites and proteinuria. Thus, these results indicate that Maydis Stigma is likely to be a promising agent in the treatment of nephrotic syndrome.

• 한국임상약학회지
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• 제30권4호
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• pp.259-263
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• 2020

Background: Dual-type calcium channel blockers (CCBs), such as efonidipine and cilnidipine, are renoprotective drugs that reportedly reduce proteinuria by dilating afferent and efferent arterioles of the glomerulus. However, studies comparing the effect of dual-type CCB on proteinuria have not been conducted. Therefore, we aimed to compare the effect of dual-type CCB (efonidipine and cilnidipine) usage patterns in hypertensive patients with chronic kidney disease (CKD). Methods: This single-center, retrospective study included 53 patients with CKD who 1) initiated efonidipine or cilnidipine treatment while on a renin-angiotensin system inhibitor and 2) had received efonidipine or cilnidipine for at least one year. We compared usage patterns between the efonidipine and cilnidipine groups during the one-year period and analyzed the following outcomes: urinary protein-to-creatinine ratio, blood pressure, and serum creatinine. Results: The study included 25 patients in the efonidipine group and 28 patients in the cilnidipine group. In both groups, blood pressure and urinary protein-to-creatinine ratios tended to decrease; however, the change during each interval was not significant. Conclusions: In patients with CKD who were on renin-angiotensin system inhibitor therapy, the addition of a dual-type CCB (i.e., efonidipine or cilnidipine) tended to reduce proteinuria; however, the change during each interval was not significant.

• Childhood Kidney Diseases
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• 제5권2호
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• pp.156-163
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• 2001

목 적 : 본 연구의 목적은 집단뇨검사의 대상으로 8세 전후의 어린이가 포함되는 것이 타당한지 또한 혈뇨 검사를 집단뇨검사에 포함시키는 것이 실효성이 있는지를 알아 보고자 하였다. 대상 및 방법 : 파주 지역 초등학생 2,804명을 대상으로 모두 3차에 걸쳐 단계적 요검사와 정밀 검사를 실시하여 단백뇨와 혈뇨의 유병율을 조사하였다. 요검사 이상자를 대상으로 정밀 검사를 시행하여 실제 신질환의 유병율을 알아보고 집단뇨검사의 유용성을 검증하였다. 결 과 : 파주 지역 초등학생 8세군에서 나타난 무증상 요검사이상 유병율은 $8.3\%$로 각각 단백뇨 $2.3\%$, 혈뇨 $5.8\%$였고 혈뇨와 단백뇨를 동시에 보인 경우는 $0.2\%$로 조사되었다. 1차 선별 검사 이상자 233명중 102명이 2차 검사에 응하여 이들 중 약 1/3인 32명이 다시 양성자로 나타났고 혈뇨가 $41.7\%$, 단백뇨가 $0\%$, 동시에 양성인 경우가 $66.7\%$로 2차 검사에 이상자로 확인되었다. 3차검사에 응한 32명중 30명은 단독 혈뇨증을 보였고 2명은 혈뇨와 단백뇨가 동시 확인되었다. 이들 단독 혈뇨증을 보인 30명 중6명은 정상으로 나타났고, 21명은 특발성 단독 현미경적 혈뇨, 나머지 3명은 요로감염증 1명, 특발성 과칼슘뇨증 1명, 단순 신낭종 1명로 확인되었다. 혈뇨와 단백뇨를 동시에 보인 2명은 만성 사구체 신염을 가지고 있는 것으로 생각되었다. 결 론 : 본 연구의 집단뇨검사에서 단백뇨와 혈뇨의 유병율 $2.3\%,\;5.8\%$로 조사되었고 이들 중 대부분이 정상으로 나타나 집단뇨검사의 특이성이 낮은 것을 알 수 있었다. 검사 대상에 8세군을 포함시키는 문제에 관해서 본 연구에서 비교적 높은 양성율을 보였다는 점을 감안하면 집단뇨검사에 8세군을 포함하는 것이 타당하다고 생각되었다.