• Title/Summary/Keyword: Protective efficacy

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Biological control of Flavobacterium psychrophilum infection in ayu (Plecoglossus altivelis altivelis) using a bacteriophage PFpW-3

  • Kim, Ji Hyung;Park, Se Chang
    • Korean Journal of Veterinary Research
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    • v.58 no.1
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    • pp.39-43
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    • 2018
  • The efficacy of using a bacteriophage (phage) to control Flavobacterium psychrophilum (F. psychrophilum) infection of ayu (Plecoglossus altivelis altivelis) was evaluated in this study. Intramuscular challenge failed to induce sufficient infection levels; therefore, a newly designed net-scratch challenge method was also used to induce bacterial infection. Administration of phage PFpW-3 in F. psychrophilum-infected ayu showed notable protective effects, increased survival rates and mean times to death. Additionally, the fate of inoculated bacteria and phage in ayu were investigated. Our results suggest that the phage PFpW-3 could be considered an alternative biocontrol agent against F. psychrophilum infections in ayu culture.

Protective effect of Kohl-Chikni Dawa against galactose-induced cataract in rats

  • T.A., Siddiqui;Z., Shadab;N., Ayasha;S.H., Alavi
    • Advances in Traditional Medicine
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    • v.4 no.2
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    • pp.82-86
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    • 2004
  • The efficacy of Kohl-Chikni Dawa (KCD), a compound ophthalmic formulation of Unani medicine, to control cataract development was explored in rats fed 25% galactose with the diet for 6 months. When one drop of 3% KCD solution was applied (once and twice daily) in both eyes for 6 months in galactose-fed rats, a significant reduction of lens opacification was noticed. The morphological changes of the lenses were observed every month by slit-lamp biomicroscope. These results suggest that the local application of 3% KCD solution possesses anticataract effect in galactose-fed rats.

Anti-Oxidative Effects of Scutellariae Radix (황금(黃芩)의 항산화 효과)

  • Oh, Won-Woo;Cho, Su-In
    • The Korea Journal of Herbology
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    • v.20 no.3
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    • pp.67-74
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    • 2005
  • Objectives : This study was carried out to determine if Scutellariae Radix have protective effect against cell injury induced by various toxic agents in rat kidney slices. Methods : Water(SWe) and methanol(SMe) extracts were prepared for this experiment. Cell injury was estimated by measuring lactate dehydrogenase(LDH). Lipid peroxidation was examined by measuring malondialdehyde. Results : SMe prevented the LDH release by CCl4, menadione, tert-butyl hydroperoxide and mercury treatment in vitro in kidney slices, but SWe prevented the LDH release by CCl4 and mercury. SMe also prevented reduction in GSH by CCl4 and lipid peroxidation induced by mercury. Conclusions : Thus, SMe may have more powerful efficacy on anti-oxidative effects when compared with SWe. And further studies have to be followed concerned with procedure of extraction of SMe and its change of effects.

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Discharge characteristics of MgO-PDP manufactured by using "all-in-vacuum" process

  • Yano, T.;Uchida, G.;Uchida, K.;Awaji, N.;Shinoda, T.;Kajiyama, H.
    • 한국정보디스플레이학회:학술대회논문집
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    • 2009.10a
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    • pp.28-30
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    • 2009
  • PDP panels with MgO protective layer are manufactured by using the "all-in-vacuum" process we have established [1]. This is the process aiming to keep the MgO surface as clean as possible after the evaporation. The panels are evaluated in term of discharge voltage, aging time, luminance, luminous efficacy, discharge time-lag. It is confirmed that the "all-in-vacuum" process particularly improves the aging time, discharge voltage and the discharge time-lag.

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Analysis of luminous efficacy of a PDP cell using a hybrid simulation with an electron-fluid and ion-particle model

  • Lee, Hae-June;Shim, Seung-Bo;Song, In-Cheol;Lee, Ho-Jun;Park, Chung-Hoo
    • 한국정보디스플레이학회:학술대회논문집
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    • 2009.10a
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    • pp.24-27
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    • 2009
  • A hybrid model has been developed which adopts a fluid model for electrons and a particle-in-cell (PIC) model for ions. Using the hybrid simulation, the discharge characteristics are investigated with the diagnostics for the electric field and the wall charge profile, density distributions of charged and excited particles, distributions of ultraviolet lights on phosphor, and the visible lights emitted from the PDP cell. Also, energy and angle distributions of the ions at the MgO protective layer are obtained for the analysis of material effect. The comparison of hybrid simulation results with experimental results as well as that with the conventional fluid simulation shows that the new model is more adequate for the simulation of PDP cells.

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A Wearable Safety Device for the Body Protection of Motorcyclists (모터사이클 운전자 신체보호용 안전장치 개발 프로세스)

  • Jang, Dong-Hwan
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.20 no.1
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    • pp.25-33
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    • 2021
  • This paper presents the development process for airbag safety devices fitted in motorcyclists' garments. Motorcycle riders often sustain multiple injuries in crashes since rider post-impact kinematics depend on several variables. This study proposes a newly inflatable safety system connected to the motorcycle by a cable. An airbag device with a mechanical triggering system is deployed when the cable detaches from its mounting clip. Airbag filling tests are performed to determine the mixing ratio of compressed gases with the severance of temperature. To estimate the airbag effectiveness to reduce riders' injuries, numerical analysis is performed using the finite element method. A comparative analysis (i.e., with and without the chosen device) was conducted to evaluate its protective efficacy. Prototype garments based on the proposed design have been created and have undergone sled tests. The proposed safety device could also be beneficial in accidents during other sports activities.

Immunogenicity and protective effects of a novel reassortant influenza live virus, NC-22-8

  • Chung, Young-Mee;Kim, Seong-Woo;Chun, Hyung-Ok;Kim, Young-Gi;Kim, Hyun-Ah;Kim, Yeon-Hee;Ha, Suk-Hoon;Chae, Myeong-Yun;Park, Wan-Je
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.135.3-136
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    • 2003
  • In the present study, type A influenza live virus, NC-22-8, which is a combination of a cold-adapted attenuated donor virus (HTCA-A101) and a wild type virus (A/New Caledonia/20/99), was constructed and the efficacy of this new virus was assessed by immunogenicity and protection tests in the mouse model. NC-22-8 (1'$10^7, 1'10^5, 1'10^3$ pfu/mouse) was intranasally administered to mice. Four weeks later, the titers of specific IgG and haemagglutinin inhibiton (HI) were measured from blood and the titer of secretary IgA (sIgA) was also detected from boncho alveolar lavage (BAL) and mucosal fluid. (omitted)

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Recent progress in vaccine development targeting pre-clinical human toxoplasmosis

  • Ki-Back Chu;Fu-Shi Quan
    • Parasites, Hosts and Diseases
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    • v.61 no.3
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    • pp.231-239
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    • 2023
  • Toxoplasma gondii is an intracellular parasitic organism affecting all warm-blooded vertebrates. Due to the unavailability of commercialized human T. gondii vaccine, many studies have been reported investigating the protective efficacy of pre-clinical T. gondii vaccines expressing diverse antigens. Careful antigen selection and implementing multifarious immunization strategies could enhance protection against toxoplasmosis in animal models. Although none of the available vaccines could remove the tissue-dwelling parasites from the host organism, findings from these pre-clinical toxoplasmosis vaccine studies highlighted their developmental potential and provided insights into rational vaccine design. We herein explored the progress of T. gondii vaccine development using DNA, protein subunit, and virus-like particle vaccine platforms. Specifically, we summarized the findings from the pre-clinical toxoplasmosis vaccine studies involving T. gondii challenge infection in mice published in the past 5 years.

Factors Influencin Resilience in Nursing Students (간호학생의 적응유연성에 영향을 미치는 요인)

  • Park, Mi-Hyang
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.11
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    • pp.614-625
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    • 2018
  • This study was conducted to investigate the level of resilience and the factors affecting resilience in nursing students, and to provide basic data to develop a program that improves resilience of nursing students. Data were collected from 155 nursing students in D city from April 15 to May 30, 2018 using the Resilience Scale, College Life Stress Scale, Self-Efficacy Scale (SES), Multi-Dimensional Scale of Perceived Social Support (MSPSS), Positive Affect Scale, and Stress Coping Strategy Scale. Data were analyzed using t-tests, ANOVA, Pearson's correlation coefficient, and multiple regression. The mean score for resilience in nursing students was 3.54 points. There was a significant difference in resilience according to academic score and satisfaction with major. Resilience was significantly correlated with self-efficacy, social support, and active stress coping strategy. Factors that impacted resilience in multiple regression were self-efficacy (${\beta}=0.39$, p<0.001), active stress coping strategy (${\beta}=0.26$, p<0.001), and social support (${\beta}=0.16$, p<0.001). These factors explained 51.0% of the variance in the resilience of nursing students. Therefore, it will be necessary to develop a program that can enhance resilience by strengthening protective factors such as self-efficacy, active stress coping strategies, and social support.

Screening for Effective Organic Farming Materials for the Control of Cucumber Scab Caused by Cladosporium cucumerinum (오이 검은별무늬병 방제에 효과적인 유기농업자재 선발)

  • Park, So-Hyang;Hong, Sung-Jun;Shim, Chang-Ki;Kim, Min-Jeong;Park, Jong-Ho;Han, Eun-Jung;Kim, Yong-Ki
    • Research in Plant Disease
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    • v.23 no.2
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    • pp.159-167
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    • 2017
  • This study was conducted to evaluate the control efficacy of the organic farming materials on cucumber scab caused by Cladosporium cucumerinum PT1 (KACC 48094). The antifungal activities in vitro as well as the suppressive effect of 43 organic farming materials on the spore germination and germ tube growth by inoculating spore suspension on cucumber seedlings in vivo were investigated. Thirteen organic farming materials inhibited the mycelial growth of C. cucumerinum and nine of these were microbial agents. In the screening using cucumber seedlings, six organic farming materials were very effective with control efficacy value of 90%. Among them, Bacillus amyloliquefaciens M27 provided suppressive effect on both mycelial growth and spore germination against cucumber scab. Finally, nine organic farming materials were selected to test the protective and curative effects, and all chosen organic farming materials significantly suppressed disease incidence when applied in the preventive action, in comparison with the curative action. Especially, Bordeaux mixture I and III gave excellent protective control efficacy with control values of 96.7% and 73.3%, respectively, whereas its curative control effect was significant low. Among these, only Thymus quinquecostatus+Sophora extract showed curative activity, although the control value was as low as 50%. This study suggests that cucumber scab can be controlled by some organic farming materials in the farmhouses under comparatively cold and wet condition and protective treatment is more important and efficient.