• The Korean Journal of Physiology and Pharmacology
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• v.25 no.4
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• pp.281-296
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• 2021

The beneficial effects of hypoxic preconditioning are abolished in the diabetes. The present study was designed to investigate the protective effects and mechanisms of repeated episodes of whole body hypoxic preconditioning (WBHP) in db/db mice. The protective effects of preconditioning were explored on diabetes-induced vascular dysfunction, cognitive impairment and ischemia-reperfusion (IR)-induced increase in myocardial injury. Sixteen-week old db/db (diabetic) and C57BL/6 (non-diabetic) mice were employed. There was a significant impairment in cognitive function (Morris Water Maze test), endothelial function (acetylcholine-induced relaxation in aortic rings) and a significant increase in IR-induced heart injury (Langendorff apparatus) in db/db mice. WBHP stimulus was given by exposing mice to four alternate cycles of low (8%) and normal air O₂ for 10 min each. A single episode of WBHP failed to produce protection; however, two and three episodes of WBHP significantly produced beneficial effects on the heart, brain and blood vessels. There was a significant increase in the levels of brain-derived neurotrophic factor (BDNF) and nitric oxide (NO) in response to 3 episodes of WBHP. Moreover, pretreatment with the BDNF receptor, TrkB antagonist (ANA-12) and NO synthase inhibitor (L-NAME) attenuated the protective effects imparted by three episodes of WBHP. These pharmacological agents abolished WBHP-induced restoration of p-GSK-3β/GSK-3β ratio and Nrf2 levels in IR-subjected hearts. It is concluded that repeated episodes of WHBP attenuate cognitive impairment, vascular dysfunction and enhancement in IR-induced myocardial injury in diabetic mice be due to increase in NO and BDNF levels that may eventually activate GSK-3β and Nrf2 signaling pathway to confer protection.

• International Area Studies Review
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• v.21 no.4
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• pp.247-268
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• 2017

This paper analyzes for companies of 2011~2014 the effects of corporate social responsibility on audit efficiency. Using KEJI Index and its individual components which is published by Citizens' Coalition for Economic Justice Institute, this paper analyzes their effects on audit efficiency of audit fees and audit hours. The results of analyses are as followings. First, corporate social responsibility(CSR) composite index did not show any significant relationship between audit fees and audit hours. However, for analyses of the effects of CSR individual components on audit efficiency, variable such as CSR fairness(CSR2), CSR social contribution(CSR3), CSR environmental protection activity(CSR5) have the negative effects on the audit fees and audit time. and CSR customer protection(CSR4), CSR employee satisfaction(CSR6) have the positive effects on the audit fees and audit time. Results suggest that independent auditors may reduce audit risks associated with possible misrepresentation of financial statements for companies with high scores of CSR fairness (CSR2), CSR social contribution(CSR3), and CSR environmental protection activity(CSR5). Also, financial statement auditors may perceive surge of discretionary expenses, and set audit risk high for companies with CSR customer protection(CSR4), and CSR employee satisfaction(CSR6). Together, KEJI Index and its individual components appear to have differential effects on audit efficiency.

• Proceedings of the Korean Geotechical Society Conference
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• 2002.03a
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• pp.523-530
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• 2002

Recently, while rockfall occurs very frequently, a lot of researches on the rockfall protection fence Is in process. But the rockfall protection fence has been installed unrelated to slope characteristics, rockfall shape and rockfall height. Therefore, in this study we suggested the effective protection fence model considering about rockfall energy and energy absorbing capacity and we verified the model by field test. According to these results, it is more reasonable to evaluate rockfall energy based on the results of simulation program, which can be consider effects of energy decrease, than use the simplified method proposed by Japanese road association. And rockfall energy is affected by the size of supports and wire rope and the space of supports. As the results of comparing rockfall energy with energy absorbing capacity, type$\circled1$(the space of supports is changed to 3.0m)can be available for generally expected rockfall except the rock slope over 30m heights. But rockfall protection fence installed at the field, it should be partially reinforced after consideration of slope particularities and construction conditions.

• Journal of Environmental Impact Assessment
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• v.12 no.5
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• pp.369-382
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• 2003

Natural resources managers have considered the landscape without detailed consideration of aesthetic values of the landscape and geomorphological significance of unique landforms. Since EIA system was introduced in 1981, values associated with landscape protection have been neglected at best compared with those values traditionally attributed to environmental protection, including clean air, water quality and species protection. Black top highways are being built without consideration of harmful effects to the sea cliffs. Sea walls and tetrapod are being installed to protect the coastal towns and fish markets for tourist. However, beach itself are experiencing accelerated erosion due to the shortage of proper coastal engineering expertise. Hotels and condominiums are under construction on a massive scale around the national parks, which substitute the scenic ridges with concrete profiles. To protect the scenic beauty of national parks, their design and construction material should be more harmonious with the surroundings. Therefore, visual impact assessment should be applied both within the national park boundary and beyond to enhance the aesthetic values of national parks.

• Proceedings of the KIEE Conference
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• 2006.07a
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• pp.151-152
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• 2006

Because power plant faults have severe effects on the power system and on mechanical maintenance of the generator, reliable protection systems are needed. In this paper, we compared and analyzed methods of the generator protection relaying system, which can defect internal faults of the generator, and surveyed the trends in generator protection using digital computing.

• Journal of Radiation Protection and Research
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• v.26 no.3
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• pp.215-224
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• 2001

In order to comply with revised national regulationson radiological protection and to implement recent nuclear data and dose conversion factors, KOPEC developed a new point kernel gamma and beta ray shielding analysis computer program. This new code, named VisualShield, adopted mass attenuation coefficient and buildup factors from recent ANSI/ANS standards and flux-to-dose conversion factors from the International Commission on Radiological Protection (ICRP) Publication 74 for estimation of effective/equivalent dose recommended in ICRP 60. VisualShieid utilizes graphical user interfaces and 3-D visualization of the geometric configuration for preparing input data sets and analyzing results, which leads users to error free processing with visual effects. Code validation and data analysis were performed by comparing the results of various calculations to the data outputs of previous programs such as MCNP 4B, ISOSHLD-II, QAD-CGGP, etc.

• Proceedings of the IEEK Conference
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• 2001.06b
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• pp.85-88
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• 2001

This paper suggests an improved switch architecture for the rechargeable battery protection IC. In the existing protection IC, charging and discharging switches composed of the CMOS transistor and the diode are external components. It is difficult to integrate the switches in a CMOS process due to the large chip-size overhead and inevitable parasitic effects. In this paper, we propose a new switch architecture of the MOSFET's 'diode connection' method. The performance and chip-size overhead are proved to be adequate for the fully integrated protection IC.

• International journal of advanced smart convergence
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• v.2 no.1
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• pp.27-29
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• 2013

This paper discusses comparative analysis of the effects of surge protection devices (SPD) upon the power line communication channels. The quality of the data transmission channel is measured based on the data rate for the various channel parameters which include channel length and application method of the lightning protection device. The performance measurements are also carried out for various lengths of the communication channel. Experiment results show that specific combination of SPDs applied in the network causes severe degradation of the channel quality which is associated with the combination of grade levels and channel lengths.

• Proceedings of the KSME Conference
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• 2001.06a
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• pp.573-578
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• 2001

For the corrosion protect ion of the natural gas transmission pipelines, two methods are used, cathodic protection and coating technique. In the case of cathodic protection, defects are embrittled by occurring hydrogen at the crack tip or material surface. It is however very important to evaluate whether cracks in the embrittled area can grow or not, especially in weld metal. In this work, on the basis of elastic plastic fracture mechanics, we performed CTOD test ing with varying test conditions, such as the potential and current density. The CTOD of the base steel and weld metal showed a strong dependence of the test conditions. The CTOD decreased with increasing cathodic potential and current density. The morphology of the fracture surface showed quasi-cleavage. Hydrogen introduced fractures, caused by cathodic overprotection.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.37C no.11
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• pp.1054-1063
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• 2012

In this paper, we introduce basic theories, effects and applications of the unequal error protection (UEP) system that is expected to play a major role in the future multi-layered broadcast system. Also we show results of surveys on the various previous studies and standards about the UEP systems, and we give prospects of standardizations and future applications of UEP based on the surveys.