• Korean Journal of Biological Psychiatry
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• v.23 no.1
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• pp.18-23
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• 2016

Depression is a complicated psychiatric illness with severe consequences. Despite recent advanced achievements of molecular neurobiology, pathophysiology of depression has not been well elucidated. Among new findings of pathophysiology of depression, the possible fast antidepressant effect by N-methyl-D-asparate receptor antagonist, such as ketamine, is regarded as a promising treatment target of depression. Ketamine stimulates the mammalian target of rapamycin (mTOR) signaling pathway and activation of mTOR signaling pathway may be a key mechanism of the antidepressant effect of ketamine. Thus, this review describes the role of mTOR signaling in the pathophysiology of depression and developing a new treatment target of depression.

• Journal of the Korean Society of Costume
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• v.54 no.3
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• pp.53-64
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• 2004

The study was done to provide domestic fashion multi-shops with basic information about the product and price strategies through an investigation the marketing strategies for domestic multi-shop dealt with imported product only. Data were collected from Interview with a buyer or a staff of marketing department of Domestic Fashion Multi-shop dealt with Imported Product only. Through the study, it was clarified that these multi-shops showed a tendency to compose of promising brands. brands set a high value on unique character or technique, and brands of promising designer noticed at the main collection. And they also extended their lines as a total life style shop dealt with accessory. shoes and home collection as well as clothing. Therefore, they had to analyze their target consumer's life style and applied this to organization of product, brands or sizing. To maintain the balance of multi-shop they bought products keeping the balance between all the brands and didn't lose variety of concept, it was demanded to develop new brands as well. Their distribution channels had to be planned by regional characteristic that could be accepted their target consumers.

• Journal of Yeungnam Medical Science
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• v.23 no.2
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• pp.143-151
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• 2006

In the past decade, the median duration of survival among patients with advanced colorectal cancer has increased from 12 months to about 18 months, primarily as a results of the introduction of irinotecan and oxaliplatin. Advances in the understanding of the molecular mechanisms underlying the development and progression of cancer have resulted in the discovery of new therapeutic interventions that target specific molecular abnormalities. Their specificity, and therefore their potential to bind preferentially and modify tumor-specific targets, sparing normal tissues and causing fewer side-effects compared to conventional cytotoxic agents, makes them an attractive therapeutic option. The future of this approach for the treatment of solid tumors is promising.

• Journal of Biomedical Engineering Research
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• v.43 no.2
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• pp.94-101
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• 2022

Recent advancement of micro/nano technology enables the development of diverse micro/nano particle-based delivery systems. Due to the multi-functionality and engineerability, particle-based delivery system are expected to be a promising method for delivery to the target cell. Since the particle-based delivery system should be delivered to the various kinds of target cell, including the cardiovascular system, cancer cell etc., it is frequently decorated with multiple kinds of targeting molecule(s) to induce specific interaction to the target cell. The surface decorated molecules interact with the cell surface expressed molecule(s) to specifically form a firm adhesion. Thus, in this study, the probability of adhesion is estimated to predict the possibility to form a firm adhesion for the multi-ligand decorated particle-based delivery system.

• 한국신재생에너지학회:학술대회논문집
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• 2009.06a
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• pp.130-133
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• 2009

$Cu_2ZnSnSe_4$(CZTSe) is one of the promising materials for the solar cell due to its abundant availability in the nature. In this study, we report the fabrication of CZTSe thin film by Pulsed Laser Deposition(PLD) method using quaternary compound target on sodalime glass substrate. The quaternary CZTSe compound target was synthesized by solid state reaction method using elemental powders of Cu, Zn, Sn and Se. Powders were milled in high purity ethanol using zirconia ball with mixed size of 1 and 3 mm at the same proportions for 72 hours milling time. The structural, chemical and mechanical properties of the synthesized CZTSe powders were investigated prior to the deposition process. The CZTSe compound powder, and $500^{\circ}C$ of sintering temperature shows the best properties for PLD target. Results show that the as-deposited CZTSe thin films with the precursors by PLD have a composition near-stoichiometric.

• Journal of the Korea Society of Computer and Information
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• v.27 no.10
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• pp.235-243
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• 2022

This paper aims to find promising export items for market expansion of defense export items. Germany, the UK, and France were selected as export target countries to obtain unstructured forecast data on weapons system acquisition plans for the next ten years by each country. Using the TF-IDF in text mining analysis, keywords that appeared frequently in data from three countries were derived. As a result of this paper, keywords for each country's major acquisition projects drawing. However, most of the derived keywords were related to mainstay weapon systems produced by domestic defense companies in each country. To discover promising export items from text mining, we proposed that the drawn keywords are distinguished as similar weapon systems. In addition, we assort the weapon systems that the three countries will get a plan to acquire commonly. As a result of this paper, it can be seen that the current promising export item is a weapon system related to the information system. Prioritizing overseas demands using key words can set clear market entry goals. In the case of domestic companies based on needs, it is possible to establish a specific entry strategy. Relevant organizations also can provide customized marketing support.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.551-560
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• 2014

Colorectal cancer (CRC) is the third most common malignancy and fourth most common cause of cancer mortality worldwide. Untreated chronic inflammation in the intestine ranks among the top three high-risk conditions for colitis-associated colorectal cancer (CAC). Signal Transducer and Activator of Transcription 3 (STAT3) protein is a member of the STAT family of transcription factors often deregulated in CRC. In this review, we try to emphasize the critical role of STAT3 in CAC as well as the crosstalk of STAT3 with inflammatory cytokines, nuclear factor (NF)-${\kappa}B$, PI3K/Akt, Mammalian Target of Rapamycin (mTOR), Notch, $Wnt/{\beta}$-catenin and microRNA (MiR) pathways. STAT3 is considered as a primary drug target to treat CAC in humans and rodents. Also we updated the findings for inhibitors of STAT3 with regard to effects on tumorigenesis. This review will hopefully provide insights on the use of STAT3 as a therapeutic target in CAC.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2002.11a
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• pp.87-90
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• 2002

In recent year, BLT($Bi_{3.25}La_{0.75}Ti_{3}O_{12}$) has been one of promising substitute materials at the ferroelectric random access memory applications. We manufactured $Bi_{3.25}La_{0.75}Ti_3O_{12}$ Target with a ceramic process. The BLT target was sintered at ${1100^{\circ}C}$ for 4 hours. Using RF magnetron sputtering, a deposited BLT thin films were estimated about ferroelectric properly as a functions of post annealing temperatures. The BLT thin films showed a promoted ferroelectric characteristics at the post annealied sample of ${700^{\circ}C}$. This sample exhibited the (117) preferred crystal orientation, current density of $3{\times}10^{-8}A/cm^2$, a remanent polarization of $8{\mu}C/cm^2$ and a coercive field of 42.1 KV/cm respectively.

• International Journal of Contents
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• v.11 no.3
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• pp.47-53
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• 2015

Visual object tracking is a fundamental problem in the field of computer vision, as it needs a proper model to account for drastic appearance changes that are caused by shape, textural, and illumination variations. In this paper, we propose a feature-based visual-object-tracking method with a sparse representation. Generally, most appearance-based models use the gray-scale pixel values of the input image, but this might be insufficient for a description of the target object under a variety of conditions. To obtain the proper information regarding the target object, the following combination of features has been exploited as a corresponding representation: First, the features of the target templates are extracted by using the HOG (histogram of gradient) and LBPs (local binary patterns); secondly, a feature-based sparsity is attained by solving the minimization problems, whereby the target object is represented by the selection of the minimum reconstruction error. The strengths of both features are exploited to enhance the overall performance of the tracker; furthermore, the proposed method is integrated with the particle-filter framework and achieves a promising result in terms of challenging tracking videos.

• BMB Reports
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• v.57 no.7
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• pp.324-329
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• 2024

The aim of the present study is to provide a rational background for silencing the V-set and transmembrane domain containing 2 like (VSTM2L) in consort with recognising soluble VSTM2L against cholangiocarcinoma. A therapeutic target against cholangiocarcinoma was selected using iterative patient partitioning (IPP) calculation, and it was verified by in vitro and in silico analyses. VSTM2L was selected as a potential therapeutic target against cholangiocarcinoma. Silencing the VSTM2L expression significantly attenuated the viability and survival of cholangiocarcinoma cells through blockade of the intracellular signalling pathway. In silico analysis showed that VSTM2L affected the positive regulation of cell growth in cholangiocarcinoma. Liptak's z value revealed that the expression of VSTM2L worsened the prognosis of cholangiocarcinoma patients. In addition, soluble VSTM2L was significantly detected in the whole blood of cholangiocarcinoma patients compared with that of healthy donors. Our report reveals that VSTM2L might be the potential therapeutic target and a soluble prognostic biomarker against cholangiocarcinoma.