• Natural Product Sciences
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• 제8권4호
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• pp.152-154
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• 2002

The methanol extract of Viscum album var. coloratum, Korean mistletoe, showed potent prolongation effects on the bleeding time in rats in vivo, and whole blood clotting time and plasma recalcification time in rats ex vivo. The prolongation effect on the bleeding time of Korean mistletoe is comparable to that of Viscum album L., European mistletoe, 185.6% and 176.5%, respectively. However, the water extracts of the both plants did not show any prolongation effects. Platelet activating factor (PAF) receptor binding assay was carried out to elucidate the action mechanisms of the extracts, and both of the methanol extracts did not show any inhibitory activity. The $LD_{50}$ of the methanol extracts of both mistletoes are more than 2 g/kg. These results suggest that the mehtanol extract of Korean mistletoe might be a potential candidate to develop new drug to improve microcirculation.

• 대한음성학회지:말소리
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• 제44호
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• pp.47-59
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• 2002

Mean F0, Jitter, Shimmer, and NHR were measured in 21 opera singers, 13 Korean traditional 'pansori' singers, and 21 non-singers. Four voice sampling conditions were ordinary /α/ prolongation, /α/ prolongation using vocal technique as if the subjects were singing, oral reading of the words of a song, and singing. One-way ANOVA and Sheffe post-hoc analysis were used to identify significant differences among the groups. The mean F0 was significantly different among the 3 groups in all conditions except for the ordinary /α/ prolongation condition. The opera singers produced lower jitter and NHR compared to 'pansori' singers and non-singers only in the singing condition.

• 정신신체의학
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• 제29권1호
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• pp.11-16
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• 2021

연구목적 항정신병약물로 인한 QTc간격연장은 심각한 심실성 부정맥을 초래할 가능성 때문에 주의가 필요한 부작용이다. 하지만 현재까지 국내에서 항정신병약물에 의한 QTc간격연장에 대한 연구는 많지 않았다. 본 연구는 조현병 환자에서 QTc간격연장에 영향을 주는 인구학적 및 임상적 변수를 알아보고자 한다. 방 법 일 병원에 입원치료를 받았던 441명 조현병 환자들의 의무기록을 후향적으로 검토하여 QTc간격과 인구학적 및 임상적 변수들을 파악하였다. QTc간격에 영향을 주는 변수를 알아보기 위해 QTc간격을 종속변수로 하여 위계적 중다회귀분석을 수행하였다. 결 과 평균 QTc간격은 417.2±28.4 ms였다. 위계적 중다회귀분석 결과 항정신병약물 단기작용주사제의 사용이 QTc간격연장의 가장 강한 예측인자였다. 결 론 본 연구는 조현병 환자에서 항정신병약물 단기작용주사제 사용이 QTc간격연장에 영향을 줄 수 있으며 조현병 환자의 치료 시 항정신병약물 단기작용주사제 사용에 보다 주의를 기울여야 함을 시사한다.

• 음성과학
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• 제12권1호
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• pp.37-43
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• 2005

The phenomenon of vocal vibrato may be regarded as an acoustic representation of one of the most rapid and continuous changes in pitch and intensity that the human vocal mechanism is capable of producing. Singers are likely to use vibrato effectively to enrich their voice. The purpose of this study was to obtain acoustic measurements (vF0 and vAm) of 45 subjects (15 trot and 15 ballad singers and 15 non-singers) and to compare acoustic measurements of the vowel /a/ produced by 3 groups on 2 voice sampling conditions (prolongation and singing of /a/). Thirty singers of trot and ballad were selected by a producer and a concert director working for the KBS (Korean Broadcasting System). The MDVP was used to measure the acoustic parameters. A two-way MANOVA was used for statistical analyses. The results were as follows; Firstly, there was no significant difference among the 3 groups in vF0 and vAm in prolongation of /a/, but in singing voice, there was a significant difference among 3 groups in vF0 and vAm. Secondly, there was an interaction between music genre and voice sampling condition in vF0, and vAm. Finally, trot singers sing with more vibrato than ballad singers. It was concluded that it is very important to analyze singers' voice including various voice conditions (prolongation, reading, conversation, and singing) and to identify differences of singing voice characteristics among music genre.

• 한국식품영양과학회지
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• 제26권1호
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• pp.144-147
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• 1997

산국의 꽃으로부터 2종의 sesquiterpene lactones을 분리정제하였으며, 각각 Compound I 과 II로 명명하였으며, 이 두 물질을 Sarcoma180에 감염된 ICR mouse에 대하여 항암효과실험을 수행한 결과 Compound I과 II의 투여농도가 10mg/kg일 때 수명 연장효과가 각 각 143%, 134%로 나타났다. 또한 Compound I 과 II 를 1mg/kg 씩을 섞어서 투여하였을 때에 158%의 수명 연장효과가 나타났다

• 대한약리학회지
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• 제14권1_2호
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• pp.41-46
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• 1978

The effects of sodium taurocholate(STC) and sodium deoxycholate(SDC) on cardiac function were examined by using isolated atria of rabbit and guinea pig and heart of anesthetized frog. Also the antiarrythmic action of STC and SDC on atrial arrhythmias induced by epinephrine or ouabain was studied. The results were following. The cholates exhibited a slight decrease in rate and contractile amplitude of the isolated rabbit atria. The cholates abolished partially the spontaneous arrhythmic occurring in isolated rabbit and guinea pig atria but no effect on the atrial arrhythmia induced by ouabain and epinephrine was observed. Concomitant administration of cholates with ouabain produced a marked prolongation of atrial arrhythmia in comparison to that of ouabain alone in both isolated rabbit and guinea pig atria. The cholates exhibited a marked prolongation in ventricular arrhythmia and cardiac arrest time in comparison to that of ouabain treatment. However, the combined treatment with cholates and ouabain produced a slight prolongation in comparison to that of ouabain alone in the heart of anesthetized frog. The above results suggest that cholates have a slight antiarrythmic effect on the heart but this effectiveness is different from those of propranolol that is non-selective antiarrhythmic drug.

• 한국식품영양과학회지
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• 제28권2호
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• pp.365-370
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• 1999

To investigate the effect of natural plants on the prolongation of optimal fermentation time of kakdugi, various kakdugies, added with hot water extract from 105 kinds of natural plants(68 medicinal plants and 37 vegetables), were fermented at 20oC until optimal fermentation time. In case of control without addition, the time required to reach the optimum acidity(0.6% lactic acid) was 60 hr. Among 105 kinds tested, 48 plant(42 medicinal plants and 6vegetables) extracts decreased the acidity after 60 hr fermentation to less than 50% of control. In addition, these extracts extended the optimal fermen tation time(>120 hr) by more than 2 folds. Moreover, among the above 48 kinds, 12 sorts of extracts raised the hardness of kakdugi, by more than 30%, compared to control. And the number of lactic acid bacteria in kakdugi added with the above 12 kinds was not smaller than that of control. In sensory test, 8 kinds of medicinal plants(including Phyllostachys edulis) were found to be acceptable. Based on these results, it is suggested that kakdugi added with 8 kinds of medicinal plants was adequate in the prolongation of optimal fermentation time of kakdugi.

• Neonatal Medicine
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• 제28권1호
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• pp.59-63
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• 2021

An important, albeit rare, cause of fetal bradycardia is long QT syndrome (LQTS). Congenital LQTS is an ion channelopathy caused by mutations in genes encoding cardiac ion channel proteins. Fetal onset of LQTS imposes high risk of life-threatening tachyarrhythmias and sudden cardiac death. Here, we report the case of a female newborn with fetal onset of bradycardia and a 2:1 atrioventricular (AV) block. After birth, a 12-lead electrocardiogram (ECG) revealed bradycardia with QT prolongation of a corrected QT (QTc) interval of 680 ms and pseudo 2:1 AV block. Genetic testing identified a heterozygous Gly402Ser (c.1204G>A) mutation in CACNA1C, confirming the diagnosis of LQTS type 8 (LQT8). The patient received propranolol at a daily dose of 2 mg/kg. Mexiletine was subsequently administered owing to the sustained prolongation of the QT interval and pseudo 2:1 AV block. One week after mexiletine inception, the ECG still showed QT interval prolongation (QTc, 632 ms), but no AV block was observed. There were no life-threatening tachyarrhythmias in a follow-up period of 13 months.

• 한국건설관리학회논문집
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• 제19권5호
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• pp.111-120
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• 2018

국내 공공 공사는 최근 공기연장 추가간접비 산정에 대한 기준의 불명확성에 따른 논란이 가중되면서 분쟁이 다대하게 발생하고 있다. 또한 연구자들도 이러한 제도의 불명확성 및 분쟁의 발생을 저감시키기 위한 노력으로 여러 제도 및 적정 실비산정을 위한 연구를 진행해 왔으나 아직 사회적 합의를 이끌어낸 기준이 부재한 실정이다. 한편 회계의 인식기준에 따른 분류체계에 대한 연구는 체계적으로 이루어져 발생주의와 현금주의에 대한 개념을 구분하여 정의하였다. 본 연구는 '발생주의'의 개념이 공기연장 추가간접비 산정기준에 적용될 수 있는 가능성을 확인하는 것을 목적으로 하였다. 이에 현장관리비 발생패턴을 분석 결과 현금주의 방식으로는 적정한 산정기준으로 산정하기 어려운 실비가 있는 것으로 확인하였으며, 특히 간접노무비 및 복리후생비와 같이 현장관리비에서 비중이 큰 항목의 경우에는 발생주의 방식의 요구가 더욱 엄정하게 제시되어야 한다는 시사점을 알 수 있었다. 또한 시공사의 청구보고서와 법원의 감정보고서를 조사하였다. 결과는 현재 공기연장 추가간접비 산정 실무는 현금주의 산정방식으로 편중되어있다는 점을 확인하였으며, 발생주의 관점으로부터 실비산정기준을 보완하여야 할 것을 대안으로 제시하였다.

• 생약학회지
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• 제14권2호
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• pp.51-59
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• 1983

Experimental studies were made with Melilotus officinalis extract which was extracted from flowers and leaves of Melilotus officinalis Dsr. (Leguminosae). In this paper, acute toxicity, analgesic action, prolongation of hypnosis time by induced pentobarbital-Nain mice, antiinflammatory effect in rats and effects on isolated intestines of mice and rats were studied, The result was as follows; 1. Very low toxicity in mice. 2. Analgesic action was recognized markedly in mice. 3. Prolongation of hypnosis time induced by pentobarbital-Na in mice was shown. 4. Relaxing action was shown on the isolated ileum in mice and antagonistic action was seen on $BaCl_2-induced$ contraction of the ileum that the relaxing effect of the intestinal smooth muscle was recognized. 5.Antiinflammatory effect was shown markedly in mice. 6.Hypotensive and vaso-dilating actions due to the vascular smooth muscle relaxation were noted in rabbits.