• Journal of the Korean Society of Mineral and Energy Resources Engineers
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• v.55 no.6
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• pp.624-634
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• 2018

Indonesia has become a net crude oil importer because of the reduction of a new oil field discovery, and Indonesia is attempting to raise investment funds through the Kerja Sama Operasi (KSO) contract to develop a small-scale field. However, the KSO has a high-risk and low-return contract system for investors, necessitating an economic evaluation to examine the feasibility of the project. This study performed economic evaluation on the development of an Indonesian small-scale field by applying the KSO contract conditions, and identified the major economic parameters through a sensitivity analysis. As a result, the oil price, CAPEX and OPEX were identified as influential factors for economic evaluation. The results also indicate that commercial production in small-scale fields is difficult. In the future, this study can be used as a reference resource for investment in oil and gas development projects in Indonesia.

• Journal of the Korea Institute of Building Construction
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• v.19 no.4
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• pp.351-359
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• 2019

Recognizing that the fundamental cause of construction safety accidents was a lack of safety management activities in the planning and design phases, the government made the Design for Safety (DFS) system mandatory in May 2016. However, awareness among ordering parties and designers regarding this system is significantly low, and the system has not been properly established due to reasons such as the need for additional work and a lack of professional manpower. In this study, the awareness of ordering parties and designers of the DFS system was analyzed through a survey, various problems in DFS work execution were identified and measures for improvement were presented. Measures to improve the efficiency in DFS work execution involve the discovery of risk factors and establishment of countermeasures, and here the establishment of a DFS work support system that enables the sharing of information between institutions is the most urgent priority. In addition, it is also urgently necessary to establish a dedicated organization in charge of DFS work, cultivate professional manpower, develop the relevant education programs and establish a proper cost calculation standard for DFS work execution by design offices.

• Journal of Coastal Disaster Prevention
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• v.4 no.3
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• pp.119-131
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• 2017

Global warming under the influence of climate change and its direct impact on glacial and sea level are known issue. However, there is a lack of research on an indirect impact of climate change such as coastal structure design which is mainly based on a frequency analysis of water level under the stationary assumption, meaning that maximum sea level will not vary significantly over time. In general, stationary assumption does not hold and may not be valid under a changing climate. Therefore, this study aims to develop a novel approach to explore possible distributional changes in annual maximum sea levels (AMSLs) and provide the estimate of design water level for coastal structures using a multiple non-crossing quantile regression based nonstationary frequency analysis within a Bayesian framework. In this study, 20 tide gauge stations, where more than 30 years of hourly records are available, are considered. First, the possible distributional changes in the AMSLs are explored, focusing on the change in the scale and location parameter of the probability distributions. The most of the AMSLs are found to be upward-convergent/divergent pattern in the distribution, and the significance test on distributional changes is then performed. In this study, we confirm that a stationary assumption under the current climate characteristic may lead to underestimation of the design sea level, which results in increase in the failure risk in coastal structures. A detailed discussion on the role of the distribution changes for design water level is provided.

• Journal of The Korean Society of Agricultural Engineers
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• v.63 no.4
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• pp.97-104
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• 2021

Despite the practical limitations of calculating the amount of inflow and supply related to the operation of agricultural reservoirs, the role of agricultural reservoirs is gradually being emphasized. In particular, as interest in disaster safety has increased, the demand for preliminary measures to prepare for disasters has been rising, for instance, pre-discharging agricultural reservoirs for flood control. The aim of this study is to analyze the plans for the flood season reservoir operation considering pre-discharge period and water level limit. Accordingly, we optimized the simulation of daily storage using the ratio correction factor (RCFs) and analyzed the amount of inflow and supply using K-HAS. In addition we developed the drought determination coefficient (k) as a indicator of water availability and applied it for supplementing the risk level criteria in the Drought Crisis Response Manual. The results showed that it would be difficult to set the water level limit during the flood period in the situation of little water supply for flood control in agricultural reservoirs. Therefore, it is necessary to operate the reservoir management regulations after measures such as securing additional storage water are established in the future.

• (The) Korean Journal of Educational Psychology
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• v.31 no.2
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• pp.265-282
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• 2017

The purpose of this study was to applicate systematic RTI educational service by providing reading fluency program to identify high-risk students with dyslexia of a shadow zone based on their growth rate. Twenty-two students of 1st to 5th graders were selected as study subjects through "2016 Kyungi-Do Project of the Dyslexia Excellence Program". An individualized reading fluency program was provided through 8-10 sessions over a period of 3 months. The program was developed based on evidence-based reading strategies with the consideration of each student's educational needs. As results, three groups were identified with their learning growth rates: concerned, improving, and discrepancy groups. The study identified three students in a discrepancy group as students with dyslexia. Based on these results, implications and suggestions for further educational identification process along with effect programs were discussed.

• Biomolecules & Therapeutics
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• v.30 no.3
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• pp.284-290
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• 2022

Oral squamous cell carcinoma (OSCC) is mostly diagnosed at an advanced stage, with local and/or distal metastasis. Thus, locoregional and/or local control of the primary tumor is crucial for a better prognosis in patients with OSCC. Platelets have long been considered major players in cancer metastasis. Traditional antiplatelet agents, such as aspirin, are thought to be potential chemotherapeutics, but they need to be used with caution because of the increased bleeding risk. Podoplanin (PDPN)-expressing cancer cells can activate platelets and promote OSCC metastasis. However, the reciprocal effect of platelets on PDPN expression in OSCC has not been investigated. In this study, we found that direct contact with platelets upregulated PDPN and integrin β1 at the protein level and promoted invasiveness of human OSCC Ca9.22 cells that express low levels of PDPN. In another human OSCC HSC3 cell line that express PDPN at an abundant level, silencing of the PDPN gene reduced cell invasiveness. Analysis of the public database further supported the co-expression of PDPN and integrin β1 and their increased expression in metastatic tissues compared to normal and tumor tissues of the oral cavity. Taken together, these data suggest that PDPN is a potential target to regulate platelet-tumor interaction and metastasis for OSCC treatment, which can overcome the limitations of traditional antiplatelet drugs.

• Journal of Environmental Impact Assessment
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• v.31 no.4
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• pp.250-264
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• 2022

The development projects subject to health impact assessment (HIA) in the current environmental impact assessment (EIA) system are limited to some projects under Article 12 of the Enforcement Decree of the Environmental Health Act (Additional Assessment Objects Subject to Health Impact Assessment Items), but health impact-related matters are being evaluated and reviewed during consultation. In particular, when a development site is planned around some pollutant sources in a residential development plan, it is evaluated and reviewed whether the site meets the risk criteria through a current concentration survey of major hazardous air pollutants. This study prepared a quantitative method to confirm the validity of the location of the residential area to be developed in the residential development plan and proposed a plan to expand the project subject to HIA within the EIA procedure. A detailed methodology was proposed by reviewing the screening and scoping procedures of the EIA system, and a case analysis of the urban development plan discussed in the past was conducted to verify the methodology.

• Molecules and Cells
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• v.45 no.10
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• pp.738-748
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• 2022

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has posed a serious threat to global public health. A novel vaccine made from messenger RNA (mRNA) has been developed and approved for use at an unprecedented pace. However, an increased risk of myocarditis has been reported after BNT162b2 mRNA vaccination due to unknown causes. In this study, we used single-cell RNA sequencing and single-cell T cell receptor sequencing analyses of peripheral blood mononuclear cells (PBMCs) to describe, for the first time, changes in the peripheral immune landscape of a patient who underwent myocarditis after BNT162b2 vaccination. The greatest changes were observed in the transcriptomic profile of monocytes in terms of the number of differentially expressed genes. When compared to the transcriptome of PBMCs from vaccinated individuals without complications, increased expression levels of IL7R were detected in multiple cell clusters. Overall, results from this study can help advance research into the pathogenesis of BNT162b2-induced myocarditis.

• Korean Chemical Engineering Research
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• v.59 no.2
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• pp.180-185
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• 2021

In accordance with the revision of the US-Korea missile guidelines, restrictions on the use of solid propellants for space launch vehicles have been completely lifted. The solid propellant can be used as a solid propellant rocket like the KSR-1 (Korea Sounding Rocket-1), and can also be used as a thrust augmentation booster for liquid fuel launch vehicles. It is known that solid propellants have a lower risk of explosion than liquid propellants. but if an accident such as an explosion at the Alcantara Launch Center in Brazil occurs, it can lead to a large-scale personal accident. In order to prevent such large-scale accidents, it is necessary to review and reflect the minimum safety distance during use, storage and combustion test of solid propellants from the planning phase of the project. In this paper, the minimum safety distance for safe use of the solid propellant is presented by dividing it into storage facilities and combustion tests.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.31 no.4
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• pp.396-416
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• 2021

Objectives: This study was conducted to analyze the trends of government R&D (R&D) projects related to laboratory safety over the past 20 years. Methods: We collected publications from various databases(DBs) with words such as laboratory(ies), lab(s), researcher(s), laboratory worker(s), safety, environment, hazard(s), risk(s), and so on. Selected publications were analyzed by the research funds and the number of projects according to the investment subject and research characteristics. Results: About 93% of the total R&D budget went to government policy projects, not scientific research. Second, from the perspective of 'safety management activities', most of the research is related to management and inspection at the organizational level. Issues that need to be discussed at the national level like policy governance are not included. Third, focusing on the 'safety management cycle', there were few studies related to 'prediction' or 'post-response'. Fourth, when an analysis framework combining the perspectives of 'safety management activities' and 'safety management cycle' is applied, most of the budget is spent on infrastructure such as digital management systems, whereas basic knowledge for prevention and production of evidence was very few. Conclusions: In order to prevent policy planning without policy evaluation, implementation without strategy, and evaluation without evidence, it is necessary to expand investment in empirical research on risks, research on the effectiveness of current application methods, and research on theory development. The government budget for laboratory safety-related projects should be managed separately from the R&D budget for scientific research. Although less than 5% of the budget allocated to scientific research is the total budget, an optical illusion occurs because both the project budget and the scientific research budget are counted as R&D budgets.