• Biomolecules & Therapeutics
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• 제16권1호
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• pp.34-39
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• 2008

Oxidative stress may represent a common link between chronic liver damage and hepatic fibrosis. In the present study, we investigated activity changes of sphingomyelin catabolic enzymes, such as sphingomyelinases and ceramidases by using dimethylnitrosamine (DMN)-treated Sprague-Dawley (SD) male rats hepatic fibrosis model as a hepatic fibrosis model. Twenty rats divided into five groups received: (1) saline; (2) DMN for 1 week, (3) DMN for 2 weeks, (4) DMN for 3 weeks, and (5) DMN for 4 weeks by intraperitoneally 10 mg/kg of body weight for three consecutive days a week. Activities of acidic and neutral sphingomyelinases and acidic, neutral and alkaline ceramidases were measured in the liver and kidney from DMN-treated rats. We found increased ceramidase activities from 2-week and/or 3-week DMN treated rat livers compared to control rat liver. Acidic sphingomyelinase and alkaline ceramidase activities were significantly increased in 3-week DMN-treated rat kidneys compared to control rat kidney. Therefore, sphingolipid metabolizing enzymes and sphingolipid metabolites are supposed to be involved in liver fibrosis, although further investigation is necessary to elucidate meanings of sphingolipids during the liver fibrosis

• 품질경영학회지
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• 제45권3호
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• pp.349-364
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• 2017

Purpose: The purpose of this study is to analyze quality control strengthening pilot project in development stages of weapon systems which ensures zero-defect. In order to achieve that, we propose collaboration support system between related organizations. Methods: First, we analyze how quality control methods has been developed from reviewing the preliminary study in commercial and defense industry. Then, we suggest improvement plans for quality control in defense industry and propose a pilot study which able to improve the recognized problems. Results: The results of this study ensures the participants in defense industry recognize the importance of quality control and form a consensus by sharing a case study. Finally, we propose the standardized work process by utilizing manual and manpower dispatching. Conclusion: As a result, this study clarifies the scope and role of relevant organizations to achieve the defense quality assurance in the total life cycle(TLC). Also, this paper guides the collaboration system between the relevant organization which differs from the commercial industry currently divided into development-production-quality.

• 한국CDE학회논문집
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• 제18권3호
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• pp.177-188
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• 2013

The construction industry consists of various and massive architectural information as an architectural process includes a variety of design stages with cooperation of many disciplines. Particularly, architectural information is generated and managed through the life cycle of a building, from conceptual design stage to the construction and maintenance. A Building Information Model (BIM) serves as a shared knowledge resource for information about a facility forming a reliable basis for decisions during its life-cycle from inception onward. BIM technology accomplished quantitative development being utilized in various disciplines. However, it is necessary to develop environment and requirement for qualitative improvement of BIM based project. Particularly, requirement is very important for architectural design evaluations. The purpose of this study is to develop and apply of quality control check-list for improving the quality of architectural design in BIM environments. To achieve this purpose, the authors have investigated case study for open BIM data quality control (software, guideline and application case) and classified quality control targets according to physical/logical quality control and data quality. In addition, the authors have defined open BIM based quality control process and developed quality control check-list. Finally, the authors have developed automatic quality check system using requirements for efficient quality control based on open BIM.

• 한국BIM학회 논문집
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• 제10권3호
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• pp.33-42
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• 2020

Recently, in the smart construction field, it is possible to construct spatial information of 3D data base quickly and accurately using drones, LiDARs and ARs,. Most public ordering institutions are pushing for the efficiency of construction work through establishing and announcing road maps and guidelines for utilizing BIM for the entire life cycle of construction. However, in most policies, the impact of 3D data on the entire life cycle is limited by only partially constructing and utilizing 3D data or by being mentioned. In addition, many public institutions, construction companies and planning companies did not actively utilize survey information during the actual construction phase, despite the possibility of using 3D survey information. In order to confirm the utilization of survey information, a total of eight private construction companies were selected and interviewed by experts. The analysis shows that most of companies lack the performance of drone measurements or have a lack of awareness of advantages, and among them, construction companies are relatively active. Based on these opinions, this study examined the usability of surveying information and examined measures to expand the utilization of survey information in legal and institutional aspects, technology development aspects and industrial development.

• 국제학술발표논문집
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• The 5th International Conference on Construction Engineering and Project Management
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• pp.196-203
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• 2013

Environmental problems like global warming have now become important issues that should be considered in all industries, including construction. In South Korea, many studies have been conducted to achieve the government's goals of reduction in environmental impacts. However, the research on buildings has only focused on CO₂ emission as a research target despite the fact that other environmental impacts resulting from ozone depletion and acidification should also be considered, in addition to global warming. In this regard, this study attempted to propose assessment criteria and methods to evaluate the environmental performance of the structures from various aspects. The environmental impact category can be divided into global impacts, regional impacts, and local impacts. First, global impacts include global warming, ozone layer depletion, and abiotic resource depletion, while regional impacts include acidification, eutrophication, and photochemical oxidation. In addition, noise and vibration occurring in the building construction phase are defined as local impacts. The evaluation methods on the eight environmental impacts will be proposed after analyzing existing studies, and the methods representing each environmental load as monetary value will be presented. The methods presented in this study will present benefits that can be obtained through green buildings with a clear quantitative assessment on structures. Ultimately, it is expected that if the effects of green buildings are clearly presented through the findings of this study, the greening of structures will be actively expanded.

• 한국군사과학기술학회지
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• 제27권2호
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• pp.203-212
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• 2024

This paper describes the establishment of defense systems test works architecture model for the efficient operation of an expanded test organization and the provision of standardized test services after the integration of proving grounds in ADD. The system engineering vee model is applied to the defense system test works to define the project management model and the unit-test management model. In order to establish the defense systems test works architecture model, the process flow of test works, artifacts by life cycle, and interrelations between regulations and test works are explained, and Integrated Test Information System for implementation of architecture model is discussed. Through the defense systems test works architecture model presented in this study, it will contribute to quickly responding to the test requirements of complex and diverse defense systems, efficiently managing projects, and providing standardized test services.

• 한국건설관리학회논문집
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• 제18권2호
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• pp.3-11
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• 2017

내 공공건축물은 총 17만 7천여 동으로 이중 15년 이상 경과하여 노후화가 진행 중인 건물이 전체 건물 수의 약 74% 달한다. 노후화된 건물로 인하여 에너지 손실이 심각한 실정이다. 노후화 건축물의 에너지 효율을 개선하여 에너지 소비량을 줄이기 위해서 정부 및 지자체에서 기존 건축물의 리모델링 수선 및 설비 교체를 통한 에너지 효율화 사업을 진행 중이다. 최근에 개정된 녹색건축물 조성지원법에서는 그린리모델링을 기존 공공건축물에 적용 활성화하고자 한다. 하지만 그린리모델링 사업에 대한 업무의 범위, 재원 마련 방안 및 발주 방식에 대한 기준이 뚜렷하지 않다. 따라서 본 연구를 통하여 그린리모델링을 활성화 할 수 있는 방안을 마련하고자 한다. 기존 건축생산 과정을 바탕으로 한 프로젝트 라이프사이클 과정에서 발생하는 업무를 기준으로 그린 리모델링 업무를 정의하였으며, 건축주 및 사업자가 재원을 마련 할 수 있는 방안 및 그린리모델링 업무 구분에 따른 발주 패키지를 도출하여 낙찰자 결정 방식 및 대가지급 방식 등을 제안하였다.

• 시스템엔지니어링학술지
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• 제16권1호
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• pp.18-24
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• 2020

The KSLV-II project with high difficulties technically requires thorough technical management during long-term life cycle more than 10 years for launching into space. The TRL is a quantitative indicator developed by NASA widely used all over the world to measure technology maturity of a system development objectively and consistently. The TRL is also used to make sure technology level and to establish a future direction in the KSLV-II project. The TRL has advantage enable to identify a technology level through quantitative indicators. However, it takes a lot of efforts such as trials and errors, time and cost to apply it to the project considering the project environments, and stakeholder needs. These include not only to establish TRL management plan from ideal, conceptual and abstractive standards/guidelines such as NASA's, but also to construct TRL management environment enable to apply and manage harmoniously. In the KSLV-II project, it is required to figure out current technology level and technology development trend in the future, to access conveniently, to share related data in real time, and to update periodically for the comprehensive TRL management. From the reason above, the TRL management environment was built by using the systems engineering tool already has been used for other system management data such as requirements in the project. It also could be accomplished a practical management basis of systems engineering from the traceability among system management data including TRL. In this paper, case study results are introduced to manage the TRL for the space launch vehicle using the systems engineering tool in the KSLV-II project.

• 한국건설관리학회논문집
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• 제10권1호
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• pp.45-57
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• 2009

교육시설물 BTL 사업은 여러 개의 시설물을 1개의 번들로 계약하며, 계약기간을 20년으로 산정하여 그 비용을 지급한다. 따라서 BTL 프로젝트 초기단계에 운영관리비를 예측하는 정확도와 발주번들에 포함되는 시설물을 어떻게 편성하느냐에 따라 비용편차가 크게 발생하게 된다. 본 연구에서는 교육시설물 BTL 사업 발주 시 운영관리 최적 번들을 구성하기 위한 방법으로 컴플리트 링키지 알고리즘을 이용하는 비용 예측 시스템을 개발하고, 이를 통해 발주번들에 포함되는 시설물 변화에 따라 제한조건들이 변화하는 경우에 대해 사용자의 의사결정 시 판단근거자료로 활용 가능하게 하고자 한다. 본 연구에서 제안하는 시스템을 활용하면 보다 효율적이고 신속한 BTL 프로젝트의 운영비 예측이 가능할 것으로 사료된다.

• 정보처리학회논문지D
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• 제9D권2호
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• pp.259-266
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• 2002

소프트웨어 개발시 중요하게 제기되는 문제점으로 소프트웨어 생명주기의 초기단계에서 개발에 투입될 노력과 비용을 추정하는 능력이다. 측정된 소프트웨어 규모인 기능점수 (FP, Function Point)로부터 프로젝트 개발에 소요되는 노력과 비용을 추정하는 회귀모델들이 제안되었다. 그러나 이들 제안된 모델들은 사용한 표본의 크기가 작고, 과거에 개발된 프로젝트를 대상으로 하고 있다. 1990년대에 개발된 789개 소프트웨어 개발 프로젝트들에 투입된 개발노력에 이들 모델을 적용한 결과 결정계수 $R^2$가 0.53 이하로 데이터의 변동을 설명하였다. 본 논문은 프로젝트 인도율(PDR)을 이용하여 동질성을 갖는 그룹으로 분류하여 개발노력을 추정하는 모델을 제안하였다. 제안된 모델은 랜덤한 잔차 분포를 갖고 있고, 대부분의 PDR 범위에서 0.99이상의 결정계수로 데이터의 변동을 설명하였다.