• Biomolecules & Therapeutics
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• v.16 no.1
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• pp.34-39
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• 2008

Oxidative stress may represent a common link between chronic liver damage and hepatic fibrosis. In the present study, we investigated activity changes of sphingomyelin catabolic enzymes, such as sphingomyelinases and ceramidases by using dimethylnitrosamine (DMN)-treated Sprague-Dawley (SD) male rats hepatic fibrosis model as a hepatic fibrosis model. Twenty rats divided into five groups received: (1) saline; (2) DMN for 1 week, (3) DMN for 2 weeks, (4) DMN for 3 weeks, and (5) DMN for 4 weeks by intraperitoneally 10 mg/kg of body weight for three consecutive days a week. Activities of acidic and neutral sphingomyelinases and acidic, neutral and alkaline ceramidases were measured in the liver and kidney from DMN-treated rats. We found increased ceramidase activities from 2-week and/or 3-week DMN treated rat livers compared to control rat liver. Acidic sphingomyelinase and alkaline ceramidase activities were significantly increased in 3-week DMN-treated rat kidneys compared to control rat kidney. Therefore, sphingolipid metabolizing enzymes and sphingolipid metabolites are supposed to be involved in liver fibrosis, although further investigation is necessary to elucidate meanings of sphingolipids during the liver fibrosis

• Journal of Korean Society for Quality Management
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• v.45 no.3
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• pp.349-364
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• 2017

Purpose: The purpose of this study is to analyze quality control strengthening pilot project in development stages of weapon systems which ensures zero-defect. In order to achieve that, we propose collaboration support system between related organizations. Methods: First, we analyze how quality control methods has been developed from reviewing the preliminary study in commercial and defense industry. Then, we suggest improvement plans for quality control in defense industry and propose a pilot study which able to improve the recognized problems. Results: The results of this study ensures the participants in defense industry recognize the importance of quality control and form a consensus by sharing a case study. Finally, we propose the standardized work process by utilizing manual and manpower dispatching. Conclusion: As a result, this study clarifies the scope and role of relevant organizations to achieve the defense quality assurance in the total life cycle(TLC). Also, this paper guides the collaboration system between the relevant organization which differs from the commercial industry currently divided into development-production-quality.

• Korean Journal of Computational Design and Engineering
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• v.18 no.3
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• pp.177-188
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• 2013

The construction industry consists of various and massive architectural information as an architectural process includes a variety of design stages with cooperation of many disciplines. Particularly, architectural information is generated and managed through the life cycle of a building, from conceptual design stage to the construction and maintenance. A Building Information Model (BIM) serves as a shared knowledge resource for information about a facility forming a reliable basis for decisions during its life-cycle from inception onward. BIM technology accomplished quantitative development being utilized in various disciplines. However, it is necessary to develop environment and requirement for qualitative improvement of BIM based project. Particularly, requirement is very important for architectural design evaluations. The purpose of this study is to develop and apply of quality control check-list for improving the quality of architectural design in BIM environments. To achieve this purpose, the authors have investigated case study for open BIM data quality control (software, guideline and application case) and classified quality control targets according to physical/logical quality control and data quality. In addition, the authors have defined open BIM based quality control process and developed quality control check-list. Finally, the authors have developed automatic quality check system using requirements for efficient quality control based on open BIM.

• Journal of KIBIM
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• v.10 no.3
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• pp.33-42
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• 2020

Recently, in the smart construction field, it is possible to construct spatial information of 3D data base quickly and accurately using drones, LiDARs and ARs,. Most public ordering institutions are pushing for the efficiency of construction work through establishing and announcing road maps and guidelines for utilizing BIM for the entire life cycle of construction. However, in most policies, the impact of 3D data on the entire life cycle is limited by only partially constructing and utilizing 3D data or by being mentioned. In addition, many public institutions, construction companies and planning companies did not actively utilize survey information during the actual construction phase, despite the possibility of using 3D survey information. In order to confirm the utilization of survey information, a total of eight private construction companies were selected and interviewed by experts. The analysis shows that most of companies lack the performance of drone measurements or have a lack of awareness of advantages, and among them, construction companies are relatively active. Based on these opinions, this study examined the usability of surveying information and examined measures to expand the utilization of survey information in legal and institutional aspects, technology development aspects and industrial development.

• International conference on construction engineering and project management
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• 2013.01a
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• pp.196-203
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• 2013

Environmental problems like global warming have now become important issues that should be considered in all industries, including construction. In South Korea, many studies have been conducted to achieve the government's goals of reduction in environmental impacts. However, the research on buildings has only focused on CO₂ emission as a research target despite the fact that other environmental impacts resulting from ozone depletion and acidification should also be considered, in addition to global warming. In this regard, this study attempted to propose assessment criteria and methods to evaluate the environmental performance of the structures from various aspects. The environmental impact category can be divided into global impacts, regional impacts, and local impacts. First, global impacts include global warming, ozone layer depletion, and abiotic resource depletion, while regional impacts include acidification, eutrophication, and photochemical oxidation. In addition, noise and vibration occurring in the building construction phase are defined as local impacts. The evaluation methods on the eight environmental impacts will be proposed after analyzing existing studies, and the methods representing each environmental load as monetary value will be presented. The methods presented in this study will present benefits that can be obtained through green buildings with a clear quantitative assessment on structures. Ultimately, it is expected that if the effects of green buildings are clearly presented through the findings of this study, the greening of structures will be actively expanded.

• Journal of the Korea Institute of Military Science and Technology
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• v.27 no.2
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• pp.203-212
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• 2024

This paper describes the establishment of defense systems test works architecture model for the efficient operation of an expanded test organization and the provision of standardized test services after the integration of proving grounds in ADD. The system engineering vee model is applied to the defense system test works to define the project management model and the unit-test management model. In order to establish the defense systems test works architecture model, the process flow of test works, artifacts by life cycle, and interrelations between regulations and test works are explained, and Integrated Test Information System for implementation of architecture model is discussed. Through the defense systems test works architecture model presented in this study, it will contribute to quickly responding to the test requirements of complex and diverse defense systems, efficiently managing projects, and providing standardized test services.

• Korean Journal of Construction Engineering and Management
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• v.18 no.2
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• pp.3-11
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• 2017

Aging buildings over 15 years reaches about 74% of 177 thousand buildings in Domestic public buildings. Due to the aging building, the energy loss is a serious problem. In order to reduce the energy usage through improving the energy efficiency on the existing buildings, the government & the local autonomous entity conduct the energy efficiency projects through the remodeling, repairing & equipment replacement on the existing buildings. The green remodeling is applied to the existing public buildings in recently revised the act on the creation and support of green building. However, the standard is not obvious that the work scope of green remodeling, financing and project delivery method. This paper propose is to suggest project delivery system for vitalizing the green remodeling. Green remodeling is defined on basis of the occurring work under project life cycle based on the existing building process and the financing method for owners and companies and the project delivery system according to work scope of green remodeling are proposed in this paper

• Journal of the Korean Society of Systems Engineering
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• v.16 no.1
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• pp.18-24
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• 2020

The KSLV-II project with high difficulties technically requires thorough technical management during long-term life cycle more than 10 years for launching into space. The TRL is a quantitative indicator developed by NASA widely used all over the world to measure technology maturity of a system development objectively and consistently. The TRL is also used to make sure technology level and to establish a future direction in the KSLV-II project. The TRL has advantage enable to identify a technology level through quantitative indicators. However, it takes a lot of efforts such as trials and errors, time and cost to apply it to the project considering the project environments, and stakeholder needs. These include not only to establish TRL management plan from ideal, conceptual and abstractive standards/guidelines such as NASA's, but also to construct TRL management environment enable to apply and manage harmoniously. In the KSLV-II project, it is required to figure out current technology level and technology development trend in the future, to access conveniently, to share related data in real time, and to update periodically for the comprehensive TRL management. From the reason above, the TRL management environment was built by using the systems engineering tool already has been used for other system management data such as requirements in the project. It also could be accomplished a practical management basis of systems engineering from the traceability among system management data including TRL. In this paper, case study results are introduced to manage the TRL for the space launch vehicle using the systems engineering tool in the KSLV-II project.

• Korean Journal of Construction Engineering and Management
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• v.10 no.1
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• pp.45-57
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• 2009

BTL (Build-Transfer-Lease) Project for Education Facilities are contracted as a package which consists of several education facilities. The general maintenance period of BTL project for education facilities is 20 years. Thus, total cost variation largely depends on the accuracy of the maintenance cost forecasting in the early stage in the life cycle of the BTL Project. This research develops a cost forecasting system using complete linkage algorithm and branch & bound algorithm to help in finding optimal bundling combination. This system helps owner's decision-making to estimate the total project cost with various constraints changing. The result of this research suggests more reasonable and effective forecasting model for the maintenance facilities package in the BTL project.

• The KIPS Transactions:PartD
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• v.9D no.2
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• pp.259-266
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• 2002

The main issue in software development is the ability of software project effort and cost estimation in the early phase of software life cycle. The regression models for project effort and cost estimation are presented by function point that is a software sire. The data sets used to conduct previous studies are of ten small and not too recent. Applying these models to 789 project data developed from 1990 ; the models only explain fewer than 0.53 $R^2$(Coefficient of determination) of the data variation. Homogeneous group in accordance with project delivery rate (PDR) divides the data sets. Then this paper presents general effort estimation models using project delivery rate. The presented model has a random distribution of residuals and explains more than 0.93 $R^2$ of data variation in most of PDR ranges.