• 한국초전도ㆍ저온공학회논문지
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• 제25권3호
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• pp.38-42
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• 2023

The evaluation of no-insulation (NI) high-temperature superconducting (HTS) typically uses the lumped equivalent circuit (LEC) model. Constant parameters in the NI HTS LEC model accurately predict voltage and central magnetic field at currents below the critical current. However, it is difficult to find constant circuit parameters that simultaneously satisfy the measured voltage and magnetic field under overcurrent conditions. Recent research highlights changes in contact resistance during transient conditions, which may impact power loss estimation in NI HTS coils. Therefore, we confirm the influence of contact resistance changes on loss calculation in the transient state for NI HTS coil. To achieve this, we introduce a measurement data analysis method based on the LEC model and compare it with the LEC model using constant circuit parameters.

• 보건행정학회지
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• 제27권2호
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• pp.149-156
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• 2017

Background: This study was conducted to evaluate the performance of the Hierarchical Condition Category (HCC) model, identify potentially high-cost patients, and examine the effects of adding prior utilization to the risk model using Korean claims data. Methods: We incorporated 2 years of data from the National Health Insurance Services-National Sample Cohort. Five risk models were used to predict health expenditures: model 1 (age/sex groups), model 2 (the Center for Medicare and Medicaid Services-HCC with age/sex groups), model 3 (selected 54 HCCs with age/sex groups), model 4 (bed-days of care plus model 3), and model 5 (medication-days plus model 3). We evaluated model performance using $R^2$ at individual level, predictive positive value (PPV) of the top 5% of high-cost patients, and predictive ratio (PR) within subgroups. Results: The suitability of the model, including prior use, bed-days, and medication-days, was better than other models. $R^2$ values were 8%, 39%, 37%, 43%, and 57% with model 1, 2, 3, 4, and 5, respectively. After being removed the extreme values, the corresponding $R^2$ values were slightly improved in all models. PPVs were 16.4%, 25.2%, 25.1%, 33.8%, and 53.8%. Total expenditure was underpredicted for the highest expenditure group and overpredicted for the four other groups. PR had a tendency to decrease from younger group to older group in both female and male. Conclusion: The risk adjustment models are important in plan payment, reimbursement, profiling, and research. Combined prior use and diagnostic data are more powerful to predict health costs and to identify high-cost patients.

• Journal of Ginseng Research
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• 제46권2호
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• pp.255-265
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• 2022

Background: Ginsenoside Rb1, a bioactive component isolated from the Panax ginseng, acts as a remedy to prevent myocardial injury. However, it is obscure whether the cardioprotective functions of Rb1 are related to the regulation of endogenous metabolites, and its potential molecular mechanism still needs further clarification, especially from a comprehensive metabolomics profiling perspective. Methods: The mice model of acute myocardial ischemia (AMI) and oxygen glucose deprivation (OGD)-induced cardiomyocytes injury were applied to explore the protective effect and mechanism of Rb1. Meanwhile, the comprehensive metabolomics profiling was conducted by high-performance liquid chromatography and quadrupole time-of-flight mass spectrometry (HPLC-Q/TOF-MS) and a tandem liquid chromatography and mass spectrometry (LC-MS). Results: Rb1 treatment profoundly reduced the infarct size and attenuated myocardial injury. The metabolic network map of 65 differential endogenous metabolites was constructed and provided a new inspiration for the treatment of AMI by Rb1, which was mainly associated with mitophagy. In vivo and in vitro experiments, Rb1 was found to improve mitochondrial morphology, mitochondrial function and promote mitophagy. Interestingly, the mitophagy inhibitor partly attenuated the cardioprotective effect of Rb1. Additionally, Rb1 markedly facilitated the phosphorylation of AMP-activated protein kinase α (AMPKα), and AMPK inhibition partially weakened the role of Rb1 in promoting mitophagy. Conclusions: Ginsenoside Rb1 protects acute myocardial ischemia injury through promoting mitophagy via AMPKα phosphorylation, which might lay the foundation for the further application of Rb1 in cardiovascular diseases.

• Molecules and Cells
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• 제38권6호
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• pp.548-561
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• 2015

By combining conventional single cell analysis with flow cytometry and public database searches with bioinformatics tools, we extended the expression profiling of thymic stromal cotransporter (TSCOT), Slc46A2/Ly110, that was shown to be expressed in bipotent precursor and cortical thymic epithelial cells. Genome scale analysis verified TSCOT expression in thymic tissue- and cell type- specific fashion and is also expressed in some other epithelial tissues including skin and lung. Coexpression profiling with genes, Foxn1 and Hoxa3, revealed the role of TSCOT during the organogenesis. TSCOT expression was detected in all thymic epithelial cells (TECs), but not in the $CD31^+$endothelial cell lineage in fetal thymus. In addition, ABC transporter-dependent side population and Sca-$1^+$ fetal TEC populations both contain TSCOT-expressing cells, indicating TEC stem cells express TSCOT. TSCOT expression was identified as early as in differentiating embryonic stem cells. TSCOT expression is not under the control of Foxn1 since TSCOT is present in the thymic rudiment of nude mice. By searching variations in the expression levels, TSCOT is positively associated with Grhl3 and Irf6. Cytokines such as IL1b, IL22 and IL24 are the potential regulators of the TSCOT expression. Surprisingly, we found TSCOT expression in the lung is diminished in lung cancers, suggesting TSCOT may be involved in the suppression of lung tumor development. Based on these results, a model for TEC differentiation from the stem cells was proposed in context of multiple epithelial organ formation.

• 한국지구물리탐사학회:학술대회논문집
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• 한국지구물리탐사학회 2006년도 공동학술대회 논문집
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• pp.285-290
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• 2006

소양댐 축조 이후 소양호에 퇴적된 퇴적물의 양과 분포상태를 파악하기 위하여, 227 km에 달하는 측선을 따라 10-20 kHz 음파탐사를 실시하였다. 측선간격은 종단면의 경우 대략 50 m, 횡단면의 경우 500 m 정도이다. 이득조절과 f-k 구조보정 과정을 거친 후, 퇴적물의 경계를 수치화하고, 38개 시추코아 자료와 대비하여 확인하였다. 댐축조 이후 퇴적물의 두께는 평균 0.25 m로 최대 8.25m에 달한다. 댐축조 이후 퇴적물의 총 부피는 이방성을 고려하여 지구통계기법으로 계산할 경우, 등방성을 가정하고 구한 경우보다 2배 이상 증가한 $5.9{\times}10^6\;m^3$에 달하는 것으로 분석된다.

• 한국지반공학회논문집
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• 제28권12호
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• pp.87-98
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• 2012

현장타설말뚝의 시공현장에서 소켓 벽면의 거칠기를 측정할 수 있는 거칠기 측정장치의 소나센서부를 개발하였으며 검증시험을 실시하였다. 모형 검증시험에서는 현장 굴착공내수 조건을 모사하여 염도, 온도, 혼탁도를 변화시켰다. 시험 결과를 통해 센서의 정밀도는 1mm임을 확인할 수 있었고 소나센서의 파형 특성상 경사면과 곡면의 측정값이 일부 분산되는 경우가 있었지만 시험에 사용된 모형의 형상은 비교적 정확하게 확인할 수 있었다. 또한 소나센서의 측정값은 염도, 온도, 혼탁도의 변화에 의한 영향을 받지 않음을 알 수 있었다.

• 한국지반공학회논문집
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• 제24권10호
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• pp.25-32
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• 2008

암반에 근입된 현장타설말뚝의 주면마찰력은 암석의 일축압축강도 외에 굴착면의 거칠기, 암반의 재료특성, 초기 수직응력, 말뚝의 직경, 암반의 절리 및 풍화도 등에 크게 영향을 받는 것으로 알려져 있다. 특히 주면마찰력에 영향을 미치는 인자 중 굴착공의 거칠기는 암반의 종류, 말뚝의 직경, 그리고 말뚝의 시공법에 따른 영향이 큰 것으로 알려져 있다. 암반의 굴착공 벽면거칠기 측정장치인 Backyoung-Kyungsung Laser Roughness Profiling System(이하 BKS-LRPS라 칭함)의 혼탁도에 대한유효측정영역 및 측정 가능 여부를 결정하기 위하여 실내모형실험을 수행하였으며, 여기서 혼탁($T_b$)와 BKS-LRPS의 유효 측정거리(Effective Measurement Distances(EMD), mm)의 관계식은 $EMD=1149.2{\times}T_{b}^{-0.64}$로 구할 수 있었다.

• 한국해양공학회지
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• 제28권1호
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• pp.55-63
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• 2014

In this paper, we propose an threshold-based Schur algorithm for estimating the media characteristics of sub-bottom multi-layers by using the signal generated by a parametric array transducer. We use the KZK model to generate a parametric array signal, and use the proposed threshold-based Schur algorithm for estimating the reflection coefficients of multiple sea bottom layers. Using computer simulation, we verify that the difference frequency component generated by the KZK model prevails over the signals of primary frequencies at long range. For the simulation, we use the transmit signal generated by the KZK and the reflected signal obtained from a lattice filter model for the seawater and sub-bottom of multi-level non-homogeneous layers. Through the simulation, we verify that the proposed threshold-based Schur algorithm can give much more accurate and efficient estimates of the reflection coefficients than methods using received signal, matched filter output signal, and normal Schur algorithm output.

• 한국군사과학기술학회지
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• 제12권4호
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• pp.415-423
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• 2009

To investigate low frequency acoustic transmissions in the Sub-Polar Front(SPF) of the East Sea, numerical experiments are conducted with Range dependent Acoustic Model(RAM) using Circulation Research of the East Asian Marginal Seas(CREAMS) data and Autonomous Profiling Explorer(APEX)) data. Significant seasonal variations of sea water properties are existed across the Sub-Polar Front(SPF) region from the north and the south. The model results show that Transmission Loss(TL) decrease(about 20dB) with ideal front in the warm region whereas TL increase(about 25dB) with ideal front in the cold region. Regardless of season(both in summer and winter), when the sound source is located in the cold region of the SPF, the model results show weak TL, compared to the case of the source in the warm region(Maximum difference of TL reaches 28dB). This difference between the cases when the source is located in the cold region and the warm region, is accounted for from the different vertical profiles of sound speed in both regions.

• 품질경영학회지
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• 제39권2호
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• pp.244-255
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• 2011

In this study, we try to evaluate the efficiency of the photonics industry using a data envelopment analysis(DEA) model. We first develope four stage procedures for selecting proper input and output variables which consist of selecting the first candidate variables from literature survey, selecting the second candidate variables through experts' discussion, measuring the partial efficiency of the selected variables based on Tofallis' profiling, and clustering some variables through the rank correlation analysis of partial efficiency proposed by Min and Kim(l998). With this procedure, we select 4 input variables(capital, number of employee, R&D cost, operating cost) and 2 output variables(sales, growth of sales) and then utilize CCR and BCC model to measure efficiencies of 26 photonics companies in Gwangju. Moreover, we perform the reference group analysis to figure out what causes inefficiencies and to provide the desirable values for input and output variables at which inefficient photonics companies become efficient. Finally, we classify 26 photonics companies into three groups such as optical communications, optical applications, and optical sources, and perform the Kruskal-Wallis test to check if there exist some differences between efficiencies of three groups.