• Title/Summary/Keyword: Profile Modification

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Effects of phylloquinone supplementation on lipid profile in women with rheumatoid arthritis: a double blind placebo controlled study

  • Kolahi, Sousan;Gargari, Bahram Pourghassem;Abbasi, Mehran Mesgari;Jafarabadi, Mohammad Asghari;Shishavan, Neda Ghamarzad
    • Nutrition Research and Practice
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    • v.9 no.2
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    • pp.186-191
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    • 2015
  • BACKGROUND/OBJECTIVES: Rheumatoid arthritis (RA) is associated with an excess mortality from cardiovascular disease which is likely attributed to an atherogenic lipid profile. Among nutritional factors vitamin K has been recently focused as a pivotal nutrient in improvement of lipid related markers. Thus, this study was designed to determine the effects of vitamin K on lipid profile in this disease. SUBJECTS/METHODS: Fifty eight patients with definitive RA were participated in the present double blind placebo controlled study. They were randomly allocated into two groups to receive vitamin $K_1$ as phylloquinone [10 mg/day] (n = 30) or placebo pills (n = 28), for eight weeks. In order to control the effects of probable confounders dietary intakes, anthropometric measurements including weight and height, clinical status using disease activity score-28 (DAS-28), physical activity and anxiety status were evaluated at baseline. Moreover, serum levels of lipid related markers including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) were measured at baseline and at the end of intervention. RESULTS: There were no significant differences between the two groups regarding any of the baseline characteristics. After adjusting for some relevant confounders, in comparison between two groups, we observed no significant changes in lipid related markers at the end of intervention. Also, there was no significant difference between before and after intervention values within groups (P > 0.05). CONCLUSIONS: Function of vitamin $K_1$ in lipid profile modification remains still controversial. This study showed that vitamin $K_1$ has no effect on lipid profile in women with rheumatoid arthritis. Further studies with a longer follow-up are required to determine the effects of vitamin K on atherogenic lipid profile.

Photoinduced Singlemode Waveguide in Optical Fluoride Glasses Using Plasma Filaments

  • Cho, Sung-Hak
    • Journal of the Optical Society of Korea
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    • v.7 no.3
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    • pp.156-159
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    • 2003
  • Permanent structure of photoinduced singlemode waveguide in optical fluoride glasses was demonstrated using the self-channeled plasma filament excited by a femtosecond (110 fs) Ti:sapphire laser ($λ_p$ = 800 nm). The photoinduced refractive index modification in ZBLAN glasses reached a length of approximately 10 - 15 mm from the input surface of the optical glass with the diameters ranging from 5 to 8 ${\mu}{\textrm}{m}$ at input intensities more than l.0 ${\times}$ $10^{12}$ W/$\textrm{cm}^2$. The graded refractive index profiles were fabricated to be a symmetric form from the center of an optical fluoride glass and a maximum value of refractive index change (ㅿn) was measured to be l.3${\times}$$10^{-2}$. The beam profile of the output beam transmitted through the modified region showed that the photoinduced refractive index modification produced a permanent structure of singlemode waveguide.

Blank Design in Multi-Stage Rectangular Deep Drawing of Extreme Aspect Ratio (세장비가 큰 다단계 초정밀 사각형 디프드로잉을 위한 블랭크 설계)

  • 박철성;구태완;강범수
    • Proceedings of the Korean Society for Technology of Plasticity Conference
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    • 2003.05a
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    • pp.258-261
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    • 2003
  • In this study, finite element analysis for multi-stage deep drawing process of rectangular configuration with extreme aspect ratio is carried out especially for the blank design. The analysis of rectangular deep drawing process with extreme aspect ratio is likewise very difficult with respect to the design process parameters including the intermediate die profile. In order to solve the difficulties, numerical approach using finite element method is performed in the present analysis and design. A series of experiments for multi-stage rectangular deep drawing process are conducted and the deformed configuration is investigated by comparing with the results of the finite element analysis. Additionally, to minimize amount of removal material after trimming process, finite element simulation is applied for the blank modification. The analysis incorporates brick elements for a rigid-plastic finite element method with an explicit time integration scheme using LS-DYNA3D.

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A modification of double projection method for adaptive analysis of Element-free Galerkin Method (적응적 Element-free Galerkin Method 해석을 위한 이중투영법의 개선)

  • 이계희;정흥진;이태열
    • Proceedings of the Computational Structural Engineering Institute Conference
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    • 2002.10a
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    • pp.615-622
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    • 2002
  • In this paper, the modification of double projection method for the adaptive analysis of Element-free Galerkin(EFG) method were proposed. As results of the double projection method, the smoothed error profile that is adequate for adaptive analysis was obtained by re-projection of error that means the differences of EFG stress and projected stress. However, it was found that the efficiency of double projection method is degraded as increase of the numerical integration order. Since, the iterative refinement to single step error estimation made the same effect as increasing of integration order, the application of the iterative refinement base on double projection method could be produced the inadequately refined analysis model. To overcome this defect, a modified scheme of double projection were proposed. In the numerical example, the results did not show degradation of double projection effect in iterative refinement and the efficiency of proposed scheme were proved.

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Optical diffraction gratings embedded in BK-7 glasses by tightly focused femtosecond laser

  • Yoon, Ji Wook;Choi, Won Suk;Kim, Hoon Young;Cho, Sung-Hak
    • Laser Solutions
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    • v.17 no.2
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    • pp.19-25
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    • 2014
  • Optical embedded diffraction gratings with the bulk modification in BK-7 glass plates excited by tightly focused high-intensity femtosecond (130fs) Ti: sapphire laser (peak wavelength = 790nm) were demonstrated. The structural modifications with diameters ranging from 400nm to $4{\mu}m$ were photo-induced after plasma formation occurred upon irradiation with peak intensities of more than $1{\times}1013W/cm^2$. The graded refractive index profile was fabricated to be a symmetric around from the center of the point at which low-density plasma occurred. The maximum refractive index change was estimated to be $1.5{\times}10^{-2}$. The two optical embedded gratings in BK-7 glass plate were demonstrated with refractive index modification induced by the scanning of low-density plasma formation.

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Modification of Wind Generated Coastal Circulation Model (풍성연안순환모델의 수정)

  • Lee, J. W.;Shin, S. H.;Kim, J. Y.;Yang, S. Y.
    • Journal of Korean Port Research
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    • v.9 no.2
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    • pp.25-38
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    • 1995
  • The wind generated circulation model describes the phenomenon based on the following physical assumptions: a) As the horizontal dimension of the flow domain is several orders of magnitude larger than vertical dimension, nearly horizontal flow is realistic. b) The time taken for circulation to develop may effect on the flow domain of the earth's rotation, the contribution of the Coriolis force. c) A flow domain of large dimension results in quite large Reynolds number and the Reynolds stresses are approximated by the turbulent mean velocity gradient. d) The circulation is forced by the shear stresses on the water surface exercised by the wind. Modification made to the depth average approximation of the convective terms and the bed shear stress terms by adopting a certain distribution of current over the depth and laboratory measurements for the bed shear expression. Modification circulation patterns, energy evolution and surface profile gave the significant differences comparing with the classical model results. The modified model results in higher free surface gradients balancing both the free surface shear and the bed shear and consequently to higher surface profiles along the coast.

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A Study on Optimization of Tooth Micro-geometry for Wind Turbine High Speed Stage Helical Gear Pair (풍력터빈용 고속단 헬리컬 기어의 치형 최적화에 관한 연구)

  • Cho, Sungmin;Lee, Do-Young;Kim, Laesung;Cho, Sangpil;Lyu, Sung-Ki
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.13 no.5
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    • pp.15-20
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    • 2014
  • The wind industry grew in the first decade of the 21st century at rates consistently above 20% a year. For wind turbine, gearbox failure can be extremely costly in terms of repair costs, replacement parts, and in lost power production due to downtime. In this paper, gear tooth micro-modification for the high speed stage was used to compensate for the deformation of the teeth due to load and to ensure a proper meshing to achieve an optimized tooth contact pattern. The gearbox was firstly modeled in a software, and then the various combined tooth modification were presented, and the prediction of transmission under the loaded torque for the helical gear pair was investigated, the normal load distribution and root stress were also obtained and compared before and after tooth modification under one torque. The simulation results showed that the transmission error and normal load distribution under the load can be minimized by the appropriate tooth modification. It is a good approach where the simulated result is used to improve the design before the prototype is available for the test.

Torsional Vibration Analysis of a Spur Gear Pair with the Variable Mesh Stiffness (기어이의 변동물림강성을 고려한 비틀림진동해석)

  • Ryu, Jae-Wan;Han, Dong-Chul;Choi, Sang-Hyun
    • Journal of the Korean Society for Precision Engineering
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    • v.16 no.12
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    • pp.99-108
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    • 1999
  • A four-degree-of-freedom non-linear model with time varying mesh stiffness has been developed for the dynamic analysis of spur gear trains. The model includes a spur gear pair, two shafts, two inertias representing load and prime mover. In the model, developed several factors such as time varying mesh stiffness and damping, separation of teeth, teeth collision, various gear errors and profile modifications have been considered. Two computer programs are developed to calculate stiffness of a gear pair and transmission error and the dynamic analysis of modeled system using time integration method. Dynamic tooth and mesh forces, dynamic factors are calculated. Numerical examples have been given, which shows the time varying mesh stiffness ha a significant effect upon the dynamic tooth force and torsional vibrations.

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Design of the propelling nozzles for the launchers and satellites

  • Haoui, Rabah
    • International Journal of Aeronautical and Space Sciences
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    • v.15 no.1
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    • pp.91-96
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    • 2014
  • The aim of this work is to determine supersonic nozzle profiles that are used in propulsion, for launchers or embarked with satellites. This design has the role of firstly, providing important propulsion, i.e. with uniform and parallel flow at exit; and secondly, to find short length profiles, without modification of the flow in the nozzle. The first elaborate program is used to determine the profile of the divergent, by using the characteristics method for an axisymmetric flow. The second program is conceived by using the finite volume method, to determine and test the profile found connected to a convergent.

Confirmatory Factor Analysis of the Environmental Health Engagement Profile (환경적 건강 관여 측정도구의 확인적 요인 분석)

  • Kim, Hyun-Kyoung
    • Korean Parent-Child Health Journal
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    • v.17 no.1
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    • pp.37-45
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    • 2014
  • Purpose: This study aimed to review measurements of environmental health behavior and assess the construct validity of Environmental Health Engagement Profile (EHEP) through confirmatory factor analysis. Methods: The literature review was performed for selection of measurements. Confirmatory factor analysis with AMOS 19.0 was used for validation of EHEP. Results: The model fitness was not appropriate in the one-factor model; $x^2=91.11$ (df=5, p<.001), Comparative Fit Index (CFI)=8.19, Non Normed Fit Index (NNFI)=6.39, and Root Mean Square Error of Approximation (RMSEA)=0.20. The model fitness was appropriate in the two-factor model; $x^2=3.19$ (df=1, p=.074), CFI=9.95, NNFI= 9.71, RMSEA=0.07. A modification of scale was found to be the most suitable for use in the investigation of environmental health behavior. Conclusion: This study confirms that a two-factor model underlies the concept of environmental health behavior. The review of measurements can help nurses and researchers to assess the environmental health behaviors.

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