The purpose of this study was to investigate the influence of professional self-concept and interpersonal relations on nursing competence of clinical nurses. This study was conducted as a descriptive cross sectional survey with 182 nurses who work at a tertiary hospital which has over 1,000 beds, located in Gyeounggi - do. The data was collected from October 11th, 2016 to October 28th, 2016. The main findings of this study were as follows. The mean score for professional self-concept was $2.65{\pm}0.29$ points in the range of 1 point to 4 points. And interpersonal relations was an average of $3.55{\pm}0.35$ points in the range of 1 point to 5 points. Nursing competence was an average of $2.65{\pm}0.39$ points in the range of 1 point to 4 points. Professional self-concept and interpersonal relations were positively correlated with nursing competence. Nursing competence was differed from clinical career(F=10.518, p<.001), working unit(F=4.139, p=.018), educational background(F=6.542, p=.002), and satisfaction on nursing(F=6.326, p<.001). The regression model with clinical career, working unit, educational background, satisfaction on nursing, 3 sub domain of professional self-concept(professional practice, satisfaction, communication), and interpersonal relation was statistically significant (F=31.94, p<.001). And this model could explain 51.5% of nursing competency(Adj R2=.515). Especially, professional practice(${\beta}=.532$, p<.001) of professional self-concept, interpersonal relations(${\beta}=.223$, p<.001), clinical career(${\beta}=.169$, p<.001), working unit: ICU (${\beta}=.169$, p<.05) were identified the factors influencing on nursing competence. Therefore, improving clinical nurses' nursing competence can be achieved with broad approach that includes improvements in professional self-concept and interpersonal relations. And also, working unit, and clinical career should be considered to develop the actual program for nursing competence, too.