• Korean Journal of Clinical Pharmacy
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• v.25 no.1
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• pp.42-49
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• 2015

Objective: The aim of this study was to investigate the difference of perception on direct-to-consumer advertisement (DTCA) of prescription drugs between healthcare providers and consumers. Methods: The online and offline survey was conducted from May 26th to June 5th, 2013. The questionnaire was composed of 15 items about perception on DTCA of prescription drugs. Results: A total of 215 healthcare providers and 202 consumers responded to the questionnaire. Consumers had an overall positive attitude on permitting DTCA of prescription drugs and carried favorable views about the influence of the DTCA of prescription drugs on providing drug information, promoting communications between healthcare providers and consumers, and improving images of healthcare providers. Healthcare providers displayed negative perception for the needs of permitting the DTCA of prescription drugs compared to consumers. They showed somewhat skeptical perception about the influence of the DTCA of prescription drugs on necessities and efficiencies of delivering drug information, promoting communications between healthcare providers and consumers, and improving images of healthcare providers. Both healthcare providers and consumers were concerned about the increase of drug prices following the increase in advertisement expenses of pharmaceutical products. Conclusion: This study identified the perception differences on direct-to-consumer advertisements of prescription drugs between healthcare providers and consumers. This study could be of much help in the process of review on permitting DTCA of prescription drugs in Korea.

• International Journal of Concrete Structures and Materials
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• v.7 no.2
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• pp.95-110
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• 2013

We report various synchrotron radiation laboratory based techniques used to characterize cement based materials in nanometer scale. High resolution X-ray transmission imaging combined with a rotational axis allows for rendering of samples in three dimensions revealing volumetric details. Scanning transmission X-ray microscope combines high spatial resolution imaging with high spectral resolution of the incident beam to reveal X-ray absorption near edge structure variations in the material nanostructure. Microdiffraction scans the surface of a sample to map its high order reflection or crystallographic variations with a micron-sized incident beam. High pressure X-ray diffraction measures compressibility of pure phase materials. Unique results of studies using the above tools are discussed-a study of pores, connectivity, and morphology of a 2,000 year old concrete using nanotomography; detection of localized and varying silicate chain depolymerization in Al-substituted tobermorite, and quantification of monosulfate distribution in tricalcium aluminate hydration using scanning transmission X-ray microscopy; detection and mapping of hydration products in high volume fly ash paste using microdiffraction; and determination of mechanical properties of various AFm phases using high pressure X-ray diffraction.

• Journal of Gastric Cancer
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• v.1 no.3
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• pp.129-135
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• 2001

Purpose: Dysplasia or flat adenoma of the stomach is regarded as a precancerous lesion. However, the frequency and the evolutionary process of malignant transformation of gastric dysplasia are still debated. In order to see whether the lesion was a monoclonal or a polyclonal proliferation, clonality was assayed by X-linked HUMARA polymorphism. Materials and Methods: DNA was extracted from the paraffin-embedded tissue of 16 consecutive cases of endoscopic biopsy, eight of which supplied both dysplastic and nondysplastic tissue for comparison. HUMARA was amplified by PCR with or without pretreatment with methylationsensitive restriction enzyme, HpaII. The amplification products were electrophoresed on polyacrylamide gel and silver-stained. Results: Among the 16 cases, 13 cases were informative and 3 cases noninformative. Of the 13 cases, one case showed skewed lyonization, rendering 12 cases to be analyzed further. A monoclonal band pattern was noted in 2 cases, and a polyclonal band pattern in 10 cases. A review of the histopathologies of the monoclonal and the polyclonal cases did not reveal features discriminating the two groups. Conclusion: These results suggest that gastric dysplasia is a disease entity heterogeneous in the genetic level, and many cases may be non-neoplastic.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.16 no.3
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• pp.16-23
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• 2017

For most machine tools, it is necessary to remove chips and coolant oil because it they will continue to be created during the manufacture of workpieces. Existing products that are in use are installed and used as they reflect depending on the characteristics of each device separately. This study proposes a method to remove the security chip as well as developing an integrated system capable of reducing coolant damage. The Leverage AutoCAD and CATIA program was used for 2D and 3D design, shapes were identified by utilizing the KeyShot program, and the load and displacement analysis of the development apparatus was performed utilizing the ANSYS program. After the prototype underwent sufficient design review, the mixed oil separation device had a complete sensor control program using the LabVIEW program. The chip design process for transferring experiments and experiments on the mixed oil cooling device were developed for performance tests of the product. The final product resulted in an increase in space utilization during commercialization, reduced installation costs, and caused social effects such as pulmonary flow reduction, which, through the economic costs, reduces pollution, resulting in various benefits to the industry, such as deceased errors in the workplace decreases.

• The Journal of the Korea Contents Association
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• v.12 no.12
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• pp.119-125
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• 2012

It is not an overstatement to say that the functions of the products change and the results determine the size and weight of the product. It took a long time to develop the small size everyday tools. One of the ways to shorten the development time was the emergence of vacuum moulds that decreased the design process significantly. In other words, the manufacturing of the product may be limited by the size and shape, but the replication of a simple structure is possible within a few hours. This study aims to review and suggest the design development through vacuum moulds as an area to realize the future additional values to the economic growth under the rapidly changing industry structures as well as securing the weaknesses of the industry structures through the productivity and competitiveness of the corporations.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.59
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• pp.3-26
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• 2013

The purpose of this paper is to examine the several points at issue in international technology transfer contract from licensor's and licensee's perspectives, and to refer them when the licensor and the licensee draw up the contract. This author analyzed the critical points of the related provisions of ICC Model International Technology Transfer Contract(2009) by citing the explanations of the Introduction of the Model Contract. The provisions of the Model Contract are generally divided into two categolies; specific conditions and general conditions. This author selected four topics in the specific conditions; Contents of the Contract, Royalty, Modification and/or Improvements of Products, and Territory and Competition. Likewise this author selected three topics in the general conditions; Resolutions of Disputes, Applicable Law and Taxes. Both parties need to be mindful of the following points in the above topics, when they draw up the contract. First, both parties should make the definitions of special terminologies clear, which are included in the Contract. Second, before the parties sign the Contract, they should check any approvals to be necessary by the both countries' governments. Third, for the calculation of the royalty, they should clear the criteria, the scope, and the object. Fourth, as the local laws or regional laws regarding the territory limitation and taxation are mandatory, any provisions of the Contract should not be inconsistent with them. Therefore, both parties should check before-hand the local laws or rules related with the provisions of the Contract. Fifth, when the parties draw up the Contract, they should examine the Provisions of Dispute Resolution in consideration of the Governing Law. Thus both parties decide to make the technology transfer contract, the three aspects namely profitability, legal conflict with mandatory rules, and sustainability of the business resulting from the Contract should be examined in advance, and then proceed the business using the technology transfer.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.23 no.1
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• pp.1-14
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• 2020

The latest definition of a prebiotic is "a substrate that is selectively utilized by host microorganisms conferring a health benefit"; it now includes non-food elements and is applicable to extra-intestinal tissues. Prebiotics are recognized as a promising tool in the promotion of general health and in the prevention and treatment of numerous juvenile diseases. Prebiotics are considered an immunoactive agent, with the potential for long-lasting effects extending past active administration of the prebiotic. Because of its extremely low risk of serious adverse effects, ease of administration, and strong potential for influencing the composition and function of the microbiota in the gut and beyond, the beneficial clinical applications of prebiotics are expanding. Prebiotics are the third largest component of human breast milk. Preparations including galactooligosaccharides (GOS), fructooligosaccharides (FOS), 2'-fucosyllactose, lacto-N-neo-tetraose are examples of commonly used and studied products for supplementation in baby formula. In particular, the GOS/FOS combination is the most studied. Maintaining a healthy microbiome is essential to promote homeostasis of the gut and other organs. With more than 1,000 different microbial species in the gut, it is likely more feasible to modify the gut microbiota through the use of certain prebiotic mixtures rather than supplementing with a particular probiotic strain. In this review, we discuss the latest clinical evidence regarding prebiotics and its role in gut immunity, allergy, infections, inflammation, and functional gastrointestinal disorders.

• Journal of Genetic Medicine
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• v.6 no.1
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• pp.25-37
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• 2009

Hereditary peripheral neuropathies can be categorized as hereditary motor and sensory neuropathies (HMSN), hereditary motor neuropathies (HMN), and hereditary sensory neuropathies (HSN). HMSN, HMN, and HSN are further subdivided into several subtypes. Here, we review the most recent findings in the molecular diagnosis and therapeutic strategy for hereditary peripheral neuropathies. The products of genes associated with hereditary peripheral neuropathy phenotypes are important for neuronal structure maintenance, axonal transport, nerve signal transduction, and functions related to the cellular integrity. Identifying the molecular basis of hereditary peripheral neuropathy and studying the relevant genes and their functions is important to understand the pathophysiological mechanisms of these neurodegenerative disorders, as well as the processes involved in the normal development and function of the peripheral nervous system. These advances and the better understanding of the pathogenesis of peripheral neuropathies represent a challenge for the diagnoses and managements of hereditary peripheral neuropathy patients in developing future supportive and curative therapies.

• Information Systems Review
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• v.11 no.2
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• pp.209-231
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• 2009

In recent, a general trend is observed towards more customized products and shorter product life cycles in manufacturing enterprises. In these enterprises, customers often wish to influence the product they order and to get a variant of product that meets their requirements. This is called as customer-oriented make-to-order manufacturing environment. This paper establishes a methodology of implementing information system for developing product data integration system (PDIS) which is suitable for customer-oriented make-to-order manufacturing enterprise, and also presents the case of implementing PDIS for a ship engine product in 'H' heavy industry using the established methodology. At present, the implemented PDIS is successfully operating. As a result, PDIS reduces delivery time and improves customer relationships. Moreover, the case shows that PDIS can be used as a tool for improving inter-department coordination within a company during product life cycle.

• Information Systems Review
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• v.9 no.2
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• pp.109-127
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• 2007

In a buyer seller transaction process, "value for money" is one of the most important criteria for a buyer's purchasing decision. The terms "value" and "money" represent a composite measure of what a buyer receives from goods and/or services and a measure of what he/she pays for them, respectively. The purpose of this paper is to help buyers select the best seller in terms of value for money. We suggest DEA models for buyer seller transactions and apply them to the case of an Internet comparison shopping site in Korea. We expect our DEA models to provide valuable information for rational buyers who want to pay the least price for high quality products/services. Moreover, we expect that our models can help sellers be more competitive by showing them how to attract buyers.