• Journal of the Korean Society of Food Science and Nutrition
• /
• v.45 no.1
• /
• pp.20-26
• /
• 2016

This study investigated the fermentation effect of Taraxacum platycarpum Dahlst. leaf extracts using Hericium ernaceum mycelia to test antioxidant and anti-inflammatory activities in vitro. The antioxidant activities of fermented or non-fermented extracts of T. platycarpum leaves were determined by 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity, ferric reducing antioxidant power, and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging activity. The leaf extract of T. platycarpum showed higher antioxidant activity than extract of fermented leaves. However, ethanolic extract of fermented T. platycarpum leaves decreased levels of nitric oxide production and pro-inflammatory cytokines such as interleukin-6 and tumor necrosis factor-${\alpha}$ in lipopolysaccharide-stimulated RAW 264.7 cells. Moreover, fermented leaf extract suppressed protein expression of inducible nitric oxide synthase in RAW 264.7 cell culture. Therefore, the enhanced anti-inflammatory activity of ethanolic extracts of fermented T. platycarpum leaves might be attributed to the molecular conversion of leaf ingredients during fermentation and the active ingredients might have specific affinity with ethanol during extraction.

• Journal of the Korean Wood Science and Technology
• /
• v.40 no.6
• /
• pp.424-430
• /
• 2012

In this study, laccase activity, rate of weight loss and degree of lignin degradation of pine wood chips were determined during the liquid and solid state incubation with Polyporus brumalis. The results showed that laccase enzyme activity at untreated wood chip was gradually decreased after 20 days, but enzyme activity with wood chip treatment showed 10 times higher than untreated ones at 60 incubation days. Rate of weight losses of pine chip and rate of lignin loss were 23.4% and 6.3% by P. brumalis during 80 incubation days. Gene expression of pblac1 from P. brumalis was 3 times increased under pine chip treatment at 40 incubation days. Consequently, laccase activity of white rot fungi, P. brumalis, was increased at incubation with wood chip and pblac1 gene was important factor of lignin degradation. Therefore, to regulate lignin degrading enzyme gene expression by using the tools of biotechnology will be able to develop superior strains and it will be useful for pretreatment of lignocellulosic biomass at bioethanol production.

• Journal of Life Science
• /
• v.30 no.2
• /
• pp.191-201
• /
• 2020

As society develops rapidly, environmental pollution is becoming a greater risk factor threatening human health. One of the major causes of air pollution that affects human health is particulate matter (PM), which contains a heterogeneous mixture of different particle sizes and chemical compositions. PM is classified by size into general PM (PM₁₀; diameter below 10 ㎛) and fine PM (PM_2.5; diameter below 2.5 ㎛). PM_2.5 can pass through the respiratory tract into the circulatory system and thence throughout the body. PM_2.5 is known to stimulate oxidative stress and inflammatory responses to cells, promoting diseases such as asthma, chronic respiratory disease, cardiovascular disease, diabetes mellitus, and immunological disorders. Although detailed molecular mechanisms for how PM stimulates disease progression still need to be elucidated, together with national efforts to reduce PM production, significant research has been conducted that demonstrates the harmfulness of PM in disease progression through in vitro and in vivo experiments. This review focuses on the harmfulness of PM in disease progression; we also introduce a biological verification method for determining the hazards of PM.

• Journal of Digital Convergence
• /
• v.14 no.6
• /
• pp.219-235
• /
• 2016

This study was performed to study the factors appear to SMEs and how differently depending on the worker ranks at the convergence age. Additionally, numerous studies and results on the factors which affect the organization's performance was to individually different approach to integrated. Especially venture was divided by a factor of enterprises and transformational dynamics factors and commutative Dynamics factors and approaches in terms of the impact transformative dynamics of which factors are organizational commitment and job satisfaction. A transformational dynamism to the four factors were such as mission and strategy, CEO Leadership, Manager, leadership, organizational culture variables. The study was based on theoretical models of organizational development, Burke and Litwin (1992). They were classified as managers and production workers. By obtaining data from employees 630 people engaged in a total of nine manufacturers were analyzed. The average variable based on the organization's Burke and Litwin (1992) theory of transformational variables is one that Nana was aware of the organizational commitment, and job satisfaction. Correlation analysis transformational dynamics variables're having an impact on job satisfaction and organizational commitment, job position is found to have moderating effects.

• Journal of Digital Convergence
• /
• v.18 no.1
• /
• pp.35-44
• /
• 2020

The purpose of this paper is to investigate various factors affecting the efficiency of China IC industry, reflecting the resource utilization and overall development level of China IC industry. In this paper, three input indicators (R&D Expenditure, Cash paid to and for employees, Total fixed assets) and two output indicators (Net profit, Sales revenue) were selected for 17 listed companies in the IC industry with operating profit of less than 1 billion yuan in 2018 and applied the technology efficiency theory and DEA analysis method to analyze the relative efficiency of the output base. The study found that one of the 17 companies analyzed was efficient, two were inefficient on an inadequate scale, and the rest were inefficient due to insufficient production technology, scale and management level. This study argues that enterprises should reduce resource input appropriately and strengthen scientific and technological innovation management to maximize resource utilization efficiency. Therefore, this study has important practical significance for improving the efficiency of IC enterprises. The Malmquist method will be used to study the total factor productivity of small and Medium-sized companies in IC industry.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.39 no.3
• /
• pp.356-362
• /
• 2010

When pine (Pinus densiflora) needles were fractionated into cold water (PD-CW), hot water (PD-HW) and methanol extract (PD-M), PD-M showed potent simulating activity (1.19-fold of the saline control) for proliferation of bone marrow cells mediated by Peyer's patch cells in vitro. MeOH extracts were prepared by homogenization, stirring or reflux to identify the method of methanol extraction, and MeOH extract by reflux method showed significantly highest intestinal immune system modulating activity (1.30-fold) in vitro. The intestinal immune system modulating effect of orally administered PD-M fractionated from pine needles also were studied in mice. Analyzing intestinal immune system modulating activity mediated Peyer's patch cells from C3H/He mice which had been fed with PD-M at different doses for 7 days, 1.0 g/kg of BW/day indicated that the bone marrow cells had proliferated (3.65-fold of 3% EtOH administered group). In addition, the amounts of IL-6 in the culture supernatant of Peyer's patch cells at 1.0 g/kg of BW/day were increased (1.13-fold) whereas the production of GM-CSF was not dose dependent. These results indicate that oral administration of PD-M enhances the secretion of hematopoietic growth factors such as GM-CSF and IL-6 from Peyer's patch cells, and these cytokines also act on modulator of bone marrow cell proliferation.

• Korean Journal of Food Science and Technology
• /
• v.44 no.1
• /
• pp.82-88
• /
• 2012

Chrysanthemum indicum L. (Asteraceae) is a traditional herbal medicine that has been used for the treatment of inflammation, hypertension, and respiratory diseases due to its strong antagonistic activity against inflammatory cytokines. The effects of Chrysanthemum indicum L. Extract (CIE) for increasing cell growth, alkaline phosphatase (ALP) activity, and collagen content were totally inhibited, suggesting that the effect of CIE might be partly involved with estrogen activity. Furthermore, the protective effects of CIE on the response of osteoblasts to oxidative stress were evaluated. Osteoblastic MC3T3-E1 cells were incubated with hydrogen peroxide and/or CIE, and markers of osteoblast function and oxidative damage were examined. CIE significantly increased cell survival, ALP activity, and calcium deposition, and decreased the production of Reactive Oxygen Species (ROS) and Tumor Necrosis Factor-${\alpha}$ (TNF-${\alpha}$) in osteoblasts. Taken together, these results indicate that the enhancement of osteoblast function by CIE may prevent osteoporosis and inflammatory bone diseases.

• Korean Journal of Food Science and Technology
• /
• v.46 no.4
• /
• pp.505-510
• /
• 2014

Kojongsi persimmon (Diospyros kaki L.) is the major cultivar of dried persimmon in Korea. The purpose of this study was to investigate the antioxidant and anti-inflammatory activities of water-soluble extracts from the calyx (PCE), peel (PPE) and leaf (PLE) of Kojongsi persimmon. PCE showed the highest total phenolic and flavonoid contents. In addition, the antioxidant activities (diphenylpicrylhydrazyl, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid), nitric oxide and reducing power) of PCE were higher than those of PPE and PLE. Moreover, PCE, PPE and PLE significantly suppressed the production of inflammatory mediators (nitric oxide and $prostaglandinE_2$) and pro-inflammatory cytokines (tumor necrosis factor-${\alpha}$ and interluekin-$1{\beta}$) by lipopolysaccharide-stimulated RAW 264.7 cells in a dose-dependent manner. PCE showed the highest anti-inflammatory activity. Thus, these results suggest that the calyx of Kojongsi persimmon may be highly valuable as a natural product owing to its high-quality functional components as well as its-antioxidant, ant-iinflammatory activities.

• Korean Journal of Agricultural and Forest Meteorology
• /
• v.14 no.2
• /
• pp.71-78
• /
• 2012

Eupatilin, one of representative medical components of mugwort, can be efficiently extracted from the 'Gangwha Sajabalssuk'. The Eupatilin content may depend on environmental factors such as soil and regional climate in addition to a genetic factor and Gangwha region has a profitable environmental condition for the mugwort growth. In this study, the climatological characteristics of Gangwha was analyzed in order to find the environmental condition of mugwort containing high Eupatilin in term of atmospheric, oceanographic and land variables. The climate of Gangwha is characterized by the relatively low daily temperature and large diurnal variation with plenty of solar radiation, long sunshine duration and less cloudiness. According to our correlation analysis, the long sunshine duration and the large diurnal temperature variation are highly correlated with the Eupatilin contents. The result implies that Gangwha has the favorable conditions for the cultivation and the habitat of the high-Eupatilin concentrated mugwort. Because of the sea surrounding Gangwha Island with low salinity and moderate wind, the salt contained in sea breeze is relatively low compared to other regions. Furthermore, Gangwha has clean atmospheric environment compared to other regions because the concentrations of toxic gases harmful to crop growth such as nitrogen dioxide ($NO_2$), sulfite gas ($SO_2$) and fine dust (PM-10) are lower in the air. The ozone ($O_3$) concentration is moderate and within the level of natural production. It is also found that moderately coarse texture or fine loamy soils known as good for water drainage and for the growth and cultivation of the 'Gangwha-mugwort' are distributed throughout the areas around mountainous districts in Gangwha, coinciding with those of mugwort habitat.

• Journal of the Korean Wood Science and Technology
• /
• v.42 no.3
• /
• pp.309-317
• /
• 2014

Harvested wood products (HWP) are known as products from the tree such as sawn wood, plywood, particle board, structural lumber, wooden interior material, wooden furniture, and paper products. Because carbon is locked up in the HWP until eventual end-use of HWP, HWP played a role as the carbon storage which has the effect of stabilizing the concentration of carbon dioxide in the atmosphere. For these reasons, the suggestion that it must admit the carbon storage effect of HWP has been constantly raised. In 2011, the 17th session of the Conference of the Parties (COP) to the United Nations Framework Convention on Climate Change (UNFCCC) which was held in Durban, South Africa, assigned "Production Approach" which targets only the HWP producted by using round wood of domestic forestry as a official method for carbon accounting. Therefore, it is necessary that each country has to determine the half-life of wood in order to correspond to the discussions and negotiations between countries in the future and to develop an inventory of product-specific domestic wood. In this study, some countries' examples of the methods and conditions for determining half-life of HWP were investigated, and it was tried to derive the factor and methodology to determine half-life span of domestic HWP appropriately.