• The Korean Journal of Physiology and Pharmacology
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• v.20 no.1
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• pp.91-99
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• 2016

(E)-3-(3-methoxyphenyl)-1-(2-pyrrolyl)-2-propenone (MPP) is an aldol condensation product resulting from pyrrole-2-carbaldehyde and m- and p- substituted acetophenones. However, its biological activity has not yet been evaluated. Since it has been reported that some propenone-type compounds display anti-inflammatory activity, we investigated whether MPP could negatively modulate inflammatory responses. To do this, we employed lipopolysaccharide (LPS)-stimulated macrophage-like RAW264.7 cells and examined the inhibitory levels of nitric oxide (NO) production and transcriptional activation, as well as the target proteins involved in the inflammatory signaling cascade. Interestingly, MPP was found to reduce the production of NO in LPS-treated RAW264.7 cells, without causing cytotoxicity. Moreover, this compound suppressed the mRNA levels of inflammatory genes, such as inducible NO synthase (iNOS) and tumor necrosis factor (TNF)-${\alpha}$. Using luciferase reporter gene assays performed in HEK293 cells and immunoblotting analysis with nuclear protein fractions, we determined that MPP reduced the transcriptional activation of nuclear factor (NF)-${\kappa}B$. Furthermore, the activation of a series of upstream signals for NF-${\kappa}B$ activation, composed of Src, Syk, Akt, and $I{\kappa}B{\alpha}$, were also blocked by this compound. It was confirmed that MPP was able to suppress autophosphorylation of overexpressed Src and Syk in HEK293 cells. Therefore, these results suggest that MPP can function as an anti-inflammatory drug with NF-${\kappa}B$ inhibitory properties via the suppression of Src and Syk.

• Journal of the Korean Society of Clothing and Textiles
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• v.31 no.8
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• pp.1286-1296
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• 2007

Hanji, the korean traditional papers were mostly made from mulberry paper. But the production and demand of hanji have decreased rapidly because mulberry paper yields were insufficient and handworked hanji procedures were complicated. Recently, the researches on hanji were carried out to improve the properties of hanji. Kenaf fibers have been interested as a substitute resource of mulberry paper for hanji production. In this research, Kenai pulps were manufactured with removal methods of lignin or hemicellulose from kenaf fibers and paper mulberry pulps with traditional alkali methods. Kenaf papers, paper mulberry, and kenaf/paper mulberry mixed papers were manufactured with their pulps. The crystallinity, fiber length, color of the pulps and tensile strength, tear strength, water absorption of the papers were investigated. The results were as follow: The removal rates of lignin of chemical retted kenaf fibers with sodium chlorite reaction for 40 minutes were 70% and were higher than 40% of double retted fibers. Paper mulberry pulps has less lignin and hemicellulose than kenaf differently. The crystallinity of paper mulberry pulps were very low with 60%, but kenaf pulps were 90%. The chemical retted CR-40-1 pulps were similar with paper mulberry pulps on fiber length & fibrilation of fibers. Tensile strength of paper mulberry were higher than kenaf papers because of fibrilation of paper mulberry, but tear strength were lower. Tensile strength and tear strength were improved on kenaf/paper mulberry 30/70 mixed papers.

• Journal of the Economic Geographical Society of Korea
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• v.18 no.4
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• pp.522-538
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• 2015

The objective of this study was to review how contract farming started in Gochang-gun and identified its characteristics among the contracting parties and the consequent changes in the region's dairy industry with regard to the contract production of organic milk in Gochang-gun, Jeollabuk-do, Korea in conjunction with the Maeil Dairy Industry Corporation. The contract was established in keeping with the product diversification strategy of the company after a crisis due to opening of the market, taking advantage of the clean environment of Gochang-gun and positive attitudes of the local government and dairy farmers. The expansion of the participating farms led to a production gap among dairy farms in the region; however, the overall concern over the conventional practice of contract farming was mitigated as the organic farming spread with the conversion of the contract farms to organic farms.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.28 no.4
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• pp.51-61
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• 2015

Objective : This research has been conducted to comparative analysis of anti-inflammatory effects to suggest a usefulness of ethanol extracts fromGentianae sino-ornata(GSO) as a functional material for inflammatory activities.Methods : Cell viability was measured by neutral red (NR) assay, and nitric oxide (NO) production in RAW264.7 cells was monitored by measuring the nitrite content in culture medium. The expressions of cyclooxigenase-2 (COX-2) was determined by western blot analysis, and Inducible nitric oxide syntase (iNOS) and cytokine were determined by reverse transcriptase-polymerase chain reaction (RT-PCR).Results : When the GSO extract was added the concentration of 5-20 ㎍/㎕, the viability of cells was maintained 90% or more at all levels. NO production was suppressed by the treatment of GSO in LPS-stimulated RAW264.7 cells. GSO inhibited the expression of iNOS, COX-2, IL-1βand IL-6 in LPS-stimulated RAW264.7 cells.Conclusions: From this results, we consider that GSO can be a useful therapeutic and preventive approach to various inflammatory diseases as a functional material for inflammatory activities.

• The Journal of the Convergence on Culture Technology
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• v.6 no.2
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• pp.207-215
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• 2020

The purpose of this study is to examine the effectiveness of PBL in a college AD/PR class. This class was run under the theme of 'Sinchon Regeneration Project' in the 'Seodaemun-gu & University Collaborative Project Program'. As a result of the pre-post surveys, the authors found a significant increase in the place attachment to Sinchon, which was considered as a critical variable in this program. This research is an important study with high practicality in the area of cultural content production education PBL. The PBL teaching method can contribute to enhancing the class satisfaction and strengthening the competitiveness of students in cultural content related majors.

• Journal of the Korean Geographical Society
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• v.50 no.6
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• pp.641-657
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• 2015

Nowadays research collaboration between the business, academic and governmental community is high on the policy agenda in all over the world, especially with regard to science-based technological innovation. The aim of this paper is to explore some of the changing spatial patterns of research collaboration by carrying out bibliometric analysis of co-authorship publications in major international and scientific journals that are jointly realized by Korean scientists and researchers in the seven science-based technologies for the period 2002~2012. Using the co-authored papers as an indicator of research collaboration with the institutional address of each co-authoring researcher and the geographic location of their affiliation, this paper describes some trends and patterns of domestic and international research collaborations. Identifying a rapid increase in the volume of co-authored papers and the trend towards multiple authorships over the last decade, the paper finds collaborative scientific research to be geographically dispersed at the different spatial scales. Despite the rising geographic dispersion of research collaboration within the nation, this paper finds that there were empirical evidences for the presence of localized knowledge production processes at regional level, and biased knowledge flows towards core areas with advanced research resources.

• Journal of Broadcast Engineering
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• v.24 no.5
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• pp.859-869
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• 2019

We are facing an era of automation where artificial intelligence works and an era of super-aging, where birth is rapidly declining. In this paper, we intend to perform the creation of an autobiography in conjunction with the generation integrated narrative storytelling, thereby exploring the potential for visual storytelling that can be extended to a variety of media format. The visual autobiography production program confirmed through an interview with the production participants that grandparents, grandchildren and granddaughter together became the main characters in the documentary, a valuable opportunity to reflect on their past memories and lives and recognize their meaning of life. The visual storytelling education program model and media life service presented in this paper will be shared by the youth and the elderly generation together and contribute to the 'sympathetic culture' as a social integration program.

• Journal of Digital Convergence
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• v.17 no.7
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• pp.89-98
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• 2019

It requires administrative supporting & Policies Aids on Maeul Community Media that confronted with reconstruction of community & interaction of residence. There are increased of community media research. This study examines the meanings of participants, the role of participants & volunteer, characteristic of community media, enlargement of residence, problems and activation of community media also conducted in-depth interviews of participants. According to the results of the analysis, the first it will be enforced administrative supporting & policies aids on Maeul Community Media. Secondly, suggests supporting of a municipal ordinance of Council. Thirdly, facilitate the education of program contents and management of community media. Finally, Supports of production costs.

• Journal of Korean Society on Water Environment
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• v.34 no.6
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• pp.661-668
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• 2018

Geosmin is volatile metabolites produced by a range of filamentous cyanobacteria which causes taste and odor problems in drinking water. Molecular ecological methods which target biosynthetic genes (geoA) are widely adopted to detect geosmin-producing cyanobacteria. The aim of this study was to investigate the potential production capability of 8 strains isolated from the Nakdong River. Ultimately, a suggestion for a genetical monitoring tool for the identification of geosmin producers in domestic waters was to be made. Geosmin was detected using solid phase microextraction gas chromatography mass spectrometry (SPME GC-MS) in two strains of Dolichospermum plactonicum (DGUC006, DGUC012) that were cultured for 28 day. The highest concentrations during the experiment period was $17,535ngL^{-1}$ and $14,311ngL^{-1}$ respectively. Additionally, geoA genes were amplified using two primers (geo78F/971R and geo78F/982R) from strains shown to produce geosmin, while amplification products were not detected in any of non-producing strains. PCR product (766 bp) was slightly shorter than the expected size for geosmin producers. According to the BLAST analysis, amplified genes were at nucleotide level with Anabaena ucrainica (HQ404996, HQ404997), Dolichospermum planctonicum (KM13400) and Dolichospermum ucrainicum (MF996872) between 99 ~ 100 %. Both strains were thus confirmed as potential geosmin-producing species. We concluded that the molecular method of analysis was a useful tool for monitoring potential cyanobacterial producers of geosmin.

• Journal of Practical Engineering Education
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• v.16 no.1_spc
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• pp.1-9
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• 2024

The introduction of smart factory digital twins is a concept that has already been proposed to increase productivity in the manufacturing industry through CPS(Cyber Physics System), and has been applied to specific industrial process stages or partially introduced in stages where simulation is required. However, with the recent development of the 4th Industrial Revolution technology, it is receiving attention again along with XR (Extended Reality) technology. However, because there are not many effective cases, this study analyzed the devices, equipment, and technology of the manufacturing process to build a digital twin applying digital threads and synchronized signals and information to control, remote control, and produce intelligent process automation equipment. A platform capable of analyzing information was proposed and developed. Through this, we designed and built an XR content service platform that can support artificial intelligence and developed it to enable control, remote control, and analysis of production information. A possible platform was proposed and developed. We hope that this study will be helpful in conducting research on many cases, and in the future, expanded research on increasing productivity in each part of the process and production is needed through intelligent models.