• 약학회지
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• 제53권6호
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• pp.303-313
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• 2009

Traditionally, Cham dang-gui (Angelica gigas Nakai) is one of the most popular herbal medicines in Asian countries including Korea. A. gigas has been used as a functional food product for treatment anemia, women's health care, a sedative, an anodyne or a tonic agent. Decursin and decursinol angelate isolated from the roots of A. gigas are pyranocoumarin compounds. Recently, as the global herbal medication market is increasing, investigations about pharmacological effects of decursin and decursinol angelate are rapidly increasing. We summarized previous studies about pharmacological effects of decursin and decursinol angelate, and reviewed relation with pharmacological effects of decursin and decursinol angelate on human disorder, focused on the approach for new drug development. Pharmacological effects of decursin and decursinol angelate were classified as anti-tumor activity, anti-bacterial activity, improvements of the circulating system, inhibition of cytochrome P-450 activity, anti-inflammation activity, anti-oxidant activity and cognitive-enhancing activites. The activity of A. gigas with improvement of the circulating system may have wide therapeutic potential for circulatory diseases, including diabetes, hyperlipidemia and atherosclerosis. Also, anti-inflammation activity A. gigas may be beneficial for the treatment and prevention of asthma, atopic dermatitis and rheumatism arthritis. This relation could potentially lead to the development of herbal new drugs. In order to development a new drug containing decursin and decursinol angelate, it is also necessary to consider the safety profile, and the information in this review would contribute to development a new drug from herbal medicine.

• 동아시아식생활학회지
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• 제20권3호
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• pp.481-490
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• 2010

The shock of melamine-contained food has been known with the incident of hospitalization or death of infants at the age of 11-month old in China. The purpose of this study was to examine consumers' risk perception, attitude and purchase behavior of melamine-contained food which recently came to the fore as a social issue, focusing on the relationship between consumers' attitude and purchase behavior based on physical risk, social risk, psychological risk, financial risk, consumers' attitude and purchase behavior. Study findings are as follows. First, the four factors of risk perception of melamine-contained food were significantly different by consumers. Consumers regarded social risk as most significant and it was followed by financial risk and psychological risk. And they regarded physical risk as most insignificant. Second, as for the difference of risk perception by demographic features, such factors as gender, age, marital status and schooling had no statistically significant influence. Third, the potential risk of melamine-contained food had a negative influence upon consumers' attitude and purchase behavior. In addition, consumers' attitude and purchase behavior were decided by perceived risks. This finding implies that consumers' attitude can accompany with negative or positive behavior and consumers' behavior can be related to social, financial and physical risks. Because the risk perception of melamine-contained food can cause consumers' distrust about all kinds of food in general, domestic manufacturers of milk product-contained confectionery and food can be harmed. In order to overcome this problem and make consumers purchase all the milk products and milk-contained food without fear, governmental agencies must reestablish systems with which the safety of imported raw materials and its processing can be insured and manufactures must improve the quality of products in a diverse and discriminative manner. This study seems to be meaningful in that it examined consumers' risk perception of melamine-contained food, a current social issue, and then looked into the influence of risk perception upon consumers" attitude and behavior, thus presenting the strategy of reestablishing the system of relationship between consumers and business entities in a desirable manner.

• 한국식품저장유통학회지
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• 제22권6호
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• pp.901-907
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• 2015

CMV 바이러스 저항성 H15 고추 도입유전자의 발현산물인 CMV-CP 단백질의 80개씩의 아미노산 비교에서 35% 보다 큰 상동성을 갖거나 8개 이상의 일련된 아미노산 염기 서열이 일치하는 알레르겐은 존재하지 않는 것이 확인되었으며, 따라서 CMV-CP 단백질 서열은 기지의 알레르겐과 구조적 및 면역학적으로 연관된 유사성이 없음을 확인하였다. 형질전환에 따른 특성 변화를 비교하기 위해 서로 다른 지역에서 재배된 CMV 바이러스 저항성 H15 고추 및 그 모본의 발현 단백질 항원 농도와 그 분포를 비교한 결과 발현된 단백질의 양상과 양은 재배 연도 및 환경적 영향에 따른 차이가 발견되었지만, 동일한 연도에 같은 장소에서 재배된 유전자변형 고추와 그 모본 사이에서의 차이는 발견되지 않아 형질전환으로 인한 특성변화는 없는 것으로 확인 되었다. 환자 혈청을 이용해 immunoblotting법과 ELISA법으로 확인한 항원-항체 반응성 비교에서도 CMV 바이러스 저항성 H15 고추와 그 모본 P2377사이에 차이가 없는 것이 확인되었다. 이러한 결과를 종합할 때, 유전자변형 고추 H15는 그 모본과 비교하여 형질전환으로 인한 알레르기성의 변화는 없는 것으로 판단된다.

• 대한한의학방제학회지
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• 제28권2호
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• pp.169-177
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• 2020

Objectives : This experiment was designed to assess the single oral toxicity of Ethanol Extract Inulae Flos (IF) ethanol extracts. IF is one of the important herbs to remove phlegmy which is the viscous turbid pathological product that can accumulate in the body, causing a variety of diseases. Nevertheless, there has been a lack of research on the pharmacology toxicity of IF. Methods : In this study, IF was orally administered to 5 weeks ICR mice as an oral dose of 2,000 or 3,000 or 5,000 mg/kg. The condition of the mice was observed for 14 days and their weights were measured every two days. Results : None of the mice died for 14 days. The abnormal clinical symptoms and anatomical signs of toxicity were not found in any treatment groups. The gain of net body weight was observed. There was also no significant difference in the organ weight. The serum biochemistry and hematological analysis showed a decrease in BUN, red blood cells, white blood cells and platelets although within the normal ranges. Conclusions : These results suggest that the 50% lethal dose of IF is more than 5,000 mg/kg. This could be thought that IF is a safe drug without acute toxicity and side effects. However, IF showed some weight loss and change in blood test, so it will need to be careful when using it for high doses.

• 대한한의학회지
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• 제38권3호
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• pp.86-95
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• 2017

Objectives: The purpose of this clinical research was to investigate the effects of herbal cosmetics containing Caffeic acid phenethyl ester (CAPE), an ingredient compound of various herbs including Vespae Nidus, on the Whitening Effects. Methods: A total of 20 subjects who visited Pusan National University Hospital from March 2nd, 2017 to April 11th, 2017 were included. In this study, we evaluated the visual evaluation, the melanin index (M) and erythema index (E) through skin analysis equipment, the subjective whitening improvement analysis, and the adverse reaction according to product use. Statistical analysis was performed with independent t-test and Mann-Whitney's U test. Statistical significance was achieved if the probability was less than 5% (p<0.05) Results: As a result of the visual evaluation, it was effective in improving skin whitening. The subjective whitening improvement analysis also showed positive results. However, no statistically significant differences were found between the test and control cosmetics in the melanin index (M) and erythema index (E) through skin analysis equipment. In the safety evaluation, some adverse reactions were reported, but no significant were observed directly from cosmetics. Conclusions: Considering the above results, we have confirmed the possibility of herbal cosmetics containing containing CAPE of Vespae Nidus Extracts.

• 유통과학연구
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• 제6권1호
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• pp.79-98
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• 2008

기업성과 평가는 일정기간동안 기업 활동의 결과로서 기업의 경쟁력 수준을 제시함과 동시에 미래 기업의 활동 방향에 대한 지침으로서 역할을 수행한다. 경영환경이 급속히 변화하는 지식정보사회에서 재무적인 측정지표에 근거한 성과측정은 그 효과성이 제한되어 있음을 부인할 수 없다. 그러나 재무지표의 비중을 너무 가볍게 여겨서는 안 될 것이다. 그 이유는 품질이나 고객만족 또는 혁신 등과 같은 기업 목표들은 매우 전략적이고 좋은 것이기는 하지만 이것들은 반드시 재무적인 성과로 연결이 되어야 하고 나아가 기업성과로 구체화되어야 하기 때문이다. 즉, 재무적 성과는 다른 관점의 성과들과 상호보완적이고 균형적인 관계를 유지해야 한다. 자동차 유통시스템의 고객만족도와 재무적 성과 사이에 차이가 있는지를 살펴본 결과 신뢰도, 고객충성도, 재구매의사 및 구전광고에서는 유의한 차이가 있는 것으로 나타났으며, 고객만족도와 재무적 성과 사이에 차이가 있는지를 살펴본 결과 재무적 성과 변수인 안정성, 성장성, 활동성에 유의한 차이가 있는 것으로 나타났다.

• 한국식품영양과학회지
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• 제8권1호
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• pp.9-14
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• 1979

The consumption of catchup is increasing due to the raising of income level and food industry and westernization of dietary life followed by economic growth. In this paper I picked up three kinds of food produced by two foreign food companies and three kinds of food by two domestic companies. The average results by experimentation on the nutritive ingredients and the standard quality was as follows; A. Nutritve ingredients; 1) Water content a) Domestic 68.3% b) Foreign 69.1% 2) Protein content a) Domestic 2.2 g b) Foreign 2.1 g 3) Fat content a) Domestic 0.1 g b) Foreign 0.1 g 4) Carbohydrate content a) Domestic 25.1 g b) Foreign 24.6 g 5) Mineral content (Ash) a) Domestic 4.4 g b) Foreign 3.9 g 6) Calcium content a) Domestic 33.5 mg b) Foreign 24.2 mg 7) Phosphorus content a) Domestic 16.1 mg b) Foreign 24.2 mg 8) Vitamin C content a) Domestic 14.6mg b) Foreign 16.0 mg B. Standard quality 1) Remains after evaporation a) Domestic 41.7% b) Foreign 38.4% 2) Free mineral acid content a) Domestic none b) Foreign none 3) Tar chromatophore a) Domestic $trace(Acid)^+$ b) Foreign none 4) Heavy metalic $elements^*$ 5) Sodium chloride content a) Domestic 3.3% b) Foreign 3.3% 6) pH level a) Domestic 3.83 b) Foreign 3.76 + The tar chromatophore elements could not be accurately measured by chromatography. * The heavy metalic elements were both under safety levels in the domestic and foreign products.

• 산업경영시스템학회지
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• 제32권2호
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• pp.120-131
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• 2009

Most world-leading companies are aware that Environment and Health and Safety Issues are critical to the product quality and sustainable growth of their company. Environment-friendly efforts are seen in almost all aspects of business operations in an advanced nation. The Extended Producer Responsibility(EPR) and EU Directive on Waste Electric and Electronic Equipment(WEEE) attempt to tackle the growing quantity of WEEE by making producers responsible for the costs of the collection and recycling of their products at the End-of-Life(EOL). To implement the RFID-based integration system for EOL household electric appliances, such as washing machines and refrigerators, we analyzed the process of collecting, recovering, and recycling the EOL products returned from the distribution points. Furthermore, we proposed a soon-to-be process using the RFID-based integration system in the metropolitan recycling center(MRC). This soon-to-be process model is composed of RFID tags, readers, ALEs, applications and several devices. Through the introduction of the RFID-based integration system, we are expecting to see increasing traceability and real-time management for EOL products from customers, and also improvements in valuable reusable materials(VRM) produced from recycling processes.

• 산업경영시스템학회지
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• 제40권3호
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• pp.18-26
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• 2017

Defense industries which require high reliability need an optimized quality management system with well-planned implementation. And the government should examine the overall status of defense industries, then establish practical policies with a proper support plan in required areas to upgrade the quality management level of manufacturers. Thus, DTaQ developed the model for 2 years from 2014, which specialized in quality management level analysis for defense industries. And a survey has been undertaken with that model by DTaQ and Korea Research Center in 2016. The surveyed companies randomly sampled among those which have more than 30 employees and delivery history over past 3 years, and finally 106 defense industries were selected. This paper present survey method and indexes for survey of defense industry quality management level. The survey was conducted in the order of planning, data collection and data processing, and the validity and reliability of the data were verified to increase objectivity of survey results. The survey contents mainly consist of system quality and management quality. System quality includes Product Development Management, Production Operation Management, supply chain quality management, Safety & Environment Management and Reliability Management, on the other hand, management quality includes Strategic Leadership, Human Resource Management, Customer Market Management and Information & Knowledge Management. Thus this proposes the current overall quality management status of the 106 defense industries and shows level differences by company sizes and manufacturing sectors based on the result of survey. Specifically, this paper enables to track the areas which need prompt government support with the policy directions to make quality management level higher. Therefore, it is expected that this can be used as reference data in establishing quality policies for military supplies in the future.

• 대한화학회지
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• 제47권2호
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• pp.127-132
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• 2003

소의 타일레리아병 진단을 위해 DNA 추출과정 없이 전혈에서 바로 중합효소연쇄반응(PCR)을 통하여 T. buffeli(buffeli/orientalis/sergenti)의 16S rRNA 유전자 단편을 증폭시킨 뒤, 증폭된 DNA를 전기영동법으로 분석하는 방법을 개발하였다. 특이유전자 단편의 증폭을 위해 formamide를 사용하여 혈액세포를 용해시켰으며, 단백질의 응고를 줄이기 위해 낮은 반응온도를 사용하는 FoLT(Formamide Low Temp.) PCR법을 이용하였다. 전혈 100-200 nL를 바로 PCR 증폭에 사용하였으며, PCR 산물(816-bp DNA)은 전기영동법으로 분석하였다. 본 결과는 T. buffeli에 감염된 소의 혈액으로부터 정제된 DNA를 사용하여 얻은 실험결과와 잘 일치하였다.