Safety Evaluation of Ethanol Extract of Inulae Flos : Single-dose Oral Toxicity Study in Mice |
Kwon, Da Hye
(Anti-Aging Research Center, Dong-eui University)
Kim, Min Young (Anti-Aging Research Center, Dong-eui University) Hwangbo, Hyun (Department of Molecular Biology, Pusan National University) Ji, Seon Yeong (Department of Molecular Biology, Pusan National University) Park, Cheol (Division of Basic Sciences, College of Liberal Studies, Dong-eui University) Choi, Yung Hyun (Anti-Aging Research Center, Dong-eui University) Hong, Su Hyun (Anti-Aging Research Center, Dong-eui University) |
1 | Park HY, Hwang YH, Jang DR, Ha JH, Kung KY, Ma JY. Acute Toxicity Study on Gumiganghwal-tang and Fermented Gumiganghwaltang Extracts. Formula Science. 2012;20(2):93-102. |
2 | Park HH, Kim SG, Park YN, Lee JA, Lee YJ, Park NY et al. Suppressive effects of britanin, a sesquiterpene compound isolated from Inulae flos, on mast cell-mediated inflammatory responses. Am J Chin Med. 2014;42(4):935-47. DOI |
3 | Lu Y, Li Y, Jin M, Yang JH, Li X, Chao GH et al. Inula japonica extract inhibits mast cell-mediated allergic reaction and mast cell activation. J Ethnopharmacol. 2012;143(1):151-7. DOI |
4 | Choi JH, Park YN, Li Y, Jin MH, Lee JA, Lee YJ et al. Flowers of Inula japonica Attenuate Inflammatory Responses. Immune Netw. 2010;10(5):145-52. DOI |
5 | Kwon DH, Kim MY, Hwanbo Hyun, Ji SY, Park C, Choi YH et al. Single Dose Oral Toxicity Test of Peucedani Radix in ICR Mice. J Int Korean Med. 2018;39(4):676-685. DOI |
6 | Han MH, Kim JW, Kim KY, Kim SG, Yu GJ, Cho YB et al. Single Dose Oral Toxicity of Schisandrae Semen Essential Oil in ICR Mice. J Life Sci. 2014;24(2):191-5. DOI |
7 | Yoo HJ, Park MY, Choi HY, Kim JD. Mouse single Oral Dose Toxicity Test of Lonicerae Flos Aqueous Extracts. Korean J Orient Med. 2010;31(3):539-553. |
8 | Jang IS, Yang CS, Lee SD, Han CH. A Review of Herbal Medicinal Products Associated with Toxic Events in Korea. J Korean Oriental Med. 2007;28(1):1-10. |
9 | Lee E, Wook PB, Hea GJ, Heung K. A Study on The Side Effects and Toxicity of Herbal Medicine. J Int Korean Med. 2002;23(2):222-7. |
10 | Im GY, Hwang YH, Lee JH, Oh YC, Cho WH, Ma JY. Acute Toxicity Study on Insampaedoksan and Fermented Insampaedok-san. Kor J Oriental Preventive Medical Society 2010;15(3):141-52. |
11 | Yoo HJ, Park MY, Choi HY, Kim JD. Mouse single Oral Dose Toxicity Test of Lonicerae Flos Aqueous Extracts. Korean J Orient Med. 2010;31(3);539-53. |
12 | OECD/OCDE. OECD guidelines for the testing of chemicals No. 425 Acute oral toxicity. 2008. |
13 | National Institute of Food and Drug Safety for Single Dose Toxicity Study (No. 2012-86), MFDS, 2012. |
14 | Korean Medicinal Herb. Seo BI, Lee JH, Choi HY, Kwon DR, Bu YM. Yeong-Rim Publishing Co., Ltd. 2004, 495-496. |
15 | Cha MR, Kim JY, Hwang JH, Park HR. Cytotoxic Activity of the Inula joponica Extracts Against Several Human Cancer Cell Lines In Vitro. Kor J Pharmacogn. 2006;37(3):130-5. |
16 | Sun WS, Kim HS, Byun KS. Studies on the volatile components of Inulae flos (Inula britannica var. chinensis REGEL). J Korean Agric Chem Soc. 34(4), 312-317, 1991. |
17 | Kim JH, Lim HS, Ha HK, Seo CS, Shin HK. Inulae Flos and its Compounds Inhibit TNF-A - and IFN-Γ-Induced Chemokine Production in HaCaT Human Keratinocytes. Evid-Based Complementary Altern Med. 2012;2012:280351. DOI |
18 | Yu ZP, Zhang JS, Zhang Q, Yu SJ, Zhang Y, Yu JH et al. Bioactive sesquiterpenoids and sesquiterpenoid glucosides from the flowers of Inula japonica. Fitoterapia. 2019; 138:104292. DOI |
19 | Park SH, Lee DH, Kim MJ, Ahn J, Jang YJ, Ha TY et al. Inula Japonica Thunb. Flower Ethanol Extract Improves Obesity and Exercise Endurance in Mice Fed A High-Fat Diet. Nutrients. 2018;11(1): E17. |
20 | Im GY, Hwang YH, Lee JH, Oh YC, Cho WK, Ma JY. Acute Toxicity Study on Insampaedoksanand Fermented Insampaedok-san. Kor J Oriental Preventive Medical Society. 2010;15(3):141-52. |
21 | U.S. Environmental Protection Agency. Health Effects Test Guidelines OPPTS 870.100, Acute Toxicity Testing Background. US EPA August, Washington, USA, 1998. |
22 | Son KH, Kim SH, Jung KY, Chang HW. Screening of Platelet Activating Factor (PAF) Antagonist from Medicinal Plants. Kor J Phamacogn. 1994;25(2):167-170. |