Objectives: Toad venom, called Chan-Su, is a traditional Oriental medicine secreted from the auricular and the skin glands of the Bufo bufo gargarizanz Cantor or B. melanosticus Schneider and has been widely used in China, Korea and other parts of Asia for the treatment of pain, heart conditions, and cancer. We examined the concentrations of the main chemical constituents within a commercially available toad venom product and compared the levels for different extraction methods. Methods: Toad venom was extracted using either cold or hot water, ethanol (EtOH), methanol (MeOH), or ethyl acetate (EtOAc), was fractionated using precipitation or reflux, and was then analyzed using thin layer chromatography (TLC), high-performance liquid chromatography (HTLC), and liquid chroma-tography - mass spectrometry (LC-MS). Individual components were identified by comparisons of the retention times, the ultraviolet spectra, and mass spectras and differences in chemical constituents for different solvents and extraction methods are presented. Results: Components with authentic standards, including serotonin and bufodienolides (cinobufagen, bufalin, cinobufalin, and resibufogenin), were detected. The water extract of toad venom contained the greatest amount of serotonin ($75.7{\pm}0.1$ mg/g), but very small amounts of bufodienolides ($3.8{\pm}0.0$ mg/g). In contrast, the use of MeOH or EtOH extraction solutions resulted in 5-26 times higher concentrations of bufodienolides, with only trace amounts of serotonin. The relative and the absolute concentrations of the component also varied based on the extraction method; i.e., EtOH extracts yielded the greatest total amounts of bufodienolides, and EtOAc precipitation had the lowest amounts of bufodienolides. Conclusions: Toad venom consists of serotonin and several bufodienolides, and the choice of solvent to extract chemical the constituents is important as a way to enrich the purported active components for treating different conditions.
This study aims to explore the variables which determine performance of inter-firm R&D cooperation. As the dependent variable is categorical - whether the new product developed by the inter-firm cooperation were sold or not-and the independent variables were interval, discriminant analysis was used. The independent variables were composed of degree of inter-firm cooperation, experience of cooperation, market attractiveness, R&D intensity, resources and competences of enterprise and efficiency of government support. A total of 144 responses were obtained. The results indicate that the degree or inter-firm cooperation is the best predictor of the performance, followed by market attractiveness, R&D intensity and resources/competences of enterprises. Whereas, the experience of cooperation and efficiency of government support program were not statistically significant predictors. The hit ratio or the percentage of cases correctly classified was 66.2%. We derived several implications of these findings in an effort to guide subsequent inquiry.
Asia-Pacific Journal of Business Venturing and Entrepreneurship
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v.13
no.6
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pp.177-189
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2018
Business environment is always full of challenges. Despite various strategic efforts, there are so many failure cases of misfit. With the weaker resource base and institutional foundation, startup firms find it more difficult to find the right spot in the stiff competition. In the middle of evolutionary process, the startup firms need proper strategies meeting the differential challenges along the multiple stages of growth. Following the idea of product life cycle, this study applies the four stages of growth-startup, initial growth, accelerated growth, matured, and decliing. The next step for the startup manager is meeting each stage of growth with proper strategic efforts, including strategy, structure, decision-making pattern, and control method. When the knowledge factor is introduced, there is a potential for higher performance. Based on the 'Detailed Survey on Startup Ventures in 2017,' this study explores the impact of the government subsidy program on the firm competitiveness and performance-along the four stages of growth. In each stage, the strategy factors showed differential impact.
This experiment was performed to verify whether dietary heat-killed Lactobacillus rhamnosus (LR) improves growth performance and modulates immune responses of weaned pigs. Ninety-six weaned pigs ([Landrace × Yorkshire] × Duroc; 6.95 ± 0.25 kg body weight [BW]; 28 d old) were randomly allocated to four treatments: 1) a basal diet without heat-killed LR (CON), 2) T1 (CON with 0.1% heat-killed LR), 3) T2 (CON with 0.2% heat-killed LR), and 4) T3 (CON with 0.4% heat-killed LR). Each treatment had six pens with four pigs (6 replicates per treatment) in a randomized completely block design. The heat-killed LR used in this study contained 1 × 109 FU/g of LR in a commercial product. Pigs were fed each treatment for four weeks using a two-phase feeding program to measure growth performance and frequency of diarrhea. During the last week of this study, all diets contained 0.2% chromic oxide as an indigestible marker. Fecal sampling was performed through rectal palpation for the consecutive three days after the four adaptation days to measure apparent total tract digestibility (ATTD) of dry matter, crude protein, and gross energy (GE). Blood sampling was also performed on day 1, 3, 7, and 14 after weaning to measure immune responses such as serum tumor necrosis factor-α (TNF-α), transforming growth factor-β1 (TGF-β1), C-reactive protein (CRP), and cortisol. The heat-killed LR increased (p < 0.05) growth rate, feed efficiency, and ATTD of GE for overall experimental period compared with CON, but reduced (p < 0.05) post-weaning diarrhea. In addition, pigs fed diets contained heat-killed had lower concentrations of serum TNF-α (d 7; p < 0.05), TGF-β1 (d 7; p < 0.10), and cortisol (d 3 and 7; p < 0.05) than pigs fed CON. In conclusion, dietary heat-killed LR improved growth rate, modified immune responses of weaned pigs, and alleviated post-weaning diarrhea.
With the emergence of new digital technologies into a supply chain, it is essential for companies to incorporate these technologies in managing their supply chains. However, various challenges have been identified in digital supply chain management, especially when it comes to its assessment. There are no universally agreed measurements for the performance of digital supply chain management within the research community so far. This paper explores an option of using user experience as one of possible measurements. Therefore, three different focus-group discussions were held and later analyzed with a qualitative content analysis. The subscription-based video on demand service, Netflix was used as an example in those discussions. Due to the fact that Netflix provides a digital product as a streamline service, user experience is critical for the company. Especially, user experience with a recommender system and related privacy issues have become significant for a company to retain existing customers and attract new customers in many fields. Since the recommender system and related privacy issues are parts of a digital supply chain, user experience can be one of appropriate measurements for digital supply chain management. This study opens a new perspective for research on performance measurements of digital supply chain management.
Hye Mi Kang;Eun Ji Park;Sun Young Park;Dae Youn Hwang;Jong-Choon Lee;Myunghoo Kim;Young Whan Choi
Journal of Life Science
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v.34
no.1
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pp.18-27
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2024
Laying hens are known to be able to 'bio-accumulate' the health-promoting ingredients of their diet into eggs. The purpose of this study was to characterize lignan-rich eggs as functional food fed with Schisandra fruit by-product (SCP). Experimental diets were formulated using yellow corn, rice bran, soybean meal, fish meal, meat bone meal, poultry meal, vitamin premix, mineral premix, CaCO3, and supplemented Schisandra chinensis by-product. This experiment conducted a completely randomized design with 5 treatments for 5 laying hens. Levels of SCP were fed control diet or each formulated diet containing 1%, 3%, 5% and 7% SCP powder. The weight of eggs and the lignan content in white and yolk of egg were investigated every 7 days. Egg production and egg weight were not affected by diet at less than 5% SCP in the diet, but were significantly reduced when the diet was supplemented with a high concentration of 7% SCP after 3 weeks. Yolks and white in eggs were analyzed by using a high performance liquid chromatography (HPLC) to determine the lignans profile. Higher dietary SCP supplementation significantly increased gomisin N and schisandrin C in Acetonitrile (p<0.05). Gomisin N in egg white increased in a concentration-dependent manner, but shisandrin C not detected. These results indicated that the use of SCP powder in layering diets was effective in egg quality and for the production of lignans fortified eggs. In conclusion, dietary supplementation of Schisandra by-product with less than 5% can produce lignans-enrich eggs used as functional foods.
Kwon, Gyoung Hoon;Chu, Hyung Gon;Kim, Jin Young;Kang, Joonhee
Journal of Sensor Science and Technology
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v.26
no.1
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pp.39-43
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2017
Development of vision system as a nondestructive evaluation system can be very useful in screening the defective mechanical parts before they are assembled into the final product. Since the tens of thousands of the mechanical parts are used in an automobile carefully inspecting the quality of the mechanical parts is very important to maximize the performance of the automobile. To sort out the defective mechanical parts before they are assembled, auto parts fabrication companies employ various inspection systems. Nondestructive evaluation systems are getting rapidly popular among various inspection systems. In this study, we have developed a vision system to inspect the inside of the brake caliper, a part that is used to compose a brake which is the most important to the safety of the drivers and the passengers. In a brake caliper, a piston is pushed against the brake disk by oil pressure, causing a friction to damp the rotation of the wheel. Inside the caliper, a groove is positioned to adopt an oil seal to prevent the oil leaks. Inspecting the groove with our vision system, we could examine the existence of the contaminants which are normally the residual tiny pieces from the machining process. We used a high resolution GigE camera, 360 degree lens to look in the inside view of the caliper at once, and a special illumination system in this vision system. We used the edge detection technique to successfully detect the contaminants which were in the form of small metal chips. Labview graphical program was used to process the digital data from the camera and to display the vision and the statistics of the contaminants. We were very successful in detecting the contaminants from the various size calipers. We think we are ready to employ this vision system to the caliper production factories.
This study sought to reduce the risk of fractures in elite youth taekwondo athletes to find out the relationship between bone mineral density which are used as indicators of early diagnosis of osteoporosis and cardiorespiratory functional capacity which is an indicator of performance and sports injury the harmful to athletes. The Pearson product-moment correlation was performed to investigate the correlation between bone mineral density, cardiorespiratory functional capacity, and sports injury. The bone mineral density and cardiorespiratory functional capacity, sports injury were examined the relationship using the Simple Linear Regression. The bone mineral density were correlated with the ventilation (r=.388), and VO2max (r=.478). Bone mineral density was correlated with sports injury (r=-.292). When the bone mineral density increased by .002 and .006, the ventilation (p=.001) and VO2max (p=.006) increased by about 1. In addition, when the bone mineral density decline by .016, the sports injury increased by about 1. Improving athletes' bone mineral density can prevent sports injury, and it can be used as a sports injury prevention program in the future.
The purpose of this study was the investigation of theoretical and empirical relationships between Piagetian and psychometric assessments of intelligence. Specifically, the factor structure of Piagetian-type scales, the relationship between Piagetian scales and psychometric intelligence tests, and differences in the factor structure of Piagetian and psychometric assessments of intelligence were studied. The subjects of this stuby were 70 children (35 boys and 35 girls) in the 1st grade of an elementary school in Seoul The Piagetian-type scales and the K-WISC were administered individually, and the General Intelligence Test was administered to groups of children. Statistical analysis of the obtained data consisted of the SPSS Computer program including factor analysis and Pearson's product moment correlation coefficient. The Piagetian-type scales were found to consist of three factors, which accounted for 55 percent of the total common-factor variance. Factor-I was a factor indicating "conservation". Factor-II was a factor indicating "moral judgements". Factor-III was a factor indicating "classification and identity". Correlations between subtests of psychometric tests and Piagetian scales were relatively low or moderate. Relations between IQs assessed by the psychometric tests and Piagetian scales were also relativeyly low or moderate. Eight factors were extracted from the joint factor analysis of psychometric intelligence tests and Piagetian scales, and they accounted for 67 percent of the total common-factor variance. Factors-I, II, III, and V consisted of subtests of psychometric assessments, and Factors-IV, VI, VII and VIII were composed of Piagetian scales. Factor-I was a factor for "reasoning ability based upon language". Factor-II was a factor for "performance ability". Factor-III was a factor for "grouping ability". Factor-IV was a factor for "conservation". Factor-V was a factor indicating "symbol and language usage ability". Factor- VI was a factor indicating "moral judgments". Factor-VII was a factor indicating "length consevation". Factor-VIII was a factor indicating "classification and identity".
The Journal of the Korea institute of electronic communication sciences
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v.12
no.2
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pp.345-352
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2017
In this paper, we design and implement an educational robot system that can use scratch education with the function of user demanding to perform robot education in actual school site in an embedded environment. It is developed to enable physical education for sensing information processing, software design and programming practice training that is the basis of robotic system. The development environment of the system is Arduino Uno based product using Atmega 328 core, debugging environment based on Arduino Sketch, firmware development language using C language, OS using Windows, Linux, Mac OS X. The system operation process receives the control command of the server using the Bluetooth communication, and drives various sensors of the educational robot. The curriculum includes Scratch program and Bluetooth communication, which enables real-time scratch training. It also provides smartphone apps and is designed to enable education like C and Python through expansion. Teachers at the school site used the developed products and presented performance processing results satisfying the missionary needs of the missionaries.
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