• Natural Product Sciences
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• 제22권4호
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• pp.293-298
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• 2016

Plant-derived triterpenoids commonly possesses biological properties such as anti-inflammatory, antimicrobial, anti-viral and anti-cancer. Luvunga scandens is one of the plant that produced triterpenoids. The aims of the study was to analyze cell cycle profile and to determine the expression of p53 unregulated modulator of apoptosis (PUMA), caspase-8 and caspase-9 genes at mRNA level in MCF-7 cell line treated with two triterpenoids, flindissol (1) and 3-oxotirucalla-7,24-dien-21-oic-acid (2) isolated from L. scandens. The compounds were tested for cell cycle analysis using flow cytometer and mRNA expression level using quantitative RT-PCR. The number of MCF-7 cells population which distributed in Sub G1 phase after treated with compound 1 and 2 were 7.7 and 9.3% respectively. The evaluation of the expression of genes showed that both compounds exhibited high level of expression of PUMA, caspase-8 and caspase-9 as normalized to ${\beta}-actin$ via activation of those genes. In summary, the isolated compounds of L. scandens plant showed promising anticancer properties in MCF-7 cell lines.

• Design & Manufacturing
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• 제14권2호
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• pp.34-41
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• 2020

Typical characteristics of medical device parts are that they can not be reused and there are many disposable products. Therefore, there is a need for an injection molding machine having excellent repeatability of molding conditions and a precision injection mold for mass production. Recently, the performance of an injection machine has made a remarkable evolution compared to the past. However, defects such as short-shot, flash, weld line, gas burning, warpage, and deformation, which are typical defects, still do not disappear at all. This is due to the lack of gas ventilation from the product cavities, even if the gas is smoothly vented from the sprue and runner of the mold. For this reason, the internal pressure of the cavity rises and is directly connected to the quality defects. In this study, an active gas vent system was designed to prevent defects due to trapped gas in the cavity. Since it can be easily adjustable in response to the molding conditions and the mold temperature changes, it is expected to improve productivity due to the reduction of the defective ratio.

• 한국경영과학회지
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• 제22권2호
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• pp.79-97
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• 1997

Many dispatching rules have been developed for the on-line control of product flow in a job shop. The introduction of a flexible manufacturing system (FMS) has added a new requirement to classical job shop control problem : the selection of machines by parts of different types. An FMS can keep a great deal of information on the status of the system, such as information on what is scheduled in the near future, with great accuracy. For example, the knowledge of the time when the next part will arrive at each machine can be neneficial for the routing. This paper tests the effects of the use of this knowledge for part routing on the parts flow time (sum of the time for waiting and service) under a simple routing procedure- a look-ahead routing procedure. A test under many operating conditions shows that the reduction of part flow time from the cases without using this information is between 1% and 11%, which justifies more study on this routing procedure at real production sites when machine capacity is a critical issue. The test results of this paper are also valid for other highly automated systems such as the semi-conductor fabrication plants for routing when the arrivals of parts in the near future are known.

• Asian Pacific Journal of Cancer Prevention
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• 제15권3호
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• pp.1423-1428
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• 2014

Iso-suillin, a natural product isolated from Suillus luteus, has been shown to inhibit the growth of some cancer cell lines. However, the molecular mechanisms of action of this compound are poorly understood. The purpose of this study was to investigate how iso-suillin inhibits proliferation and induces apoptosis in a human hepatoma cell line (SMMC-7721). We demonstrated the effects of iso-suillin on cell proliferation and apoptosis in SMMC-7721 cells, with no apparent toxicity in normal human lymphocytes, using colony formation assays and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) analysis. Western blotting was used to examine the expression of $G_1$ phase-regulated and apoptosis-associated protein levels in iso-suillin treated SMMC-7721 cells. The results indicated that iso-suillin significantly decreased viability, induced $G_1$ phase arrest and triggered apoptosis in SMMC-7721cells. Taken together, these results suggest the potential of iso-suillin as a candidate for liver cancer treatment.

• 무역상무연구
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• 제42권
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• pp.337-364
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• 2009

Trade remedy is the system that additional duty or import quantity restriction would be imposed on the import products, in case that unfair imports damage domestic industry or even proper import products damage significantly domestic industry. The system is secured by the act of unfair trade practice investigation & industrial damage remedy, tariff act, WTO agreement. Anti-dumping duty act is the system that duties are assessed with the equal or less amount of the difference between normal transaction price and dumping price, in case that the product imported under dumping price causes or may cause damages in domestic industry, or the development of domestic industry should be delayed practically. Recently, the problems related with anti-dumping duty imposed as the part of the trade remedy occur frequently. It is necessary to discuss whether the anti-dumping duty act is practically trade remedy which does comply with GATT regulations and WTO agreements as the criteria of international law and is in line with the intent of domestic act in the suffered country, or it does return to protective trade or reduce the protection of consumer. On the basis of this discussion, it would be difficult to impose the antidumping duty on industrial products in order to protect domestic industry, when considering the expected free trade agreements of Korea-US, Korea-China and Korea-Japan. In order to survive under the current severe competition of world trade market, companies should raise the competitiveness by themselves without relying on the current trade acts to provide with a certain protection. This thesis should bring those attentions.

• 한국경영과학회지
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• 제18권3호
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• pp.151-157
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• 1993

In this paper, we investigate the effects of yield randomness for lot-sizing in a multi-stage production system. The practical importance of incorporating yield randomness into production models has been emphasized by many researchers. Yield randomness, especially in semiconductor manufacturing, poses a mojor challenge for production planning and control. The task becomes even more difficult if the demand for final product is uncertain. An attempt to meet the demand with a higher level of confidence forces one to release more input in the fabrication line. This leads to excessive work-in-process (WIP) inventories which cause jobs to spend unpredictably longer time waiting for the machines. The result is that it is more difficult to meet demand with exceptionally long cycle time and puts further pressure to increase the safety stocks. Due to this spiral effect, it is common to find that the capital tied in inventory is the msot significant factor undermining profitability. We propose a policy to determine the quantity to be processed at each stage of a multi-stage production system in which the yield at each stage may be random and may need rework.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2004년도 춘계학술대회 논문집
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• pp.269-272
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• 2004

The present study used a diagrammatic analysis of 6 sigma quality control and Taguchi method for injection molding process of monitor back-cover, evaluated the influence on the cycle time with part design, mold design, molding process and standardization activity involving design & molding, adopted analysis of sensitivity and effective factors of the part design and molding process conditions for productivity, identified main design molding factors, as critical ones influencing on the quality and productivity, of which is summarized as design guidance. The main contribution factors for cycle time can be sequentially enumerated as follows; hot spot, part thickness, coolant inlet temperature, melt temperature cooling line layout, etc.. As a first step critical factors of the design process of current monitor housing were investigated. And the optimal and better critical factors found in the first step were applied to a new product proving our process was correct. Moldflow software was used for injection molding simulation, and Minitab software for the statistical analysis. Finally, the productivity was increased by about 33 percents for our specific case.

• 한국CDE학회논문집
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• 제19권2호
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• pp.157-168
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• 2014

In this paper, HSE (Health and Safety Environments) research with smart device and biometrics is conducted for the worker's HSE enhancement in the manufacturing shop floor. Today, various kinds of smart devices are popularized extensively. In addition, the wearable type devices are being introduced such as google glass very recently. Smart device of werable type is exptected to bring great opportunity out in terms of HSE functionality. Smart devices of phone or tablet type are being used for on-line work between control center and manufacturing shop floor by virtue of wireless communication. However, those devices are not appropriate for detecting of worker's physical senses such as temperature and pulse. In this paper, we developed a glass type smart device and required funictions for HSE enhancement with the investigation of biometrics technology. Also, required sensors are investigated for the detecting of temperature, pulse and noxious gasses. Smart device of glass type has advantages in that most senses of personnel are gathered around faces, and also it's possible to detect neutral axis of body because the wearing location is fixed. We expect that the proposing HSE product of glass type smart device could contribute the enhancement of the HSE of manufacturing shop floor.

• 한국항만경제학회지
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• 제22권4호
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• pp.39-58
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• 2006

정보공유와 신뢰, 피드백을 바탕으로 한 파트너십 시스템은 각 협력사간 반품물류관리에 있어 보다 효율적인 성과를 얻을 수 있게 한다. 이 사례연구는 홈쇼핑업체와 각 협력사간 웹 기반의 파트너십 시스템을 통한 반품물류관리 개선 성과를 보여주고 있다. 첫째, 협력사간 거래비용과 작업시간을 감소시키고 있으며, 둘째, 생산라인의 집중화 및 계획 관리가 가능토록 하였다. 마지막으로 신속하고 정확한 반품관련 업무처리가 가능해지고 피드백을 통해 제품의 품질 향상을 도모할 수 있음을 보여주고 있다.

• International Journal of Advanced Culture Technology
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• 제8권3호
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• pp.90-100
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• 2020

Our overall society circulates in line with the economical situations characterized by production and consumption and companies play the role of providing products and services, thus taking very significant responsibilities for the socioeconomical and cultural aspects in society. Therefore, when designers attempt to think of a way to enable companies and society to share their values and propose specific concepts and visualize outcomes, it is very critical to be able to understand economical philosophy and management strategies that interconnect companies with society and seek out proper design approaches. Recently, the world's enterprise and management culture tend to connect products and services provided by companies through chains of social values. Based on the abovementioned shift in the management paradigm, the researcher investigates and analyzes actual cases of attempts by Samsung Electronics to achieve its social impacts and studies actual roles and approaches of in-house designers with creativity and insights of humanity with regard to these attempts. Each case is selected from various fields such as the company's products and service development, business systems, culture, and external strategies and the ultimate goal is to learn about actual insights and approaches of designers to make contributions to the company's management with social impacts. Especially, humanity and creative thinking of many designers working in the manufacturing industry can have significant contributions to achieving its management with social impacts and effects of sustainable management.