• Journal of The Korean Astronomical Society
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• v.52 no.6
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• pp.217-225
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• 2019

We apply a modified Convolutional Neural Network (CNN) model in conjunction with transfer learning to predict whether an active region (AR) would produce a ≥C-class or ≥M-class flare within the next 24 hours. We collect line-of-sight magnetogram samples of ARs provided by the SHARP from May 2010 to September 2018, which is a new data product from the HMI onboard the SDO. Based on these AR samples, we adopt the approach of shuffle-and-split cross-validation (CV) to build a database that includes 10 separate data sets. Each of the 10 data sets is segregated by NOAA AR number into a training and a testing data set. After training, validating, and testing our model, we compare the results with previous studies using predictive performance metrics, with a focus on the true skill statistic (TSS). The main results from this study are summarized as follows. First, to the best of our knowledge, this is the first time that the CNN model with transfer learning is used in solar physics to make binary class predictions for both ≥C-class and ≥M-class flares, without manually engineered features extracted from the observational data. Second, our model achieves relatively high scores of TSS = 0.640±0.075 and TSS = 0.526±0.052 for ≥M-class prediction and ≥C-class prediction, respectively, which is comparable to that of previous models. Third, our model also obtains quite good scores in five other metrics for both ≥C-class and ≥M-class flare prediction. Our results demonstrate that our modified CNN model with transfer learning is an effective method for flare forecasting with reasonable prediction performance.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.3
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• pp.781-784
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• 2012

The aim of this study was to evaluate the effect of the adenovirus-mediated double suicide gene (CD/TK) for selective killing of gastric cancer cells. Gastric cancer cells SCG7901 and normal gastric epithelial cell lines were infected by adenoviruses Ad-survivin/GFP and Ad-survivin/CD/TK. GFP expression and CD-TK were detected by fluorescence microscopy and reverse transcriptase polymerase chain reaction (RT-PCR), respectively. After treatment of the infected cells with the pro-drugs ganciclovir (GCV) and/or 5-FC, the cell growth status was evaluated by methyl thiazolyl tetrazolium assay. Cell cycle changes were detected using flow cytometry. In nude mice bearing human gastric cancer, the recombinant adenovirus vector was injected directly into the tumor followed by an intraperitoneal injection of GCV and/or 5-FC. The subsequent tumor growth was then observed. The GFP gene driven by survivin could be expressed within the gastric cancer line SCG7901, but not in normal gastric epithelial cells. RT-PCR demonstrated the presence of the CD/TK gene product in the infected SCG7901 cells, but not in the infected normal gastric epithelial cells. The infected gastric cancer SCG7901, but not the gastric cells, was highly sensitive to the pro-drugs. The CD/TK fusion gene system showed significantly greater efficiency than either of the single suicide genes in killing the target cells (P<0.01). Treatment of the infected cells with the pro-drugs resulted in increased cell percentage in G0-Gl phase and decreased percentage in S phase. In nude mice bearing SCG7901 cells, treatment with the double suicide gene system significantly inhibited tumor growth, showing much stronger effects than either of the single suicide genes (P<0.01). The adenovirus-mediated CD/TK double suicide gene driven by survivin promoter combined with GCV an 5-FC treatment could be an effective therapy against experimental gastric cancer with much greater efficacy than the single suicide gene CD/TK combined with GCV or 5-FC.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.1049-1052
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• 2013

Background: Studies have shown that alterations of steroid hormone metabolism, particularly involving testosterone, affect the risk of prostate cancer. Therefore, genetic variation in genes of enzymes which are involved could be of importance. The gene most interest is CYP17, whose enzyme product has an essential role in testosterone hormone synthesis. Some studies have indicated that the A2 allele polymorphism of CYP17 associated with increased risk of prostate cancer that could be affected by ethnicity. Therefore, the aim of this study was determination of presence or absence of the A2 allele in patients with prostate cancer. Materials and Methods: We studied the association of A2 allele and prostate cancer among 74 patients with prostate cancer and 128 healthy men which were referred to hospitals of SBMU. Results: This study revealed a significant association between prostate cancer risk and the A2 allele in an Iranian population so that A1A2 and A2A2 genotypes were more common in cases than controls with P-values of 0.029 and 0.010, respectively. Conclusions: Results of our study support a possible role of the A2 allele in sporadic prostate cancer development in Iran, in line with findings elsewhere.

• Journal of Oral Medicine and Pain
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• v.17 no.2
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• pp.27-35
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• 1992

The purpose of this study was to evaluate the size of the temporomandibular joint space by the increase of the occlusal force on the working side and the non-working side during unilateral biting. For the study, 22 normal adults, age from 23 to 25, who had normal or class I molar relationship and had no symptoms on TMJ area and masticatory muscles were selected. Transcranial TMJ radiograph was taken during unilateral biting with the sensor of occlusal load measuring device (MPM-3000 ; Nihon Kohden Kogyo Co. Ltd., Japan) on 1st molar teeth of right and left side given to force of 0kg, 10kg, 20kg and 30kg respectively with Accurad-200(Denar Corperation's product). The radiographs were traced on the screen, with enlaged as 5 times. The size of temporomandibular joint space at anterior, superior and posterior compartment were measured with Dumas's method (reference line between squamotympanic fissure and the lowest point of articular eminence). The following results were obtained by this study. 1. The size of anterior TMJ space showed a tendency to decrease on the working side and increase on the non-working side by the increase of the occlusal force, but had no statistical significancy (P>0.05). 2. The size of superior TMJ space showed a tendency to increase on the working side and decrease on the non-working side by the increase of the occlusal force (P<0.05). 3. The size of posterior TMJ space showed a tendency to decrease on both working and nonworking side, but had no statistical significancy (P>0.05)

• Journal of the Korean Society of Costume
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• v.61 no.6
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• pp.60-73
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• 2011

Men's fashion has not much changed due to the pervasive patriarchy Because of the change of gender roll and attitude towards one's appearance and fashion, men began to express themselves with fashion in the late 90's. The purpose of this study is to categorize men's image and their fashion styles from Korean TV dramas to provide informations for predicting men's fashion trend in rapidly changing market. Through the analysis of three dramas with 30% or more of audience rating by all age groups from January to July, 2009, nine distinctive male images were selected and their styles were analyzed; silhouette, details, materials, color, accessories, and hair-style. The results are as follows: In the past holding neat and straight line silhouettes but today shows tight silhouette. In color and detail, the use of brilliant chromatic colors, use of hight saturation colors, big and brilliant pattern, ruffles, frills, beads, knitwear, mix matched new composed materials, and light materials are dominant. While short and simple shape of hair-styles were predominant in the past, now we see more varied hair length. Not only that, variety of perms and colors are showed on TV screens. Hence, the results show that a lot of radical change has happened in the men's fashion, and marketing propositions that reflects this change in men's fashion market are requested along with trendy emotional product development and coordination proposals, and finally calls for more multilateral study and market search of male consumers.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.22 no.6
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• pp.874-880
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• 2018

3D modeling is extensively used in the field of architecture, machinery and contents production such as movies. Modeling is a time-consuming task. In order to compensate for these drawbacks, attempts have recently been made to reduce the production period by applying 3D scanning technology. 3D scanning for small objects can be done directly with laser or optics, but large buildings and sculptures require expensive equipment, which makes it difficult to acquire data directly. In this study, 3D modeling data for a large object is acquired using photometry with using drones to acquire the image data. The maintenance method for uniform spacing between the sculpture and the drone, the measurement method for the flight line were presented. In addition, we presented a production environment that can utilize the obtained 3D point cloud data for animation and a rendered animation result to find ways to make it in various environments.

• The Transactions of the Korean Institute of Power Electronics
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• v.15 no.1
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• pp.69-74
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• 2010

In a grid connected variable speed wind turbine, the PCC voltage and the wind power fluctuate as the wind velocity changed. And this voltage variation is changed due to location of PCC. This paper calculate the value of PCC voltage variation which is proportional to the product of the line impedance from the ideal generator to the PCC and the wind turbine output current. And to reduce this PCC voltage variation, this paper calculate the required reactive power analytically using the vector diagram method. Output reactive current is changed, if the reactive current is limited by inverter capacity or grid code have the margin of voltage variation. If the grid connected inverter is controlled by proposed algorithm, the PCC voltage variation is minimized though the wind turbine output change at random. To verify calculated voltage variation and required reactive power, this paper utilized Matlab and PSCAD/EMTDC simulation and real small wind turbine and power system in Sapsido, island in the Yellow Sea.

• Design & Manufacturing
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• v.13 no.4
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• pp.45-50
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• 2019

The fourth industrial revolution calls for an integrated talent by improving working-level skills within the big framework of creativity and convergence. Therefore, university education focuses on solving the problem of practical ability education by improving employment ability. Based on this improvement in practical skills, this study is based on the field-based design curriculum of Capstone. Currently, the Capstone Design Course is being implemented at most universities, extending its scope to the fields of engineering, humanities, social studies and arts. However, there is a limit to the core concept of Capstone design education and capacity education developed in line with the foreign educational environment and applied directly to our nation's university education. In terms of overseas cases, the core focus is to develop practical, design, and prototype capabilities by forming a team among all grades and multidisciplinary institutions to support the capital and manpower of the industry. However, the nation's industrial linkage and curriculum have difficulties in carrying out multi-disciplinary education. In this study, students were asked to team up and solve the challenges that the industry needs based on the expertise acquired in the lower grade curriculum by applying majors and 3D printing through the first and second semester courses of the fourth grade to address these limitations. In addition, business skills for the process of creativity and leadership experience in our country through a suitable design capstone class to review the efficiency of education by applying a model. In order to achieve the purpose of Capstone design subject, the goal setting, class model composition, class model application, verification and evaluation, and final class model development procedures were carried out. Through this process, it will be used as a basic material for educating design class capstone design.

• Natural Product Sciences
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• v.18 no.2
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• pp.130-136
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• 2012

In the present work, we have collected 19 species of macroalgae (9 Phaeophta and 10 Rhodophyta) f rom all around of Korea: Dictyopteris divaricata, D. prolifera, Myelophycus cavus, Papenfussiella kuromo, Petalonia zosterifolia, Petrospongium rugosum, Rugulopteryx okamurae, Sargassum fulvellum, S. muticum, Callophyllis japonica, Gloiopeltis tenax, Gracilaria longissima, Gracilaria vermiculophylla, Grateloupia asiatica, Grateloupia lanceolata, Grateloupia sparsa, Grateloupia turuturu, Grateloupia sp, and Polyopes affinis. The macroalgal species were extracted by 70% ethanol (EtOH) for 24 h and evaluated its inhibitory effects on ${\alpha}$-glucosidase. Among ethanol extracts, Myelophycus cavus showed the most effectively inhibitory activity ($IC_{50}$, 2.17 ${\mu}g/ml$) against ${\alpha}$-glucosidase, followed by Sargassum fulvellum (<$IC_{50}$, 8.13 ${\mu}g/ml$), Dictyopteris prolifera ($IC_{50}$, 16.66 ${\mu}g/ml$), Rugulopteryx okamurae ($IC_{50}$, 50.63 ${\mu}g/ml$), and Petrospongium rugosum ($IC_{50}$, 101.62 ${\mu}g/ml$). Furthermore, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay showed no cytotoxicity on mouse pre-adipocytes cell line (3T3-L1). These results suggest that some edible macroalgae merit further evaluation for clinical usefulness as anti-diabetic functional foods.

• Natural Product Sciences
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• v.21 no.3
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• pp.162-169
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• 2015

Hamamelis japonica (Hamamelidaceae), widely known as Japanese witch hazel, is a deciduous flowering shrub that produces compact clumps of yellow or orange-red flowers with long and thin petals. As a part of our ongoing search for phenolic constituents from this plant, eleven phenolic constituents including six flavonol glycosides, a chalcone glycoside, two coumaroyl flavonol glycosides and two galloylated compounds were isolated from the flowers. Their structures were elucidated as methyl gallate (1), myricitrin (2), hyperoside (3), isoquercitrin (4), quercitrin (5), spiraeoside (6), kaempferol 4'-O-β-glucopyranoside (7), chalcononaringenin 2'-O-β-glucopyranoside (8), trans-tiliroside (9), cis-tiliroside (10), and pentagalloyl-O-β-D-glucose (11), respectively. These structures of the compounds were identified on the basis of spectroscopic studies including the on-line LCNMR-MS and conventional NMR techniques. Particularly, directly coupled LC-NMR-MS afforded sufficient structural information rapidly to identify three flavonol glycosides (2 - 4) with the same molecular weight in an extract of Hamamelis japonica flowers without laborious fractionation and purification step. Cytotoxic effects of all the isolated phenolic compounds were evaluated on HCT116 human colon cancer cells, and pentagalloyl-O-β-D-glucose (11) was found to be significantly potent in inhibiting cancer cell growth.