• The Korean Journal of Physiology and Pharmacology
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• v.12 no.4
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• pp.143-148
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• 2008

Caveolin-1 (CAV1) is an integral membrane protein that may function as a scaffold for plasma membrane proteins and acts as a tumor suppressor protein. One causative factor of chemotherapy-resistant cancers is P-plycoprotein (P-gp), the product of the multidrug resistance-1 gene (MDR1), which is localized in the caveolar structure. Currently, the interactive roles of CAV1 and MDR1 expression in the death of cancer cells remain controversial. In this study, we investigated the effects of indomethacin on the cell viability and the expression levels of MDR1 mRNA and protein in a CAV1-siRNA-mediated gene knockdown hepatoma cell line (SK-Hep1). Cell viability was significantly decreased in CAV1-siRNA-transfected cells compared with that of control-siRNA-transfected cells. Furthermore, the viability of cells pretreated with CAV1 siRNA was markedly decreased by treatment with indomethacin (400${\mu}$M for 24 h). However, the protein and mRNA levels of MDR1 were unchanged in CAV1-siRNA-transfected cells. These results suggest that CAV1 plays an important role as a major survival enzyme in cancer cells, and indomethacin can sensitively induce cell death under conditions of reduced CAV1 expression, independent of MDR1 expression.

• Korean Journal of Human Ecology
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• v.24 no.1
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• pp.97-109
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• 2015

Recently, because the market for compression wear now includes all consumers, not just professionals, various items for recovery after exercising or for enhanced effects from exercise have been introduced. In this research, a systematic and stepwise design process was proposed to develop compression garment that has both functional area and appropriate pressure to protect the knee when exercising. The U-V format functional area that wraps underneath the knee was selected by considering the shape and change in the skin length when bending the knee. After the selection of the functional area, a total of seven knee design areas, including the existing product, were designed to determine the appropriate pressure. After various movements, the compression garment was ranked in terms of support of the knee, level of pressure, discomfort of seam line, and comfort of popliteal; the preferred design was selected using the quad method. Four compression wear garments were produced using two selected preferred designs; the wear evaluation was performed using a seven-point Likert scale. As a result, the optimal reduction rate of the pattern was calculated based on Ziegert and Keil's method. The applied percentage of the fabric stretch at the upper part of the crotch was 66% for the width and 50% for the length; for the lower part of the crotch, only 66% for the width was applied. Moreover, it was determined that the design of the U-V knee protection part was preferred when a 7 mm square was placed at a 1 mm distance because this not only supports the knee but also allows the fabric to accommodate various skin deformations.

• Journal of the Korean Society of Safety
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• v.33 no.3
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• pp.15-20
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• 2018

There have been a number of major fatal fire accidents in Korea recently. The number of fires in 2017 were 44,178, which is not only increasing number of fires but also increasing in casualties. Particularly, the fire at Jecheon Sports Center, which suffered many casualties, is expected to have a huge impact. The cause of the fire has not been determined yet, but heat waves on the ceiling have also been pointed out. As such, the copper heating waves, which are used as a preventive measure against damage of pipes due to freezing of pipes, etc., always have a fire hazard. To determine the possibility of a flame-resistant heated fire, a positive electric cable product was used to artificially ignite and analyze the results. In case of a short circuit, the external covering of the positive electric cable is damaged, but not short circuit unless the heating material surrounding the wire is damaged. Due to the characteristics of heating cable for preventing copper waves, the chances of insulation becoming more severe due to moisture and temperature changes are higher than normal wires. If the internal heating system is carbonized by insulating deterioration without damage to the outer coating, it is likely to cause trekking, to form a winding loop in the heating materials, and to cause short circuit in the heated materials. For the positive temperature line, if the middle is shorted, the current continues to flow to the short circuit unless the breaker disconnects. Consequently, a heated fire that does not cut off the power immediately may leave multiple marks or cuts.

• Journal of Korea Multimedia Society
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• v.14 no.3
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• pp.356-367
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• 2011

In this paper, we proposed a new car engine sealing inspection system based on image processing and understanding. The car engine sealing inspection plays very important role for protecting leakage caused by inappropriate sealing, which is a crucial point for productivity of car engines. The proposed inspection system has been aimed to enhance the previously proposed sealing inspection systems based on image processing, which have high computation complexity and low performance for correctly inspecting some contamination by oil with similar color with that of sealing. Moreover, the previously proposed system has a difficulty in installing the camera system on the sealing machine. The proposed system considers a difference of images before and after sealing obtained from one static camera. By utilizing a difference of images, the proposed system shows very robust performance using a proposed simple depth checking algorithm for some contamination cases by oil with similar color with that of sealing and the total inspection system is simple and cheap to implement. According to the experiments conducted in a real car product line, the proposed inspection system shows better inspection performance and needs smaller implementation cost than three other previously proposed system working in current car sealing inspection systems.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.16 no.12
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• pp.2747-2754
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• 2012

This thesis explains the development of multiple LCD system with the additional function to maximize the utilization of PC contents. The newly developed system is composed of host LCD and slave LCD. Host LCD decodes and outputs the image and voice of NTSC, PAL, SECAM signals. It also converts the decoded signals into LVDS signals before transmitting them to slave LCD stage. In addition, the installation of CF Memory and USB Memory helps display multi-media data. Unlike the host LCD, since not including the tuner and memory part, the slave LCD can't receive TV signals and play video signals. It only has the function to receive LVDS image signals and display on a LCD panel. This newly developed multi-LCD system has competitiveness in various aspects. With its simple structure, the failure rate, price and display power are relatively low due to its simplification of the control part. It has price and functional competitiveness as the product whose host LCD can control the entire slave LCD in terms of channel, volume, and video output.

• KIPS Transactions on Software and Data Engineering
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• v.4 no.2
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• pp.65-70
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• 2015

In the PCB(Printed Circuit Board) manufacturing industry, the yield is an important management factor because it affects the product cost and quality significantly. In real situation, it is very hard to ensure a high yield in a manufacturing shop because products called chips are made through hundreds of nano-scale manufacturing processes. Therefore, in order to improve the yield, it is necessary to analyze main fault process and equipment that cause low PCB yield. This paper proposes a systematic approach to discover fault-causing processes and equipment by using a logistic regression and a stepwise variable selection procedure. We tested our approach with lot trace records of real work-site. A lot trace record consists of the equipment sequence that the lot passed through and the number of faults for each fault type in the lot. We demonstrated that the test results reflected the real situation of a PCB manufacturing line.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.17 no.5
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• pp.48-54
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• 2018

With the 4th industry era, smart factories are emerging. In the era of multi-product small scale production, unmanned transportation vehicles are rapidly increasing in utilization of unmanned transportation vehicles that carry and arrange goods in the work space. The conventional unmanned vehicle detected its position by using the guided line method and the position based method for indoor location recognition and movement. This method has disadvantages of initial high cost and maintenance / maintenance. In this paper, to solve the disadvantages, the method of predicting the direct path of the unmanned vehicle through the Kalman filter is verified using the white LED marker of the warehouse and the position data and the image data of the white LED marker recognition image. Through this, the reliability of the linear movement which occupies the most part in the lattice structure is secured. It is also expected that the reliance on additional position sensors will also be reduced.

• Bulletin of the Korean Chemical Society
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• v.35 no.3
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• pp.833-838
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• 2014

The energy- and time-dependent branching to the competing dissociation paths are studied by theory for coupled unimolecular dissociations of the o-, m-, and p-chlorotoluene radical cations to $C_7{H_7}^+$ (benzylium and tropylium). There are four different paths to $C_7{H_7}^+$, three to the benzylium ion and one to the tropylium ion, and all of them are coupled together. The branching to the multiple paths leads to the multiexponential decay of reactant with the branching ratio depending on both internal energy and time. To gain insights into the multipath branching, we study the detailed kinetics as a function of time and internal energy on the basis of ab inito/RRKM calculations. The number of reaction steps to $C_7{H_7}^+$ is counted for each path. Of the three isomers, the meta mostly goes through the coupling, whereas the para proceeds with little or no coupling. In the beginning, some reactants with high internal energy decay fast to the benzylium ion without any coupling and others rearrange to the other isomers. Later on all three isomers dissociate to the products via long-lived intermediates. Thus, the reactant shows a multiexponential decay and the branching ratio varies with time as the average internal energy decreases with time. The reciprocal of the effective lifetime is taken as the rate constant. The resulting rate-energy curves are in line with experiments. The present results suggest that the coupling between the stable isomers is thermodynamically controlled, whereas the branching to the product is kinetically controlled.

• Journal of Ocean Engineering and Technology
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• v.28 no.2
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• pp.160-166
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• 2014

Because of industrial development, industrial facilities are becoming more complex and diversified. Plant industries are focused on productivity improvement, cost reduction, and product uniformity by simplifying production processes using automated control. Furthermore, plant industries require higher pressures and temperatures to improve energy efficiency. For this reason, the valves used in plants are operated under harsh conditions. Globe valves and gate valves are mainly used for high pressure these days. However, these valves have various problems, including low maintainability and high cost, due to structural problems. Therefore, butterfly and ball valve applications are increasing in industrial plants. This paper suggests a quadruple-offset butterfly valve that is applicable to bi-direction use, and the principle design parameters are suggested. The selected design parameters are an eccentric flange center line and shaft centerline(Offset 1), an eccentric seat centerline and disc shaft centerline(Offset 2), the angle between the flange centerline and seat wedge angle(Offset 3), the angle between the vertical direction of the disc shaft centerline and seat centerline(Offset 4), and the seat engagement angle. To analyze the interaction effect of the design parameters, ANOM and ANOVA were performed with an orthogonal array. The parameters were found to have effects in the following order: Offset 2, Offset 1, engagement angle, Offset 3, and Offset 4. The interaction between the parameters was insignificant.

• Journal of the Korean Ceramic Society
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• v.41 no.4
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• pp.289-296
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• 2004

Whisker and short rod shaped hydroxyapatite (Ca$_{10}$(PO$_4$)$_{6}$(OH)$_2$ with stoichiometric composition (Ca/P=1.62 -1.67, molar ratio) has been synthesized by hydrolysis and hydrothermal reaction of aqueous $\alpha$-Ca$_3$(PO$_4$)$_2$($\alpha$-TCP) solution (pH 11), respectively. The shape of resultant HAp was mainly dependent on synthetic route and the microstructural development was on processing condition. In hydrolysis processing, the degree of intersection of whiskerlike particles and agglomeration in the apsis line increased with increasing reaction time. In hydrothermal synthesis, the reaction product obtained under excessive reaction time ($\geq$3 h at 20$0^{\circ}C$) was severely agglomerated without further grain growth above certain critical size (0.75 ${\mu}{\textrm}{m}$ in length, 0.3${\mu}{\textrm}{m}$ 11m in diameter).