• Journal of Pharmaceutical Investigation
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• v.40 no.spc
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• pp.83-95
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• 2010

Over the years, nanoparticle drug delivery systems have demonstrated versatile potentials in biological, medical and pharmaceutical applications. In the pharmaceutical industry nanotechnology research has mainly focused on providing controlled drug release, targeting their delivery to specific organs, and developing parenteral formulations for poorly water soluble drugs to improve their bioavailability. Achievement in polymer industry has generated numerous polymers applicable to designing nanoparticles. From viewpoints of product development, a nanocarrier material should meet requirements for biodegradability, biocompatibility, availability, and regulatory approval crieteria. Albumin is indeed a material that fulfills such requirements. Also, the commercialization of a first albumin-bound paclitaxel nanoparticle product (Abraxane$^{TM}$) has sparked renewed interests in the application of albumin in the development of nanoparticle formulations. This paper reviews the intrinsic properties of albumin, its suitability as a nanocarrier material, and albumin-based parenteral formulation approaches. Particularly discussed in detail are albumin-based particulate injectables such as Abraxane$^{TM}$. Information on key roles of albumin in the nab$^{TM}$ technology and representative manufacturing processes of albumin particulate products are provided. It is likely that albumin-based particulate technology would extend its applications in delivering drugs, polypeptides, proteins, vaccines, nucleic acids, and genes.

• Journal of the Korean Society for Precision Engineering
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• v.15 no.8
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• pp.174-182
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• 1998

This paper describes a research work of developing a computer-aided design and machining of irregular shaped-sheet metal product for blanking or piercing operation. An approach to the CAD/CAM system is based on the knowledge-based rules. Knowledge for the CAD/CAM system is formulated from plasticity theories, experimental results and the empirical knowledge of field experts. The system has been written in AutoLISP on the AutoCAD and in customer tool kit on the SmartCAM with a personal computer and is composed of nine modules, which are input and shape treatment, flat pattern-layout, production feasibility check, blank-layout, strip-layout, die-layout, data conversion, modelling, and post-processor module. Based on knowledge-based rules, the system is designed by considering several factors, such as material and thickness of product, complexities of blank geometry and punch profile, diameter and material of a wire, and availability of press. This system is capable of generating NC data automatically according to drawings of die-layout module. Results which are carried out in each module will provide efficiencies to the designer and the manufacturer of blanking or piercing die in this field.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.19 no.12
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• pp.1252-1259
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• 2009

Due to the international competition and global pressure, the roll speed is increased. However, higher speeds increase the power density in the process as well as the plant's potential to react with vibrations. Under certain operating conditions, vibrations may occur, which again cause chattermarks, strip rupture or coil break fault. The appropriate condition monitoring is needed to improve product quality and availability. The aim of condition monitoring is to reduce maintenance costs, increase productivity and improve product quality. This paper proposes a condition monitoring tool designed for the classification of coil break fault. This method is used to cold rolling mill for faults monitoring based on vibration and motor current signals. The results show that the performance of classification has high accuracy based on experimental work.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.10
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• pp.959-968
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• 2020

Research underlined that Small and Medium Enterprises' performance is enhanced by different types of innovation capabilities. This research tends to present a comprehensive model to explain the relationship between innovation capabilities and SMEs' financial and operational performance. Specifically, this study tends to achieve three objectives: explores the set of product, process, organizational and marketing innovation capabilities possessed by owners/managers of SMEs and their impact on Chinese manufacturing SMEs' operational and financial performance dimensions, identify the determinants of innovation capabilities, and determine the contextual factors that moderate innovation capabilities and SMEs' performance. This research employed a qualitative research method using in-depth interviews with eight owners/managers of Chinese manufacturing SMEs. Research findings revealed that product and marketing innovation capabilities have a significant impact on SMEs' financial performance while process and organizational innovation capabilities positively influence SMEs' operational performance. The major determinants of innovation capabilities involved availability of sufficient organizational resources, entrepreneurial orientation, knowledge development and external networks. The contextual moderating factors on the relationship between innovation capabilities and SMEs' performance involved internal factors which are: SME size, SMEs' owner/manager work experience, entrepreneurial mindset; and external factors: market dynamism and cooperation strategies. This paper ends by drawing some concluding remarks and proposing future research avenues.

• Journal of the Korea Safety Management & Science
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• v.4 no.2
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• pp.71-81
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• 2002

Today's environment of enterprise is changing. They have to face customer' demands with the right product, the right service and supply them at the right time. And also cut down logistics and inventory cost and bring up the profit as much as they can. This means the change of putting enterprise first in importance to putting customer first importance. therefore to correspond to customer's demand, shorting lead time is becoming a essential condition. The answer to this changes of environment is supply chain management. In the Supply chain, The ATP function doesn't only give customers to conformation of delivery. It can be used by the core function with ATP rule that can reconcile supplies and demands on the supply chain. Therefore We can be acquire the conformation about on the due date of supplier by using the ATP function of management about real and concurrent access on the supply chain, also decide the affect about product availability due to forecasting or customer's orders through the ATP. In this paper, It consolidates the necessity on a CTP and analyzes data which is concerned of ATP. Under the these environments, defines the ATP rule that can improve the customer value and data flow related the LTV(Life Time Value) and builds on a algorithm.

• The Journal of Information Systems
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• v.23 no.2
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• pp.49-66
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• 2014

In today's competitive business environment it is a necessary condition for a company to produce high-quality product for its survival and growth. That is the case in the auto-part industry as well where the international standards, ISO/TS 16949 certification, are required by customers to adopt mandatory. This study presents a successful implementation of quality management system(QMS) in a major auto-part manufacturer in Korea, utilizing SAP's QM(qualaity management) module and a mobile office system. The QMS brought the company "A" a variety of benefits such as real-time availability of product-inspection data, speedy decision-making, reduction in time required for defect-handling, ease of vertical integration of business partners in supply chain, and ease of business process standardization between headquarters and overseas subsidiaries. It is expected that the findings of this study can be used as a useful guideline for companies to consider implementing ERP-based quality management systems successfully.

• International Journal of Advanced Culture Technology
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• v.8 no.2
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• pp.270-276
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• 2020

In this paper, we analyze the buyer's joint pricing and lot-sizing model in a two-stage supply chain consisting of the supplier, the buyer and the customer. It is assumed that the supplier will permit a certain fixed period for settling the amount the buyer owes to him for the items supplied in order to stimulate the demand for the product. Generally, credit transactions would have a positive effect to the buyer. The availability of credit transactions from the supplier effectively reduces the cost of holding stocks for the buyer and therefore, the buyer has a lot of price options to choose his sales price for a customer in anticipation of increased the customer's demand and, as a result, it will appear to increase the buyer's inventory levels. On the other hand, in the case of decaying products in which their utility decay over time, the decaying rate with time may be expected to reduce inventory levels. In this regard, we need to analyze how much the length of credit period and the decaying rate affect the buyer's pricing and lot-sizing policy. For the analysis, we consider the situation where the customer's demand is represented as a linearly decreasing function of the buyer's sales price. From this perspective, we formulate the buyer's annual net profit and analyze the effect of the length of credit period and decaying rate of the product on the buyer's inventory policy numerically.

• Journal of the Korean Society of Clothing and Textiles
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• v.31 no.4 s.163
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• pp.615-623
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• 2007

This study aimed to construct an effective decision-making model on selection of cloth stores using AHP technique. The proposed AHP structure consists of three levels. The highest level includes the cloth stores alternative which are department store, specialty store, and a clothes store. The second level consists of the key performance measurements for evaluating the optimal selection of cloth stores, such as location, facilities, product, service, and promotion. The lowest level consists of items which affects the performance measurements in the upper level. The items are convenience location, courteous service, decor/ambience, availability of parking, etc. The data for this research were collected from questionnaires of 132 in Busan. Data were analyzed by frequency and AHP. As the result of this study, 'product' was decided as a most important item in department store, while 'location' was decided as a most important item in specialty store and a clothes store. And 'variety goods' evaluated as that of first priority in the totality evaluation items in department store, but 'convenience location' evaluated as that of first priority in the totality evaluation items specialty store and a clothes store.

• Proceedings of the Korea Technical Association of the Pulp and Paper Industry Conference
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• 2000.06a
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• pp.34-39
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• 2000

Today's size of production operations in the packaging paper sector I sconstantly increasing , featuring integral processing systems, high-speed paper machines, and the increased marketing of lower basis weight products. The risk factors involved in these large investments lie more than ever in the available furnish potential and ongoing requirements for further closure of water loops and lower operating costs. A comparison is drawn between recovered paper furnish mixtures used in European mills with regard to fibre properties, strength potential and contaminant content, Both the furnish situation and development trends in modern fluting and testliner machines are instigating concept changes in stock preparation, the approach flow as well as in process water and rejects technology. Developments are currently focussed for example on more efficient debris separation using fine slotted screening, optimized refining , more systematic process water management with loop separation and integral water clarification as well as more efficient removal of microstickies, fillers and fines through appropriate combination of rejects handling and water clarification processes. Product quality differentiation depends decisively on strength characteristics as a function of refining , fines removal , paper machine technology, and sizing . Maximum availability of today's high speed paper machines and , as a result, cost effective production can be ensured by optimum balancing of all subsystems with in the overall concept and by reliable control of problems with contaminants and deposits.

• Journal of the Korean Society for Precision Engineering
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• v.17 no.8
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• pp.198-206
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• 2000

This paper describes a research work of developing automated progressive process planning system for working electric products. An approach to the CAD system in based on the knowledge-based rules. Knowledge for the CAD system is formulated from plasticity theories experimental results and the empirical knowledge of field experts. The system has been written in AutoLISP on the AutoCAD with a personal computer and is composed of three main modules which are input and shape treatment flat pattern layout and strip layout module. Based on knowledge-based rules the system is design by considering several factors such as radius and angle of bend material and thickness of product complexities of blank geometry and punch profile bending sequence and availability of press. Strip layout drawing automatically generated by piercing with punch profiles divided into for external area is simulated in 3-D graphic forms including bending sequences for the product with piercing and bending. Results obtained using the modules enable the manufacture of electronic products to be more efficient in this field.