• 대한약리학회지
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• 제29권1호
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• pp.157-163
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• 1993

n-Alkanols의 분자적 약리작용기전 탐구에 기초자료를 제공하기 위하여 소의 신선한 대뇌피질로부터 분리한 synaptosomal plasma membrane vesicles (SPMV) 지질 이중층의 측방확산운동에 미치는 n-alkanols의 영향을 형광 probe법으로 검색하였다. n-Alkanols는 SPMV 지질 이중층의 측방확산운동 범위와 속도를 농도 의존적으로 증가시켰고 1-nonanol까지는 탄소수가 두개 증가될 때마다 그 효력은 약 10배 가량 증가되었으나 탄소수 10개인 1-decanol의 효력은 오히려 감소되는 경향을 나타내었다.

• Journal of Pharmaceutical Investigation
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• 제39권1호
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• pp.29-36
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• 2009

Since the quality of final products is significantly affected by the homogeneity of powder mixture, the powder blending process has been regarded as one of the critical pharmaceutical unit processes, especially for solid dosage forms. Accordingly, the monitoring to determine a blending process' end-point based on a faster and more accurate in-line/on-line analysis has attracted enormous attentions recently. Among various analytical tools, NIR (near-infrared) spectroscopy has been extensively studied for PAT (process analytical technology) system due to its many advantages. In this study, NIR spectroscopy was employed with an optical fiber probe for the in-line monitoring of fluid-bed blending process. The position of the probe, the ratio of binary powder mixture, the powder size differential and the back-flush period of the shaking bag were examined as principal process parameters. During the blending process of lactose and mannitol powders, NIR spectra were collected, corrected, calibrated and analyzed using MSC and PLS method, respectively. The probe position was optimized. A reasonable end-point was predicted as 1,500 seconds based on 5% RSD value. As a consequence, it was demonstrated that the blending process using a fluid-bed processor has several advantages over other methods, and the application of NIRS with an optical fiber probe as PAT system for a fluid-bed blending process could be high feasible.

• 한국공작기계학회:학술대회논문집
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• 한국공작기계학회 2001년도 추계학술대회(한국공작기계학회)
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• pp.214-219
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• 2001

One of the major limitations of productivity and quality in metal cutting is the machining accuracy of machine tools. The machining accuracy is affected by geometric errors, thermally-induced errors, and the deterioration of the machine tools. Geometric and thermal errors of machine tools should be measured and compensated to manufacture high quality products. In metal cutting, the machining accuracy is more affected by thermal errors than by geometric errors. In this study, the compensation device and temperature-based algorithm have been presented in order to compensate thermal error of machine tools under the real-time. The thermal error is modeled by means of angularity errors of a column and thermal drift error of the spindle unit which are measured by the touch probe unit with a star type styluses, a designed spherical ball artifact, and five gap sensors. In order to compensate thermal characteristics under several operating conditions, experiments performed with five gap sensors and manufactured compensation device on the horizontal machining center.

• 한국지반공학회지:지반
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• 제14권2호
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• pp.79-92
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• 1998

실내모형실험으로 전기비저항치와 오염된 흙의 물리적 성질과의 상관관계를 규명하기 위해서 요소분석을 수행하였다. 세가지의 모래질 구에 산업폐기물매립지의 침출수를 첨가하여 모형실험에 이용했다. 혼합토의 전기비저항치는 비저항콘을 모사한 프로브를 제작하여 측정했다. 실내모형실험에서는 흙의 함수비, 간극비. 단위중량, 함수비 및 침출수의 농도를 변화시키면서 혼합토의 전기비 저항치를 계측했다. 실험결과는 흙의 종류 및 단위중량보다는 흙의 함수비, 간극수의 전도성이 전기비저항치에 큰 영향를 미치고 있음을 알 수 있었다.

• 한국정밀공학회지
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• 제17권1호
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• pp.120-128
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• 2000

One of the major limitations of productivity and quality in metal cutting is the machining accuracy of machine tools. The machining accuracy is affected by geometric errors, thermally-induced errors, and the deterioration of the machine tools. Geometric and thermal errors of machine tools should be measured and compensated to manufacture high quality products. In metal cutting, the machining accuracy is more affected by thermal errors than by geometric errors. This paper models of the thermal errors for error analysis and develops on-the-machine measurement system by which the volumetric error are measured and compensated. The thermal error is modeled by means of angularity errors of a column and thermal drift error of the spindle unit which are measured by the touch probe unit with a star type styluses and a designed spherical ball artifact (SBA). Experiments, performed with the developed measurement system, show that the system provides a high measuring accuracy, with repeatability of $\pm$2${\mu}{\textrm}{m}$ in X, Y and Z directions. It is believed that the developed measurement system can be also applied to the machine tools with CNC controller. In addition, machining accuracy and product quality can be improved by using the developed measurement system when the spherical ball artifact is mounted on the modular fixture.

• 열처리공학회지
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• 제35권5호
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• pp.246-254
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• 2022

The high-temperature oxidation behavior of Cr-Mo steel AISI 4115 in air at different temperatures (600, 850, 950℃) for 120 min was studied by mass gain analysis, phase analysis (optical microscopy, electron probe micro-analysis, x-ray diffraction) and hardness measurement of each iron oxide-phase. The oxidation scales that formed on oxidation process consisted outer layer (Hematite), middle layer (Magnetite) and the inner layer (Chromite). In the case of 850 and 950℃, the oxidation mass gain per unit area of AISI 4115 steel increased according to the logarithmic rate as atmospheric pressure increased. Especially, It has been observed that with an increase in the atmospheric pressure at 600℃, the oxidation mass gain per unit area changed from a linear to logarithmic relationship.

• 분석과학
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• 제15권6호
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• pp.540-549
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• 2002

The arrangement of encapsulated Ar atoms in the molecular-dimensioned cavities of fully dehydrated zeolite A of unit-cell composition $Cs_3Na_8HSi_{12}Al_{12}O_{48}$ ($Cs_3$-A) has been studied crystallographically to probe the confinement effect of guest species in microporous environment. Atoms of Ar were encapsulated in the cavities of $Cs_3$-A by treatment with 410 atm of Ar at $400^{\circ}C$ for two days, followed by cooling at room temperature. The crystal structure of $Cs_3Na_8H$-A(4Ar) ($P_e$ = 410 atm, $a=12.245(2){\AA}$, $R_1=0.0543$, and $R_2=0.0552$) has been determined by single crystal X-ray diffraction technique in the cubic space group $Pm\bar{3}m$ at 21 (1) $^{\circ}C$ and 1 atm. Encapsulated Ar atoms are distributed in three crystallographic distinct positions: 1.5 Ar atoms per unit cell opposite 6-rings, 1.5 opposite four-rings in the large cavity, and finally 1.0 in the sodalite-unit. The possible structures of argon clusters, such as $Ar_2$, $Ar_3$, and $Ar_4$, are proposed.

• 한국지반공학회논문집
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• 제33권11호
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• pp.5-19
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• 2017

본 연구는 전통적인 다짐관리방법의 문제점을 보완하고자 TDR(Time Domain Reflectometry)을 이용하여 지반의 함수비와 건조단위중량을 측정하는 연구를 수행하였다. 개발된 Flat TDR 시스템의 측정값을 검증하기 위해 여섯 가지 시료를 대상으로 실내실험을 수행하였다. 또한 실내실험을 바탕으로 현장시험을 수행하여 현장 적용성을 검토하였고, 신뢰성을 확보하기 위해 Purdue TDR 시스템과 비교실험을 수행하여 정밀도를 확인하였다. 또한 유한요소해석을 수행하여 Flat 프로브의 영향범위를 확인하였다. 그 결과 약 10cm의 영향범위를 확인하였고, 실내실험결과 함수비는 평균적으로 약 0.4%의 오차를 보이며, 건조단위중량의 경우 약 1.6%의 오차를 보였다. 현장시험의 경우 함수비는 0.8%, 건조단위중량의 경우 2.5%의 오차를 보였다. 실험 결과를 통하여 Flat TDR 시스템의 측정값은 기존의 TDR 시스템보다 정확한 값을 도출하는 것을 확인할 수 있었다.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2003년도 생물공학의 동향(XII)
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• pp.630-633
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• 2003

Transfer of an electron from one site to another in a molecular or between molecules and/or electrodes is one of the most fundamental and ubiquitous processes in chemistry, biology and physics. In this study fusion proteins composed by green fluorescent protein(GFP) and cytochrome b562 were used in fabricating molecular array as an electron sensitizer and electron acceptor, Protein formation onto the substrate was performed by the self-assembly technique. The fusion protein film were analyzed using scanning probe microscope(SPM), Surface Plasmon Resornance(SPR) and hybrid STM/I-V. The results suggest that the proposed molecular photodiode can be used as a basic unit of the memory device.

• Nuclear Engineering and Technology
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• 제29권2호
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• pp.175-180
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• 1997

It has been known that eater-side corrosion of fuel rods in nuclear reactor is accompanied with the metallic loss of wall thickness and hydrogen pickup in the fuel dadding tube. The fuel dad corrosion is one of the major factors to be controlled to maintain the fuel integrity during reactor operation. An oxide later thickness measuring device equipped with ECT probe system was developed by KAERI, and whose performance test was carried out in NDT(Non-destructive Test) hot-cell or PIE(Post Irradiation Examination) Facility. At first, the calibration/performance test was executed for the unirradiated standard specimen rod fabricated with several kinds of plastic thin films whose thickness ore predetermined, and the result of which showed a good precision within 10% of discrepancy. And then, hot test us peformed for the irradiated fuel rod selectively extracted from J44 fuel assembly discharged from Kori Unit-2. The data obtained with this device were compared with the metallographic result obtained from destructive examination in PIEF hot-cell on the same fuel rod to verify the validity of the measurement data.