• 한국산학기술학회논문지
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• 제13권3호
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• pp.1014-1020
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• 2012

본 논문은 3D 캐드모델을 기반으로 작업자의 수작업 및 설계오류를 최소화하는 금형설계 지원 툴 개발에 초점을 맞춘다. 금형설계 지원범위는 자동차 산업의 프레스 금형설계 공정에서 필수 요소인 선직 곡면 생성 및 옵셋, 패딩력 자동산출, 수정사항을 반영하는 재료표 자동출력, 홀 가공데이터 자동 산출, 원소재 크기 출력 및 검증 등 이다. 개발한 시스템을 주요 범용 3D 모델러 중 하나인 프로엔지니어의 확장 메뉴형태로 탑재하기 위하여 프로엔지니어 API와 Visual C++를 사용하여 개발하였다.

• 한국자동차공학회논문집
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• 제22권7호
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• pp.152-157
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• 2014

Pro-program function of Pro/E has been utilized to expedite the design process of bellows. Design parameters selected for bellows design are manipulated to obtain the shapes user specified. User-oriented function may automate the bellows design process and this function may enable to reduce the design time remarkably. Generated bellows solid model has been applied to study of design sensitivity and optimum design. Among the selected design parameters, thickness of bellows affects system response most. Control-ring installed bellows may reduce the stress and prove to be an effective element for heavy load. The finite element analysis results combined with 3D model generated by pro-program may provide the feasible design directions to the bellows designer.

• 천문학회보
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• 제42권2호
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• pp.62.1-62.1
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• 2017

In space weather forecast, it is important to determine three-dimensional properties of CMEs. Using 29 limb CMEs, we examine which cone type is close to a CME three-dimensional structure. We find that most CMEs have near full ice-cream cone structure which is a symmetrical circular cone combined with a hemisphere. We develop a full ice-cream cone model based on a new methodology that the full ice-cream cone consists of many flat cones with different heights and angular widths. By applying this model to 12 SOHO/LASCO halo CMEs, we find that 3D parameters from our method are similar to those from other stereoscopic methods (i.e., a triangulation method and a Graduated Cylindrical Shell model). In addition, we derive CME mean density (${\bar{\rho}_{CME}}={\frac{M_{total}}{V_{cone}}}$) based on the full ice-cream cone structure. For several limb events, we determine CME mass by applying the Solarsoft procedure (e.g., cme_mass.pro) to SOHO/LASCO C3 images. CME volumes are estimated from the full ice-cream cone structure. For the first time, we derive average CME densities as a function of CME height for several CMEs, which are well fitted to power-law functions. We will compare densities (front and average) of geoeffective CMEs and their corresponding ICME ones.

• 대한약침학회지
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• 제20권1호
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• pp.29-35
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• 2017

Objectives: Aging is an unconscious and gradual process that can lead to changes in biological systems. Induction of oxidative stress and apoptosis, hepatotoxicity and neurotoxicity are involved in the aging process. Regarding the antioxidant property of black seed oil, the aim of this study was to evaluate the anti-aging effect of Nigella sativa (N. sativa) oil on d-galactose-induced aging in mice. Methods: For induction of aging, D-galactose (500 mg/kg, subcoutaneously SC) was administrated to male mice for 42 days. Animals were treated with D-galactose alone or with b lack seed oil (0.1, 0.2, 0.5 mL/kg, intraperitoneally (ip)). Additionally, vitamin E (200 mg/kg) was used as a positive control. At the end of treatment, the malondialdehyde (MDA) and the glutathione (GSH) contents in brain and liver tissues were measured. Also, enzymes in serum, including aspartate aminotransferase (AST) and alanine amino transferase (ALT), were determined. The levels of the proteins Bax, Bcl2, caspase-3 (pro and cleaved) in brain and liver tissues were evaluated. Results: Administration of D-galactose (500 mg/kg, SC) for 42 days increased serum levels of ALT and AST, as well as the MDA content, in brain and liver tissues, but decreased the GSH content. Additionally, the levels of apoptotic proteins, including Bax, procaspase-3 and caspase-3 cleaved, were markedly increased. N. sativa oil (0.1 and 0.2 mL/kg) diminished the levels of the biochemical markers ALT and AST. Administration of black seed oil (0.1, 0.2 and 0.5 mL/kg) reduced lipid peroxidation and at doses 0.1 and 0.2 mL/kg significantly recovered the GSH content. The oil decreased Bax/Bcl2 levels and at 0.1 mL/kg down-regulated the expressions of caspase-3 (pro and cleaved) proteins in brain and liver tissues. Conclusion: Through its antioxidant and anti-apoptosis properties, black seed oil exhibited an anti-aging effect in a model of aging induced with D-galactose.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2005년도 가을 학술발표논문집 Vol.32 No.2 (1)
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• pp.709-711
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• 2005

이 논문에서는 CATIA, PRO-E 등의 CAD에서 3D 모델을 생성할 때 사용하는 파라메트릭 솔리드 모델링 기법에서 일반적으로 사용하는 방법보다 모델링 데이터의 용량을 크게 줄일 수 있는 방법에 대하여 고찰한다. 3D 파라메트릭 솔리드 모델링 기법은 기본적인 상세 솔리드들을 생성하여 부울(Boolean) 연산으로 이들을 조합하여 복잡한 형상(geometric object)을 만드는데 이 과정에서 많은 부울 연산이 수행된다. 그런데 각각의 상세 솔리드들의 크기가 필요 이상으로 크게 만들어 짐으로써 생성된 모델의 데이터 용량이 방대하게 되고 생성시간에도 영향을 미친다. 여기에서는 실무 경험을 바탕으로 처음에 생성된 상세 솔리드의 불필요한 부분을 제거하여 부울 연산에 알맞은 크기로 변경하여 모델링 데이터의 용량을 줄이는 방법을 제안한다.

• Interdisciplinary Bio Central
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• 제2권3호
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• pp.8.1-8.5
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• 2010

Introduction: Recently identified human homologues of ALKB protein have shown the activity of DNA damaging drugs, used for cancer therapy. Bioinformatics study of hABH2 and hABH3 had led to the discovery of a novel DNA repair mechanism. Very little is known about structure and function of hABH4, one of the members of this superfamily. Therefore, in present study we are intended to predict its structure and function through various bioinformatics tools. Materials and Methods: Modeling was done with modeler 9v7 to predict the 3D structure of the hABH4 protein. This model was validated with the program Procheck using Ramachandran plot statistics and was submitted to PMDB with ID PM0076284. The 3d2GO server was used to predict the functions. Residues at protein ligand and protein RNA binding sites were predicted with 3dLigandSite and KYG programs respectively. Results and Discussion: 3-D model of hABH4, ALKBH4.B99990003.pdb was predicted and evaluated. Validation result showed that 96.4 % residues lies in favored and additional allowed region of Ramachandran plot. Ligand binding residues prediction showed four Ligand clusters, having 24 ligands in cluster 1. Importantly, conserved pattern of Glu196-X-Pro198- Xn-His254 in the functional domain was detected. DNA and RNA binding sites were also predicted in the model. Conclusion and Prospects: The predicted and validated model of human homologue hABH4 resulted from this study may unveil the mechanism of DNA damage repair in human and accelerate the research on designing of appropriate inhibitors aiding in chemotherapy and cancer related diseases.

• 한국식품과학회지
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• 제40권4호
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• pp.436-442
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• 2008

본 연구를 통하여 피부 미용 소재로 알려져 있는 콜라겐 펩타이드를 섭취한 후 혈중에 나타나는 소화분해산물 중 콜라겐 특유의 아미노산인 hydroxyproline과 이것의 dipeptide 형태인 Pro-Hyp이 피부에 미치는 영향을 알아보고자 하였다. 피부 미용 소재를 경구 섭취하는 사람의 피부는 광노화 및 자연노화가 어느 정도 진행된 상태이므로, 이와 유사한 조건을 조성하기 위해 경구 투여를 시작하기 전에 hairless mouse에 7주간 주 3회 UV를 조사하여 주름을 선유발시켰다. 군 분리를 시킨 후 7주간 경구로 실험물질을 주 5회 반복 투여하면서, 주 3회 UV 조사를 병행하였으며, 시험 기간 중 임상증상, 체중변화를 관찰하였고, 3회 (0,4. 7주차) 피부주형을 채취하여 영상 분석을 실시하였으며, 2회 (0,7 주차)의 피부탄력측정 및 1회(7주차)의 TEWL측정을 병행하였다. 실험종료 후 피부조직의 병리조직학적 검사(H&E, Masson-Trichrome stain) 및 피부두께 측정을 실시하였다. 실험기간 중 이상 임상증상을 보이거나 사망한 개체는 없었으며, 체중에 대한 통계적으로 유의한 변화는 관찰할 수 없었다. 피부 육안관찰 시 NC군에 비해 UC군의 피부 주름 증가가 뚜렷하였으며, 시험군들은 UC군에 비해 주름 증가가 적었다. 경구 투여 0, 4, 7주차에 제작된 replica의 주름 지표를 통계 처리한 결과, UV/H군과 UV/P군은 DC군에 비해 감소경향은 보였으나 유의적인 차이는 없었다. 탄력측정검사 결과 UV를 쬐지 않은 NC군은 UC군에 비해 UA/UF, Ur/Ue, Ur/Uf 지표에서 유의적인 증가를 보였다. UV/H군과 UV/P군은 모두 0, 7주차 모두 유의적인 차이를 보이지 않았다. 피부 보습력 측정 결과 NC군 및 모든 실험군에서 UC군에 비해 유의적인 TEWL 감소를 관찰할 수 있었다. 피부 두께의 경우 NC군, UV/H군, UV/P군은 UC군에 비해 피부 두께가 유의적으로 감소하였다. 진피층에서의 교원질 확인을 위해 실시한 Masson-Trichrome stain의 경우 UC군에서는 상부 진피층에서의 염색상 소실이 관찰되었으나, 모든 실험군에서 진피층 손상이 거의 관찰되지 않아 실험물질에 의한 회복을 확인 할 수 있었다. 이상의 실험 결과 hydroxyproline, Pro-Hyp의 경구반복투여시 자외선에 의해 광노화가 유발된 피부에 보습 효과, 피부 두께 감소 효과, 진피층 손상 회복 효과를 유의적으로 확인할 수 있었으며, 단, 피부 주름 개선 정도는 통계적 유의성은 없이 경향성만을 확인할 수 있었다. Hydroxyproline과 이를 함유하는 dipeptide 형태의 Pro-Hyp를 경구 투여한 시험으로부터 확인한 피부 보습 및 진피층 회복 효과는 이 물질들이 유래된 콜라겐을 도포 또는 섭취했을 때 피부에 나타날 수 있는 작용들과 상통하며, 단독 미용 소재로도 활용될 수 있는 가능성을 보여주었다. 본 연구에서는 콜라겐 펩타이드를 섭취 시 체내에 흡수되어 혈액을 통해 각 조직에 운반되는 분해 산물이 피부에 미치는 영향을 동물 시험을 통해 살펴보았는데, 향후 연구에서는 관절, 혈관과 같은 다른 생체 조직들에 미치는 영향에 대해서도 검증해 볼 필요가 있다.

• 한국자동차공학회논문집
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• 제8권4호
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• pp.158-168
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• 2000

Vehicle driving simulators can provide engineers with benefits on the development and modification of vehicle models. One of the most important factors to realistic simulations is the fidelity given by a motion system and a real-time visual image generation system. Virtual reality technology has been widely used to achieve high fidelity. In this paper the virtual environment including a visual system like a head-mounted display is developed for a vehicle driving simulator system by employing the virtual reality technique. virtual vehicle and environment models are constructed using the object-oriented analysis and design approach. Accordint to the object model a three dimensional graphic model is developed with CAD tools such as Rhino and Pro/E. For the real-time image generation the optimized IRIS Performer 3D graphics library is embedded with the multi-thread methodology. Compared with the single loop apprach the proposed methodology yields an acceptable image generation speed 20 frames/sec for the simulator.

• Nutrition Research and Practice
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• 제8권3호
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• pp.284-291
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• 2014

BACKGROUND/OBJECTIVES: The aim of this study was to investigate the effects of exercise (EX) and Korean red ginseng (KRG) on inflammation mechanism in aging model rats with diet-induced atherosclerosis. MATERIALS/METHODS: Forty-eight male Sprague-Dawley rats were divided into 6 groups: Young control (Y-C), Aging control (A-C), A-C with HFD (AHF), AHF with EX (AHF-EX), AHF-EX with KRG (AHF-EX+RG), and AHF with KRG (AHF-RG). Aging was induced by D-gal (100mg/kg) and atherosclerosis was induced by HFD (60% fat) for 9 weeks. The experimental rats were performed swimming (60 min/day, 5 days/week) and supplied KRG orally (dose of 200 mg/kg) for 8 weeks. All rat aorta samples were harvested for biochemical and immunohistochemical analyses. REULTS: The EX and KRG supplementation significantly inhibited body weight and levels of TC, TG, LDL-C, and enhance of HDL-C compared with untreated AHF groups. AHF-EX, AHF-EX+RG, and AHF-RG group showed a decreased plasma CRP and increase plasma NO activities compared to AHF group. In addition, these groups revealed reduced 4-HNE, NF-kB, TNF-, ${\alpha}$, IL-6, COX-2, ICAM-1, VCAM-1 and enhanced eNOS expression in the aorta. CONCLUSION: These results suggest that EX alone, KRG alone, and combined treatment of EX and KRG may be an effective anti-inflammatory therapeutic for the atherosclerosis, possibly acting via the decreased of CRP and pro-inflammation proteins and the increased NO and eNOS.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2006년도 춘계학술대회 논문집
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• pp.309-310
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• 2006

This paper is about the development of surface inspection of bearing inner and outer race using machine vision. Before this system is developed, most inspections are performed by workers' naked eye. To improve both the inconvenience and incorrectness, another new tester is introduced. This system has the three sections mainly. First one is the mechanism section which transfers bearing manufactured from previous process line to the testing process in plant. Another is the inspection system which is composed of two parts: computer vision and measurement system using laser diode which inspects the defects of the bearing inner or outer race. The other is the pneumatic cylinder part controlled by Programmable Logic Controller(PLC). The system which is developed shows favorable results, and that has the advantage of convenience and correctness compared to previous system.