• Clinical and Experimental Pediatrics
• /
• 제57권3호
• /
• pp.153-156
• /
• 2014

Toxic epidermal necrolysis is an unpredictable and severe adverse drug reaction. In toxic epidermal necrolysis, epidermal damage appears to result from keratinocyte apoptosis. This condition is triggered by many factors, principally drugs such as antiepileptic medications, antibiotics (particularly sulfonamide), nonsteroidal anti-inflammatory drugs, allopurinol, and nevirapine. Lamotrigine has been reported potentially cause serious cutaneous reactions, and concomitant use of valproic acid with lamotrigine significantly increases this risk. We describe a case of an 11-year-old girl with tic and major depressive disorders who developed toxic epidermal necrolysis after treatment with lamotrigine, and who was diagnosed both clinically and pathologically. Children are more susceptible to lamotrigine-induced rash than adults, and risk of serious rash can be lessened by strict adherence to dosing guidelines. Unfortunately, in our case, the patient was administered a higher dose than the required regimen. Therefore, clinicians should strictly adhere to the dose regimen when using lamotrigine, especially in children.

• Asian-Australasian Journal of Animal Sciences
• /
• 제5권2호
• /
• pp.199-215
• /
• 1992

Sources of organic waste materials for aerobic and/or anaerobic degradation, or for composting of solid wastes in Germany were estimated. The basic microbiology and the energetics of these processes were compared with special emphasis on anaerobic degradation, for which a general degradation scheme of carbohydrates is presented. Advantages of anaerobic over aerobic treatment processes are pointed out and conditions for maintaining a highly stable anaerobic process as well as producing a sanitized, hygienic product are discussed. Reactor systems suitable for efficient treatment of wastes with a high or low proportion of suspended solids are principally compared and results of laboratory studies on the degradation of several wastes and animal manures summarized. Finally, a piggery slurry treatment factory for an ultimate slurry processing to obtain a dry fertilizer and a harmless, disposable liquid, as it is in operation in Helmond/Holland, is presented and preliminary process data are presented.

• 대한화학회지
• /
• 제14권2호
• /
• pp.155-160
• /
• 1970

The kinetics of the pepsin-catalyzed hydrolysis of N-carbobenzoxy-L-glutamyl-L-tyrosine at pH 3.5 and $37^{\circ}C$ were determined by a spectrophotometric technique. The pepsin used was further purified on a Sephadex G-75 column. The kinetics data were Km = l.7 ${\times}10^{-3}M,\;-{\Delta}F^{\circ}$ = 3.99Kcal/mole, and $k^3=\;2.1{\times}10^{-2}\;sec^{-1}$. An analysis of the above data and other investigators' data obtained from some dipeptides led to the following conclusions. (1) Phenylalanyl residues in a synthetic peptide are bound to pepsin more strongly than glutamyl or tyrosyl residues, supporting the theory that a part of the binding region of the active center is hydrophobic. (2) Dipeptides are bound to pepsin principally through their side chains and the binding involves both side-chain residues. (3) The nature of amino acids in dipeptides $R_2-R_1,\;affect\;the\;k_3$ values.

• Imaging Science in Dentistry
• /
• 제34권4호
• /
• pp.203-207
• /
• 2004

Basal cell nevus syndrome (BCNS) is principally characterized by cutaneous basal cell carcinomas, multiple odontogenic keratocysts and skeletal abnormalities. Our patient represented several characteristics of BCNS, such as, multiple odontogenic keratocysts, facial nevus, calcification of falx cerebri, parietal bossing and mental retardation. The cyst on posterior mandible showed recurrent and newly developing tendency.

• The Korean Journal of Pain
• /
• 제7권2호
• /
• pp.273-276
• /
• 1994

The cervicogenic headache is not well defined for its characteristics and development of disease. It is developed by many causes including trauma principally. But, most cases have no radiologically specific clue for diagnosis. So, past hisory and clinical symptoms and signs are important for clinician to detect and diagnose the disease. Our clinic had treated the 2 cases of cervicogenic headache with different methods, and the patients were well respond the therapy.

• 한국자동차공학회논문집
• /
• 제4권3호
• /
• pp.147-155
• /
• 1996

This study investigated the characteristics of ultrasonic-energy-added diesel fuel. We compared the characteristics used H-NMR spectrum, FT-IR spectrum, viscosity and surface tension between conventional diesel fuel and ultrasonic-energy-added diesel fuel. The result are obtained as follow : We knew that ultrasonic energy result to reduce BI and weaken viscosity and surface tension. Also, the ultrasonic energy caused to reduce aromatics Ha and increase Alkanes Hγ. The effect of ultrasonic-energy-added dieselfuel was principally caused by change of chemical structures and a physical characteristics.

• Journal of Chest Surgery
• /
• 제22권6호
• /
• pp.1106-1110
• /
• 1989

We experienced 53 cases of tuberculous peripleural abscess, which had been proved by histopathological study, from Jan. 1980 to Dec. 1988. In 53 cases of abscesses, mean age was 25 years which was ranged from 1 year and 3 months old boy to 61 years old female [Male: Female=1.4: 1]. The location of the lesion was mainly right-sided [62%] and lateral predilection [53%]. In most of cases [85%], there was history of pulmonary tuberculosis and pleural thickening, but negative mycobacterial culture in the pus. Rib involved cases, confirmed by histopathologic examination, were 38.9% of all cases, which were all removed during operation. Combined pathologic lesions were all cleared at the same time, principally. There were 8 cases of recurred, of which at the same sided, 7 cases and contralateral sided, 1 case.

• 대한기계학회논문집
• /
• 제10권5호
• /
• pp.618-624
• /
• 1986

본 논문에서는 최근까지 제시된 동방향 성층이상유동의 직접접촉응축열전달계 수에 대한 여러가지 상관관계식들을 검토하고 실험결과와 비교하여 적절한 관계식을 제시하고자 한다.

• 한국가정과학회지
• /
• 제2권1호
• /
• pp.110-113
• /
• 1999

Clothing shape is principally described in seven factors that are composed of clothing design, clothing material, clothing size, pattern design, sewing method and body motion etc. The aims of this study was to measurement out-line space-shape variation of clothing fitness with body by using the image processing. The subjects for direct anthropometric measurements were 248 female college students aged from 19 to 22. The data were statistically analyzed by principal analysis and cluster analysis. The results selected one somatotype. for the out-line space-shape variation of clothing fitness with body, there dimensional clothing shapes measured. and cross-sectional clothing shape obtained by the measurement was considered to be space wave form. The out-line space-shape variation of clothing fitness with body was observed between the node number and amplitudes of clothing wave form, and node number was determined at the maxim of space-shape amplitude, and the space-shape amplitudes have related with aspect ratio of cross-sectional shape. (Korean J of Human Ecology 2(1) :110-113, 1999)

• 대한수의학회지
• /
• 제34권2호
• /
• pp.229-235
• /
• 1994

The hemal nodes of the Korean native cattle were studied by gross anatomy and light microscopy. Hemal nodes were spherical or ovoid in shape, and red or black in colors. A hemal node consisted of a thick capsule and a hilum, and had extensive subcapsular and deep sinuses distended by a great number of erythrocytes. Although a few lymphatic nodules and tissues were seen in the parenchyma, no typical cortex and medulla was defined. Blood vessels occurred, but lymph vessel was not observed in nodes. The stroma of the hemal node was composed of reticular cells and fibers. The parenchyma consisted of many erythrocytes and lymphocytes, and a few macrophages and megakaryocytes. The capsule and trabecula was a collagenous connective tissue with smooth muscle cells. B-lymphocytes were principally located in the lymphatic nodules of the hemal node. T-lymphocytes were scattered in the diffuse lymphatic tissues of the hemal node.