• Molecular & Cellular Toxicology
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• 제2권3호
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• pp.185-192
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• 2006

To elucidate the molecular mechanisms associated with early renal injury induced by gentamicin, the most commonly used antibiotics worldwide in the treatment of Gram-negative bacterial infections. We have identified genes differentially expressed at different duration of gentamicin administration. C57BL/6 female mice were treated daily with gentamicin (20 mg/kg, 100 mg/kg, and 200mg/kg) for 7 days and then sacrificed at day 1, 3, and 7 after administration. Standard blood biochemistry and histopathological observation indicative of nephrotoxicity were made. Total RNA was extracted from the kidney for microarray analysis using Affymetrix $GeneChip^{\circledR}$. Five hundred and seventy eight genes were identified as being either up-or down-regulated over 2-fold changes during early renal injury (p<0.05) and were analyzed by hierarchical clustering. The results showed that the genes involved in early immune responses were differentially regulated during early renal injury. Principal component analysis (PCA) confirmed sample separation according to the degree of renal toxicity. In addition, we identified two potential biomarkers that may predict early renal toxicity. This data may contribute to elucidate of the genetic events during early renal injury and to discover the potential biomarkers for nephrotoxicity induced by gentamicin.

• 자원환경지질
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• 제53권4호
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• pp.363-381
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• 2020

The polymetallic Co, Ni, Cu, As, Au, and Ag deposits of Bou Azzer East are located in the western part of the Bou Azzer inlier in the Central Anti Atlas, Morocco. Six stages of emplacement of the mineralization have been identified. Precious metals (native gold and electrum) are present in all stages of this deposit except the early nickeliferous stage. From the Statistical analysis of the Co, As, Ni, Au, and Ag contents of a set of 501 samples, shows that the Pearson correlation coefficient between As-Co elements (0.966) is the highest followed by that of the Au-Ag couple (0.506). Principal component analysis (PCA) and hierarchical ascending classification (HAC) of the grades show, that Ni is associated with the pair (As-Co) and Cu is rather related to the pair (Au-Ag). The kriging maps show that the highest values of the Co, As and Ni appear in the contact of the serpentinite with other facies, as for those of Au and Ag, in addition to anomalous zones concordant with those of Co, Ni and As, they show anomalies at the extreme South and North of the study area. The development of the anomalous Au and Ag zones is mainly along the N40-50°E and N145°E directions.

• 한국식생활문화학회지
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• 제32권2호
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• pp.150-161
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• 2017

This study was conducted to identify sensory characteristics of soy-meat samples by trained panels and to observe the relationship between these sensory characteristics and consumer acceptability of the samples. Descriptive analysis was performed on eight samples; four types of patty style soy-meat samples (Soy-meat Patty; SP) made with a Ddukgalbi recipe (YSP, VSP, LSP, and SSP) and four types of Bulgogi style soy-meat samples (Soy-meat Bulgogi; SB) made with a Bulgogi recipe (YSB, VSB, LSB, and SSB). Seven panelists were trained, and they evaluated the appearance, odor/aroma, flavor/taste, texture/mouth feel, and after taste attributes of these samples. Forty attributes were generated by panelists, and 37 attributes were significantly different across products (p<0.05). The SB group was characterized by beef, leek, and garlic flavor as well a sweetness, denseness, slipperiness, chewiness, and pepper after taste. The SP group was characterized by roughness, particle size, rancid oil flavor, raw bean flavor, astringent, sourness, and adhesiveness. Consumer test (n=125) showed that the VSB sample had the highest scores for acceptability of appearance, flavor, texture, and overall liking. The PLSR results show that the attributes that were more positively associated with acceptance of soy-meat samples were beef taste, wetness, and chewiness, whereas the raw bean smell and rancid oil flavor attributes were negative.

• 동아시아식생활학회지
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• 제22권6호
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• pp.836-850
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• 2012

This study was conducted to identify the sensory characteristics of the Korean traditional confectionery, dasik, prepared under different conditions and to compare their consumer acceptance in Korea. To accomplish this, descriptive analysis of eight samples prepared using two types of rice cake powder, dasik (Rflour, Rflour_Omija), brown rice powder red ginseng dasik (Brice_Ginseng_P), pinepollen dasik (PineP), black sesame dasik (BSesame), bean dasik (Rbean), and two types of mungbean starch dasik (Starch_Omija, Starch_Greentea), was conducted by ten trained panelists. In addition, 81 consumers evaluated the overall acceptance (OL), acceptance of appearance (APPL), odor (ODL), flavor (FLL), and texture (TXTL) of the samples using a 9-point hedonic scale, as well as the perceived intensities of sesame flavor, sweetness, and hardness using a 9-point just-about-right (JAR) scale. Partial least square- regression (PLSR) indicated that the BSesame and Rbean samples, which had significantly (p<0.05) high roasted sesame, burnt, greasy, glossy, and cooked chestnut flavor scores, had the highest acceptability and consumer desire scores. Additionally, the PineP and Rflour_Omija samples, which had relatively high particle size, transparency, roughness, spoiled tofu, fermentation and raw rice flavor scores, were the least preferred samples. Therefore, roasted sesame, burnt, greasy, glossy, and cooked chestnut flavor attributes were considered drivers of "liking" whereas particle size, transparent, roughness, spoiled tofu, fermentation, and raw rice flavor attributes acted as drivers of "disliking" among consumers.

• 한국습지학회지
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• 제11권1호
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• pp.65-73
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• 2009

황구지천과 청미천의 본류와 폐천에서 하도형태, 식물상 및 식생분포 특성을 분석하였다. 항공사진과 옛 지형도를 분석한 결과, 폐천은 제방축조에 의해 사행하도가 단절되어 형성된 것으로 나타났다. 전체 식물종수와 귀화식물 백분율은 본류가 폐천에 비해 높았다. 두 폐천에서 수생, 습생식물 종수의 백분율은 각각의 본류에서 보다 높았다. 주성분분석결과 폐천과 본류 사이의 식물상 구조는 황구지천이 청미천에 비해 비교적 유사하게 나타났다. 두 폐천에서 수생, 습생 식물 분포 면적비율은 각각의 본류에 비해 높았다. 두 폐천에서 우점식물은 정수식물인 줄이었다. 따라서 폐천의 식물상과 식생분포는 습생, 정수 생태계의 특성을 나타내었으며 경관수준에서 다양성을 제공하였다.

• 조명전기설비학회논문지
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• 제20권6호
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• pp.55-62
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• 2006

본 논문에서는 3상 유도전동기의 고장진단을 수행하기 위해 패턴인식에 기반을 둔 진단 알고리즘을 제안한다. 실험 장치는 유도전동기 구동의 기계적 모듈과 고장신호를 구하기 위한 데이터 획득 모듈로 구성하였다. 진단 절차를 위한 첫 번째 단계로서 전처리 과정은 획득한 전류를 단순화하고 정규화 하는 것을 수행한다. 데이터의 단순화 과정은 3상전류를 Concrodia 벡터의 크기로 변환하는 것을 적용한다. 다음으로 특징 추출 단계를 커널 주성분 분석과 선형판별분석으로 수행하며, 마지막으로, 분류기는 방사기저함수 네트워크를 사용한다. 다양한 부하에 대하여 몇몇의 전기적 고장과 기계적 고장 하에서 획득한 데이터를 이용하여 제안된 방법의 타당성을 검증한다.

• Journal of Microbiology and Biotechnology
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• 제29권4호
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• pp.548-557
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• 2019

Staphylococcus species have a ubiquitous habitat in a wide range of foods, thus the ability to identify staphylococci at the species level is critical in the food industry. In this study, we performed rapid identification of Staphylococcus species using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight mass spectrometry (MALDI-TOF MS). MALDI-TOF MS was evaluated for the identification of Staphylococcus reference strains (n = 19) and isolates (n = 96) from various foods with consideration for the impact of sample preparation methods and incubation period. Additionally, the spectra of isolated Staphylococcus strains were analyzed using principal component analysis (PCA) and a main spectra profile (MSP)-based dendrogram. MALDI-TOF MS accurately identified Staphylococcus reference strains and isolated strains: the highest performance was by the EX method (83.3~89.5% accuracy) at species level identification (EDT, 70.3~78.9% accuracy; DT, less than 46.3~63.2% accuracy) of 24-h cultured colonies. Identification results at the genus level were 100% accurate at EDT, EX sample preparation and 24-h incubation time. On the other hand, the DT method showed relatively low identification accuracy in all extraction methods and incubation times. The analyzed spectra and MSP-based dendrogram showed that the isolated Staphylococcus strains were characterized at the species level. The performance analysis of MALDI-TOF MS shows the method has the potential ability to discriminate between Staphylococcus species from foods in Korea. This study provides valuable information that MALDI-TOF MS can be applied to monitor microbial populations and pathogenic bacteria in the food industry thereby contributing to food safety.

• 천문학회보
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• 제44권1호
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• pp.42.2-42.2
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• 2019

Turbulence is one of the natural phenomena in molecular clouds. It affects gas density and velocity fluctuation within the molecular clouds and controls the mode and tempo of star formation. However, despite many years of study, the properties of turbulence remain poorly understood. As part of the Taeduk Radio Astronomy Observatory (TRAO) Key Science Program (KSP), "mapping Turbulent properties In star-forming MolEcular clouds down to the Sonic scale (TIMES; PI: Jeong-Eun Lee)", we have fully mapped two star-forming molecular clouds, the Orion A and the Ophiuchus molecular clouds, in 3 sets of lines ($^{13}CO$ J=1-0, $C^{18}O$ J=1-0, HCN J=1-0, $HCO^+$ J=1-0, CS J=2-1, and $N_2H^+$ J=1-0) using the TRAO 14-m telescope. We apply a statistical analysis, Principal Component Analysis (PCA), which can recover an underlying turbulent-power spectrum from an observed P-P-V spectral map. We compare turbulence properties not only between the two clouds, but also between different parts within each cloud. We present the first result of our observation program.

• Mass Spectrometry Letters
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• 제14권2호
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• pp.42-47
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• 2023

Carthamus tinctorius L. (known as safflower) is a valuable oil plant whose importance is increasing rapidly in the world due to its high adaptation to arid regions. The seeds of this unique plant are especially used in edible oil, soap, paint, varnish and lacquer production. Its flowers are used in vegetable dye production and medicinal purposes beside its features as a coloring and flavoring in food. After the oil is removed, the remaining pulp and plant parts are used as animal feed, and dry straw residues are used as fuel. Beside all these features, its usage as a herbal medicinal plants for various diseases has gained importance on recent years. In this study, it was designed a plant metabolomic approach which transfers all the recent data processing strategies of untargeted metabolomics in clinical applications to the present study. Q-TOF LC/MS-based analysis of the extracts (70% ethanol, hexane, and chloroform) for both seed and flowers was performed using a C18 column (Agilent Zorbax 1.8 µM, 100 × 2.1 mm). Differences were observed in seed and fruit extracts and these differences were visualized using principal component analysis (PCA) plots. The total number and intersections of the peaks in the extracts were visualized using peak count comparison graph. Based on the experimental results, the number of the detected peaks for seeds was higher than the ones for the flowers for all solvent systems to extract the samples.

• 한국물환경학회지
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• 제38권6호
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• pp.275-281
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• 2022

To maintain water quality after water treatment, monitoring whether the quality of treated tap water quality changes is essential. However, current investigations are insufficient to prevent secondary contamination in drinking water supply systems. This study investigated Gyeonggi's e apartment where a red water problem occurred and monitored the water quality and corrosiveness of the overall water supply system to the apartment from June 2021 to April 2022. In a comparison of drinking water quality after water treatment and the influent of the reservoir, turbidity and heavy metal concentrations were increased and residual chlorine was decreased due to increases in temperature. Correlation analysis and principal component analysis (PCA) indicated that a low level of residual chlorine may cause the abscission of Mn²⁺ and Fe²⁺ through microorganism activation, which also causes a high level of turbidity. The corrosion index (LI) in the influent of the reservoir tank was increased due to Ca²⁺ and temperature. These results indicate that the corrosiveness of drinking water and the deterioration of drinking water quality were mainly increased between the drinking water treatment plant and the reservoir tank's influent. The findings provide clear evidence that it is essential to manage water supply systems and reservoir tanks to prevent the secondary contamination of drinking water.