• Molecules and Cells
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• 제43권2호
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• pp.188-197
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• 2020

Cells are designed to be sensitive to a myriad of external cues so they can fulfil their individual destiny as part of the greater whole. A number of well-characterised signalling pathways dictate the cell's response to the external environment and incoming messages. In healthy, well-ordered homeostatic systems these signals are tightly controlled and kept in balance. However, given their powerful control over cell fate, these pathways, and the transcriptional machinery they orchestrate, are frequently hijacked during the development of neoplastic disease. A prime example is the Wnt signalling pathway that can be modulated by a variety of ligands and inhibitors, ultimately exerting its effects through the β-catenin transcription factor and its downstream target genes. Here we focus on the interplay between the three-member family of RUNX transcription factors with the Wnt pathway and how together they can influence cell behaviour and contribute to cancer development. In a recurring theme with other signalling systems, the RUNX genes and the Wnt pathway appear to operate within a series of feedback loops. RUNX genes are capable of directly and indirectly regulating different elements of the Wnt pathway to either strengthen or inhibit the signal. Equally, β-catenin and its transcriptional co-factors can control RUNX gene expression and together they can collaborate to regulate a large number of third party co-target genes.

• 한국주거학회논문집
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• 제26권2호
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• pp.1-12
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• 2015

The era of globalization has ushered in dramatic changes in the past decade covering a wide range of distinct political, economic and cultural trends whereby people adapt their houses to suit their needs and desires. This paper discusses the process of change analytically, emphasizing the importance of understanding the transformation of Lao traditional houses and its impact factors to the transformation and adaptation to suit with globalization trend, and conservation of the characteristics of traditional houses. This study takes place in Luangprabang, an ancient city of Lao PDR, which was designated as a world heritage city in 1995 as it is rich with diverse, tangible and intangible values. Five cases of traditional house in Luangprabang are examined to understand their transformation through time, by analyzing the basic spatial formation, components and elements, especially to find out the impact factors to such transformation. The study revealed that the transformation of the traditional house is subject to not just one single factor, but to a number of factors, where globalization, regulation, economy, and social aspect factors play a prime role and are the root for all these changes. The case study also indicates that these changes are connected to the benefits of income generation as a survival strategy for the low and middle-income people in Luangprabang as well as the housing demands. In the transition period a new residential type appeared accordingly, in which living spaces were categorized according to their general functions. There was a harmony between people's needs and the physical characteristics of the house.

• 치위생과학회지
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• 제18권5호
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• pp.280-287
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• 2018

Dental hygienists are important members of any dental clinic. They are recognized as reflecting the dental clinic's image because they spend a lot of time with patients. The longer the dental hygienist is employed, the better the relationship with the patients and the medical service provided. The purpose of the present study was to develop a scale to measure factors of long-term employment among dental hygienists. The basic questions were constructed by analyzing tools used to measure job embeddedness and satisfaction. Forty-one questions were developed that measured organizational fit (13), interpersonal relationships (8), job satisfaction (7), duty satisfaction (6), recognition (4), and self-esteem (3). A questionnaire survey was conducted, and the responses from 297 dental hygienists in dental clinics, after the exclusion of 20 incomplete surveys, were used for the exploratory and confirmatory factor analyses. As revealed by exploratory factor analysis, long-term employment intention was composed of 7 factors consisting of 29 items after the exclusion of 12. The subsequent confirmatory factor analysis revealed 4 factors ("organizational fit," "professional identity," "job connectivity," and "interpersonal relationship") consisting of 16 items, after the exclusion of 13. $Cronbach^{\prime}s\;{\alpha}$ were 0806, 0.836, 0.700, and 0.684 for the four factors. This study is meaningful in that it developed a long-term employment factor measurement tool that can be applied to domestic dental hygienists. Future studies will need to focus more on professional identity and job outcomes. The results of this study and future related ones could be used to improve dental hygienist's continuous service.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제14권9호
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• pp.3841-3857
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• 2020

RSA is one of the best well-known public key cryptosystems. This methodology is widely used at present because there is not any algorithm which can break this system that has all strong parameters within polynomial time. However, it may be easily broken when at least one parameter is weak. In fact, many weak parameters are already found and are solved by some algorithms. Some examples of weak parameters consist of a small private key, a large private key, a small prime factor and a small result of the difference between two prime factors. In this paper, the new weakness of RSA is proposed. Assuming Euler's totient value, Φ (n), can be rewritten as Φ (n) = ad + b, where d is the private key and a, b ∈ ℤ, if a divides both of Φ (n) and b and the new exponent for the decryption equation is a small integer, this condition is assigned as the new weakness for breaking RSA. Firstly, the specific algorithm which is created for this weakness directly is proposed. Secondly, two equations are presented to find a, b and d. In fact, one of two equations must be implemented to find a and b at first. After that, the other equation is chosen to find d. The experimental results show that if this weakness has happened and the new exponent is small, original plaintext, m, will be recovered very fast. Furthermore, number of steps to recover d are very small when a is large. However, if a is too large, d may not be recovered because m which must be always written as m = h^a is higher than modulus.

• Journal of Biosystems Engineering
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• 제3권1호
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• pp.33-46
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• 1978

To get the goal of self-supply of food grain, improvement of post-harvest grain operations in rural area is under consideration as an important task of agriculture in Korea. This is study is focused on elimination of losses and deteriorations of grain and reduction of labour requirements and funds for post-harvest grain operations. The purpose of this study are presentation of basic data referring to conventional post-harvest grain operations in rural area and suggestion of improving methods for the operations, and also finding out reasonable operating processes of the operations. The result of this study are follows; 1. Grain drying in-the-filed which is performed before threshing has major factors of grain loss during drying, and so should be restrained as possible. Combine harvesting system is recommended among other king of mechanized harvesting systems for restraining in-the-field drying and securing available labors for drying. 2. It is predicted that mechanical grain drying could be prevalent when combine harvesting is taken place. Recommended grain drier for pre-combine harvesting system and for combine harvesting system is batch-type drier and circulating -type drier, respectively. 3. As existing farm storages for grain have insufficient spaces and offer poor conditions for grain storing , it is greatly needed to build up new storage which store only grains. And it is concluded that storing grain in community common storages in desirable. 4. Power supplying system for milling machinery in local milling plants, that a large capacity prime mover supplies power to 4 to 6 kinds of milling machinery simultaeously, should be converted to a system of several small capacity prime movers supplying power to each machiner y for the purpose of reducing extra consumption of energy. 5. Governmental grain, of which Korean farms produced, should be milled and stored in the local milling plant successively for the purpose of reducing transportation fee and stroing facilities. 6. Furture post-havest grain operations-drying, storing and milling should be periormed successively in he community common plant. And average optimum processing capacity of the plant is estimated about 300 metric ton of grain every year.

• 한국콘텐츠학회논문지
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• 제18권7호
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• pp.253-261
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• 2018

이 연구의 목적은 현대 정책학의 이론적 근거를 조선왕조의 유교정치 사례에서 찾는 것이다. 분석대상은 조선왕조실록에 기록된 유교 관련 기사이다. 연구방법은 문헌조사에 근거한 사례분석이며, 빅데이터 기술을 적용해 모집단 전체를 분석하였다. 분석결과 정책분야, 왕조별특징, 분야별주제, 정책변화, 결정요인을 확인했다. 조선의 유교정책은 제도, 조직, 재정, 애민, 예(禮) 다섯 분야이다. 왕조별특징으로 세종, 성종, 영조, 정조를 중심으로 정치적인 맥이 계승되었다. 분야별주제는 전기는 공자 중심의 예(禮)를, 후기는 주자 중심의 제도를, 위기 시 맹자 중심의 재정이 주된 내용이다. 정책변화는 초기 건국, 전기 정비, 중기 위기, 후기 재건, 말기 몰락 시기로 구분되었다. 결정요인은 빈번히 거론된 공자보다 주자나 정자가 큰 것을 확인했다. 이 연구는 한글과 한자를 병기한 사전을 구축하여 해석과 맥락분석의 정확성을 높였다. 유교정치를 서양의 정책학적 관점에서 분석하여 동양의 정책학 구현의 가능성을 발견하였다.

• Journal of Information Processing Systems
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• 제6권3호
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• pp.335-346
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• 2010

The present study investigates the difficulty of solving the mathematical problem, namely the DLP (Discrete Logarithm Problem) for ephemeral keys. The DLP is the basis for many public key cryptosystems. The ephemeral keys are used in such systems to ensure security. The DLP defined on a prime field $Z^*_p of random prime is considered in the present study. The most effective method to solve the DLP is the ICM (Index Calculus Method). In the present study, an efficient way of computing the DLP for ephemeral keys by using a new variant of the ICM when the factors of p-1 are known and small is proposed. The ICM has two steps, a pre-computation and an individual logarithm computation. The pre-computation step is to compute the logarithms of a subset of a group and the individual logarithm step is to find the DLP using the precomputed logarithms. Since the ephemeral keys are dynamic and change for every session, once the logarithms of a subset of a group are known, the DLP for the ephemeral key can be obtained using the individual logarithm step. Therefore, an efficient way of solving the individual logarithm step based on the newly proposed precomputation method is presented and the performance is analyzed using a comprehensive set of experiments. The ephemeral keys are also solved by using other methods, which are efficient on random primes, such as the Pohlig-Hellman method, the Van Oorschot method and the traditional individual logarithm step. The results are compared with the newly proposed individual logarithm step of the ICM. Also, the DLP of ephemeral keys used in a popular password key exchange protocol known as Chang and Chang are computed and reported to launch key recovery attack.

• 대한수의학회지
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• 제49권4호
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• pp.345-349
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• 2009

Polychlorinated biphenyls (PCBs) are synthetic organic compounds with two benzene rings and well known environmental pollutants. This study examined the effect of persistent exposure to 2,$3^{\prime}$,4,$4^{\prime}$,5-pentachlorobiphenyl (PCB118) on the proinflammatory and proapoptotic factors in male rats. Male Sprague Dawley rats were administered weekly intraperitoneal injections of either PCB118 (20 mg/kg) dissolved in corn oil or corn oil alone. One week after 2 and 5 administrations, the rats were sacrificed by a pentobarbital injection. The effect of PCB118 on the expression of cyclooxygenase 2 (COX-2), cytosolic phospholipase A2 (cPLA2), peroxisome proliferator-activated receptor gamma, Bcl and Bcl-2-associated X protein (BAX) was investigated. The level of COX-2 and cPLA2 expression was higher in the PCB118-treated rats than the control. These results suggest that PCB118 has a proinflammatory effect in rats.

• 한국전자통신학회논문지
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• 제11권7호
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• pp.693-700
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• 2016

현재 사용되고 있는 유한체 GF(q)위의 non-supersingular 타원곡선 이산대수문제에 기반한 공개키 암호법의 안전성을 보장하기 위해서는 타원곡선의 위수의 크기와 소인수의 크기를 계산하는 일이 매우 중요하다. 그런데 타원곡선의 위수를 구하는 전통적인 방법인 Schoof 알고리즘은 매우 복잡하여 지금도 개선작업이 진행중이다. 본 논문에서는 복잡한 Schoof 알고리즘을 피하기 위하여, 표수가 2인 유한체의 합성체$GF(2^m)=GF(2^{rs})=GF((2^r)^s)$ 위에서 Weil 정리를 이용하여 타원곡선의 위수를 계산하는 방법을 제안한다. 또한, 그에 따른 알고리즘과 그 알고리즘을 적용한 프로그램을 실행하여 타원곡선 암호법에 사용될 수 있는 효율적인 곡선으로 ${\sharp}E(GF(2^5))=36$일 때의 합성체 $GF(2^5)^{31})$ 위에서 위수에 $10^{40}$ 이상인 소인수를 포함하는 non-supersingular 타원곡선을 찾을 수 있었다.

• 한국대기환경학회지
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• 제30권5호
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• pp.423-433
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• 2014

This study examined the short-term variability of $CO_2$ concentrations measured at the Gosan site ($33^{\circ}17^{\prime}N$, $126^{\circ}10^{\prime}E$) in Jeju, Korea for the last 9 years from 2002 to 2010. The weekly distribution shows higher $CO_2$ concentrations during weekends than weekdays which implies the impact of local emissions because Jeju Island is one of the top tourist attraction in Korea. In diurnal variation, $CO_2$ concentration reached the maximum at 6 am and the minimum at 1 pm. The high $CO_2$ concentrations were mostly associated with lower wind speed (below 4 m/s) and easterlies, which was typical of summer night. In other seasons, however, the high concentrations were encountered under strong westerlies (8~16 m/s), which implies the influence of Chinese outflows. $CO_2$ concentrations were found to be highly correlated with meteorological parameters including wind speed, temperature, humidity, and solar radiation except for winter.